ライフサイエンスコーパス: denticle

1 t, give rise to odontoblasts of trunk dermal denticles.

2 uro (SoxN), cooperates with Svb to shape the denticles.

3 ion of Dachsous we can alter the polarity of denticles.

4 uired for proper maturation of the cuticular denticles.

5 uce either naked cuticle or trichomes called denticles.

6 ral extensions of the arista, and the larval denticles.

7 n filaments at the base of developing larval denticles.

8 variable substitution of naked cuticle with denticles.

9 o be important for the morphogenesis of both denticles and bristles.

10 Here we use the pattern of larval denticles and muscle attachments and ask how this patter

11 cells to secrete a characteristic pattern of denticles and naked cuticle that decorate the larval cut

12 We show that teeth and denticles are deeply homologous developmental modules wi

13 of continuous successional regeneration, new denticles arise only asynchronously with growth or after

14 llo mutant embryos secrete a lawn of ventral denticles; armadillo mutants also exhibit dorsal closure

15 based protrusions (ABPs; which comprise each denticle) at their posterior edge.

16 Teeth and denticles belong to a specialized class of mineralizing

17 ty of denticle types present in the anterior denticle belt and the smooth or naked cuticle constituti

18 acent denticle regions together to result in denticle belt fusions by stage 15.

19 les and specification of an eighth abdominal denticle belt.

20 quired for morphogenesis of normal abdominal denticle belts and maxillary mouth hooks, both Hox-depen

21 segmentally repeated pattern of alternating denticle belts and smooth cuticle: spitz group genes, wh

22 s, including loss and/or fusion of abdominal denticle belts and stripe-specific defects in pair-rule

23 Medial fusion of denticle belts is also a hallmark of spitz group genes,

24 The final pattern of the denticle belts is the product of this antagonism between

25 enticle, resulting in a segmental pattern of denticle belts separated by smooth, or 'naked', cuticle.

26 ence in shape between abdominal and thoracic denticle belts.

27 pe consisting of patches of naked cuticle in denticle belts.

28 pecification of naked cuticle separating the denticle belts.

29 Serrate, two genes expressed in prospective denticle belts.

30 ion of the odontode GRN from nonregenerating denticles by sox2+ progenitors native to the oral taste

31 g in a posterior direction specifies diverse denticle cell fates in the anterior portion of the adjac

32 encodes a transcription factor required for denticle construction.

33 We provide evidence that these denticles derive from a segmental zone of embryonic cell

34 svb (dovo) is required for epidermal cuticle/denticle differentiation and is genetically downstream o

35 ote naked cuticle cell fate but show reduced denticle diversity and dorsal patterning.

36 mooth cell fates, the signals that establish denticle diversity are unknown.

37 phenotype of wgPE2, an allele that produces denticle diversity but no naked cuticle.

38 In the abdominal epidermis, Serrate promotes denticle diversity by precisely localizing a single cell

39 diameters is required for the generation of denticle diversity, suggesting that intercellular transp

40 fied by a cellular pathway distinct from the denticle diversity-generating pathway.

41 al dermal skeleton consisting of tooth-like "denticles" embedded within their skin.

42 segment, there is a competition between the denticle fate specified by EGFR signalling and the naked

43 of EGFR signalling; high levels specify the denticle fate, while lower levels maintain smooth-cuticl

44 s that stimulate EGFR signalling, induce the denticle fate, while Wingless signalling antagonizes the

45 grailed-dependent signal specifying anterior denticle fates.

46 both smooth and denticle field cells during denticle field alignment.

47 he induction of stripe expression in certain denticle field cells appears to be the primary mechanism

48 , across the parasegment, on both smooth and denticle field cells during denticle field alignment.

49 this parasegment-wide polarity, prospective denticle field cells express an asymmetry, uniquely reco

50 expands, as judged by the expression of the denticle field determinant Ovo/Shaven baby.

51 If Serrate-Notch signaling is absent, the denticle field narrows while the smooth cell field expan

52 territory, which is to define the extent of denticle field specification.

53 Cells of the prospective denticle field, but not the adjacent smooth field, align

54 ctomyosin contractility, in combination with denticle-field-specific effectors, helps execute the cel

55 hanges the structure of actin bundles during denticle formation in ck mutants.

56 ch is sufficient to cell-autonomously direct denticle formation.

57 moving SoxN activity eliminated the residual denticles found in svb mutant embryos.

58 annot produce the morphological diversity of denticles found in wild-type belts.

59 orate the adult Drosophila epidermis and the denticles found on the embryo have been used in studies

60 autonomously and non-autonomously to specify denticle hook orientation via interaction with the micro

61 anism by which developmental pathways assign denticle hook orientation.

62 column-specific denticle pattern, including denticle hook orientation.

63 dentified cell that makes a forward-pointing denticle in the first larval stage may make a backward-p

64 st larval stage may make a backward-pointing denticle in the second and third larval stages.

65 that EGFR signalling specifies the anterior denticles in each segment of the larval abdomen.

66 isms directing development of teeth and skin denticles in sharks, where both odontode types are retai

67 targets to orchestrate the proper shaping of denticles in the Drosophila embryonic epidermis.

68 proportion of ray-finned fish teeth to shark denticles in the Paleocene.

69 he binary choice to produce naked cuticle or denticles is affected by the transcriptional regulation

70 eth, the principal skeletal tissue of dermal denticles is dentine.

71 ment, that we can change the polarity of the denticles made by larval cells as they progress between

72 We conclude that proper denticle morphogenesis requires transcriptional regulati

73 essing ectopic SoxN with svb rescued diverse denticle morphologies.

74 und, ck mutations do not significantly alter denticle morphology, suggesting a specific interaction w

75 Denticle number and spacing are reduced under space-limi

76 nd statistical modeling, we demonstrate that denticle number and spacing scale with cell length over

77 ogenic, and so the embryonic origin of trunk denticle odontoblasts remains unresolved.

78 cells to produce either a distinctly shaped denticle or no denticle, resulting in a segmental patter

79 junctional localization, but not its role in denticle organization, are recapitulated by mutations in

80 We present evidence that denticle orientation is determined almost entirely by Da

81 communities around the globe: Whereas shark denticles outnumber ray-finned fish teeth in Cretaceous

82 al activation function, no longer directs A1 denticle pattern in embryonic epidermal cells.

83 ehog are essential to the elaboration of the denticle pattern in the epidermis of Drosophila embryos.

84 This precise denticle pattern is conserved throughout all drosophilid

85 Instead, it mimics Antp in directing T2 denticle pattern, and it can rescue the cuticular loss-o

86 for multiple aspects of this column-specific denticle pattern, including denticle hook orientation.

87 ver, no single morphogen organises the whole denticle pattern.

88 Actin-rich denticle precursors cover the ventral surface of the Dro

89 r the planar polarized organization of actin denticle precursors, adherens junction proteins and micr

90 l target genes of SoxN that are expressed in denticle-producing cells and that are regulated independ

91 between stages 12 and 14, bringing adjacent denticle regions together to result in denticle belt fus

92 ce either a distinctly shaped denticle or no denticle, resulting in a segmental pattern of denticle b

93 ggest that the orientation of the individual denticle rows, in both the anterior compartment (which m

94 hat the relationship between cell length and denticle spacing can be recapitulated by specific mathem

95 ions in embryos and larvae and that accurate denticle spacing requires an intact microtubule network

96 l epithelium is essential for proper ventral denticle specification and this planar movement is disti

97 f Drosophila consist of six to seven rows of denticles that are oriented, some pointing forwards, som

98 ally alter the morphology of the hook-shaped denticles that decorate the ventral surface of the wg mu

99 y enriched in pseudopods, microvilli, axons, denticles, the border cell process, and other membrane p

100 ed to differentiate either smooth cuticle or denticle type cuticle.

101 al cells secrete a diverse array of anterior denticle types and a posterior expanse of naked cuticle;

102 s allows a reliable prediction of individual denticle types and polarity suggesting that contact-depe

103 ll-fate decisions: the production of diverse denticle types and the specification of naked cuticle se

104 ype intrasegmental pattern: the diversity of denticle types present in the anterior denticle belt and

105 ifferentiate into smooth cuticle or distinct denticle types.

106 In cells that do not produce denticles, Ubx-VP16 appears to have largely retained its

107 ls construct actin-based protrusions, called denticles, which exhibit stereotyped, column-specific di

108 ruptions that include replacement of ventral denticles with naked cuticle, which suggests that the mu