ライフサイエンスコーパス: deoxy

1 ioglycosyl donor 14 and 5-azido-3-O-benzyl-5-deoxy-1,2-O-isopropylidene-beta-d-fructopyranose (23) to

2 6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]fluoro-2,5-anhydro-mannitol (1-[(18)F]FDA

3 Uptake of 1-deoxy-1-[(18)F]fluoro-d-fructose (1-[(18)F]FDF), 6-deoxy

4 describes a stepwise optimization of DFG (1-deoxy-1-fructosylglycine) formation from glycine and glu

5 seven of which were new, including seven 11-deoxy-16R-hydroxy-PTM congeners.

6 (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine (7a) show

7 bility, and RNase H substrate activity of 2'-deoxy-2',4'-difluoroarabino-modified nucleic acids.

8 2'-Deoxy-2',4'-difluoroarabinouridine (2,'4'-diF-araU) was

9 ynthesis and conformational properties of 2'-deoxy-2',4'-difluorouridine (2',4'-diF-rU) and cytidine

10 te compounds-[(18)F]Clofarabine; 2-chloro-2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranosyl-adenine

11 arabinofuranosyl-adenine ([(18)F]CFA) and 2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranosyl-guanine

12 re, we show that a novel PET radiotracer, 2'-deoxy-2'-[18F]fluoro-9-beta-D-arabinofuranosylguanine ([

13 clinically efficacious ProTide prodrug of 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine is provided.

14 bine and other 2'-modified analogs, i.e., 2'-deoxy-2'-fluoro-2'-C-methylcytidine (MeFdC) and 2'-fluor

15 cting xeno-nucleic acid (XNA) aptamers, a 2'-deoxy-2'-fluoroarabinonucleotide (FANA) aptamer (referre

16 n a stereoselective way in six steps from 2'-deoxy-2'-fluoroarabinouridine (2'-F-araU).

17 Among tested compounds 4'-chloromethyl-2'-deoxy-2'-fluorocytidine (2c) exhibited the most promisin

18 nucleosides with canonical nucleobases or 2'-deoxy-2'-fluoroisocytidine ((F)iCd, 1c) and 2'-deoxy-2'-

19 oxy-2'-fluoroisocytidine ((F)iCd, 1c) and 2'-deoxy-2'-fluoroisoguanosine ((F)iGd, 3c) were synthesize

20 mation as observed for ribonucleosides or 2'-deoxy-2'-fluororibonucleosides.

21 We designed novel 4'-modified 2'-deoxy-2'-fluorouridine (2'-F U) analogues with the aim t

22 RNA octamers with (R)- or (S)-5'-C-methyl-2'-deoxy-2'-fluorouridine [(R)- or (S)-C5'-Me-2'-FU, respec

23 We found that phosphoramidate prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides form a novel class

24 r derivative that belongs to the class of 2'-deoxy-2'-spirooxetane uridine nucleotide prodrugs which

25 ls the formation of substantial levels of 2'-deoxy-2'-spirooxetane uridine triphosphate (8), a potent

26 , and its inhibition has been a target for 2-deoxy-2,3-didehydro-d-N-acetylneuraminic acid (Neu5Ac2en

27 se in that its primary reaction product is 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en,

28 2-deoxy-2-(18)F-fluorodeoxysorbitol ((18)F-FDS) is an anal

29 y of X-ray radiation and 15% per MBq/ml of 2-deoxy-2-[(18)F]-fluoro-d-glucose ([(18)F]FDG).

30 uoro-2,5-anhydro-mannitol (1-[(18)F]FDAM), 2-deoxy-2-[(18)F]fluoro-d-glucose (2-[(18)F]FDG), and 6-de

31 We aimed to correlate 2-deoxy-2-[(18)F]fluoroglucose/positron emission tomograph

32 Here we report a new PET probe, 2-deoxy-2-[(18)F]fluororibose ([(18)F]-2-DFR), for use in

33 Falchi et al present their experience with 2-deoxy-2-[18F] fluoroglucose/positron emission tomography

34 FDG), a substrate for SGLTs and GLUTs; and 2-deoxy-2-[F-18]-fluoro-d-glucose (2-FDG), a substrate for

35 ed in human tumor xenografts in mice using 2-deoxy-2-[F-18]fluoro-D-glucose ((18)F-FDG) PET imaging.

36 Finally, 2-deoxy-2-[F-18]fluoro-d-sorbitol ((18)F-FDS) can be easil

37 c syntheses of (-)-ADMJ and (+)-ADANJ, the 2-deoxy-2-amino analogues of (-)-1-deoxymannojirimycin and

38 The glucose analog [(18)F]fluoro-2-deoxy-2-d-glucose ([(18)F]-FDG) is commonly used in PET/

39 r uptake, lower background) than (124)I-1-(2-deoxy-2-fluoro-1-d-arabinofuranosyl)-5-iodouracil for bo

40 Two isomeric aryl 2-deoxy-2-fluoro-beta-glucosides react with a beta-glucosi

41 site, the lack of efficient turnover of a 2-deoxy-2-fluoro-substrate, and several unsuccessful attem

42 op and validate a novel PET probe, [(18)F]-2-deoxy-2-fluoroarabinose ([(18)F]DFA), for in vivo imagin

43 nd practical method for the synthesis of C-2 deoxy-2-iodo glycoconjugates in self-assembled structure

44 The preparation of challenging 2-deoxy-2-iodo-beta-D-allo precursors of 2-deoxy-beta-D-ri

45 nt d-allo and d-manno derivatives produced 2-deoxy-2-iodoglycosides with stereoselectivities in the s

46 onors for the stereoselective synthesis of 2-deoxy-2-iodohexopyranosyl glycosides.

47 +)]-induced cyclization, and the resulting 2-deoxy-2-iodohexopyranosyl-1-thioglycosides were used as

48 d and four isomers of caffeoyl-2,7-anhydro-3-deoxy-2-octulopyranosonic acid were identified for the f

49 yl-(1-->4)-alpha-l-rhamnopyranosyl-(1-->3)-2-deoxy-2-trichlor oacetamido-beta-d-glucopyranoside, the

50 ta-D -galactopyranosyl-(1-->3)]-6-O-benzyl-2-deoxy-2-trichloroacetamido-beta-D-glucopy ranoside.

51 n 8-azido-3,6-dioxaoctyl 4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-beta-D-glucopyranoside afford

52 f 8-azido-3,6-dioxaoctyl 4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-beta-d-glucopyranoside with 3

53 PET with 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) can be used t

54 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is a function

55 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is a prolifer

56 The radiotracer 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is commonly u

57 feration is a hallmark of transformation, 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) might be supe

58 te molecular and cellular determinants of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET and diffu

59 Quantitative 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET has poten

60 parametric methods for quantification of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET in advanc

61 This pilot study aimed to evaluate 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET/CT, a PET

62 was to investigate whether sex influences 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake and ti

63 ge in standardized uptake values (SUVs) of 3'deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) using PET wit

64 To achieve our goal, PET/CT imaging with 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) was used to m

65 we demonstrate the multistep synthesis of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) with high yie

66 performed with the PET tracers (18)F-FDG, 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT), and (18)F-fl

67 py using serial PET/CT with (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT).

68 tissue proliferation uses the PET tracer 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT).

69 studies (such as the proliferation probe 3'-deoxy-3'-(18)F-fluorothymidine [(18)F-FLT]).

70 ng of cellular proliferation with PET and 3'-deoxy-3'-(18)F-fluorothymidine or 2'-(18)F-fluoro-5-meth

71 Molecular imaging with the PET tracer 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) allows asse

72 3'-Deoxy-3'-[(18)F]fluorothymidine positron emission tomogr

73 Here we show that (18)F-FLT PET ((18)F- 3'-deoxy-3'-fluorothymidine positron emission tomography) r

74 sed a novel method of cell tracking using 3'-deoxy-3'-L-[(18)F]-fluorothymidine ((18)F-FLT); a clinic

75 droxymethyl] butyl) guanine] and FLT (18F-3'-deoxy-3-'fluorothymidine), respectively.

76 ino esters gave the protected forms of the 3-deoxy-3-aminosphingoid base targets.

77 syntheses of a range of N- and O-protected 3-deoxy-3-aminosphingoid bases have been achieved using tw

78 decade-long reported method to access both 3-deoxy-3-fluoro- and 4-deoxy-4-fluorogalactopyranose.

79 strategy to access orthogonally protected 3-deoxy-3-fluorogalactopyranose and acetylated 4-deoxy-4-f

80 I)-OH in 8-azido-3,6-dioxaoctyl 6-O-benzyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosy

81 Peracetylated 2-acetylamino-2-deoxy-3-O-methyl-D-mannose decreases cell surface sialyl

82 2-Acetylamino-2-deoxy-3-O-methyl-D-mannose inhibits the human ManNAc kin

83 piration whereas their glycolytic flux and 2-deoxy-(3)H-glucose uptake rates were largely unaffected.

84 r flux analysis as well as their uptake of 2-deoxy-(3)H-glucose.

85 xy (34, MRS4202 (S); 55, MRS4380 (N)) and 5'-deoxy 38a (MRS4203 (S)) analogues, containing 7- and N(6

86 c radioactive glucose analog, alpha-methyl-4-deoxy-4-[(18)F]fluoro-D-glucopyranoside (Me4FDG), which

87 ranoside (Me-4FDG), a substrate for SGLTs; 4-deoxy-4-[F-18]-fluoro-d-glucose (4-FDG), a substrate for

88 R,4S)-3,4-dihydroxy-L-proline, 1,5-anhydro-4-deoxy-4-amino-D-glucitol, and 1,5-anhydro-4-deoxy-4-amin

89 -deoxy-4-amino-D-glucitol, and 1,5-anhydro-4-deoxy-4-amino-L-iditol] has been prepared via stereospec

90 oro-N-acetylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-fluoro-N-acetylgalactosamine (4FGalNAc), were pr

91 ridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosamine (4FGlcNAc) and UDP-4-

92 oxy-3-fluorogalactopyranose and acetylated 4-deoxy-4-fluorogalactopyranose.

93 ethod to access both 3-deoxy-3-fluoro- and 4-deoxy-4-fluorogalactopyranose.

94 This led to the synthesis of 4-deoxy-4-fluoroxylose linked to 4-methylumbelliferone tha

95 Salvadenosine, (1) a rare 5'-deoxy-5'-(methylthio) nucleoside, was isolated from the

96 rhodium to generate the rhodium analogue 5'-deoxy-5'-adenosylrhodibalamin (AdoRbl).

97 on, we determined the relative amounts of 5'-deoxy-5'-methylthioadenosine, an intermediate of the Met

98 f phosphoramidite derivatives of all four 5'-deoxy-5'-thioribonucleosides is described.

99 ed the possibility of replacement of T by 2'-deoxy-5-(hydroxymethyl)uridine (5hmU) in the genomic DNA

100 on suggested a mode of binding similar to 5'-deoxy-5-iodotubercidin and other known inhibitors.

101 f the water soluble carbohydrates known as 6-deoxy-6-(omega-aminoalkyl)aminocelluloses, which produce

102 1-[(18)F]fluoro-d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF), 1-deoxy

103 (18)F]fluoro-d-glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]fluoro-d-glucose (6-[(18)F]FDG) was studi

104 o buildup of the toxic intermediate 2-keto-3-deoxy-6-phosphogluconic acid rather than a specific requ

105 oxy-6-sulfogluconolactone (SGL) lactonase, 6-deoxy-6-sulfogluconate (SG) dehydratase, and 2-keto-3,6-

106 lves an NAD(+)-dependent SQ dehydrogenase, 6-deoxy-6-sulfogluconolactone (SGL) lactonase, 6-deoxy-6-s

107 Sulfoquinovose (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the pla

108 tablished by detecting 2'-deoxy-preQ0 and 2'-deoxy-7-amido-7-deazaguanosine in enzymatic hydrolysates

109 Another preQ0 derivative, 2'-deoxy-7-formamidino-7-deazaguanosine, was found in the E

110 The NO donors NOC-18 and N-(2-deoxy-alpha,beta-d-glucopyranose-2-)-N2-acetyl-S-nitroso

111 nd other group 13 metal enolates furnished 6-deoxy-alpha-D,L-altropyranose derivatives in up to 99% y

112 human fibroblasts with benzyl-2-acetamido-2-deoxy-alpha-D-galactopyranoside, an inhibitor of O-linke

113 ide antigen Kdo(2-->8)Kdo(2-->4)Kdo (Kdo = 3-deoxy-alpha-d-manno-oct-2-ulopyranosonic acid), displays

114 t the hydroboration of methyl 2,3-O-methyl-6-deoxy-alpha-d-xylo-hex-5-enopyranoside resulted in exclu

115 lycosides which upon dehalogenation gave C-2 deoxy amino acid glycoconjugates.

116 The orthogonally protected deoxy amino l-sugar building blocks could be stereoselec

117 However, the unusual deoxy amino l-sugars present in the bacterial glycoconju

118 t methodology to access a variety of unusual deoxy amino l-sugars starting from readily available l-r

119 ns and oligosaccharides contain several rare deoxy amino l-sugars which are virtually absent in the h

120 Recently, we have synthesized the deoxy-analog of S-geranyluridine and showed the geranyla

121 rded the corresponding 4-O-benzoyl-6-bromo-6-deoxy analogue, which was coupled with 3,4,6-tri-O-acety

122 oxidative deamination reactions of 4-amino-4-deoxy and 2-amino-2-deoxy hexopyranosides and a common m

123 ed Fe(d) spin count, indicating HS Fe(II) in deoxy and LS Fe(II) in carboxy.

124 is of beta-(1-->2)-C-saccharides employing 3-deoxy- and 3-C-branched glycals as hermaphroditic substr

125 of catecholic and non-catecholic 3-oxy- (and deoxy)-anthocyanidins.

126 The time-course of VCF responses to ATP, 2'-deoxy ATP, 3'-deoxy ATP, Ap5A and alphabetameATP were ag

127 se of VCF responses to ATP, 2'-deoxy ATP, 3'-deoxy ATP, Ap5A and alphabetameATP were agonist dependen

128 ion (NO3 (-) ) and N(6) -(2-phenylethyl)-2'-deoxy-ATP (d-PATP), which almost completely rectifies th

129 MANT-3'-dATP [2'-O-(N-methylanthraniloyl)-3'-deoxy-ATP] (Ki, 16.7 nM).

130 Treatment with the DNA demethylating agent 5-deoxy-azacytidine does not increase Xi expression ahead

131 The 6-deoxy-beta-d-ido-heptopyranoside related to the capsular

132 t is the first successful synthesis of the 6-deoxy-beta-d-ido-heptopyranoside, which could possess in

133 oc-1-[5-O-(4,4'-dimethoxytrityl)-3-O-nosyl-2-deoxy-beta-D-lyxofuranosyl] thymine precursor on the EWO

134 mer featuring an unusual [-->3)-2-O-acetyl-6-deoxy-beta-D-manno-heptopyranosyl-(1-->] as the repeatin

135 The synthesis of 6-deoxy-beta-D-manno-heptosides was investigated using bot

136 3-Deoxy-beta-d-manno-oct-2-ulosonic acid (beta-Kdo) glycos

137 g 2-deoxy-2-iodo-beta-D-allo precursors of 2-deoxy-beta-D-ribo-hexopyranosyl units and other analogue

138 rect synthesis of biologically significant 2-deoxy-beta-glycosides has been developed via O-alkylatio

139 the synthesis of trans-1,2-, cis-1,2-, and 2-deoxy-beta-glycosides.

140 family GH105, producing the final product 4-deoxy-beta-l-threo-hex-4-enepyranosyl-uronic acid.

141 iminutive analogue (+)-C(8)-desmethoxy-C(11)-deoxy-C(12)-didesmethylirciniastatin (6).

142 These are rapidly N-acylated to 1-deoxy-"ceramides" with very uncommon biophysical propert

143 ular and electronic structures of unligated (deoxy), CO-inhibited (carboxy), and O2-bound (oxy) hemes

144 cytes, the Gardos channel is activated under deoxy conditions, leading to cellular dehydration due to

145 affected in both acute kidney injury and in deoxy-corticosterone acetate and sodium chloride (deoxy-

146 -corticosterone acetate and sodium chloride (deoxy-corticosterone acetate salt)-induced chronic hyper

147 demonstrated that the triphosphate of 2',3'-deoxy-D-apio-D-furanoadenosine (1), in contrast to that

148 ine the catalytic function of the combined 3-deoxy-d-arabino heptulosonate-7-phosphate synthase (DAH7

149 athway enzymes: chorismate mutase (CM) and 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7

150 hanism observed for Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase, the

151 The 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase (DAHP

152 N(6)-(2-Deoxy-D-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-

153 s bioactive components, including N-alpha-(1-deoxy-D-fructos-1-yl)-L-arginine (FruArg).

154 -phenyl carbamate (PUGNAc), O-(2-acetamido-2-deoxy-D-galactopyranosylidene)amino N-phenyl carbamate (

155 mino group of l-Glu to C-4'' of UDP-4-keto-6-deoxy-d-GlcNAc to form UDP-4-amino-FucNAc and 2-oxogluta

156 l is NAD(+)-dependent and has distinct UDP-6-deoxy-d-GlcNAc-5,6-ene 4-oxidase, 5,6-reductase, and 5-e

157 d enzyme, which we named Pal, converts UDP-6-deoxy-D-GlcNAc-5,6-ene to UDP-4-keto-6-deoxy-L-AltNAc.

158 UDP-d-GlcNAc to an uncommon UDP-sugar, UDP-6-deoxy-D-GlcNAc-5,6-ene.

159 probes were: alpha-methyl-4-[F-18]-fluoro-4-deoxy-d-glucopyranoside (Me-4FDG), a substrate for SGLTs

160 lacto-configured inhibitors O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate (PU

161 eucine (DON) to decrease or O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate (PU

162 Ac transferase with PUGNAC (O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate).

163 by labelling cells with 2'-[(18)F]-fluoro-2'-deoxy-D-glucose ((18)F-FDG).

164 The combination of 2-deoxy-D-glucose (2-DG) and UA-4 induced cell cycle arres

165 7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino]-2-deoxy-D-glucose (2-NBDG) reports on glucose uptake and T

166 tment with low doses of the glucose analog 2-deoxy-d-glucose (2DG) on ADPKD progression in orthologou

167 limidazole (NDI) with glycolytic inhibitor 2-deoxy-d-glucose (2DG).

168 he labeled glucose analogue 2[(18)F]fluoro-2-deoxy-D-glucose (FDG).

169 ed with dynamic PET imaging of [18F]fluoro-2-deoxy-D-glucose at two occasions with 24-hour interval b

170 aphy after an injection of [(18)F]2-fluoro-2-deoxy-d-glucose before the OGTT, and the rate of glucose

171 PET with [18F]fluoro-2-deoxy-D-glucose can be used to image cellular metabolism

172 rain had a significant effect on [F]fluoro-2-deoxy-D-glucose net uptake rate Ki in high-strain lipopo

173 or RVLM was elicited by microinjections of 2-deoxy-D-glucose or 5-thio-D-glucose in anesthetized, eug

174 ments of B6.Sle1Sle2.Sle3 mice with either 2-deoxy-D-glucose or metformin were sufficient to prevent

175 bese normal subjects with [(18)F]-2-fluoro-2-deoxy-D-glucose positron emission tomography imaging.

176 emission tomography with [(18)F]-2-fluoro-2-deoxy-D-glucose scan in addition to noncontrast computed

177 glucose-free medium or in the presence of 2-deoxy-D-glucose upon CCCP treatment.

178 to alanine (Q282A) doubled the Km(app) for 2-deoxy-d-glucose uptake and eliminated cis-allostery (sti

179 abolites modulated (14)C-D-glucose and (14)C-deoxy-D-glucose uptake into hepatic HepG2 cells.These da

180 [18F]fluoro-2-deoxy-D-glucose uptake rate was computed for the total l

181 [(18)F]fluoro-2-deoxy-D-glucose uptake rate was computed for the whole l

182 Overload-induced [(3)H]-2-deoxy-d-glucose uptake was not inhibited by d-fructose,

183 5 days, muscle weights and ex vivo [(3)H]-2-deoxy-d-glucose uptake were assessed.

184 or tidal hyperinflation had [(18)F]fluoro-2-deoxy-D-glucose uptakes similar to controls.

185 are treated with the hexokinase inhibitor, 2-deoxy-d-glucose, indicating that a functional glycolytic

186 ular metabolism, and a treatment combining 2-deoxy-D-glucose, which inhibits glucose metabolism, and

187 toirradiated cells even in glucose-free or 2-deoxy-D-glucose-treated conditions.

188 with dynamic PET imaging of [(18)F]fluoro-2-deoxy-D-glucose.

189 ATGU) glucose uptake with [(18) F]2-fluoro-2-deoxy-D-glucose/positron emission tomography, lipolysis

190 hioglycoside leading to the formation of a 3-deoxy-d-glycero-d-galacto-2-nonulosonic acid (KDN) deriv

191 configuration to the corresponding 2-keto-3-deoxy-D-glycero-D-galacto-nonulopyranosidonic acid (KDN)

192 tion extending the d-hexose to the desired 6-deoxy-d-heptose.

193 In plants, 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) is a monosacchar

194 3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) is an essential

195 3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) is an essential

196 d at the non-reducing end by a beta-linked 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) residue.

197 on of waaA resulted in increased levels of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) sugar in membran

198 ide with two mannose (Man) and one each of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo), Gal, GalN, and

199 Kdo (3-deoxy-d-manno-oct-2-ulosonic acid) is an eight-carbon su

200 chain is terminated by a beta-linked Kdo (3-deoxy-d-manno-oct-2-ulosonic acid) residue added by a th

201 by interaction of anhydro-Kdo (4,7-anhydro-3-deoxy-d-manno-oct-2-ulosonic acid) with Arg343 and Asp32

202 ng N-acetylgalactosamine (GalNAc) and beta-3-deoxy-d-manno-octulosonic acid (betaKdo).

203 dary acyltransferase, LpxL, as well as the 3-deoxy-d-manno-octulosonic acid (Kdo) transferase, KdtA.

204 ate, the first step in the biosynthesis of 3-deoxy-D-manno-octulosonic acid (Kdo), an essential compo

205 eta-[1-naphtho[2,3-d]imidazol-2(3H)-one)]-2'-deoxy-d-ribofuranose and 1'-beta-[1-naphtho[2,3-d]imidaz

206 e and 1'-beta-[1-naphtho[2,3-d]imidazole]-2'-deoxy-d-ribofuranose and their use for quantifying O(6)-

207 a wider pattern of endothelial plasticity: 2-deoxy-d-ribose and VEGFA produce transcriptional program

208 othelial cells, VEGFA and the TYMP product 2-deoxy-d-ribose cooperatively repress tight junction prot

209 Starting from 2-deoxy-d-ribose, the product is obtained in a 6.7% overal

210 DXPS catalyzes the formation of 1-deoxy-d-xylulose 5-phosphate (DXP), a branch point metab

211 a feedback inhibition of the chloroplastic 1-deoxy-D-xylulose 5-phosphate (DXP)/2-C-methyl-D-erythrit

212 lastic 2-C-methyl-d-erythritol 4-phosphate/1-deoxy-d-xylulose 5-phosphate pathway (MEP/DOXP), and its

213 Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key en

214 The enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) is a key en

215 ce of the first enzyme of the MEP pathway (1-deoxy-D-xylulose 5-phosphate synthase, DXS) by pathway p

216 1-Deoxy-D-xylulose-5-phosphate (DXP) reductoisomerase (DXR

217 ts homologue FR900098 (2) potently inhibit 1-deoxy-d-xylulose-5-phosphate reductoisomerase (Dxr), a k

218 yl-D-erythritol 4-phosphate pathway enzyme 1-deoxy-D-xylulose-5-phosphate synthase (DXS).

219 igated the effects of Solanum lycopersicum 1-deoxy-d-xylulose-5-phosphate synthase (SlDXS), Arabidops

220 Feedback inhibition of 1-deoxy-D-xylulose-5-phosphate synthase activity by accumu

221 ooxygenase 2 and increases of its product 15-deoxy Delta-prostaglandin J2 as well as cyclooxygenase 2

222 ined the involvement of cyclooxygenase 2, 15-deoxy Delta-prostaglandin J2, and peroxisome proliferato

223 staglandin J2 as well as cyclooxygenase 2/15-deoxy Delta-prostaglandin J2-dependent activation of per

224 ced lung injury involves cyclooxygenase 2/15-deoxy Delta-prostaglandin J2-dependent activation of per

225 roduction of the signaling lipid molecule 15-deoxy-delta 12,14 prostaglandin J2 (15-d-PGJ2) and confe

226 We report that the eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopent

227 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) is natura

228 ged shear stress exposure (>12 h) induced 15-Deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) synthesis

229 (specifically, the data suggest roles for 15-deoxy-Delta(12,14)-prostaglandin-J2 and lipoxin A4, both

230 TRPA1 (PGA1, 8-iso-prostaglandin A2, and 15-deoxy-Delta-prostaglandin J2) were measured in biopsies

231 12 prostaglandin J2 (Delta(12)-PGJ2), and 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2).

232 ligands (rosiglitazone, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2) decrease levels of be

233 cts of three different PPARgamma ligands (15-deoxy-Delta12,14-prostaglandin J2, troglitazone, and ros

234 hosphono-peramivir (6a), the dehydration and deoxy derivatives (7a and 8a) as well as their correspon

235 ments for monosaccharides, their methoxy and deoxy derivatives, disaccharides and sugar alcohols in (

236 vels in silks and pericarps expressing the 3-deoxy flavonoid R2R3-MYB regulator P1, suggesting that Z

237 In its ferrous deoxy form, GLB-33 GD is capable of reversibly binding O

238 Comparing the properties of the deoxy forms of ATP demonstrated the importance of the 2'

239 The (1)H NMR spectra of the CO and deoxy forms of these mutants indicate that substitutions

240 eir glucose conjugates, generating 1-amino-1-deoxy-fructose and its derivatives.

241 y, is synthesized from an intermediate named deoxy-fructosyl-glutamine (DFG), which is also an opine

242 new metabolic chemical reporter, 6-Alkynyl-6-deoxy-GlcNAc (6AlkGlcNAc), for the identification of O-G

243 say, and glucose uptake determined through 2-deoxy glucose 6 phosphate luminescence.

244 e moiety in rhamnosylisoorientin to 4-keto-6-deoxy glucose, resulting in maysin.

245 py in the inflammatory phase with the drug 2-deoxy-glucose (2DG), lesions were diminished compared wi

246 h glucose and imidazolinone formation with 3-deoxy-glucosone at the guanidine side-chain.

247 8-Hydroxy-deoxy guanosine and malondialdehyde levels as markers of

248 otho, improved malondialdehyde and 8-hydroxy-deoxy guanosine levels, and also deteriorated renal func

249 e stress (nitrotyrosine, urinary 8-hydroxy-2-deoxy-guanosine) and inflammation (IL-1beta mRNA, F4/80

250 DOSI images of the tissue concentrations of deoxy-hemoglobin (ctHHb), oxy-hemoglobin (ctHbO2), water

251 n reactions of 4-amino-4-deoxy and 2-amino-2-deoxy hexopyranosides and a common mechanism is formulat

252 .g., glucose/fructose, C6H12O6, keto-hexose, deoxy-hexose, (P < 0.01)), with significant downregulati

253 uctures to a higher resolution, trans-acting deoxy-inhibited structure of the ribozyme, and conclude

254 edlings or tobacco BY-2 cells with 8-azido 8-deoxy Kdo (Kdo-N3 ) followed by coupling to an alkyne-co

255 zymatic product of Pen and Pal, UDP-4-keto-6-deoxy-L-AltNAc, is converted to CMP-pseudaminic acid by

256 UDP-6-deoxy-D-GlcNAc-5,6-ene to UDP-4-keto-6-deoxy-L-AltNAc.

257 of cationic substituents, such as 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoehthanolamine (pE

258 demonstrated that incorporation of 4-amino-4-deoxy-l-arabinose (l-Ara4N) to the lipid A moiety of lip

259 e attachment of the cationic sugar 4-amino-4-deoxy-l-arabinose to lipid A, a reaction catalyzed by th

260 lipid-to-lipid glycosyltransferase 4-amino-4-deoxy-L-arabinose transferase (ArnT).

261 y-L-fuconate via dehydratase, (iii) 2-keto-3-deoxy-L-fuconate cleavage to pyruvate and L-lactaldehyde

262 dehydrogenase, (ii) dehydration to 2-keto-3-deoxy-L-fuconate via dehydratase, (iii) 2-keto-3-deoxy-L

263 on the conversion of an L-rhamnose into a 6-deoxy-L-talose residue at a late stage of the synthetic

264 and 6-deoxy-l-talose residues in which the 6-deoxy-l-talose residues are variably replaced with O-ace

265 heteropolymer with repeating d-glucose and 6-deoxy-l-talose residues in which the 6-deoxy-l-talose re

266 on, we show that this is indeed the case for deoxy-Mb.

267 We found that the 2-azido-2-deoxy moiety is more beta-directing than its C-2-O-benzy

268 inides and their corresponding 2,3-dehydro-2-deoxy-N-acetylneuraminic acid derivatives is described.

269 he suicide substrate arabinosyl-2'-fluoro-2'-deoxy NAD(+) (F-araNAD(+)), dimeric F-araNAD(+), to indu

270 and regulates appearance of the free ferrous deoxy-NGB, which is the redox active form of the protein

271 By this methodology the first synthesis of deoxy-nor-abiesesquine B, a sesquiterpene, was also achi

272 ears to be the most important checkpoint for deoxy-NTP discrimination.

273 33 transports uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport me

274 mechanism and SLC25A36 cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by unipor

275 articular, deamination of adenine moiety in (deoxy)nucleoside triphosphates, resulting in formation o

276 isiae Rim2 gene, which encodes a pyrimidine (deoxy)nucleotide carrier.

277 inkages by an engineered polymerase using 3'-deoxy- or 3'-O-methyl-NTPs as substrates.

278 The resemblance of the 3'-deoxy pacidamycin moiety with the synthetic anti-retrovi

279 This was established by detecting 2'-deoxy-preQ0 and 2'-deoxy-7-amido-7-deazaguanosine in enz

280 in situ; reductive N-methylation then gave 3-deoxy-(+)-preussin B as the major diastereoisomeric prod

281 B, the C(2)-epimer of (-)-preussin B, and 3-deoxy-(+)-preussin B have been developed, using the dias

282 lds (from phenylacetaldehyde) were 19% for 3-deoxy-(+)-preussin B over seven steps, 8% for the C(2)-e

283 In contrast, paromamine is reduced to a deoxy product when incubated with AprD4/AprD3/NADPH.

284 a nucleotide antiporter and prefers various (deoxy-) purine nucleotides as substrates.

285 t in the first example of a no-carrier-added deoxy-radiofluorination.

286 nt homo-oligomer DNA sequences containing 10 deoxy-ribonucleotides of thymine, adenine, cytosine, or

287 cues damage-stalled replication by inserting deoxy-ribonucleotides opposite DNA damage sites resultin

288 The protocol is analogous to (deoxy)ribozyme selections, but it enables the developmen

289 SM proteins, butirosin biosynthetic enzyme 2-deoxy-scyllo-inosamine dehydrogenase (BtrN) and molybden

290 at catalyzes the two-electron oxidation of 2-deoxy-scyllo-inosamine to amino-dideoxy-scyllo-inosose,

291 D requires duplex RNA and is sensitive to 2'-deoxy substitution at nucleotides opposite the editing s

292 e shown to possess clusters of rhamnose, a 6-deoxy sugar with non-polar characteristics.

293 that p-toluenesulfonic anhydride activates 2-deoxy-sugar hemiacetals in situ as electrophilic species

294 developed via O-alkylation of a variety of 2-deoxy-sugar-derived anomeric alkoxides using challenging

295 us sensu lato group produce CDP-3-C-methyl-6-deoxy sugars for the formation of cereose-containing gly

296 into the roles of the uncommon 3-C-methyl-6-deoxy sugars in cell-surface recognition and host-pathog

297 especially true in cases such as beta-linked deoxy-sugars, where the outcome of the reaction cannot b

298 The synthesis of four l-2'-deoxy-threose nucleoside phosphonates with the natural n

299 yzes synthesis of the sole de novo source of deoxy-thymidylate.

300 ly a 2.6- to 6-fold differential in rates of deoxy versus ribo addition (kpol).