ライフサイエンスコーパス: deoxyadenosine

1 ical anticancer drug cladribine (2-chloro-2'-deoxyadenosine).

2 5'-deoxy-5'-(methylthio)adenosine and not 5'-deoxyadenosine.

3 interstrand cross-links with the opposing 2'-deoxyadenosine.

4 probing any target sequence containing a 2'-deoxyadenosine.

5 2'-deoxycytidine, 2'-deoxyguanosine, and 2'-deoxyadenosine.

6 2 in the presence of 2'-deoxyguanosine or 2'-deoxyadenosine.

7 arbon bond homolysis and the formation of 5'-deoxyadenosine.

8 ransfer from [octanoyl-d(15)]H-protein to 5'-deoxyadenosine.

9 zes the deglycosylation of the mismatched 2'-deoxyadenosine.

10 f 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine.

11 concluded an efficient route to 3'-amino-3'-deoxyadenosine.

12 sites located on the C5' methyl group of 5'-deoxyadenosine.

13 hat SP lyase cleaved S-AdoMet to generate 5'-deoxyadenosine.

14 mole or the Ado kinase inhibitor 5'-amino 5'-deoxyadenosine.

15 denine demonstrated increased sensitivity to deoxyadenosine.

16 opposing thymidine, 2'-deoxycytidine, or 2'-deoxyadenosine.

17 , where the major SAM derived products is 5'-deoxyadenosine.

18 ons formed by electron transfer from O to 2'-deoxyadenosine.

19 as improved by in situ removal of product 5'-deoxyadenosine.

20 s reductively cleaved to L-methionine and 5'-deoxyadenosine.

21 uI provides good yields of the 8-arylated-2'-deoxyadenosines.

22 2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N(6)-gamma-HMHP-dA) adducts are formed

23 1-hydroxymethyl-2-hydroxypropan-1,3-diyl)-2'-deoxyadenosine (1,N(6)-HMHP-dA), in tissues of laborator

24 N1-methyl-deoxyadenosine (1-MeA) is formed by methylation of deoxy

25 Cordycepin (3'-deoxyadenosine, 1a) is a powerful trypanocidal compound

26 2-Fluorocordycepin (2-fluoro-3'-deoxyadenosine, 1b) was identified as a selective, poten

27 atom linking C2 of a dG nucleoside to C6 of deoxyadenosine (2).

28 tion by HHV8 TK, while 2'-deoxyguanosine, 2'-deoxyadenosine, 2'-deoxycytidine, and corresponding anal

29 The deamination of 2'-deoxyadenosine, 2'-deoxyguanosine, and 2'-deoxycytidine

30 e incorporated into DNA in the form of [2H2]-deoxyadenosine (%[2H2]-dA enrichment) was determined by

31 ([3H]2-chloro-N6-methyl-(N)-methanocarba-2'-deoxyadenosine 3',5'-bis-phosphate) indicated a nearly h

32 3)H]2-chloro-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine 3',5'-bisphosphate 5 in a newly developed

33 gues of oligonucleotides by the oxidation of deoxyadenosine 3',5'-bisphosphorothioate (3) was attempt

34 ), approximately 20 microM) as well as by 2'-deoxyadenosine 3'-AMP (IC(50), approximately 2 microM),

35 ACIX was essentially insensitive to 2'-deoxyadenosine 3'-monophosphate, a known blocker of AC a

36 2-Chloro-N(6)-methyl-(N )-methanocarba-2'-deoxyadenosine-3',5'- bisphosphate (MRS2279) was develop

37 nists MRS2279 (K(i) = 13 nM), N(6)-methyl-2'-deoxyadenosine-3',5'-bisphosphate (MRS2179; K(i) = 84 nM

38 We have used RB69 DNA pol and 3-deaza-2'-deoxyadenosine (3DA), an analogue of 2-deoxyadenosine, w

39 romo)-dediazoniation of 3',5'-di-O-acetyl-2'-deoxyadenosine (4) gave the 6-[chloro (5, 63%) or bromo

40 p of 3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine (4) occurs at C-10 of the epoxides.

41 The nonpolar isosteres of 2'-deoxyadenosine, 4-methylbenzimidazole beta-deoxynucleosi

42 ne 5'-monophosphate (T-dTMP) but not adenine-deoxyadenosine 5'-monophosphate (A-dAMP) mismatches.

43 that AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5'-monophosphonate, ACP) directly activat

44 deoxyribozymes that transfer the 2'-azido-2'-deoxyadenosine 5'-monophosphoryl group (2'-Az-dAMP) from

45 nucleotides (dNTP) containing biotinlated 2'-deoxyadenosine 5'-triphosphate (biotin-dATP) by terminal

46 activation of hepatoma cell lysates with 2'-deoxyadenosine 5'-triphosphate (dATP) results in the for

47 forming a Hoogsteen base pair with incorrect deoxyadenosine 5'-triphosphate (dATP).

48 -(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxyadenosine 5'-triphosphate], shows a 17-fold enhance

49 bstracts an H-atom from substrate to form 5'-deoxyadenosine (5'-Ado) and the alpha-Lys* radical (stat

50 ethionine (SAM) is converted to 5'-chloro-5'-deoxyadenosine (5'-ClDA) in a reaction catalyzed by a SA

51 ion of the non-native substrate 5'-chloro-5'-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deoxyadenosin

52 and catalyzed formation of 0.60 equiv of 5'-deoxyadenosine (5'-dA) and 0.27 equiv of lipoylated H-pr

53 kinetics of deuterium incorporation into 5'-deoxyadenosine (5'-dA) during the reaction were followed

54 exed with S-adenosylhomocysteine (SAH) or 5'-deoxyadenosine (5'-dAdo) and l-methionine (l-Met).

55 M) enzyme, catalyzing homolysis of SAM to 5'-deoxyadenosine (5'-dAdo) in the presence of paromamine.

56 thioadenosine (MTA), adenosine (Ado), and 5'-deoxyadenosine (5'-dAdo).

57 idenced by the transfer of deuterium into 5'-deoxyadenosine (5'-dAH).

58 eine (SAH), 5'-methylthioadenosine (MTA), 5'-deoxyadenosine (5'-DOA), and 6-amino-6-deoxyfutalosine.

59 '-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deoxyadenosine (5'-FDA).

60 y the adenosine kinase inhibitor 5'-amino-5'-deoxyadenosine (5'A5'dAdo), indicating that the metaboli

61 MTA, SAH and 5'-deoxyadenosine (5'dADO) are product inhibitors of these

62 of two weakly cytotoxic compounds, 8-aza-2'-deoxyadenosine (5) and 8-bromo-2'-deoxyadenosine (9), ha

63 veral enzymes to release (5'S)-8,5'-cyclo-2'-deoxyadenosine [(5'S)-cdA] from dinucleotides and oligod

64 roxy-2'-deoxyguanosine, (5'-S)-8,5'-cyclo-2'-deoxyadenosine, (5'-R)-8,5'-cyclo-2'-deoxyguanosine, and

65 hosphate (DB-dATP), were synthesized from 2'-deoxyadenosine-5'-monophosphate in a six step procedure.

66 using miRNA as a primer and incorporating 2'-deoxyadenosine-5'-O-(1-thiotriphosphate) as a dATP alter

67 -(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxyadenosine-5'-triphosph ate (deac-aminoATP), to stud

68 ogs, N(6)-[4-azidobenzoyl-(2-aminoethyl)]-2'-deoxyadenosine-5'-triphospha+ ++ te (AB-dATP) and N(6)-[

69 )-diazirin-3-yl]benzoyl-(2-aminoethyl) ]-2 '-deoxyadenosine-5'-triphosphate (DB-dATP), were synthesiz

70 8-Azido-5'-aziridino-5'-deoxyadenosine (6), a novel cofactor mimic, was synthesi

71 fication and quantification of 8,5'-cyclo-2'-deoxyadenosine (8,5'-cdAdo) in DNA by liquid chromatogra

72 ng chemistry has been extended to 8-bromo-2'-deoxyadenosine (8-BrdA) and 5-iodo-2'-deoxyuridine (5-Id

73 xo-2'-deoxyguanosine (8-oxo-dG) and 8-oxo-2'-deoxyadenosine (8-oxo-dA) in diseased RPE could provide

74 ne (8-oxoG:dC) and Hoogsteen base pairs with deoxyadenosine (8-oxoG:dA).

75 completion than the corresponding 8-bromo-2'-deoxyadenosine (8BrdA) couplings.

76 8-Vinyl-2'-deoxyadenosine (8vdA) is a fluorophore with a quantum yi

77 , 8-aza-2'-deoxyadenosine (5) and 8-bromo-2'-deoxyadenosine (9), have been prepared.

78 (5'-([(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine) (a substrate analogue that transaminates

79 oxy-2(E)-decenal is a precursor of etheno-2'-deoxyadenosine, a highly mutagenic lesion found in human

80 7 exhibits very low deaminase activity on 2'-deoxyadenosine, a substrate that is readily hydrolyzed b

81 T. brucei cultivated in the presence of deoxyadenosine accumulates high levels of dATP in an ade

82 ere we show that T. brucei treated with 1 mm deoxyadenosine accumulates higher dATP levels than mamma

83 Because BcPh DEs form substantial amounts of deoxyadenosine adducts at dA, their adverse effects on h

84 n DNA polymerase eta (pol eta) encounters N6-deoxyadenosine adducts formed by trans epoxide ring open

85 anosine and N(6)-(2-hydroxyestrogen-6-yl)-2'-deoxyadenosine adducts induced by quinones of 2-hydroxye

86 For deoxyadenosine/adenosine analogues to remain intact and

87 2'-bromo-2'-deoxyadenosine, and 2'-chloro-2'-deoxyadenosine (all with beta-d-ribo configurations).

88 3'-Deoxyadenosine, also known as cordycepin, is a known pol

89 ard, 5'-(diaminobutyric acid)-N-iodoethyl-5'-deoxyadenosine ammonium hydrochloride (AAI), to generate

90 s containing adenosyl moieties, including 5'-deoxyadenosine, AMP, ADP, and methylthioadenosine, to pu

91 in- 4-amine) N(8)-(2'deoxyribonucleoside), a deoxyadenosine analog (UB), pairs with each of the natur

92 Clofarabine is the first deoxyadenosine analog that shows promise in adult and pe

93 TP and the incorporation of cordycepin, a 2'-deoxyadenosine analogue, into the 3'-terminal position.

94 Phosphoramidite-protected quadracyclic 2'-deoxyadenosine analogues qAN1 (donor) and qAnitro (accep

95 opment of additional novel C2-substituted 3'-deoxyadenosine analogues to be evaluated in development

96 f 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine analogues was designed and synthesized in

97 on at the C-6 position, leading to N-aryl 2'-deoxyadenosine analogues, is more sensitive to the ligan

98 10-tetrahydrobenzo[a]pyrene (BaP DE-2) by 2'-deoxyadenosine and 2'-deoxyguanosine is described.

99 hyl- and 7,12-dimethyl- derivatives) with 2'-deoxyadenosine and 2'-deoxyguanosine were prepared by th

100 yethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine were synthesized, a

101 Rate constants for deamination of 2'-deoxyadenosine and 2'-deoxyguanosine, which could not be

102 r than the rates of glycoside cleavage in 2'-deoxyadenosine and 2'-deoxyguanosine.

103 )-etheno-2'-deoxyguanosine, 1,N(6)-etheno-2'-deoxyadenosine and 3,N(4)-etheno-2'-deoxycytidine arisin

104 BciD catalyzed the conversion of SAM into 5'-deoxyadenosine and BChlide c or d into BChlide e or f, r

105 llows that dissociation of methionine and 5'-deoxyadenosine and binding of a second equivalent of Ado

106 Deoxyadenosine and deoxycytidine exhibited comparable re

107 The observation of multiply deuterated 5'-deoxyadenosine and deuterated S-adenosylmethionine when

108 ic and strictly anaerobic conditions were 5'-deoxyadenosine and hydroxocobalamin, which suggested int

109 ing occurs via reaction with the opposing 2'-deoxyadenosine and is independent of O(2).

110 uires AdoMet and flavodoxin and generates 5'-deoxyadenosine and methionine, suggesting that biotin sy

111 sis of the model adducts N(6)-(1-pyrenyl)-2'-deoxyadenosine and N(2)-(1-pyrenyl)-2'-deoxyguanosine as

112 side derivatives N(6)-(6-benzo[a]pyrenyl)-2'-deoxyadenosine and N(2)-(6-benzo[a]pyrenyl)-2'-deoxyguan

113 The isotope distributions of 5'-deoxyadenosine and p-cresol were evaluated using deuteri

114 0517) to evaluate levels of adenosine and 2'-deoxyadenosine and real-time PCR to quantify TREC levels

115 nK reaction revealed that 1 equiv each of 5'-deoxyadenosine and S-adenosyl-homocysteine are produced

116 Some of the cross-links between 2'-deoxyadenosine and the oxidized abasic sites, 5'-(2-phos

117 d to the 5'-deoxyadenosyl radical to form 5'-deoxyadenosine and the pro-S hydrogen is transferred to

118 n and that one SAM (SAM1) is converted to 5'-deoxyadenosine and the second SAM (SAM2) is converted to

119 ve orientation of the C5' methyl group of 5'-deoxyadenosine and the substrate radical in vitamin B(12

120 e formation of S-adenosylhomocysteine and 5'-deoxyadenosine and the transfer of a methyl group to l-v

121 pore, oligonucleotides with 5' overhangs of deoxyadenosines and deoxythymidines up to nine bases in

122 r >> Cl for 2'-O-tosyladenosine, 2'-bromo-2'-deoxyadenosine, and 2'-chloro-2'-deoxyadenosine (all wit

123 l toward the DNA-bases 2'-deoxyguanosine, 2'-deoxyadenosine, and 2'-deoxycytidine and proteins.

124 Efficient conversions of adenosine, 2'-deoxyadenosine, and related adenine nucleosides into 6-h

125 ase coproducts S-adenosylhomocysteine and 5'-deoxyadenosine, and to require cobalamin.

126 ysis revealed a stoichiometric mixture of 5'-deoxyadenosine, aquocobalamin, and allylmalonyl-CoA.

127 ransferred to the GRE, and methionine and 5'-deoxyadenosine are also formed.

128 Since MTAP substrates MTA and 5'deoxyadenosine are prone to toxicities associated with a

129 ynthesis of 1,N6-ethano- and 1,N6-propano-2'-deoxyadenosine are reported in order to demonstrate the

130 neous quantification of formylglycine and 5'-deoxyadenosine as a function of time indicates an approx

131 vels of the ADA substrates, adenosine and 2'-deoxyadenosine, as well resulting dATP levels and S-aden

132 2 cofactor containing O at the 5'-end and 2'-deoxyadenosine at the 3'-end was studied by femtosecond

133 Introduction of a deoxyadenosine at the depurination site of short RNA oli

134 denosine (1-MeA) is formed by methylation of deoxyadenosine at the N1 atom.

135 alamin is accompanied by the formation of 5'-deoxyadenosine at the same rate, and the generation of c

136 (3S)-3-aminocarboxypropyl]-N-methylamino}-5'-deoxyadenosine (azaSAM) as measured by spectroelectroche

137 = 2.3 A) (2)H in the C5' methyl group of 5'-deoxyadenosine, (b) two weakly coupled (r(eff) = 4.2 A)

138 ,8-dihydrodiol-9,10-epoxide (N2-dG-BPDE); N6-deoxyadenosine-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxi

139 es E(NADH/3'-keto-adenosine) and E(NAD(+)/3'-deoxyadenosine) but was absent for the complex E(NADH/3'

140 of thymocyte development is not adenosine or deoxyadenosine, but a phosphorylated derivative of an AD

141 ly protected against lower concentrations of deoxyadenosine by the ability to cleave it and use the a

142 ues, such as 10 (N6-cyclopentyl-3'-ureido-3'-deoxyadenosine), by >100-fold, while decreasing the affi

143 mined for their ability to handle 3-deaza-2'-deoxyadenosine (c3dA), an analog of 2'-deoxyadenosine la

144 type II I-compounds contained 8,5'-cyclo-2'-deoxyadenosine (cA).

145 ylamine derivatives of both adenosine and 2'-deoxyadenosine can be prepared via simple S(N)Ar reactio

146 ing the stereoisomeric R and S 5',8-cyclo-2'-deoxyadenosine (cdA) and 5',8-cyclo-2'-deoxyguanosine (c

147 damage products including the 8,5'-cyclo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine (c

148 8,5'-cyclo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine ge

149 nce that both (5'R)- and (5'S)-5',8-cyclo-2'-deoxyadenosine (cdA) in a CAG repeat tract caused CTG re

150 still accelerates in response to 2-chloro-2'-deoxyadenosine (Cl-dAdo).

151 ues, such as the antineoplastic, 2-chloro-2'-deoxyadenosine (cladribine) and puromycin, a protein syn

152 The nucleoside analog 2-chloro-2'-deoxyadenosine (CldAdo; cladribine) is effective in the

153 f the clinical agent cladribine (2-chloro-2'-deoxyadenosine, CldAdo), which is the drug of choice aga

154 as indicated by the phosphate dependence of deoxyadenosine cleavage in T. brucei cell extracts and i

155 iated protection is less efficient at higher deoxyadenosine concentrations.

156 -deoxyguanosine (cyclo-dG) and 8,5'-cyclo-2'-deoxyadenosine (cyclo-dA) in five different strains of E

157 ells, the oxidative DNA lesion 8,5'-cyclo-2'-deoxyadenosine (CydA) induces prolonged stalling of RNA

158 yclic amines of deoxyguanosine (dG N(2)) and deoxyadenosine (dA N(6)) in DNA.

159 site-specific N2-deoxyguanosine (dG) and N6-deoxyadenosine (dA) adducts derived from BaP 7,8-diol 9,

160 ed benzo[a]pyrene 7,8-diol 9,10-epoxide (DE) deoxyadenosine (dA) adducts of known absolute configurat

161 l stable BPQ-deoxyguanosine (dG) and two BPQ-deoxyadenosine (dA) adducts.

162 has been utilized to synthesize covalent 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) adducts o

163 tereomeric pairs of diol epoxide-adducted 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) nucleosid

164 appreciable levels in vivo by deamination of deoxyadenosine (dA) and deoxyguanosine (dG), respectivel

165 uantitatively measure low levels of DNA base deoxyadenosine (dA) and its isotopologues (e.g., dA M+1)

166 NA nucleosides and their isotopologues (e.g. deoxyadenosine (dA) M + 1, dA M + 2, dA M + 3), as well

167 of the lesion directs misincorporation of 2'-deoxyadenosine (dA) opposite it.

168 nd benzo[c]phenanthrene (BcPh) DE adducts at deoxyadenosine (dA) or deoxyguanosine (dG) bases in four

169 specific bulky, covalent adducts at N(6) of deoxyadenosine (dA) or N(2) of deoxyguanosine (dG) on We

170 e report that BP adducts at the +1 and -2 N6-deoxyadenosine (dA) positions flanking the scissile phos

171 ol 9,10-epoxide were introduced at single N6-deoxyadenosine (dA) positions within the 3'-G+5G+4G+3A+2

172 cross-link between abasic (Ap) sites and 2'-deoxyadenosine (dA) residues was recently reported, but

173 richia coli DNA polymerase I incorporated 2'-deoxyadenosine (dA) six times more frequently than 2'-de

174 When the 2'-deoxyadenosine (dA) was substituted with adenosine (A),

175 es the initial conversion of the nucleosides deoxyadenosine (dA), deoxyguanosine (dG), and deoxycytid

176 The purine deoxyribonucleoside, deoxyadenosine (dA), is directly isolated from hydrolysa

177 n, was used to form a volatile derivative of deoxyadenosine (dA).

178 gen atom abstraction from the N6-amine of 2'-deoxyadenosine (dA*).

179 (6)-[3-methoxyestra-1,3,5(10)-trien-6-yl]-2'-deoxyadenosine (dA-N(6)-3MeE), which were embedded in si

180 exocyclic N(6)() amino group of the central deoxyadenosine, dA(6), through trans addition at C10 of

181 Deoxyadenosine (dAdo) is a DNA breakdown product that am

182 he radical was found to be located on the 2'-deoxyadenosine (dAdo) moiety of DNA.

183 rations of extracellular adenosine (Ado) and deoxyadenosine (dAdo).

184 e findings, we are naming this new enzyme 5'-deoxyadenosine deaminase (DadD).

185 Deuterium transfer from substrate to deoxyadenosine demonstrated that the substrate radical i

186 Deoxyguanosine, deoxyadenosine, deoxythymidine, and deoxycytidine were u

187 condensation occurred also with an analogous deoxyadenosine derivative on polyuridylic acid and with

188 various aryl iodides provides 8-arylated 2'-deoxyadenosine derivatives in good yields.

189 Cob(II)alamin and 5'-deoxyadenosine derived from 5'-deoxyadenosylcobalamin ar

190 f 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine did inhibit HIV-1 growth and infectivity,

191 ulates up to approximately 0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates

192 s report we show that 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), a nucleoside analog that retains

193 tiffer on going from adenosylcobalamin to 5'-deoxyadenosine, even though the 5'-carbon remains formal

194 After attaching a 25-mer poly-2'-deoxyadenosine extension to these structures, unraveling

195 the nontoxic nucleoside analogue 2-fluoro-2'-deoxyadenosine (F-dAdo) is a "subversive substrate." Pho

196 The corresponding lesions derived from 2'-deoxyadenosine, Fapy.dA and 8-oxo-dA, were not detectabl

197 P), presumably by radical addition of the 5'-deoxyadenosine followed by oxidative decarboxylation to

198 ignificant difference is the substitution of deoxyadenosine for riboadenosine at A76, which mimics th

199 DNA on the 3' or the 5' side of the adducted deoxyadenosine for the 1S- and 1R-adducts, respectively.

200 etheno-2'-deoxycytidine and 1,N(6)-etheno-2'-deoxyadenosine, formed from 2,3-epoxyaldehydes of endoge

201 nduces the formation of cob(II)alamin and 5'-deoxyadenosine from adenosylcobalamin at the active site

202 enes nuclease A to generate macrophage-toxic deoxyadenosine from DNA.

203 a-HOPdG) and gamma-hydroxy-1,N(6)-propano-2'-deoxyadenosine (gamma-HOPdA).

204 f alkyl- or arylthiols to 7-vinyl-7-deaza-2'-deoxyadenosine gave a series of 7-[2-(alkyl- or arylsulf

205 ified by mass spectrometry as 5'-mercapto-5'-deoxyadenosine, generated by direct attack of the 5'-deo

206 lpha were mimicked by 2-chloro-adenosine >3'-deoxyadenosine> adenosine but not by a variety of other

207 zido-5'-(diaminobutyric acid)-N-iodoethyl-5'-deoxyadenosine, has been accomplished in 10 steps from c

208 responding modifications of thymidine and 2'-deoxyadenosine have not been assessed, though significan

209 h viperin reductively cleaves SAM to form 5'-deoxyadenosine in a slow, uncoupled reaction characteris

210 adenosine of the RTA depurination site with deoxyadenosine in a small RNA stem-loop increased k(cat)

211 capable of cleaving SAM to methionine and 5'-deoxyadenosine in an uncoupled reaction (k(obs) = 0.011

212 hree times higher than those of 8-hydroxy-2'-deoxyadenosine in pig liver DNA.

213 ional effects of AP sites substituted for 2'-deoxyadenosine in the first (ap7), second (ap13) or thir

214 mino group on a nearby 2-deoxyguanosine or 2-deoxyadenosine in the opposite strand.

215 aining a catalytically inactive analog of 2'-deoxyadenosine in which a single 2'-H atom was replaced

216 [2-(alkyl- or arylsulfanyl)ethyl]-7-deaza-2'-deoxyadenosines in 45-85% yields.

217 ing tools based on directed deamination of 2-deoxyadenosines in DNA/RNA hybrids.

218 by ADAR were used to target six different 2-deoxyadenosines in the M13 bacteriophage ssDNA genome.

219 sess the efficacy of cladribine (2-chloro-2'-deoxyadenosine) in the treatment of ECD.

220 Indeed, 3'-deoxyadenosine inhibits HIV-1 proviral DNA synthesis in

221 S-adenosylmethionine into methionine and 5'-deoxyadenosine is observed during the reaction.

222 fer of (3)H to AdoMet, while no tritiated 5'-deoxyadenosine is observed.

223 Deoxyadenosine is preferentially incorporated opposite C

224 also consistent with the contention that 5'-deoxyadenosine is the sole mediator of hydrogen transfer

225 za-2'-deoxyadenosine (c3dA), an analog of 2'-deoxyadenosine lacking the minor groove electron pair.

226 mumol/L (normal value, <1.5 mumol/L) and 2'-deoxyadenosine levels of 0.7, 2.7, and 2.4 mumol/L (norm

227 Lowering adenosine and 2'-deoxyadenosine levels using ADA enzyme therapy decreased

228 f 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811), but not pentamidine, berenil

229 er membrane protein Ag43 in E. coli requires deoxyadenosine methylase (Dam) and OxyR.

230 hylated template DNA, which is essential for deoxyadenosine methylase (Dam)- and OxyR-dependent phase

231 Mutants in deoxyadenosine methyltransferase (dam) from many Gram-ne

232 activation is associated with loss of the 5'-deoxyadenosine moiety from the active site, precluding r

233 -yloxymethyl]-phosphonic acid) is a dAMP (2'-deoxyadenosine monophosphate) analog that maintains its

234 syntheses of authentic N(6)-carboxymethyl-2'-deoxyadenosine (N(6)-CMdA) and N(4)-carboxymethyl-2'-deo

235 osine (O(6)-MedG), and N(6)-carboxymethyl-2'-deoxyadenosine (N(6)-CMdA).

236 re, although formaldehyde can result in N(6)-deoxyadenosine, N(2)-deoxyguanosine, and N(4)-deoxycytid

237 mmune function and less elevated erythrocyte deoxyadenosine nucleotides than his 4-year-old affected

238 oxyguanosine (OG) or an 8-oxo-7,8-dihydro-2'-deoxyadenosine (OA) nucleotide and Escherichia coli sing

239 rred from the methyl group of SAM2 to the 5'-deoxyadenosine of SAM1 and the other two hydrogens of th

240 ir of 7,8-dihydro-8-oxo-2'-deoxyguanosine-2'-deoxyadenosine (OG*A) mismatches in DNA.

241 from 7, 8-dihydro-8-oxo-2'-deoxyguanosine:2'-deoxyadenosine (OG:A) mispairs.

242 ionarily conserved and were enriched in poly-deoxyadenosine or poly-deoxythymidine sequences.

243 ound that LGE(2) reacted with deoxycytidine, deoxyadenosine, or deoxyguanosine in vitro to form coval

244 xsA, reveals that OXT-A is derived from a 2'-deoxyadenosine phosphate in an OxsB-catalysed ring contr

245 ibitor of adenosine kinase, the major thymic deoxyadenosine phosphorylating enzyme, or with bcl-2 tra

246 ntroduced at single N2-deoxyguanosine and N6-deoxyadenosine positions within the 3'-G(+5)G(+4)G(+3)A(

247 conformational preferences of the 8-aryl-2'-deoxyadenosine products have been determined by detailed

248 3'-Amino-3'-deoxyadenosine proved to be 7-fold more potent at the H2

249 nificant accumulation of (5'R)-8,5'-cyclo-2'-deoxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyaden

250 enzyme able to reductively cleave SAM to 5'-deoxyadenosine radical and is competent in FeMo-co matur

251 Conversion of NETs to deoxyadenosine requires two enzymes, nuclease and adenos

252 or adenylate cyclase inhibitors, H89 and di-deoxyadenosine, respectively, indicating a cAMP-mediated

253 oxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyadenosine (S-cdA) in liver DNA of neil1(-/-) mice t

254 olites S-adenosylhomocysteine, adenosine, 5'-deoxyadenosine, S-methyl-5'-thioadenosine, methionine, a

255 age in T. brucei cell extracts and increased deoxyadenosine sensitivity in TbMTAP knockdown cells.

256 en C2'-endo and C2'-exo conformations at the deoxyadenosine site moves the 3'- and 5'-phosphorus atom

257 ence of a more flexible ribosyl group at the deoxyadenosine site.

258 series of duplex DNA substrates containing a deoxyadenosine stereospecifically modified by a covalent

259 rst native fluorination enzyme, 5'-fluoro-5'-deoxyadenosine synthase, from this organism.

260 analyzing the mode of action of 5'-fluoro-5'-deoxyadenosine synthase, the only known enzyme capable o

261 a duplex DNA containing an alpha-anomeric 2'-deoxyadenosine:T base pair.

262 her turnover number (kcat) and Km values for deoxyadenosine than for the regular substrate, methylthi

263 or neplanocin A) or a nonsubstrate (i.e., 3'-deoxyadenosine), the independent domain motion associate

264 gene product catalyzes the conversion of 5'-deoxyadenosine to 5'-deoxyinosine as its major product b

265 we observe the 3'-hydroxyl of the conserved deoxyadenosine to be close to one of the two divalent me

266 relative to the transfer of tritium from 5'-deoxyadenosine to either substrate or product.

267 thymine radical abstracts a hydrogen from 5'-deoxyadenosine to regenerate the 5'-deoxyadenosyl radica

268 lity contained truncations in the regulatory deoxyadenosine tract element (DATE) of the HGF gene prom

269 angstroms, both alone and in complex with 3'-deoxyadenosine triphosphate (3'-dATP).

270 east poly(A) polymerase (PaP) to incorporate deoxyadenosine triphosphate (dATP) at the 3'-OH of an RN

271 plexes with either GS-9148-diphosphate or 2'-deoxyadenosine triphosphate (dATP), and a post-incorpora

272 nitrobenzyl group to the N(6)-position of 2'-deoxyadenosine triphosphate (dATP), which, upon incorpor

273 show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex wit

274 phocyte apoptosis by being phosphorylated to deoxyadenosine triphosphate (dATP).

275 bine triphosphate to its normal counterpart, deoxyadenosine triphosphate (median, 2.2; range, 0.2 to

276 onformation nucleotide North-methanocarba-2'-deoxyadenosine triphosphate (N-MC-dATP).

277 nce of metal ions (Pb(2+)), small molecules (deoxyadenosine triphosphate) and nucleic acids homologou

278 ormation at a physiological concentration of deoxyadenosine triphosphate.

279 ve dinucleosides composed of adenosine or 2'-deoxyadenosine units joined by flexible linkers were stu

280 f the hydroxyl groups leading to 8-fluoro-2'-deoxyadenosine using TASF in methylene chloride demonstr

281 al method for efficient N(6)-arylation of 2'-deoxyadenosine via copper-catalyzed direct coupling with

282 netic isotope effect for the formation of 5'-deoxyadenosine was 0.76 +/- 0.02, which suggests a late

283 The Km for 5'-deoxyadenosine was found to be 14.0 +/- 1.2 muM with a k

284 he basal compartment, whereas that for (14)C-deoxyadenosine was from the basal to the apical compartm

285 In each case, no detectable arylation of 2'-deoxyadenosine was noted.

286 plicability in that only N(6)-(1-pyrenyl)-2'-deoxyadenosine was prepared by this method; on the other

287 ase IV (Endo IV) to efficiently incise alpha-deoxyadenosine was used as a tool to determine the confi

288 hich the cationic adduct was mismatched with deoxyadenosine, was refined using molecular dynamics cal

289 However, the products cob(III)alamin and 5'-deoxyadenosine were observed upon inactivation of 5,6-LA

290 umol/L); the mean levels of adenosine and 2'-deoxyadenosine were respectively 12.0- and 27.6-fold hig

291 nases are involved in the phosphorylation of deoxyadenosine when ADA is absent, and suggests an alter

292 effects associated with the formation of 5'-deoxyadenosine when glutamate mutase was reacted with [5

293 e effect associated with the formation of 5'-deoxyadenosine when the enzyme is reacted with [5'-(3)H]

294 that DadD is involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5

295 pears to have a high binding affinity for 2'-deoxyadenosine, which explains the mandatory requirement

296 za-2'-deoxyadenosine (3DA), an analogue of 2-deoxyadenosine, which has the same HB pattern opposite T

297 escapes these defenses by converting NETs to deoxyadenosine, which triggers the caspase-3-mediated de

298 butyldiphenylsilyl 5'-protected 8-ethynyl-2'-deoxyadenosine with the corresponding bromoanthraquinone

299 Pd/Cu-mediated direct arylation of 2'-deoxyadenosine with various aryl iodides provides 8-aryl

300 93 cells conferred resistance to 2-chloro-2'-deoxyadenosine, with a 49-fold increase in the IC(50) in