ライフサイエンスコーパス: deoxycytidine kinase

1 The compounds were similar as substrates of deoxycytidine kinase.

2 s a poor phosphorylation substrate for human deoxycytidine kinase, a pro-nucleotide form of the 4-bro

3 s spectrophotometric assay for thymidine and deoxycytidine kinase activities by coupling nucleoside 5

4 tivation was significantly less dependent on deoxycytidine kinase and on nucleoside transporters, and

5 dine (RO-9187) were excellent substrates for deoxycytidine kinase and were phosphorylated with effici

6 EGF and the gemcitabine metabolizing enzyme, deoxycytidine kinase, are specifically bound by HuR in p

7 The ratio of deoxycytidine kinase/CDA transcripts significantly corre

8 We used a human deoxycytidine kinase containing three amino acid substit

9 ation in a heterologous system with a 244-bp deoxycytidine kinase core promoter.

10 Deoxycytidine kinase (dCK) activity was approximately 22

11 planation that emerged from enzyme assays of deoxycytidine kinase (dCK) and deoxycytidine monophospha

12 the nucleoside salvage pathway (NSP) enzymes deoxycytidine kinase (dCK) and thymidine kinase (TK1).

13 the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1).

14 Deoxycytidine kinase (DCK) controls the rate-limiting st

15 We hypothesized that PET probes for deoxycytidine kinase (dCK) could be used to differentiat

16 ch as cladribine, require phosphorylation by deoxycytidine kinase (dCK) for pharmacological activity.

17 n, we report the crystal structures of human deoxycytidine kinase (dCK) in complex with the L-nucleos

18 d inhibition of ribonucleotide reductase and deoxycytidine kinase (dCK) in multiple cancer cell lines

19 Deoxycytidine kinase (dCK) is a rate limiting enzyme cri

20 Deoxycytidine kinase (dCK) is a rate-limiting enzyme in

21 Deoxycytidine kinase (dCK) is an essential nucleoside ki

22 Human deoxycytidine kinase (dCK) is responsible for the phosph

23 The physiological role of human deoxycytidine kinase (dCK) is to phosphorylate deoxynucl

24 pancreatic cancer cells, HuR associates with deoxycytidine kinase (dCK) mRNA, which encodes the enzym

25 hough in vitro investigations using purified deoxycytidine kinase (dCK) or deoxyguanosine kinase (dGK

26 Deoxycytidine kinase (dCK) phosphorylates a number of nu

27 human-derived reporter genes based on human deoxycytidine kinase (dCK) suitable for clinical PET.

28 Human deoxycytidine kinase (dCK) uses nucleoside triphosphates

29 nucleotide purine analog, is a substrate for deoxycytidine kinase (dCK), a key enzyme in the deoxyrib

30 (18)F-FAC retention in cells requires deoxycytidine kinase (dCK), a rate-limiting enzyme in th

31 Deoxycytidine kinase (dCK), a rate-limiting enzyme in th

32 r with either deoxyguanosine kinase (dGK) or deoxycytidine kinase (dCK), and is heterotropically acti

33 ilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (dCK), and ribonucleotide reductase

34 In this article, we describe a deficiency in deoxycytidine kinase (DCK), one of the major enzymes of

35 enzymes, ribonucleotide reductase (RNR) and deoxycytidine kinase (dCK), via distinct molecular mecha

36 leukemia (B-CLL) cells have high activity of deoxycytidine kinase (dCK), we hypothesized that these l

37 We wanted to understand why human deoxycytidine kinase (dCK), which is related to HSV1-TK

38 oximately by 2 orders of magnitude in the 2'-deoxycytidine kinase (dCK)-deficient CEM/dCK(-) cell lin

39 step in which they are monophosphorylated by deoxycytidine kinase (dCK).

40 ivation is phosphorylation of the prodrug by deoxycytidine kinase (dCK).

41 o more cytotoxic than gemcitabine HCl in the deoxycytidine kinase deficient (CCRF-CEM/dCK(-/-)) tumor

42 was more active than gemcitabine against two deoxycytidine kinase-deficient cell lines.

43 uman sodium-iodide symporter (hNIS), a human deoxycytidine kinase double mutant (hdCKDM), and herpes

44 Deoxycytidine kinase (EC 2.7.1.74, dCK) is central to dr

45 The virus expressing human deoxycytidine kinase failed to replicate acutely in neur

46 ncy on the nucleoside salvage pathway enzyme deoxycytidine kinase for the maintenance of a proper bal

47 methionine levels, and/or methylation of the deoxycytidine kinase gene.

48 Inhibition of deoxycytidine kinase had little effect on radiocarbon in

49 omoter, was superior to thymidine kinase and deoxycytidine kinase in its ability to achieve high leve

50 Deoxycytidine kinase is the rate-limiting process in the

51 Inhibition of adenosine kinase and deoxycytidine kinase prevented the accumulation of dATP

52 s on the initial monophosphorylation step by deoxycytidine kinase showed that the catalytic efficienc

53 hymidine kinase, deoxycytidine as does human deoxycytidine kinase, the cytosolic kinase whose amino a

54 Human deoxycytidine kinase triple mutant (hdCK3mut) is a nonim

55 For deoxycytidine kinase, we coupled the reaction to a thymi

56 Transcripts of deoxycytidine kinase were 2.6-fold higher in DS compared

57 anscripts of cystathionine-beta-synthase and deoxycytidine kinase were a median 12.5- and 2.6-fold hi

58 cherichia coli cytosine deaminase, and human deoxycytidine kinase were investigated in metastatic hum