ライフサイエンスコーパス: deoxygenate

1 without the need for reaction mixtures to be deoxygenated.

2 Conversion of normal deoxygenated, adult hemoglobin (HbA) in high concentrati

3 We found that the reaction of nitrite with deoxygenated AHb1 and AHb2 generates NO gas and iron-nit

4 These results demonstrate that deoxygenated AHb1 and AHb2 reduce nitrite to form NO via

5 Extensive dimerization of liganded but not deoxygenated alpha-cpbeta was observed by gel chromatogr

6 es were identified by HPLC/QToF-MS to be the deoxygenated analogs.

7 etailed herein can be used to access both C4-deoxygenated and C4-oxygenated cladiellins and briarelli

8 structures of these two mutants in both the deoxygenated and CO-liganded states.

9 elementary steps by which carbon monoxide is deoxygenated and coupled, but a single metal site that c

10 alpha 103(G10) and His alpha 122(H5) in both deoxygenated and ligated hemoglobin by NMR spectroscopy.

11 re able to measure the migration velocity of deoxygenated and metHb-containing erythrocytes, exposed

12 ontrast microscopy to confirm aggregation of deoxygenated and oxygenated hemoglobins below their solu

13 The influent water was initially deoxygenated and the emissions and concentration distrib

14 asing H2 production over three times that of deoxygenated aqueous solutions alone.

15 hotosensitization by rose bengal (RB(2-)) in deoxygenated aqueous solutions resulting in one-electron

16 concentrations over TiO(2) under UV light in deoxygenated aqueous suspensions is described.

17 nly the ditriflate 8a gave the corresponding deoxygenated aromatic scaffold.

18 erfused for 20 min with neutrophil-depleted, deoxygenated blood in Perfadex solution.

19 of the Fontan circuit allows for shunting of deoxygenated blood to the systemic circulation.

20 lar resistance and right-to-left shunting of deoxygenated blood.

21 lation of a C2-symmetric diol to form the C9-deoxygenated bryostatin A-ring.

22 We show that plasma from deoxygenated, but not from oxygenated, blood produces th

23 The halogenated products were deoxygenated by PCl3 or PBr3.

24 The monorhenium(VII) complex is deoxygenated by PMe2Ph to give the rhenium(V) compound (

25 thC moiety is an intermediate on the path to deoxygenated, C-C coupled products.

26 Thus, rapidly deoxygenated CDB3-bound hemoglobin alphabeta dimers reac

27 were increased in O2 compared with those in deoxygenated cells at the same free [Mg2+]i, by about 6-

28 l volume during incubation in vitro, whereas deoxygenated cells become dehydrated, and therefore more

29 K+-Cl- cotransport was minimal in deoxygenated cells but substantial in oxygenated ones.

30 Cl- cotransporter, was revealed by depleting deoxygenated cells of Mg2+.

31 ssess sickle cell deformability after mixing deoxygenated cells with buffer that was partially or ful

32 By contrast, in deoxygenated cells, although the transporter activity wa

33 s; that of the Gardos channel was greater in deoxygenated cells.

34 ulation of KCC was similar in oxygenated and deoxygenated cells; that of the Gardos channel was great

35 [Mn2(L)(mcb)(Ru((CF3)2-bpy)2)](PF6)3 (4) in deoxygenated CH2Cl2 solution results in emission charact

36 Primary alcohols can be deoxygenated cleanly and in yields of 60-95% by reductio

37 together with 11-cis-13-cis-isomers and the deoxygenated compound (3EZ,5EZ,8E)-3,7-dimethyl-9-(2,6,6

38 system was found to afford the corresponding deoxygenated compounds.

39 near-steady benzene emission at the initial deoxygenated condition, the emission was reduced by abou

40 xide by red blood cells under oxygenated and deoxygenated conditions at different hematocrit percenta

41 rmal morphology and membrane mechanics under deoxygenated conditions due to the polymerization of hem

42 ned this reaction and found that under fully deoxygenated conditions the product stoichiometry is 1:1

43 Moreover, under deoxygenated conditions, conversion to the aromatic pyri

44 2.48%, n=5) were recorded in oxygenated and deoxygenated conditions, with response times of 2s and 5

45 ding selenenic ester, is also observed under deoxygenated conditions.

46 L and 17-20 mg/L, and then decreased back to deoxygenated conditions.

47 c cofactor that stabilizes the low-affinity, deoxygenated conformation of the hemoglobin tetramer.

48 me in the R (oxygenated conformation) and T (deoxygenated conformation) allosteric quaternary structu

49 otophysical properties of these molecules in deoxygenated cyclohexane, including their absorption spe

50 eep CNN exhibits good performance even for a deoxygenated dataset and distinguishes the subtle differ

51 The kinetics of CO binding to the deoxygenated derivatives following rapid mixing and of C

52 hese variants as well as the tendency of the deoxygenated derivatives to dissociate into alphabeta di

53 active at high concentration (1 mM), but the deoxygenated derivatives were inactive.

54 tiomerically pure haloconduritols or certain deoxygenated derivatives with either terminal alkynes or

55 that was capable of measuring oxygenated and deoxygenated (Dhb) hemoglobin specifically in the mucosa

56 In this investigation, sickle RBCs were deoxygenated either continuously or in 15-minute cycles

57 b+) influxes were measured in oxygenated and deoxygenated equine red blood cells, whose free [Mg2+]i

58 .18x10(-6)) but lower than that of the fully deoxygenated erythrocyte (3.33x10(-6)).

59 We find that deoxygenated erythrocytes scavenge nitric oxide faster t

60 te reductase activity of deoxyhemoglobin and deoxygenated erythrocytes.

61 Nitrite is reduced by deoxygenated ferrous hemes, such that heme deoxygenation

62 ridged peroxide) can be fully reduced to the deoxygenated form with four equivalents of cobaltocene.

63 transitions from the oxygenated form to the deoxygenated form.

64 ydroxylated (haterumalides NC and ND) and C9 deoxygenated forms (haterumalides NA, NB, and NE; via de

65 fference in magnetism between oxygenated and deoxygenated forms of the protein and, along with consid

66 Deoxygenated GbX reduces nitrite to form nitric oxide (N

67 m total Hb (tHb), oxygenated Hb (oxyHb), and deoxygenated Hb (deoxyHb) concentrations.

68 ated during crystallization experiments with deoxygenated Hb (deoxyHb): one crystal type was composed

69 lly, we show that intracellular S1P promotes deoxygenated Hb anchoring to the membrane, enhances the

70 0 v 26.5 mm Hg), and the lower solubility of deoxygenated Hb S Antilles than Hb S (approximately 11 v

71 udies, indicating that the polymerization of deoxygenated Hb S can be significantly slowed by relativ

72 hreonine at beta 87 in the polymerization of deoxygenated Hb S.

73 eous nitric oxide (NO) are equilibrated with deoxygenated Hb, all NO added can be accounted for in te

74 S (HbS), which is the concentration of fully deoxygenated HbS in equilibrium with polymer (C(SAT)), i

75 a ligand and is a good model for permanently deoxygenated heme.

76 rotocatechuic acid 3,4-dioxygenase system to deoxygenate hemoglobin solutions enzymatically.

77 hemoglobin (oxy-Hb) was reduced (P<0.01) and deoxygenated hemoglobin (deoxy-Hb) showed a near signifi

78 cess, and that the reaction between GSNO and deoxygenated hemoglobin (deoxyHb) did not conform to sec

79 in (tHb), oxygenated hemoglobin (oxyHb), and deoxygenated hemoglobin (deoxyHb) were computed from the

80 elationships of cerebral blood volume (CBV), deoxygenated hemoglobin (Hbr), and light scatter (LS) as

81 globin (HbO2) and decreased concentration of deoxygenated hemoglobin (HHb) in the prefrontal cortex a

82 entration, in comparison to COHbS, COHbA, or deoxygenated Hemoglobin A (HbA), none of which have the

83 10(-6) mm(3) s/kg for erythrocytes with 100% deoxygenated hemoglobin and 3.66 x 10(-6) mm(3) s/kg for

84 es to blood flow regulation by reaction with deoxygenated hemoglobin and tissue heme proteins to form

85 The reduction of nitrite by deoxygenated hemoglobin chains has been implicated in re

86 partial pressure of oxygen decreases and the deoxygenated hemoglobin formed reduces the nitrite regen

87 hanges in cortical oxygenated hemoglobin and deoxygenated hemoglobin inferring prefrontal activation

88 hanges in cortical oxygenated hemoglobin and deoxygenated hemoglobin inferring prefrontal activation

89 to formation of iron nitrosyl hemoglobin in deoxygenated hemoglobin preparations and a radical in ox

90 ggests that the reaction between nitrite and deoxygenated hemoglobin provides a mechanism by which ni

91 The solubility of deoxygenated hemoglobin S (HbS), which is the concentrat

92 Vaso-occlusion occurs when deoxygenated hemoglobin S polymerizes and erythrocytes s

93 derived from contributions of oxygenated and deoxygenated hemoglobin spectral signatures extracted fr

94 s at beta37 also alter the properties of the deoxygenated hemoglobin tetramer.

95 The reaction of deoxygenated hemoglobin with limited quantities of nitri

96 he presence of blood hypoxia (high levels of deoxygenated hemoglobin) in the liver and kidneys that w

97 ack to NO by the nitrite reductase action of deoxygenated hemoglobin, acidic disproportionation, or x

98 d by concentration changes in oxygenated and deoxygenated hemoglobin, were assessed in the frontal co

99 and oxygenated hemoglobin, and decreases in deoxygenated hemoglobin.

100 hemoglobin and least pronounced for rapidly deoxygenated hemoglobin.

101 een this anion and the ferrous heme group of deoxygenated hemoglobin.

102 ing in considerable dissociation of even the deoxygenated hemoglobins into alphabeta dimers at microm

103 We show that deoxygenated human neuroglobin reacts with nitrite to fo

104 isation in cells from sickle trait patients (deoxygenated hyperosmotic sucrose solutions at pH 6) sup

105 which the amino inositol unit is cleaved and deoxygenated in a homologous fashion.

106 y of sickle cell disease; namely, that cells deoxygenated in the microcirculation are not merely unde

107 nce of human epithelial tissue as it becomes deoxygenated in vivo, we can resolve the fluorescence sp

108 erved the triplet-state lifetime of aqueous, deoxygenated indole and several indole derivatives to be

109 ients with sickle cell disease (SCD) lyse in deoxygenated isosmotic non-electrolyte solutions.

110 HbSC individuals showed progressive lysis in deoxygenated isosmotic sucrose solution at pH 7.4 to a l

111 n an in situ perfused mouse liver model with deoxygenated Krebs-Henseleit buffer followed by oxygenat

112 re we present the 2.9-A crystal structure of deoxygenated lamprey hemoglobin in an orthorhombic cryst

113 ver grafts from Lewis rats underwent HOPE or deoxygenated machine perfusion for 1 hour before implant

114 Molecular recognition using a series of deoxygenated maltose analogues was used to determine the

115 to those for simple nitric oxide binding to deoxygenated Mb and Hb.

116 After the training period, deoxygenated Mb kinetics during muscle contraction were

117 dation of ETBE by PPHA photosensitization in deoxygenated media (Lambda = 11 +/- 1).

118 nd accounts for up to 30% of the reaction in deoxygenated medium upon irradiation with polychromatic

119 e role of band 3 in mediating the oxygenated/deoxygenated metabolic transition was examined by treati

120 sis of 1-(3-alkynoxy)-9,10-anthraquinones in deoxygenated methanol leads to moderate yields (35-45%)

121 ubility behavior, and phase distributions of deoxygenated mixtures of Hb S with 70-kDa dextran, a rel

122 generation of NO. from nitrite reduction by deoxygenated myoglobin activates canonical soluble guany

123 We have shown that deoxygenated myoglobin in the heart can reduce nitrite t

124 We recently discovered that deoxygenated neuroglobin converts nitrite to nitric oxid

125 e always greater in oxygenated cells than in deoxygenated ones, and changes in free [Mg2+]i of the ma

126 .04 mM (mean +/- S.E.M., n = 5; P < 0.05) in deoxygenated ones.

127 , X=halide) demonstrate high efficiencies in deoxygenated organic solvents but do not function in air

128 cilitates the conversion of oxy-alphaHb to a deoxygenated, oxidized [Fe(III)], nonreactive form in wh

129 er oxygenated incubation or rapid oxygenated/deoxygenated (oxy/deoxy) cycling (70 seconds per cycle).

130 Thus the deoxygenated permutated beta subunits generate an interm

131 Oxygenated PFE, but not deoxygenated PFE, resulted in PRU decreases to baseline

132 al additional streamlined total syntheses of deoxygenated PI analogues are reported.

133 pha(2)(P)beta(2)(S) does not polymerize when deoxygenated; pig alpha-chain completely neutralizes the

134 These reactants deoxygenate predominantly via decarbonylation (C-C cleav

135 rom beta-xylo-furanose affords exclusively a deoxygenated product; whereas, under the same reaction c

136 ed to pool blood from donors, detoxifies and deoxygenates pulmonary effluent blood, and permits exami

137 texture alteration inside the oxygenated and deoxygenated RBCs.

138 ss validation method both for oxygenated and deoxygenated RBCs.

139 sical basis of the wide variety of shapes of deoxygenated red cells from patients with sickle cell an

140 M (mean +/- s.e.m., n = 4) in oxygenated and deoxygenated red cells, respectively.

141 [Mg2+]i inhibited it, in both oxygenated and deoxygenated red cells.

142 s the radical-mediated elimination of H2O to deoxygenate ribonucleotides, an example of 'spin-centre

143 e of the pulmonary artery and aorta to guide deoxygenated right ventricular blood into the lungs and

144 en showed reduced photostability compared to deoxygenated samples.

145 K+ influx in fully deoxygenated sheep red cells showed substantial volume a

146 The rLbII was reversibly oxygenated/deoxygenated, showing that it is a functional hemoglobin

147 We found that the deformability of deoxygenated sickle cells did not regain its optimal val

148 port that increased erythrocyte S1P binds to deoxygenated sickle Hb (deoxyHbS), facilitates deoxyHbS

149 cell disease (SCD) is the polymerization of deoxygenated sickle hemoglobin (HbS).

150 kinetics of changes in the deformability of deoxygenated sickle red blood cells when they are expose

151 s in vivo, and transnitrosation reactions of deoxygenated SNO-Hb are proposed as a mechanism leading

152 ow oxygen tension if this were to occur from deoxygenated SNO-Hb.

153 ge of 3-5 in the air-saturated and partially deoxygenated solution are examined here.

154 following excitation of the Ru complexes in deoxygenated solutions, the radiative (k(r)) and nonradi

155 Deoxygenated SS RBCs caused a persistent 1.5-fold PRU in

156 r obstruction was induced by the infusion of deoxygenated SS RBCs into ex vivo preparations with or w

157 ely 30% increase in solubility for the fully deoxygenated state, along with a significant increase in

158 denaturation, pentacoordinate in the ferrous deoxygenated state, and oxygen-avid.

159 ty generated by hemoglobin S polymers in the deoxygenated state.

160 ling human hemoglobin between oxygenated and deoxygenated states.

161 Staurosporine (2 microM) inhibited deoxygenated-stimulated K+ influxes, but not those stimu

162 Interaction with AE1 promotes the deoxygenated structure in SNO-haemoglobin, which subserv

163 emoglobin [from the R (oxygenated) to the T (deoxygenated) structure] that releases the NO group.

164 e ability of Tyl1a and TylB to process a C-2 deoxygenated substrate and a CDP-linked substrate was al

165 near physiological temperatures to occur in deoxygenated sucrose solutions at pH 7.4.

166 deoxy-beta-D-threo-hexopyranose) is a highly deoxygenated sugar component of several important natura

167 al sediment matrix consisting of pH-buffered deoxygenated sulfidic agar.

168 presented here suggest that the successively deoxygenated sulfur and nitrogen species produced during

169 imited by the binding of the first CO to the deoxygenated T state of the protein.

170 s a large effect on the beta subunits in the deoxygenated T state, but very little effect on the alph

171 rous variables besides the properties of the deoxygenated T state.

172 s increasingly difficult for subunits in the deoxygenated T-state tetramer to assume higher oxygen af

173 xchange rates were found to be higher in the deoxygenated-T than in ligated-R state.

174 exanes while tertiary silanes give partially deoxygenated tetraol and triol products.

175 Attempts were made to deoxygenate the 9,10-dimesylate, ditosylate, and ditrifl

176 While the condensation steps deoxygenate the alcohol components, the dehydrogenations

177 oposed where trialkylphsophine chalcogenides deoxygenate the oleic acid or phosphonic acid surfactant

178 the microcirculation, including 1 capable of deoxygenating the sRBC environment to monitor changes in

179 Triplet C ((3)P) atoms will deoxygenate to give CO plus CH(2) ((3)B(1)) as the major

180 ate in the synthesis of (-)-citrinadin A was deoxygenated to generate a dehydroxy compound that was e

181 both terminal and internal vicinal diols are deoxygenated to olefins in good yield.

182 paced to increase workload and perfusate was deoxygenated to study the effects of myocardial hypoxia.

183 sulting amino alcohol was alkylated and then deoxygenated using a Lewis acid and Et(3)SiH to give the

184 l-3,5-bisphosphate (PI3,5P2), and a range of deoxygenated versions are reported.

185 ia characterised by diel fluctuations of hot-deoxygenated water coupled with tidally driven persisten

186 on and postprocessing of black phosphorus in deoxygenated water.

187 ries between 0.2 mM (oxygenated) and 0.6 mM (deoxygenated), well above the measured [Mg2+]i(1/2).