ライフサイエンスコーパス: denticola

1 in the flagellar assembly and motility of T. denticola.

2 (previously T. forsythensis), and Treponema denticola.

3 cherichia coli reporter constructs and in T. denticola.

4 the isolates showed cross-reactivity with T. denticola.

5 eneity four of the five PTS proteins from T. denticola.

6 were Fusobacterium nucleatum and Prevotella denticola.

7 play important roles in the virulence of T. denticola.

8 e first family includes the sequence from T. denticola.

9 was cloned from genomic DNA libraries of T. denticola.

10 is involved in the tissue penetration by T. denticola.

11 rmedia, Prevotella nigrescens, and Treponema denticola.

12 equently was performed to localize Msp in T. denticola.

13 ogy to the major sheath protein of Treponema denticola.

14 T. pallidum flaA gene from the plasmid in T. denticola.

15 twork in the biology and pathogenicity of T. denticola.

16 pact that TDE0214 has on the virulence of T. denticola.

17 , P. intermedia, T. forsythia, and Treponema denticola.

18 givalis, Tannerella forsythia, and Treponema denticola.

19 rom the pathogenic oral spirochete Treponema denticola.

20 onas micra, Filifactor alocis, and Treponema denticola.

21 ontribute to periodontal diseases (Treponema denticola)(1).

22 ingivalis, 3.41 (1.78, 6.58), P = 0.0003; T. denticola, 1.99 (0.992, 4.00), P = 0.052; T. forsythia,

23 n was investigated for P. gingivalis 381, T. denticola 35405, and mixtures of the two organisms using

24 alis 381 formed synergistic biofilms with T. denticola 35405.

25 ), Tannerella forsythia (98%/84%), Treponema denticola (94%/74%), Parvimonas micra (86%/62%), Campylo

26 d structure in the oral spirochete Treponema denticola, a keystone pathogen of periodontitis was repo

27 entified and include the anaerobe Prevotella denticola, a Lysobacter sp., and members of the Ricketts

28 Treponema denticola, a member of the subgingival biofilm at diseas

29 The oral spirochete Treponema denticola, a periodontal pathogen associated with human

30 Treponema denticola, a periodontal pathogen, is relatively resista

31 In Treponema denticola, a ribbon-like structure of cytoplasmic filame

32 Treponema denticola, a spirochete associated with periodontitis, i

33 Treponema denticola, a spirochete indigenous to the oral cavity, i

34 To reveal the role of c-di-GMP in T. denticola, a TDE0214 deletion mutant (TdDelta214) was co

35 hatidylcholine is a major phospholipid in T. denticola, accounting for 35-40% of total phospholipid.

36 ngivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and den

37 olecular patterns (PAMPs) responsible for T. denticola activation of the innate immune system are cur

38 T. denticola, along with Porphyromonas gingivalis and Bacte

39 While T. denticola also induced IL-6 and IL-8 production, these l

40 ontaneous coumermycin A1-resistant Treponema denticola, an Escherichia coli-T. denticola shuttle vect

41 Treponema denticola, an important contributor to periodontitis, ev

42 order to analyze the functions of LrrA in T. denticola, an lrrA-inactivated mutant of strain ATCC 354

43 nidase (TDE0471) was identified in Treponema denticola, an oral spirochaete associated with human per

44 hbB Ab can compete with FH for binding to T. denticola and block dentilisin-mediated FH cleavage.

45 ted with the extracytoplasmic fraction of T. denticola and expresses multifunctional properties.

46 Wild-type fliG genes from T. denticola and from Treponema pallidum were cloned into t

47 We examined the ability of Treponema denticola and its acylated outer membrane PrtP protease

48 T. denticola and its purified protease induced both MMP-2 a

49 the global regulatory networks of Treponema denticola and other oral spirochetes.

50 enables high-level expression of genes in T. denticola and possesses an efficient selectable marker t

51 e genetic regulatory mechanisms of Treponema denticola and present an overview of the possible roles

52 Treponema denticola and Prevotella intermedia (P = 0.01 and P = 0.

53 ciated Treponema spp. of the oral cavity (T. denticola and T. medium/T. vincentii) or genital area (T

54 In vitro growth of T. denticola and T. pectinovorum as a function of modificat

55 hal outcome following infection with both T. denticola and T. pectinovorum, suggesting an endotoxin-l

56 h protein (MOSP(N) and MOSP(C)) of Treponema denticola and that TprC(C) is solely responsible for bet

57 Wild-type T. denticola and the purified PF triggered activation of NF

58 he gene encoding trypsin-like activity in T. denticola and thus facilitate molecular-level studies of

59 The genomes of Treponema denticola and Treponema pallidum contain a gene, licCA,

60 e virulence of the oral treponemes Treponema denticola and Treponema pectinovorum.

61 ogs from the less invasive species Treponema denticola and Treponema phagedenis.

62 eful in studying the virulence factors of T. denticola and uncultivatible pathogenic spirochetes.

63 of mono-infection of the dental pulp with T. denticola and with polymicrobial "red-complex" organisms

64 includes Porphyromonas gingivalis, Treponema denticola, and "Tannerella forsythia" (opinion on name c

65 forsythia, Prevotella intermedia, Treponema denticola, and Aggregatibacter actinomycetemcomitans was

66 the MotB proteins of T. pallidum, Treponema denticola, and Borrelia burgdorferi have membrane topolo

67 ncluding Porphyromonas gingivalis, Treponema denticola, and Campylobacter rectus, were highest in pat

68 gingivalis, Tannerella forsythia, Treponema denticola, and Candida albicans.

69 enum, Porphyromonas endodontalis, Prevotella denticola, and Cryptobacterium curtum.

70 The plasmid was electroporated into T. denticola, and double-crossover recombinants which had t

71 ed to purify a 52-kDa CGase activity from T. denticola, and high pressure liquid chromatography elect

72 gingivalis, Tannerella forsythia, Treponema denticola, and Prevotella intermedia was evaluated quali

73 gingivalis, Tannerella forsythia, Treponema denticola, and Streptococcus oralis were measured with r

74 study we hypothesized that P. gingivalis, T. denticola, and T. forsythia are synergistic in terms of

75 st rats were infected with P. gingivalis, T. denticola, and T. forsythia as a consortium.

76 oE(-/-) mice infected with P. gingivalis, T. denticola, and T. forsythia as a polymicrobial infection

77 se results documented that P. gingivalis, T. denticola, and T. forsythia not only exist as a consorti

78 l parameters and levels of P. gingivalis, T. denticola, and T. forsythia, but not A. actinomycetemcom

79 found in Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythensis, to determine the

80 ation of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia and some evidence su

81 Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia are periodontal path

82 ted with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia for 12 weeks.

83 Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia have been strongly i

84 sting of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, as an oral lavage e

85 omitans, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, as well as Actinomy

86 vels of Gram-negative bacteria and Treponema denticola, and the prevalence of Porphyromonas gingivali

87 o induce a robust MCP-1 production, while T. denticola appeared to inhibit this activity of the fibro

88 l other pts genes in both T. pallidum and T. denticola are actively expressed, the primary sensory tr

89 hat regulate the inflammatory response to T. denticola are currently unresolved.

90 Both Porphyromonas gingivalis and Treponema denticola are frequently associated together in these or

91 l Treponema species, in particular Treponema denticola, are associated with the progression of human

92 , periodontal pathogens, including Treponema denticola, are believed to initiate the destructive infl

93 Spirochetes, including Treponema denticola, are implicated in the pathogenesis of periodo

94 a primary virulence determinant in Treponema denticola, as well as the parental ortholog for the Trep

95 presence of the periodontopathogen Treponema denticola, as well as with the clinical parameters of pe

96 revalence of Porphyromonas gingivalis and T. denticola associated significantly with ABL, whereas oth

97 , and the vector was transformed into the T. denticola ATCC 33520 flgE erythromycin-resistant knockou

98 gene, but the gene was not identified in T. denticola ATCC 33520.

99 ) mice (n = 24) were orally infected with T. denticola ATCC 35404 and were euthanized after 12 and 24

100 utation caused a reduction of swarming in T. denticola ATCC 35405 and consequently attenuated tissue

101 the rC-Msp fragment, blocked adhesion of T. denticola ATCC 35405 cells to a range of host protein mo

102 Southern blot analysis demonstrated that T. denticola ATCC 35405 expresses the lrrA gene, but the ge

103 tream from the previously isolated Treponema denticola ATCC 35405 prtB gene coding for a chymotrypsin

104 Wild-type T. denticola ATCC 35405 was found to penetrate the tissue l

105 d residues, has been identified in Treponema denticola ATCC 35405.

106 onstrated that hbpA is present in several T. denticola ATCC strains and clinical isolates, but not in

107 te 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated wit

108 rmedia, Prevotella nigrescens, and Treponema denticola before and following mechanical periodontal th

109 Nonetheless, we demonstrated that T. denticola binds significantly less hbetaD-2 and -3 than

110 Elevated salivary MMP-8 and T. denticola biofilm levels displayed robust combinatorial

111 The licCA gene was disrupted in T. denticola by erythromycin cassette mutagenesis, resultin

112 ase inhibitors did not enhance killing of T. denticola by h beta D-2, suggesting that degradation of

113 odifies the flagellin proteins (FlaBs) of T. denticola by O-linkage at multiple sites near the D1 dom

114 anisms responsible for the recognition of T. denticola by the innate immune system and the underlying

115 the purification and characterization of T. denticola CGase.

116 P-1 levels were significantly lower after T. denticola challenge, and the kinetics suggested that thi

117 Functional domains of the T. denticola CheA and CheY proteins are highly conserved wi

118 The Treponema denticola cheA gene, encoding the central kinase of the

119 rated the interrupted tap1 genes into the T. denticola chromosome, creating Tap1-deficient mutants.

120 The Treponema denticola chymotrypsin-like protease (CTLP) is implicate

121 ent in situ hybridization (FISH) revealed T. denticola clusters in both gingival and aortic tissue of

122 These results prove that T. denticola contains the entire three-step pathway to prod

123 ase was statistically significant for log T. denticola counts.

124 T. denticola Cpt catalyzed in vitro phosphatidylcholine for

125 T. denticola Cpt complemented a Saccharomyces cerevisiae CP

126 evealed that the TDE0143 deletion mutant (T. denticola DeltatbpA) had a decreased ability to transpor

127 The two known chemoreceptors of T. denticola, DmcA and DmcB, also appear to be involved in

128 T. denticola DNA was detected in the spleen, heart, and bra

129 Thus it appears that T. denticola does contain a licCA-dependent CDP-choline pat

130 Treponema denticola does not appear to produce siderophores, so it

131 Treponema pallidum and Treponema denticola encode within their genomes homologues of ener

132 on with the two other previously purified T. denticola enzymes, gamma-glutamyltransferase and cystaly

133 The gene encoding the Treponema denticola factor H-like protein 1 (FHL-1) binding protei

134 In this report, the structure of the T. denticola FH-binding protein, FhbB, was solved to 1.7 A

135 The Treponema denticola FhbB protein contributes to immune evasion by

136 in 381 rgpB and fimA genes as well as the T. denticola flgE and cfpA genes.

137 The complete T. denticola flgE gene was cloned into the shuttle vector p

138 Here, we show that T. denticola FlgE self-catalyses an interpeptide crosslinki

139 ics of humoral immune responses to Treponema denticola following primary infection, reinfection, and

140 TDE0471 protects T.denticola from serum killing by preventing the depositio

141 cter species, Eikenella corrodens, Treponema denticola, Gemella haemolysans, Granulicatella adiacens,

142 ence of a predicted 52-kDa protein in the T. denticola genome data base.

143 The T. denticola genome is considerably larger in size than the

144 Analysis of the T. denticola genome reveals factors mediating coaggregation

145 in an apparently noncoding region of the T. denticola genome unannotated contigs.

146 oplasmic protein encoded in the annotated T. denticola genome.

147 T. denticola genomic DNA was detected in oral plaque sample

148 T. denticola grown in a serum-free medium did not exhibit i

149 Treponema denticola harbours a genetic locus with significant homo

150 Indeed, T. denticola has been shown to have an iron-regulated 44-kD

151 Based on these results, we propose that T.denticola has evolved a strategy to scavenge host sialic

152 The results indicate that T. denticola has high pathogenicity, including disseminatio

153 Thus, T. denticola has two novel hemin binding proteins which may

154 ivalis, Bacteroides forsythus, and Treponema denticola in 150 children and adolescents, 4 to 16 years

155 ngivalis in 15%, B. forsythus in 14%, and T. denticola in 18% of all subjects.

156 High levels of Treponema denticola in subgingival dental plaque are associated wi

157 (previously T. forsythensis), and Treponema denticola in the plaque.

158 nas gingivalis, Tannerella forsythia, and T. denticola) in inducing disseminating infections in wild-

159 In this study, we demonstrate that T. denticola induces innate immune responses via the utiliz

160 T. denticola-infected mice had higher levels of horizontal

161 T. denticola infection altered the expression of genes know

162 riodontal disease induced by chronic oral T. denticola infection and atherosclerosis in hyperlipidemi

163 ies confirm a causal link for active oral T. denticola infection with both atheroma and periodontal d

164 cificity, were not capable of resolving a T. denticola infection.

165 tease, dentilisin, is not responsible for T. denticola insensitivity to defensins and examined severa

166 y of outer membrane complexes involved in T. denticola interaction with host cells and tissue.

167 Treponema denticola is a consensus periodontal pathogen that has r

168 Treponema denticola is a predominantly subgingival oral spirochete

169 Treponema denticola is an important contributor to periodontal dis

170 The oral spirochete Treponema denticola is an important pathogen that is associated wi

171 Treponema denticola is an indigenous oral spirochete that inhabits

172 T. denticola is closely associated with periodontal disease

173 ajor sheath (or surface) protein (Msp) of T. denticola is implicated in adhesion of bacteria to host

174 nd a gold drug, auranofin, against Treponema denticola is mediated through inhibition of the metaboli

175 We showed that T. denticola is resistant to h beta D-1 and -2.

176 be widely distributed and conserved among T. denticola isolates.

177 The spirochete dental pathogen Treponema denticola lacks a purK gene and contains a class II purE

178 Because T. denticola lacks lipopolysaccharides that serve as target

179 CPT1 mutant, and expression of the entire T. denticola LicCA-Cpt pathway in E. coli resulted in phosp

180 e), and group 3 (Treponema putidum/Treponema denticola-like) were present in 96.1%, 98%, and 76.5% of

181 opathic to host cells, and FhbB, a unique T. denticola lipoprotein that binds complement regulatory p

182 severely reduced, indicating that CheA in T. denticola mainly controls cellular reversal and that act

183 genome encodes 12 orthologs of the Treponema denticola major sheath protein (Msp) prompted us to reex

184 n localization and oligomerization of the T. denticola major surface protein (Msp).

185 the unusual outer membrane composition of T. denticola may discourage cationic peptide binding.

186 that ERK1/2 and p38 play a major role in T. denticola-mediated pro- and anti-inflammatory cytokine p

187 the primary function of FHL-1 binding by T. denticola might be to facilitate adherence to FHL-1 pres

188 to help assess the role of fliG in Treponema denticola motility.

189 h antibodies (above the median) to Treponema denticola (odds ratio [OR]=1.7; 95% CI, 1.2 to 2.3), Pre

190 An isogenic T. denticola opdB mutant was constructed by allelic replace

191 In contrast, growth of T. denticola or T. pectinovorum under iron-limiting conditi

192 3); and P. gingivalis, P. nigrescens, and T. denticola (OR 2.59); with severe periodontitis (OR 4.65)

193 1); and P. gingivalis, P. nigrescens, and T. denticola (OR 2.70) with the clinical diagnosis of sligh

194 6); and P. gingivalis, P. nigrescens, and T. denticola (OR 3.29).

195 R 4.17); P. gingivalis, B. forsythus, and T. denticola (OR 4.06); and P. gingivalis, P. nigrescens, a

196 B. forsythus (OR 3.84); P. gingivalis and T. denticola (OR 4.17); P. gingivalis, B. forsythus, and T.

197 P. gingivalis (OR = 1.12, 0.67-1.88) and T. denticola (OR = 1.34, 0.83-2.12) measured in plaque.

198 to 7.03), but at lower risk for carrying T. denticola (OR, 0.42; 95% CI, 0.17 to 0.98).

199 were infected with either P. gingivalis, T. denticola, or T. forsythia in monomicrobial infections o

200 athione metabolism in the oral spirochete T. denticola; our results suggest that glutathione metaboli

201 belief that Msp forms an array within the T. denticola outer membrane and demonstrate, instead, that

202 reas freeze-fracture EM revealed that the T. denticola outer membrane contains heterogeneous transmem

203 The Treponema denticola outer membrane lipoprotein-protease complex (d

204 hete, contains 12 orthologs of the Treponema denticola outer membrane major sheath protein has engend

205 ether Msp forms an array on or within the T. denticola outer membrane.

206 Age, PBI, and presence of Treponema denticola (P <0.03) are related to periodontal condition

207 ey pathogens P. gingivalis, T. forsythia, T. denticola, P. micra, C. rectus, and E. nodatum show stat

208 nificant for P. gingivalis, T. forsythia, T. denticola, P. micra, C. rectus, and E. nodatum.

209 T. denticola parent and isogenic mutant strains, as well as

210 ding the contribution of FHL-1 binding in T. denticola pathogenesis and in development of periodontal

211 g the potential causative role of chronic T. denticola periodontal infection and vascular atheroscler

212 study, we investigated the role played by T. denticola periplasmic flagella (PF), unique motility org

213 of production of another phospholipid in T. denticola, phosphatidylethanolamine, was elevated consid

214 vances our understanding of the role that T. denticola plays in the development and progression of pe

215 the cellular location and topology of the T. denticola polypeptide.

216 Those included Treponema denticola, Porphyromonas gingivalis, Tannerella forsythi

217 Our findings show that T. denticola possesses a unique phosphatidylcholine synthes

218 A novel gene was identified in the Treponema denticola prcA-prtP protease operon.

219 2/1 and TLR2/6 heterodimers revealed that T. denticola predominantly utilizes TLR2/6 for the inductio

220 nt mutants of T. denticola, we found that T. denticola preferentially binds FH and not FHL-1, and tha

221 T. denticola produces a number of virulence factors, includ

222 The periodontal pathogen Treponema denticola produces dentilisin, a serine protease of the

223 thione by the periodontal pathogen Treponema denticola produces hydrogen sulfide, which may play a ro

224 suggest a specific mechanism by which the T. denticola protease may disrupt homeostatic processes req

225 Cleavage of FH by the T. denticola protease, dentilisin, may contribute to the lo

226 Bound FH is rapidly cleaved by the T. denticola protease, dentilisin.

227 methods, we previously demonstrated that T. denticola proteases are not responsible for decreased vu

228 ptidases, the preferred substrate for the T. denticola protein is Cys-Gly (k cat/Km of 8.2 microm(-1)

229 uch as Porphyromonas gingivalis or Treponema denticola) provided highly accurate predictions of perio

230 We demonstrate that T. denticola PurE (TdPurE) is AIR carboxylase, the first ex

231 In the human pathogen T. denticola, purine biosynthesis should depend on availabl

232 ia (formally T. forsythensis), and Treponema denticola relative to 40 oral bacteria at each test site

233 onemal proteases is not a major factor in T. denticola resistance.

234 -T. denticola shuttle vector that renders T. denticola resistant to coumermycin was constructed.

235 Moreover, the enzymatic activity(ies) in T. denticola responsible for glutathione breakdown was inac

236 Allelic replacement mutagenesis of cpt in T. denticola resulted in abrogation of phosphatidylcholine

237 Immunofluorescence analysis of intact T. denticola revealed that only MOSP(C) contains surface-ex

238 ides in other bacteria, and their role in T. denticola's relative resistance to beta-defensins was in

239 de which enters the cytoplasm may explain T. denticola's relative resistance to human beta-defensins.

240 sette (ABC) efflux pumps had no effect on T. denticola's susceptibility to hbetaD-2 or -3.

241 Nonpolar deletion of prcB in T. denticola showed that PrcB is required for production of

242 truction of a new Escherichia coli-Treponema denticola shuttle vector based on the naturally occurrin

243 Treponema denticola, an Escherichia coli-T. denticola shuttle vector that renders T. denticola resis

244 a, Prevotella intermedia (Pi), and Treponema denticola significantly more in group A than group B.

245 Here we demonstrate that T. denticola specifically binds FHL-1 via a 14-kDa, surface

246 Wild-type T. denticola stimulated the production of the cytokines tum

247 rotein kinase (MAPK) signaling pathway in T. denticola-stimulated monocytes identified a prolonged up

248 These findings suggest that T. denticola stimulates the innate immune system in a TLR2-

249 Previous studies have indicated that T. denticola stimulates the innate immune system through To

250 imulate, and the complemented PF-positive T. denticola strain restored the activation.

251 were challenged with T. pectinovorum and T. denticola strains, and the supernatants were analyzed fo

252 P. gingivalis 381, but not T. denticola strains, formed biofilms in vitro.

253 synergistic biofilms when incubated with T. denticola strains.

254 The prcB gene is conserved in T. denticola strains.

255 gingivalis, Tannerella forsythia, Treponema denticola, Streptococcus oralis, and Actinomyces naeslun

256 The Treponema denticola surface protease complex, consisting of PrtP p

257 Using published peptide sequences of a T. denticola surface-associated oligopeptidase with BANA-hy

258 Treponema denticola synthesizes phosphatidylcholine through a licC

259 PDD-associated Treponema isolates and in T. denticola, T. medium, and T. phagedenis.

260 comparative purposes, one strain each of T. denticola, T. medium, T. vincentii, and T. phagedenis.

261 ty with the partial sequence of CfpA from T. denticola, T. vincentii, and T. pallidum subsp. pertenue

262 mitans), Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia (previously T. forsythen

263 omitans, Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Actinomyces naeslun

264 Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Aggregatibacter act

265 rtium of Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Fusobacterium nucle

266 T. denticola tap1 and flanking DNA were identified, cloned,

267 he nucleotide (nt) sequence of the Treponema denticola (Td) DNA gyrase beta-subunit gene (gyrB) has b

268 Prevotella intermedia and Treponema denticola (Td) levels were lower in the mucositis group

269 g), Tannerella forsythia (Tf), and Treponema denticola (Td) was performed using real-time polymerase

270 A chemotaxis gene cluster from Treponema denticola (Td), a pathogenic spirochete associated with

271 s (Pg), Tannerella forsythia (Tf), Treponema denticola (Td), and Dialister pneumosintes were determin

272 (Pg), Prevotella intermedia (Pi), Treponema denticola (Td), and Escherichia coli using reverse trans

273 the air-sensitive oral spirochete, Treponema denticola (Td), is a principal enzymatic scavenger of su

274 onstituent of the cell envelope of Treponema denticola (TDE) and one of its principal virulence deter

275 the trans-enoyl-CoA reductase from Treponema denticola (tdTer), which has been utilized for the engin

276 two-component regulatory system (TCS) of T. denticola that is formed by the products of open reading

277 thway of glutathione metabolism in Treponema denticola that releases H(2)S.

278 this study we investigated the ability of T. denticola to bind the complement regulatory proteins fac

279 m human serum proteins; it is required for T.denticola to grow in a medium that mimics gingival crevi

280 ydrazone, increased the susceptibility of T. denticola to killing by hbetaD-3, demonstrating a potent

281 iety of thiol compounds as substrates for T. denticola to produce H(2)S.

282 ability of FHL-1 bound to the surface of T. denticola to serve as a cofactor for factor I-mediated c

283 ed with Treponema pectinovorum and Treponema denticola to test three specific hypotheses: (i) these t

284 ed to detect Treponema amylovorum, Treponema denticola, Treponema maltophilum, Treponema medium, Trep

285 ingly, unlike the T. pallidum orthologue, T. denticola TroR (TroR(Td)) possesses a C-terminal Src hom

286 disease-associated oral spirochete Treponema denticola using an oral epithelial cell line-based exper

287 T. denticola virulence, as evaluated by lesion size, was in

288 rodens, Bacteroides forsythus, and Treponema denticola was investigated in 25 smokers and 25 non-smok

289 em to generate specific mutants in Treponema denticola was utilized to determine if Tap1 was essentia

290 Importantly, GNA, when added to T. denticola, was able to compete with glutathione and inhi

291 by using dentilisin-deficient mutants of T. denticola, we found that T. denticola preferentially bin

292 givalis, Tannerella forsythia, and Treponema denticola were determined using RT-PCR.

293 ivalis, Bacteroides forsythus, and Treponema denticola were identified from multiple subjects, but ty

294 givalis, P. intermedia, T. forsythia, and T. denticola were more prevalent in CP; however, their mere

295 ix months after SRP, the counts of Treponema denticola were significantly reduced in both groups (bot

296 observed in SCID mice mono-infected with T. denticola, whereas abscesses were rare in SCID mice infe

297 st that the dmcB gene codes for an MCP in T. denticola which may interact with other MCPs in these or

298 We have cloned the gene of GGT from T. denticola, which contains an open reading frame of 726 b

299 used in future studies of interactions of T. denticola with host cells and tissue.

300 in (h beta D) binding, we postulated that T. denticola would resist killing by h beta D.