ライフサイエンスコーパス: dentin

1 sion; control]) and 2 substrates (enamel and dentin).

2 r content and a different micro-structure of dentin.

3 al ligament and cementum to expose the tooth dentin.

4 P scaffold, despite being separated from the dentin.

5 hypophosphatemia and defects in the bone and dentin.

6 mplex, tough, and damage-tolerant coating on dentin.

7 procedure that aims to regenerate reparative dentin.

8 t for the formation and regeneration of root dentin.

9 se was increased in Res.A- and Res.B-treated dentin.

10 ing incremental lines of deposition in tooth dentin.

11 plays a major role in the mineralization of dentin.

12 erns that easily abrades from the underlying dentin.

13 in (DSPP) are essential for the formation of dentin.

14 22-29% of the variability of Mn in prenatal dentin.

15 s (DPSCs), which are capable of regenerating dentin.

16 dation and remineralization of demineralized dentin.

17 omato(+) cells to cells secreting reparative dentin.

18 to stimulate the regeneration of reparative dentin.

19 tal defects but featured less affected molar dentin.

20 e ( P = 0.002), with no changes in enamel or dentin.

21 g self-etch and universal adhesives to human dentin.

22 erosion-abrasion lesions on human enamel and dentin.

23 Dentin, a major tooth component, is formed by odontoblas

24 applied in the self-etch mode on midcoronal dentin according to the respective manufacturer's instru

25 phobic- and hydrophilic-rich phase mimics of dentin adhesive polymerize similarly and 2) to determine

26 Current dentin adhesives are sensitive to moisture, as evidenced

27 Dentin adhesives were applied to the surface of sound de

28 ate the hydraulic conductance of bovine root dentin after irradiation with a 980-nm diode laser, with

29 ptical microscopic analyses showed defective dentin, alveolar and calvarial bones, and sutures during

30 sr2-Cre;Fam20C(fl/fl) mice showed remarkable dentin and alveolar bone defects, while their enamel did

31 d biochemical techniques to characterize the dentin and alveolar bone of Dmp1 KO/DSPP Tg mice compare

32 e enamel and ameloblast defects, while their dentin and alveolar bone were not significantly affected

33 the craniofacial mesenchymal cells that form dentin and alveolar bone.

34 er of enamel-like material remained over the dentin and at the outer tooth surface, but between these

35 f the future root, differentiate and secrete dentin and cementum.

36 Enzymes of both families are present in dentin and collectively capable of degrading virtually a

37 ion of the Wnt/beta-catenin pathway; Sost in dentin and Dkk1 in bone, as previously demonstrated.

38 ves the caries resistance property of bonded dentin and does not cause irreversible pulpal damage to

39 ich Fam20C was ubiquitously inactivated, had dentin and enamel defects as well as hypophosphatemic ri

40 We analyzed Mn in dentin and enamel of shed teeth; maternal, cord, and chi

41 ckened dentin and enhanced mineralization of dentin and enamel toward the apical end.

42 These bioengineered teeth contain dentin and enamel with ameloblast-like cells and rests o

43 Significant production of organized dentin and enamel-like tissues was observed in dTB-recel

44 lved phosphorus content of mineral tissue in dentin and enamel; they show a lack of signal from pulp

45 which likely leads to the observed thickened dentin and enhanced mineralization of dentin and enamel

46 re no significant correlations between Mn in dentin and Mn concentrations in maternal blood or matern

47 rospects related to the regeneration of both dentin and pulp tissue and, more recently, to root canal

48 in mechanical properties of caries-affected dentin and reduce the ability of caries-affected dentin

49 when MDP scaffolds are intercalated between dentin and the odontoblast region, a finding that has si

50 toblasts, the predentin, and the mineralized dentin, and MMP9 was able to specifically bind to DSP.

51 ronment, erodes hydroxyapatite in enamel and dentin, and promotes hydrolysis of the adhesive.

52 ne cathepsins present in saliva, mineralized dentin, and/or dentinal fluid may affect the dentin cari

53 g decreased dentin mineral density, abnormal dentin architecture, widened predentin and irregular pre

54 Root-dentin area showed significant increases in type III, bu

55 d odontoblast-like cells organized along the dentin, as assessed by immunostaining for nestin and den

56 The amount of dentin-associated mineralized tissue formed in teeth wit

57 Dentin beams were totally demineralized in H3PO4 (10%) a

58 The findings provide clear evidence that the dentin bioactivities of PACs are source dependent, resul

59 Dentin biomodification was assessed by the modulus of el

60 rrangement, and chemical properties of three dentin biomodifiers.

61 ation over time and the improvement of resin-dentin bond durability.

62 tance potential of acid-etched human coronal dentin bonded using augmented pressure adhesive displace

63 gic temperature-to improve the durability of dentin bonding by addressing these 3 issues simultaneous

64 Thus, the longevity of dentin bonding can only be improved with enhanced qualit

65 toration is unsatisfactory, and longevity of dentin bonding is one of the major culprits.

66 mproving a number of critical properties for dentin bonding, including deactivation of oral pathogens

67 a mechanism for improving bond longevity in dentin bonding.

68 ions were also observed for ABCG2, PKD2, the dentin/bone SCPP sub-family, EDNRA, TJFBR1, NKX2-3, IFT8

69 e, widened predentin and irregular predentin-dentin boundary.

70 nd bioactive pulp-capping materials, driving dentin bridge formation without causing cytotoxic effect

71 Dentin can be described as a biological composite with c

72 in dentin, mainly focusing on their role in dentin caries pathogenesis and loss of collagen in the a

73 dentin, and/or dentinal fluid may affect the dentin caries process at the early phases of demineraliz

74 enamel lesions (CAE), and caries active with dentin carious lesions (CA).

75 PF) and from enamel carious lesions (PE) and dentin carious lesions (PD) were collected.

76 oanthocyanidins, could protect demineralized dentin collagen from collagenolytic activities following

77 sec of GSE treatment rendered demineralized dentin collagen inert to bacterial collagenase digestion

78 post-digestion morphology of an acid-etched dentin collagen layer that underwent PA treatment for ti

79 t potential for the regeneration of the pulp-dentin complex, particularly in necrotic, immature perma

80 d in the functional regeneration of the pulp-dentin complex.

81 Levels of Mn measured in tooth dentin constitute a promising biomarker of perinatal exp

82 ic linkage, and suggest their involvement in dentin cross-linking activity.

83 2-Cre;Fam20C(fl/fl) mice were independent of dentin defects and hypophosphatemia.

84 arity 20-C (FAM20C) were associated with the dentin defects and whether hypophosphatemia in the knock

85 To determine if the dentin defects in the Sox2-Cre;Fam20C(fl/fl) mice were a

86 These results indicate that the dentin defects in the Sox2-Cre;Fam20C(fl/fl) mice were i

87 There were no differences in enamel and dentin densities between GACI and control teeth.

88 Although the formation of bones and dentin depends on the self-assembly of type I collagen v

89 mice, potentially resulting from defects in dentin deposition and ameloblast differentiation.

90 esis with osteodentin formation and impaired dentin deposition leading to limited root elongation.

91 tivate the morphogen on-demand and to induce dentin differentiation solely within that specific spati

92 hesives were applied to the surface of sound dentin disks in 4 experimental groups: non-antibacterial

93 Remineralization of dentin during dental caries is of considerable clinical

94 iquitously inactivated had severe defects in dentin, enamel, and bone, along with hypophosphatemia.

95 opic ossicles in vivo with ultrastructure of dentin, enamel, cementum, and bone.

96 riginal position defines the location of the dentin-enamel junction (DEJ) in mature teeth.

97 ed on this positive result, the simultaneous dentin etching and collagen protecting of GSE-containing

98 ap progress could be seen on both enamel and dentin even after irradiation; furthermore, typical toro

99 Dentin sialophosphoprotein (DSPP) is a dentin extracellular matrix protein that is processed in

100 Dentin sialoprotein (DSP) is a dentin extracellular matrix protein.

101 st acidic protein found predominantly in the dentin extracellular matrix.

102 DSPP has never been isolated or detected in dentin extracts.

103 ppeared as a bright scattered area mainly on dentin floor and rapidly progressed along the cavity flo

104 ypical toroidal gap patterns appeared at the dentin floor of BF and SBU.

105 ed nearly perfect sealing performance on the dentin floor up to the 10 min that images were recorded.

106 Experimental primers were applied to dentin for 20 s, covered with hydrophobic resin layer, a

107 Studies on crown dentin formation have been a major focus in tooth develo

108 e EphB2/ephrinB1 system that govern tertiary dentin formation in vitro and in vivo.

109 n potently stimulate and expedite reparative dentin formation is still underexplored.

110 al factor) in controlling root but not crown dentin formation points to a new concept: tooth crown an

111 lved in dental mesenchymal cell lineages and dentin formation through regulation of its target gene e

112 To understand the role of Osx in dentin formation, we analyzed mice in which Osx was subj

113 Initial crown dentin formation-primary dentinogenesis-occurred fairly

114 ese materials is known to mediate reparative dentin formation.

115 functions in odontoblast differentiation and dentin formation.

116 e a therapeutic target to enhance reparative dentin formation.

117 sruptions in odontoblast differentiation and dentin formation.

118 DSP mutations cause dentin genetic diseases.

119 higher Mn levels in prenatal than postnatal dentin (geometric mean (GM) = 0.51 vs 0.16 Mn:Ca, p < 0.

120 is processed into dentin sialoprotein (DSP), dentin glycoprotein (DGP) and dentin phosphoprotein (DPP

121 3 parts: dentin sialoprotein (DSP), DPP, and dentin glycoprotein (DGP).

122 tin sialoprotein, dentin phosphoprotein, and dentin glycoprotein.

123 The dentin hydraulic conductance was evaluated at four time

124 dentin promoted significant reduction in the dentin hydraulic conductance, mainly with higher energy

125 ated with patient discomfort due to cervical dentin hypersensitivity (CDH) and esthetic dissatisfacti

126 Dentin hypersensitivity (DH) is a clinical condition wit

127 Dentin hypersensitivity (DH) is a painful, exaggerated r

128 life of patients 180 days after treatment of dentin hypersensitivity (DH) with laser and cyanoacrylat

129 izing dentifrices to provide rapid relief of dentin hypersensitivity (DH).

130 chanical or thermal stimulation that induces dentin hypersensitivity and dental pain and if pannexin

131 Thus, ATP signaling may participate in dentin hypersensitivity and dental pain.

132 upport a plausible role for ATP signaling in dentin hypersensitivity and dental pain.

133 Dentin hypersensitivity treatments are based on the phys

134 g supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding.

135 ar mineralization pattern characteristic for dentin in hypophosphatemic rickets.

136 Dentin in permanent teeth rarely undergoes resorption in

137 fferentiation of lesions for both enamel and dentin in polished or natural surfaces.

138 Furthermore, the interradicular dentin in these mice showed severe hypoplastic features,

139 echanical or cold stimulation to the exposed dentin induced ATP release in an in vitro human tooth pe

140 F, and SB had significantly lower enamel and dentin initial gaps than the control and GB (P < 0.05).

141 esin polymerization, improvement in adhesive-dentin interactions, and establishment of auxiliary bond

142 in the 10% and 5% 10-MDP experimental primer-dentin interface along with lower intensity XRD peaks.

143 The percentages of sealed enamel and dentin interface area (E%, D%) were calculated using Ami

144 Slices containing the adhesive-dentin interface were covered with fluorescein-conjugate

145 etermine the extent of nanolayering in resin-dentin interfaces after application of commercialized 10

146 ering structures have been reported in resin-dentin interfaces created by adhesives that contain 10-m

147 The sparsity of nanolayering in resin-dentin interfaces created by commercialized adhesives ch

148 tion/cavitation but no clinical/radiographic dentin involvement, 12% (95% CI, 6%-22%) of dentists/the

149 ne, increasing to 74% (95% CI, 56%-86%) with dentin involvement.

150 ) to enhance the biomechanical properties of dentin involves collagen cross-linking of the 1.3-4.5 nm

151 The major phosphoprotein in dentin is the aspartic acid and serine-rich protein call

152 confined to enamel (not reaching the enamel-dentin junction), 21% (95% confidence interval [CI], 15%

153 proximal lesions extending up to the enamel-dentin junction, 48% (95% CI, 40%-56%) of dentists/thera

154 se confined to enamel or reaching the enamel-dentin junction.

155 sease, including short molar roots with thin dentin, lack of acellular cementum, and osteoid accumula

156 SP and BF dentin lesions were significantly different from GB and

157 e intermolecular interactions in biomodified dentin macromolecules.

158 escribes these enzymes and their presence in dentin, mainly focusing on their role in dentin caries p

159 nd 10,000 thermal cycles, gaps at enamel and dentin margins were measured at 8 locations on cross-sec

160 d grape seed extract [e-GSE]) and applied to dentin matrices to determine changes to the mechanical p

161 he stiffness of the completely demineralized dentin matrices.

162 onal expression of osterix, osteocalcin, and dentin matrix acidic phosphoprotein 1.

163 certained when coated on collagenase-treated dentin matrix and control, native human dentin matrix un

164 nical properties and biodegradability of the dentin matrix and favorable resin adhesion mechanisms.

165 at multiscale interactions of OPACs with the dentin matrix create tight biointerfaces with hydrophobi

166 is showed that in Tgfbr2(cko) mice radicular dentin matrix density was reduced in the molars.

167 The e-GSE-modified dentin matrix exhibited remarkably low collagen solubili

168 We used dentin matrix protein (Dmp)-1-mediated Ghr knockout (DMP

169 For example, mutations in dentin matrix protein 1 (DMP-1) result in increased FGF2

170 Dentin matrix protein 1 (DMP1) and dentin sialophosphopr

171 Dentin matrix protein 1 (DMP1) is a non-collagenous calc

172 regulates mineral homeostasis by repressing dentin matrix protein 1 (DMP1) via the vitamin D recepto

173 such as osteocalcin, bone sialoprotein, and dentin matrix protein 1 (DMP1) was also suppressed.

174 ng revealed more abundant osteopontin (OPN), dentin matrix protein 1 (DMP1), and matrix extracellular

175 collagen (procollagen I) and a reduction in dentin matrix protein 1 (DMP1), which is partially respo

176 These mice were bred with a dentin matrix protein 1 (DMP1)-Cre line for overexpressi

177 The altered levels of dentin matrix protein 1 and osteopontin in Fam20C-defici

178 Dmp1 (dentin matrix protein 1), Dkk1 (Dickkopf WNT signaling p

179 e Fam20C-deficient bone had a lower level of dentin matrix protein 1, and higher levels of osteoponti

180 bone, reduced processing of procollagen and dentin matrix protein 1, remarkably high bone turnover a

181 BLINGs): bone sialoprotein, osteopontin, and dentin matrix protein 1, respectively.

182 phosphorylated full-length human recombinant dentin matrix protein-1 (17-513 AA), this bioinspired ap

183 of SLRPs (asporin, lumican, and decorin) and dentin matrix protein-1 (DMP1, a mechanosensory/osteocyt

184 d into osteopontin-, bone sialoprotein-, and dentin matrix protein-1-enriched fractions by anion-exch

185 ated dentin matrix and control, native human dentin matrix under physiological levels of calcium and

186 nvolves physicochemical modifications to the dentin matrix, reduced tissue biodegradation, and bridgi

187 elastic-like behavior of the e-GSE-modified dentin matrix, which was not affected by H-bond destabil

188 s critical for mineral deposition within the dentin matrix.

189 ll-defined tooth structures with mineralized dentin matrix.

190 amounts of these products are present in the dentin matrix.

191 nd dentin with high expression levels in the dentin matrix.

192 nes and stage-specific proteases involved in dentin maturation.

193 ted if ATP is released from dental pulp upon dentin mechanical or thermal stimulation that induces de

194 Dentin-methacrylate biointerfaces with robust and stable

195 c and dynamic nanomechanical analyses, resin-dentin microtensile bond strength, and micropermeability

196 ntinogenesis imperfecta, including decreased dentin mineral density, abnormal dentin architecture, wi

197 odontoblasts that functions in skeletal and dentin mineralization by initiating deposition of hydrox

198 This suggests that the Dspp-independent dentin mineralization defects in Trps1-Tg mice are a res

199 ichondrium in Trps1 mutant mice and impaired dentin mineralization in Col1a1-Trps1 transgenic mice, i

200 n of the dentin volume and no improvement of dentin mineralization in double transgenic mice in compa

201 Normal dentin mineralization requires two highly acidic protein

202 in the structure of intramembranous bone and dentin mineralization using 3 different age groups of DS

203 d a preodontoblastic cell line as a model of dentin mineralization.

204 ompatibility, and bonding characteristics to dentin of a unique doxycycline (DOX)-encapsulated halloy

205 In addition, dentin of double-Tg mice has an irregular mineralization

206 ithin genes expressed in both the enamel and dentin of teeth of other vertebrate species, indicating

207 at the interface of the odontoblasts and the dentin or into the pulp core of mandible slices and subs

208 associated with higher Mn levels in prenatal dentin (p < 0.05).

209 of NF-kappaB-transgenic double mutants, the dentin phenotype, notably in the roots, was rescued and

210 In this study we demonstrate that dentin phosphophoryn (DPP) is internalized by several ce

211 aspartic acid and serine-rich protein called dentin phosphophoryn (DPP).

212 Dentin phosphophoryn is nature's most acidic protein fou

213 Dentin phosphoprotein (DPP) is the most abundant noncoll

214 protein (DSP), dentin glycoprotein (DGP) and dentin phosphoprotein (DPP).

215 sphoprotein (DSPP) into dentin sialoprotein, dentin phosphoprotein, and dentin glycoprotein.

216 Levels of Mn in prenatal dentin, prenatal maternal blood, and 24 month urine were

217 Laser irradiation of exposed dentin promoted significant reduction in the dentin hydr

218 el, comprehensively evaluate their effect on dentin properties.

219 hat DSP may serve as a therapeutic agent for dentin-pulp complex regeneration in dental caries.

220 elopment of the calvaria, alveolar bone, and dentin-pulp complex.

221 regeneration, which may be useful in future dentin-pulp engineering strategies that target fibroblas

222 e used as permanent filling materials at the dentin-pulp interface in direct contact with irreversibl

223 Dentin-pulp regeneration is closely linked to the presen

224 Because dentin-pulp regeneration is known to be regulated locall

225 ve and incipient interventions targeting the dentin-pulp regeneration process by linking the neurite

226 mechanism in one of the initial steps of the dentin-pulp regeneration process, linking pulp fibroblas

227 tic tool in targeting the fibroblasts in the dentin-pulp regeneration process.

228 ic strategy of targeting pulp fibroblasts in dentin-pulp regeneration.

229 g beneath carious injury, a critical step in dentin-pulp regeneration.

230 g that intact IP-DPSCs may be inadequate for dentin/pulp regeneration.

231 (IP-DPSCs) are considered to be suitable for dentin/pulp regeneration.

232 osuppressive functions of IP-DPSCs to enable dentin/pulp regeneration.

233 ndicate a promising therapeutic strategy for dentin/pulp tissue engineering in future endodontic trea

234 be a promising new therapeutic strategy for dentin/pulp tissue engineering in future endodontic trea

235 which was stronger in enamel (r = 0.63) than dentin (r = 0.35).

236 -4 (and caries less than halfway through the dentin, radiographically) were examined with ICDAS, DIAG

237 pair and none to halfway or more through the dentin, radiographically).

238 we attempted to improve the impaired in vivo dentin regeneration and in vitro immunosuppressive funct

239 gamma (IFN-gamma) treatment enhanced in vivo dentin regeneration and in vitro T cell suppression of I

240 -term stability of MSCs and efficacy in pulp-dentin regeneration demand further investigation.

241 onstrated promising results in terms of pulp-dentin regeneration in vivo through autologous transplan

242 e, cell proliferation, multipotency, in vivo dentin regeneration, and immunosuppressive activity, sug

243 internal resorption in the root canal, pulp/dentin regeneration, and root resorption in orthodontic

244 suggest that it alone does not support pulp-dentin regeneration.

245 critical insight for applications of FGF2 in dentin regeneration.

246 o of pA to pB was determined to be ideal for dentin remineralization, based on hydroxyapatite (HA) mo

247 f peptides derived from DMP1 can be used for dentin remineralization.

248 There were areas of dentin resoprtion alternating with areas of osteodentin

249 mesenchymal dental pulp cells in attenuating dentin resorption in homeostasis are also reviewed.

250 bility may be responsible for the absence of dentin resorption in homeostasis.

251 Mesenchymal attenuation of dentin resorption may have implications in internal reso

252 to 84% and 94% of the lesions on enamel and dentin, respectively.

253 to 81% and 91% of the lesions in enamel and dentin, respectively.Asfc, Sa, and Tfv were able to diff

254 After 8 wk, multiple dentin/root resorption lacunae were present in root dent

255 sgenic (Trps1-Tg) mice demonstrate defective dentin secretion and mineralization, which are associate

256 Bone and dentin share similar biochemical compositions and physio

257 Dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP) are essential for the

258 Dentin sialophosphoprotein (Dspp) as a differentiation m

259 cific, participates with MMP-2 in processing dentin sialophosphoprotein (DSPP) into dentin sialoprote

260 Dentin sialophosphoprotein (DSPP) is a dentin extracellu

261 Dentin sialophosphoprotein (DSPP) is a precursor protein

262 ized as a part of a larger compound protein, dentin sialophosphoprotein (DSPP).

263 Immunohistochemistry reveals deposition of dentin sialophosphoprotein by odontoblasts into the adja

264 In contrast, no mineralization or dentin sialophosphoprotein deposition is evident around

265 ization requires two highly acidic proteins, dentin sialoprotein (DSP) and phosphophoryn (PP).

266 Dentin sialoprotein (DSP) is a dentin extracellular matr

267 Dentin sialoprotein (DSP) is essential for dentinogenesi

268 llular matrix protein that is processed into dentin sialoprotein (DSP), dentin glycoprotein (DGP) and

269 P is a chimeric protein composed of 3 parts: dentin sialoprotein (DSP), DPP, and dentin glycoprotein

270 as assessed by immunostaining for nestin and dentin sialoprotein (DSP).

271 ion and potential interaction of MMP-20 with dentin sialoprotein was confirmed by coimmunoprecipitati

272 ssing dentin sialophosphoprotein (DSPP) into dentin sialoprotein, dentin phosphoprotein, and dentin g

273 root wall as assessed by immunostaining for dentin sialoprotein.

274 the degradation of completely demineralized dentin specimens in contact with a filler-free or 2 ion-

275 Dentin specimens were bonded with Clearfil SE Bond (CSE)

276 Sixty bovine root dentin specimens were divided into six groups (n = 10 in

277 single chemical entity capable of enhancing dentin stiffness.

278 t pannexin channels are involved in external dentin stimulation-induced ATP release.

279 carbenoxolone significantly reduced external dentin stimulation-induced ATP release.

280 with areas of osteodentin formation in root dentin surface in the observed 8 wk.

281 formed pulp cells that attached to the inner dentin surface of the RS and infiltrated into the dentin

282 stable adhesion were created on e-GSE-primed dentin surfaces, leading to a dramatic decrease of the i

283 Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and t

284 in and reduce the ability of caries-affected dentin to remineralize.

285 partially dissolved apatite crystallites in dentin treated with the 15% 10-MDP primer.

286 lasts and their processes extending into the dentin tubules.

287 n surface of the RS and infiltrated into the dentin tubules.

288 uring the development, growth, and repair of dentin using mouse molars as a model.

289 analyses revealed partial correction of the dentin volume and no improvement of dentin mineralizatio

290 ceptor ablation exhibited a reduced tertiary dentin volume, mineral density, and ephrinB1 expression

291 n studies on demineralized and deproteinized dentin wafer is a powerful tool to determine the functio

292 an indirect composite and a glass ceramic to dentin was also evaluated.

293 For XPB, dentin was etched and treated with 0.3 M EDC for 1 min a

294 Prenatal Mn levels in dentin were correlated with Mn loadings and concentratio

295 most abundant noncollagenous protein in the dentin, where it plays a major role in the mineralizatio

296 on is in the extracellular mineralization of dentin, whereas in the kidney it may participate in calc

297 ess, fracture toughness and bond strength to dentin while demonstrating reduced contraction stress.

298 , HA was nucleated on collagenase-challenged dentin with as little as 20 min of 1:4 peptide incubatio

299 the craniofacial skeleton, namely, bone and dentin with high expression levels in the dentin matrix.

300 diaminetetraacetic acid (EDTA)-demineralized dentin with or without zoledronate-containing primer (Zo

301 root resorption lacunae were present in root dentin with robust RANKL and OPG expression.