ライフサイエンスコーパス: deoxycorticosterone

1 urosteroids, allopregnanolone and tetrahydro-deoxycorticosterone.

2 one metabolites migrated at the same rate as deoxycorticosterone.

3 After 7 days of treatment with deoxycorticosterone (2 mg/day), an increased number of H

4 ase-3 (NOS3) expression in rats treated with deoxycorticosterone acetate (DOCA) and high salt.

5 (SD), spontaneously hypertensive (SHR), and deoxycorticosterone acetate (DOCA) hypertensive single c

6 sverse aortic constriction (TAC) surgery and deoxycorticosterone acetate (DOCA) pellet implantation.

7 Arteries from deoxycorticosterone acetate (DOCA)-salt and N(omega)-nit

8 ertensive mice with kidney injury induced by deoxycorticosterone acetate (DOCA)-salt compared to the

9 Deoxycorticosterone acetate (DOCA)-salt hypertension is

10 ugmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a

11 scular superoxide level is also increased in deoxycorticosterone acetate (DOCA)-salt hypertension, wh

12 ound that CXCL16 is induced in the kidney in deoxycorticosterone acetate (DOCA)-salt hypertension.

13 th CTLA4-Ig reduced both angiotensin II- and deoxycorticosterone acetate (DOCA)-salt-induced hyperten

14 hat are administered the aldosterone-mimetic deoxycorticosterone acetate (DOCA).

15 studied 2 weeks later) mice without and with deoxycorticosterone acetate administration, all in the s

16 Exogenous deoxycorticosterone acetate and deletion of the P2Y(2) r

17 vels in thoracic aortas when challenged with deoxycorticosterone acetate and high-salt diet (DOCA-sal

18 er the induction of severe hypertension with deoxycorticosterone acetate and salt, proteinuria, impai

19 Compared with sham mice, sham plus deoxycorticosterone acetate mice had mild hypertrophy wi

20 on mice, transverse aortic constriction plus deoxycorticosterone acetate mice had similar left ventri

21 taneous implantation of a controlled-release deoxycorticosterone acetate pellet, and given 1% saline

22 ion per se were studied in uninephrectomized deoxycorticosterone acetate salt-treated rats, where the

23 ust sodium appetite (e.g., sodium depletion, deoxycorticosterone acetate) decrease lateral hypothalam

24 ropriate for salt status, mineralocorticoid (deoxycorticosterone acetate) excess causes hypertrophy,

25 prevented decreases in the ECu50 induced by deoxycorticosterone acetate-no salt treatment.

26 In aortas of mice with deoxycorticosterone acetate-salt (DOCA-salt) hypertensio

27 se in RMR in response to a high-fat diet and deoxycorticosterone acetate-salt (DOCA-salt) treatments,

28 pes in the brain, ADAM17 upregulation during deoxycorticosterone acetate-salt hypertension occurs sel

29 To test this hypothesis, we used the deoxycorticosterone acetate-salt model of neurogenic hyp

30 ebrospinal fluid of nontransgenic mice after deoxycorticosterone acetate-salt treatment and were acco

31 Deoxycorticosterone acetate-salt treatment in nontransge

32 have shown that stimuli like angiotensin II, deoxycorticosterone acetate-salt, and excessive catechol

33 +) intake regardless of the presence of high deoxycorticosterone acetate.

34 cement therapy with either corticosterone or deoxycorticosterone acetate.

35 Administration of the mineralocorticoid deoxycorticosterone-acetate (DOCA) in combination with h

36 1-hydroxylase, converting progesterone to 11-deoxycorticosterone and 17alpha-hydroxyprogesterone (17a

37 o develop an in vitro CYP11B2 assay using 11-deoxycorticosterone as a substrate.

38 3alpha,5alpha-THDOC is synthesized from deoxycorticosterone (DOC) by metabolism in adrenals and

39 ceptor-modulating neurosteroids derived from deoxycorticosterone (DOC) play a role in stress-related

40 one oxetanone (Dex-Ox), progesterone (Prog), deoxycorticosterone (DOC), and RU486.

41 Male rats pretreated with both deoxycorticosterone (DOC; a synthetic precursor of aldos

42 metry further identified as major species of deoxycorticosterone metabolites 3beta,6alpha,21-trihydro

43 apid transformation of both progesterone and deoxycorticosterone; one of the progesterone metabolites

44 OMCD tubules from deoxycorticosterone pivalate (DOCP)-treated rats were pe

45 ns of aldosterone, corticosterone, cortisol, deoxycorticosterone, pregnenolone, and progesterone in b

46 ynthesized in the brain from progesterone or deoxycorticosterone, respectively, by the sequential act

47 cells was initiated with the addition of 11-deoxycorticosterone, the immediate substrate of aldoster

48 ven access to concentrated saline (3% NaCl), deoxycorticosterone-treated rats drank eight times more