ライフサイエンスコーパス: deoxyguanosine

1 dition to increased urine secretion of 8-oxo-deoxyguanosine.

2 anscriptional markers but positive for 8-oxo-deoxyguanosine.

3 ass that most tightly bind the nucleoside 2'-deoxyguanosine.

4 s factors are known to attack preferentially deoxyguanosine.

5 : thymidine > deoxyuridine >> deoxyinosine > deoxyguanosine.

6 sylase activity for the excision of 8-oxo-2'-deoxyguanosine.

7 in its apo form and in complex with 8-oxo-2'-deoxyguanosine.

8 pproximately 120-fold relative to unmodified deoxyguanosine.

9 s of PNPs and is essential for catabolism of deoxyguanosine.

10 dihydroxy-5,6-dihydrothymine, mispaired with deoxyguanosine.

11 -2'-deoxyguanosine, and (5'-S)-8,5'-cyclo-2'-deoxyguanosine.

12 ycoside cleavage in 2'-deoxyadenosine and 2'-deoxyguanosine.

13 r to those observed for 8-oxo-7,8-dihydro-2'-deoxyguanosine.

14 -deoxyuridine, 2'-deoxyuridine, and 8-oxo-2'-deoxyguanosine.

15 avidin to DNA containing oxidatively damaged deoxyguanosine.

16 ators, O(6)-benzylguanine and O(6)-benzyl-2'-deoxyguanosine.

17 stereoisomeric adducts than in unmodified 2'-deoxyguanosine.

18 evident by increased levels of 8-hydroxy-2'-deoxyguanosine.

19 were active against the hydroxylation of 2'-deoxyguanosine.

20 of ribose pseudorotation in guanosine and 2'-deoxyguanosine.

21 anosine from oxidation; and 1,N(2)-etheno-2'-deoxyguanosine, 1,N(6)-etheno-2'-deoxyadenosine and 3,N(

22 Using a fused-core silica column, 2'-deoxyguanosine (2dG) and 5-methyl-2'-deoxycytidine (5mdC

23 xycytidine (5mdC) to the internal standard 2-deoxyguanosine (2dG) in mass signal were used to quantif

24 llyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (3) and of the 6-amino group of 3',5'-di-

25 hes for the synthesis of 2'-C-beta-methyl-2'-deoxyguanosine (3) via 2'-radical deoxygenation.

26 llyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (3).

27 e and showed sigmoidal enzyme kinetics (K0.5(deoxyguanosine) = 302 +/- 12 mum; kcat = 14 min(-1)).

28 changes was the accumulation of 8-hydroxy-2'-deoxyguanosine, 4-hydroxynonenal protein adducts, and ni

29 hy/mass spectrometry to measure 8-hydroxy-2'-deoxyguanosine, (5'-S)-8,5'-cyclo-2'-deoxyadenosine, (5'

30 oumarin tags to the terminal phosphate of 2'-deoxyguanosine-5'-tetraphosphate.

31 from K2S2O8 or four-electron oxidation of 2'-deoxyguanosine-5'-triphosphate (dGTP) from singlet oxyge

32 8-Nitro-2'-deoxyguanosine (8-nitrodG) is a relatively unstable, mut

33 ly and nitratively damaged DNA (8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NO2Gua)) a

34 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and human neutrophil elastase/al

35 fluid (GCF) and salivary levels of 8-hydroxy-deoxyguanosine (8-OHdG) as a marker of oxidative deoxyri

36 on of 2'-deoxyguanosine to give 8-hydroxy-2'-deoxyguanosine (8-OHdG) as assessed by RP-HPLC (MS).

37 is presented to monitor urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) down to the pmol/L level.

38 An 8-hydroxy-2'-deoxyguanosine (8-OHdG) ELISA assay was used to quantify

39 We also measured 8-hydroxy-2-deoxyguanosine (8-OHdG) levels as a marker of oxidative

40 8-Hydroxyl-2'-deoxyguanosine (8-OHdG) was analyzed by immunohistochemi

41 authors examined whether urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), a biomarker of global DNA oxida

42 issue sections were stained for 8-hydroxy-2' deoxyguanosine (8-OHdG), an indicator of hydroxyl radica

43 vention for assessing levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative DNA damage biomark

44 8-Hydroxy-2'-deoxyguanosine (8-OHdG), the predominant marker of oxida

45 d a marker of oxidative stress, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were determined in these sample

46 tDNA damage is the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which can cause mutations when

47 peroxidation; (ii) formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG); (iii) decrease in proliferating

48 peripheral blood leukocytes and 8-hydroxy-2'-deoxyguanosine (8-OHDG; an oxidative DNA damage marker)

49 nt of oxidative DNA lesions such as 8-oxo-2'-deoxyguanosine (8-oxo-dG) and 8-oxo-2'-deoxyadenosine (8

50 Fapy.dG and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) are formed in DNA by hydroxyl

51 ly insert dAMP opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) during translesion DNA synthes

52 ts, but preventing both 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) formation and DNA fragmentatio

53 8-oxo-7,8-dihydroxy-2'-deoxyguanosine (8-oxo-dG) has high mutagenic potential a

54 VB-induced formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) in vivo.

55 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) is one of the most common oxid

56 with an intermediate of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG).

57 d DNA strand breaks and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) formation) in human lung cel

58 by the comet assay) and 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dGuo).

59 ative stress biomarkers 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and malondialdehyde were measur

60 oxidation in DNA, with 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) as a major product.

61 In the presence of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) damage, many DNA polymerases ex

62 7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-oxodG) is a well-known marker of oxida

63 8-Oxo-2'-deoxyguanosine (8-oxodG) is one of the most important ox

64 8-Hydroxy-7,8-hydro-2'-deoxyguanosine (8-oxodG) is selectively oxidized by [Os(

65 DNA oxidation sites, and 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) is the initial product.

66 idative stress, urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most frequently measured

67 ion of Akt and tuberin, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) levels, and 8-oxoG-DNA glycosyl

68 icularly in hydrolysing 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) present at 3'-end of DNA.

69 lls generates mutagenic 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxodG), which may initiate diseases re

70 7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-oxoG) is a major lesion that is a cons

71 rom oxidative stress is 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxoG) that has ambiguous coding potent

72 The oxidized nucleotide, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxoG), is one of the most abundant DNA

73 NA synthesis, including 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxoG), one of the most abundant DNA le

74 es (ROS), primarily as 7, 8-dihydro-8-oxo-2'-deoxyguanosine (8-oxoG), which is repaired by 8-oxoguani

75 major oxidative adduct 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxoG).

76 oxyguanosine-8-yl)-4-aminobiphenyl and N-(2'-deoxyguanosine-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,

77 d to label the deoxynucleoside adducts N-(2'-deoxyguanosine-8-yl)-4-aminobiphenyl and N-(2'-deoxyguan

78 suitably sized cations like K(+), 8-aryl-2'-deoxyguanosine (8ArG) derivatives self-assemble into set

79 halonucleosides in aqueous media, 8-bromo-2'-deoxyguanosine (8BrdG) couplings were slower to reach co

80 change from baseline in urinary 8-hydroxy-2'-deoxyguanosine (8OH2'dG), a marker of oxidative DNA dama

81 ed here to the determination of 8-hydroxy-2'-deoxyguanosine (8OHdG), a biomarker of oxidative stress

82 rotocol relies on the addition of 7-deaza-2'-deoxyguanosine, a dGTP analog to the PCR mixture and a n

83 comitant increase in the production of 8-oxo-deoxyguanosine, a marker for oxidative DNA damage, in hu

84 factor 2, and increased 8-oxo-7,8-dihydro-2'-deoxyguanosine, a marker of DNA damage.

85 associated with reduced (P<0.01) 8-hydroxy-2-deoxyguanosine, a marker of oxidative stress.

86 highly mutagenic imidazole ring-opened AFB1-deoxyguanosine adduct (AFB1-Fapy-dG).

87 (TLS) DNA polymerases in bypassing the C8-2'-deoxyguanosine adduct (dG-C8-IQ) formed by 2-amino-3-met

88 hyl-3H-imidazo[4,5-f]quinolin-2-yl)amino]-2'-deoxyguanosine adduct (IQ) at the third guanine in the N

89 y demonstrated that the peroxidation-derived deoxyguanosine adduct, 3-(2-deoxy-beta-D-erythropentofur

90 eloped and validated using an O(6)-methyl-2'-deoxyguanosine adduct, which induced the expected GC-->A

91 to react with DNA forming exocyclic acrolein-deoxyguanosine adducts (Acro-dG).

92 and gamma-hydroxy-1, N(2)-cyclic propano-2'-deoxyguanosine adducts (alpha-OH-Acr-dG and gamma-OH-Acr

93 cently demonstrated that heptanone-etheno-2'-deoxyguanosine adducts are formed in the DNA of rat inte

94 y in vivo and in vitro, forming six major MC-deoxyguanosine adducts of known structures.

95 ne and O(6)-[4-oxo-4-(3-pyridyl)but-1-yl]-2'-deoxyguanosine adducts was specifically preferred at the

96 tructural and biological impact of 8-aryl-2'-deoxyguanosine adducts, an efficient protocol is require

97 tion protocols were developed for 7-deaza-2'-deoxyguanosine affording the 7- and 8-iodo isomers.

98 The novel 2'-deoxyguanosine analog Entecavir (ETV) is a potent inhibi

99 Entecavir (ETV; Baraclude) is a novel deoxyguanosine analog with activity against hepatitis B

100 The large-sized deoxyguanosine analogue was prepared from an intermediat

101 cleotides containing 7-octadiynyl-7-deaza-2'-deoxyguanosine and 5-octadiynyl-2'-deoxycytidine with un

102 f oxidative DNA damage, namely, 8-hydroxy-2'-deoxyguanosine and 8,5'-cyclopurine-2'-deoxynucleosides.

103 Plasma levels of 8-hydroxy-2'-deoxyguanosine and 8-isoprostane were examined in the co

104 Levels of plasma 8-hydroxy-2'-deoxyguanosine and 8-isoprostane were significantly high

105 on of BPDE-N(2)-dG, an adduct formed between deoxyguanosine and a diol epoxide metabolite of BaP, wit

106 DNA and the DNA lesions 7,8-dihydro-8-oxo-2'-deoxyguanosine and cyclobutane pyrimidine dimer but with

107 mitochondrial oxidative stress (8-hydroxy-2' deoxyguanosine and glutathione depletion), mitochondrial

108 , of the various purines and pyrimidines, 2'-deoxyguanosine and guanine were most reactive with D-glu

109 en assessed, which has revealed that both 2'-deoxyguanosine and guanosine are incompatible with the P

110 increased levels of the heptanone-etheno-2'-deoxyguanosine and heptanone-etheno-2'-deoxycytidine add

111 ine as the analogues of N(7)-hydroxyethyl-2'-deoxyguanosine and N(7)-oxoethyl-2'-deoxyguanosine, resp

112 nd synthesis of N(7)-hydroxyethyl-9-deaza-2'-deoxyguanosine and N(7)-oxoethyl-9-deaza-2'-deoxyguanosi

113 We found that N7-methyl-2'-deoxyguanosine and N7-[4-oxo-4-(3-pyridyl)but-1-yl]guani

114 ion, renal cortical expression of 8-hydroxy--deoxyguanosine and NADPH oxidase subunits was not differ

115 runs, while the formation of O(6)-methyl-2'-deoxyguanosine and O(6)-[4-oxo-4-(3-pyridyl)but-1-yl]-2'

116 Folate ester derivatives of O6-benzyl-2'-deoxyguanosine and of O6-[4-(hydroxymethyl)benzyl]guanin

117 as shown as increased levels of 8-hydroxy-2'-deoxyguanosine and p53 protein.

118 an RSQXE motif; it was also shown to target deoxyguanosine and showed sigmoidal enzyme kinetics (K0.

119 ts two different equilibrium patterns toward deoxyguanosine and thymidine substrates.

120 dgt gene catalyses the hydrolysis of dGTP to deoxyguanosine and triphosphate.

121 mmon oxidative DNA lesions, such as 8-Oxo-2'-deoxyguanosines and UV light-induced DNA damage, faithfu

122 ced increases in damage to DNA (8-hydroxy-2'-deoxyguanosine) and proteins (nitrotyrosinylation).

123 yclo-2'-deoxyadenosine, (5'-R)-8,5'-cyclo-2'-deoxyguanosine, and (5'-S)-8,5'-cyclo-2'-deoxyguanosine.

124 its natural substrates, 2'-deoxycytidine, 2'-deoxyguanosine, and 2'-deoxyadenosine.

125 The deamination of 2'-deoxyadenosine, 2'-deoxyguanosine, and 2'-deoxycytidine led to accelerated

126 Each enzyme class (deoxycytidine, deoxyguanosine, and deoxythymidine kinases, as well as t

127 bituric acid reactive substances, 8-hydroxy--deoxyguanosine, and H2O2 and plasma thiobarbituric acid

128 hyde can result in N(6)-deoxyadenosine, N(2)-deoxyguanosine, and N(4)-deoxycytidine adducts in vitro.

129 , measured as reactive oxygen species, 8-oxo-deoxyguanosine, and protein carbonyls formation, were gr

130 ause a specificity switch from guanine to 2'-deoxyguanosine, and to impart an altered structure for a

131 N7-Alkyl-2'-deoxyguanosines are major adducts in DNA that are genera

132 actly the same amount of heptanone-etheno-2'-deoxyguanosine as its 15(S)-enantiomer.

133 binding factor, RNA polymerase II, and 8-oxo-deoxyguanosine as markers of recent incorporation, trans

134 -deoxyguanosine and N(7)-oxoethyl-9-deaza-2'-deoxyguanosine as the analogues of N(7)-hydroxyethyl-2'-

135 hesis of the cis adducts of BaP DE-2 with 2'-deoxyguanosine as well as the first synthesis of both dA

136 that C forms a non-perturbing base pair with deoxyguanosine, as designed.

137 Individual 2'-deoxyguanosines at positions dG5, dG10, dG14 and dG15 of

138 sourea, with O6-benzyl-3'-O-(gamma-folyl)-2'-deoxyguanosine being most active.

139 odification at these sites with N2-benzyl-2'-deoxyguanosine (BndG) blocked interaction with PKR's dsR

140 yrimidine dimers (CPDs) and BaP diol epoxide-deoxyguanosine (BPDE-dG), which are removed from the gen

141 and deaminates exclusively guanosine and 2'-deoxyguanosine but no other aminated purines, pyrimidine

142 at accurately bypasses some damaged forms of deoxyguanosine, but also generates single-base deletion

143 ers by 40% (P < 0.0002) and for 8-hydroxy-2'-deoxyguanosine by 61% (P < 0.01 compared with vehicle co

144 anosine caps, but is not adept at removing a deoxyguanosine cap.

145 9-Deaza-2'-deoxyguanosine (CdG) is a C-nucleoside and an analogue o

146 lo-2'-deoxyadenosine (cdA) and 5',8-cyclo-2'-deoxyguanosine (cdG) pairs that have been detected in ce

147 lo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine (cdG) tandem lesions.

148 principal DNA-AGE, N(2)-(1-carboxyethyl)-2'-deoxyguanosine (CEdG), is formed as a mixture of R and S

149 marker of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, colocalized to mitochondria, indicating

150 aggression; more specifically, 8-hydroxy-2'-deoxyguanosine correlated with measures reflecting a his

151 lammatory molecules containing deoxycytosine-deoxyguanosine (CpG).

152 c alpha-methyl-gamma-hydroxy-1,N2-propano-2'-deoxyguanosine (Cr-PdG) adducts from biologically releva

153 Cyclic crotonaldehyde-derived deoxyguanosine (CrA-PdG) adducts can undergo ring openin

154 cluding (5'S) diastereomers of 8,5'-cyclo-2'-deoxyguanosine (cyclo-dG) and 8,5'-cyclo-2'-deoxyadenosi

155 amido-2-iminohydantoin (d2Ih), 5',8-cyclo-2'-deoxyguanosine (cyclo-dG), and the free base guanine (Gu

156 The adduct derived from attack of 2'-deoxyguanosine (d-G) on 11, 28, is a familiar C-8 adduct

157 ance assignment at NA of a self-assembled 2'-deoxyguanosine derivative presenting two different molec

158 9-beta-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative.

159 Specifically, two isomeric 8-aryl-2'-deoxyguanosine derivatives with a transposed pair of met

160 ct nucleotide opposite some N(2)-modified 2'-deoxyguanosine derivatives.

161 tochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by

162 8-Substituted 7-deaza-2'-deoxyguanosines destabilize canonical (aps) DNA as well

163 esize covalent 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) adducts of benzo[a]pyrene (BaP) seri

164 Deoxyguanosine (dG) adducts of the PAH benzo[a]pyrene (B

165 e limit of quantification (LOQ) of the major deoxyguanosine (dG) adducts of these carcinogens ranged

166 lysis of oxygen (O)-linked biaryl ether 8-2'-deoxyguanosine (dG) adducts produced by phenolic toxins

167 electronic properties of C(8)-heteroaryl-2'-deoxyguanosine (dG) adducts with C(8)-substituents consi

168 yntheses of all three epimeric lesions of 2'-deoxyguanosine (dG) and liquid chromatography-tandem mas

169 te characterization of four novel stable BPQ-deoxyguanosine (dG) and two BPQ-deoxyadenosine (dA) addu

170 hazardous air pollutant, reacts readily with deoxyguanosine (dG) in DNA to produce cyclic 1, N2-propa

171 oxide-adducted 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) nucleosides.

172 bonucleoside (dSp) lesions resulting from 2'-deoxyguanosine (dG) or 8-oxo-7,8-dihydro-2'-deoxyguanosi

173 FdC was quantitated and reported relative to deoxyguanosine (dG) since dG is the complementary base f

174 DNA showing a preference for reaction at 2'-deoxyguanosine (dG) sites.

175 Four-electron oxidation of 2'-deoxyguanosine (dG) yields 5-guanidinohydantoin (dGh) as

176 sion of the nucleosides deoxyadenosine (dA), deoxyguanosine (dG), and deoxycytidine (dC) into their m

177 Like 2'-deoxyguanosine (dG), CdG should form a stable base pair

178 vo by deamination of deoxyadenosine (dA) and deoxyguanosine (dG), respectively, and can miscode.

179 pon oxidation of the heterocyclic ring in 2'-deoxyguanosine (dG), the initial electrophilic intermedi

180 cognize guanine/hypoxanthine, adenine, or 2'-deoxyguanosine (dG).

181 ents that form adducts at the N2-position of deoxyguanosine (dG).

182 Platinum-modified 2'-deoxyguanosine, dG, and several dinucleotide fragments,

183 n ranged from 57% to 89% and steady-state 2'-deoxyguanosine (dGuo) concentration median was 1.8 micro

184 s level was sufficient to increase plasma 2'-deoxyguanosine (dGuo) concentrations in all patients.

185 tablished that forodesine in the presence of deoxyguanosine (dGuo) inhibits the proliferation of T ly

186 However, if deoxyguanosine (dGuo) is limited in host tissue, the enz

187 lpha)-acetyllysine methyl ester (Lys) and 2'-deoxyguanosine (dGuo) was used to study structural aspec

188 containing CpG (unmethylated deoxycytidylyl-deoxyguanosine dinucleotide) motifs activate endosomal T

189 cid and synthetic unmethylated deoxycytidine-deoxyguanosine dinucleotides, which mimic bacterial DNA,

190 and dose-dependent increase in 8-hydroxy-2'-deoxyguanosine DNA adducts consistent with cumulative RO

191 y of bulky and potentially carcinogenic N(2)-deoxyguanosine DNA adducts in human cells.

192 ich is related to HSV1-TK and phosphorylates deoxyguanosine, does not accept acyclic guanine analogue

193 -deoxyguanosine (dG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) oxidation have generated much atten

194 In fact, addition of deoxyguanosine during the 5-FC incubation reverses the d

195 ning the genotoxic lesion 1, N (2)-etheno-2'-deoxyguanosine (epsilonG), paired to dC.

196 N(2)-Furfuryl-deoxyguanosine (fdG) is carcinogenic DNA adduct that ori

197 ne (MeFapy-dG) arises from N7-methylation of deoxyguanosine followed by imidazole ring opening.

198 Substituting deoxyguanosine for G, to eliminate this hydrogen bond, r

199 osine from nitrosative deamination; 8-oxo-2'-deoxyguanosine from oxidation; and 1,N(2)-etheno-2'-deox

200 purified and tested by replicating DNA past deoxyguanosine (G) or 8-oxoG.

201 stigated the 10S (+)-trans-anti-[BP]-N(2)-2'-deoxyguanosine (G*) adduct in double-stranded DNA.

202 cts, such as gamma-hydroxy-1,N(2)-propano-2'-deoxyguanosine (gamma-HOPdG) and gamma-hydroxy-1,N(6)-pr

203 at TiO(2) nanoparticles induced 8-hydroxy-2'-deoxyguanosine, gamma-H2AX foci, micronuclei, and DNA de

204 lo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine generated in DNA by both endogenous oxida

205 on of a series of C8-arylamine adducts of 2'-deoxyguanosine has been examined.

206 enal-derived DNA-adduct, heptanone-etheno-2'-deoxyguanosine (HepsilondGuo) from 2.41 +/- 0.35 to 6.31

207 acted with deoxycytidine, deoxyadenosine, or deoxyguanosine in vitro to form covalent adducts with a

208 thyl-deoxyCytidine, 2,6-Diaminopurine or Iso-deoxyGuanosine) in place of the standard T, C, A or G to

209 A minor groove on the 3'-side of the modifed deoxyguanosine, in the DB[a,l]P-derived adduct the DB[a,

210 Deoxyguanosine is a weaker substrate than deoxyinosine,

211 yrene (BaP DE-2) by 2'-deoxyadenosine and 2'-deoxyguanosine is described.

212 inding pocket is distorted, and the adducted deoxyguanosine is in a syn conformation, exposing its Ho

213 can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol b

214 uranosyl-guanine ([(18)F]F-AraG)-for dCK and deoxyguanosine kinase (dGK), a dCK-related mitochondrial

215 ucleotide reductase, thymidine kinase 2, and deoxyguanosine kinase by siRNA transfection to examine h

216 current findings implicate these effects on deoxyguanosine kinase in the causal mechanism.

217 ertension in a subset of patients and lowers deoxyguanosine kinase levels in vitro; the current findi

218 rare homozygous p.N46S mutation in DGUOK, a deoxyguanosine kinase required for mitochondrial DNA rep

219 in [N(2)-methyl-(1,3-dimethoxyanthraquinone)-deoxyguanosine, LdG] embedded DNAs utilizing phosphorami

220 The 8,5'-cyclo-2'-deoxyguanosine lesion (cdG) has been recently reported t

221 by incomplete repair of closely spaced 8-oxo-deoxyguanosine lesions, whereas the cytotoxicity of amin

222 staining assay and by measuring 8-hydroxy-2'-deoxyguanosine levels and, as a genetic instability endp

223 logical and functional changes, 8-hydroxy-2'-deoxyguanosine levels in total DNA, mtDNA deletions, and

224 extracts and by increased serum 8-hydroxy-2'-deoxyguanosine levels in vivo in rats.

225 Furthermore, the N(2)-ethylidene-2'-deoxyguanosine levels increased in both Aldh2-knockout m

226 H2 sharply diminished the N(2)-ethylidene-2'-deoxyguanosine levels.

227 Oxidation of deoxyguanosine/lysine mixtures with Na2IrCl6 or sulfate

228 on was performed on both the malondialdehyde-deoxyguanosine (M(1)dG) adduct and the O(6)-carboxymethy

229 N7-Methyl-2'-deoxyguanosine (m7dG) is the predominant lesion formed b

230 ylation is the genotoxic lesion N7-methyl-2'-deoxyguanosine (m7dG).

231 MS derivatization method for the analysis of deoxyguanosine monophosphate adducts that demonstrates e

232 henanthriplatin binds more effectively to 5'-deoxyguanosine monophosphate than to N-acetyl methionine

233 G-->A mutations at N(2)-(1-carboxyethyl)-2'-deoxyguanosine (N(2)-CEdG) and N(2)-carboxymethyl-2'-deo

234 es the formation of N(2)-(1-carboxyethyl)-2'-deoxyguanosine (N(2)-CEdG) as the major stable DNA adduc

235 nosine (N(2)-CEdG) and N(2)-carboxymethyl-2'-deoxyguanosine (N(2)-CMdG) sites.

236 DNA to form adducts, including N(2)-ethyl-2'-deoxyguanosine (N(2)-Et-dG).

237 n for 48 hours were evaluated for (E)-alpha-(deoxyguanosine-N(2)-yl)-tamoxifen (dG-N(2)-TAM) adduct f

238 idence has shown that N2-(1-carboxyethyl)-2'-deoxyguanosine (N2-CEdG) is a major marker for AGE-linke

239 We prepared N7-methyl-2'-deoxyguanosine (N7mdG)-containing DNA using a transition

240 (dPer) recognizes in DNA the O(6)-benzyl-2'-deoxyguanosine nucleoside (O(6)-Bn-dG), formed by exposu

241 oyed in peptide synthesis, several different deoxyguanosine nucleotide phosphoramidates and phosphomo

242 eous quantification of O(6)-carboxymethyl-2'-deoxyguanosine (O(6)-CMdG), O(6)-methyl-2'-deoxyguanosin

243 '-deoxyguanosine (O(6)-CMdG), O(6)-methyl-2'-deoxyguanosine (O(6)-MedG), and N(6)-carboxymethyl-2'-de

244 O(6)-Methyl-2'-deoxyguanosine (O(6)-MeG) is a ubiquitous DNA lesion, fo

245 ding bulky O(6)-[4-oxo-4-(3-pyridyl)but-1-yl]deoxyguanosine (O(6)-POB-dG) lesions.

246 ons of O(6)-[4-(3-pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine (O(6)-POBdG) as well as O(2)- and O(4)-[4

247 e (M(1)dG) adduct and the O(6)-carboxymethyl-deoxyguanosine (O(6)CMdG) adduct to demonstrate the appl

248 arly evolution of life, 8-oxo-7,8-dihydro-2'-deoxyguanosine (O) may have functioned as a proto-flavin

249 analogue of the abundant promutagen 8-oxo-2'-deoxyguanosine (OdG).

250 o-2H-oxal-5-one (Z) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (OG) in double stranded DNA.

251 8-Oxo-7,8-dihydro-2'-deoxyguanosine (OG), a prevalent product of oxidative st

252 tissue, to oxidize E2 in the presence of 2'-deoxyguanosine or 2'-deoxyadenosine.

253 with the exocyclic amino group on a nearby 2-deoxyguanosine or 2-deoxyadenosine in the opposite stran

254 d templates or DNA lesions, such as 8-oxo-2'-deoxyguanosine or cyclobutane pyrimidine dimer, even in

255 nucleobase, specifically 8-(4'-phenylethynyl)deoxyguanosine, or EG, have been investigated.

256 measures the lifetime cerebral 8-hydroxy-2'-deoxyguanosine (oxo8dG) levels and the activity of the D

257 The modified base 8-oxo-7,8-dihydro-2'-deoxyguanosine (oxoG) is a common DNA adduct produced by

258 have synthesized for the first time the 6-Se-deoxyguanosine phosphoramidite and incorporated it into

259 ss (urinary malondialdehyde and 8-hydroxy-2'-deoxyguanosine, plasma fibrinogen, and white blood cells

260 Concomitant increases occur in 8-hydroxy-2'-deoxyguanosine, point mutations and deletions in kidney

261 y 6 and 24 hours, the number of 8-hydroxy-2'-deoxyguanosine-positive cells were approximately 59% (P

262 The number of 8-hydroxy-2'-deoxyguanosine-positive cells were decreased before UV i

263 th the oxidative damage markers 8-hydroxy-2'-deoxyguanosine (r = 0.53, P < 0.001) and prostaglandin F

264 ine nucleoside phosphorylase did not improve deoxyguanosine recycling by dGK in WT cells.

265 The deoxyguanosine released by SAMHD1 from dGTP can be phosp

266 ucts, base propenal or malondialdehyde, with deoxyguanosine residues in DNA.

267 pomethylating dinucleotide of decitabine and deoxyguanosine resistant to degradation by cytidine deam

268 ethyl-2'-deoxyguanosine and N(7)-oxoethyl-2'-deoxyguanosine, respectively.

269 asurement of the level of S(6)-methylthio-2'-deoxyguanosine (S(6)mdG) in DNA of cells treated with th

270 ) method and measured the level of 6-thio-2'-deoxyguanosine ((S)dG) and S(6)mdG in genomic DNA of fou

271 lyl residues on the properties of 7-deaza-2'-deoxyguanosine, such as fluorescence, sugar conformation

272 e for N(2)-(trans-methylisoeugenol-3'-yl)-2'-deoxyguanosine, the major adduct of methyleugenol (1.7-2

273 xylation of benzoate and hydroxylation of 2'-deoxyguanosine to give 8-hydroxy-2'-deoxyguanosine (8-OH

274 The Michael addition of deoxyguanosine to HNE yields four diastereomeric exocycl

275 ith hydrogen replacing the amino group in 2'-deoxyguanosine, to further characterize the structural a

276 tT protein in Escherichia coli removes 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guano

277 Intracellular deoxyguanosine triphosphate (dGTP) increase was very mod

278 Specifically, we find that intracellular deoxyguanosine triphosphate (dGTP) levels positively cor

279 N(2) -Alkyl-2'-deoxyguanosine triphosphate (N(2) -alkyl-dGTP) derivativ

280 pool by the enzymatic hydrolysis of 8-oxo-2'-deoxyguanosine triphosphate and from genomic DNA by 8-ox

281 In human DKD, increased urine 8-oxo-deoxyguanosine was associated with rapid DKD progression

282 8-hydroxy-2'-deoxyguanosine was only increased in mitochondrial DNA.

283 The O(6)-carboxymethyl-2'-deoxyguanosine was previously detected in isolated DNA u

284 Similarly, UV-induced formation of 8-oxo-deoxyguanosine was reduced by PAF and 5-HT receptor anta

285 iquid chromatography analysis of 8-hydroxy-2-deoxyguanosine, we measured oxidative DNA damage in the

286 DNA damage represented by N(2)-ethylidene-2'-deoxyguanosine were higher in the oesophagus of Aldh2-kn

287 Levels of 8-hydroxy-deoxyguanosine were increased in periodontal lesions of

288 ne and oxidative marker 7,8-dihydro-8-oxo-2'-deoxyguanosine were increased moderately in glyoxalase 1

289 The gamma-folate esters of O6-benzyl-2'-deoxyguanosine were more potent alkyltransferase inactiv

290 - derivatives) with 2'-deoxyadenosine and 2'-deoxyguanosine were prepared by these methods.

291 ropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine were synthesized, and their antiviral act

292 for deamination of 2'-deoxyadenosine and 2'-deoxyguanosine, which could not be determined directly b

293 tually resected; and (iii) BPh adducts at N2-deoxyguanosine, which intercalate via the minor groove,

294 ts selective and high-affinity binding of 2'-deoxyguanosine, which is consistent with its occurrence

295 oxidized nucleoside is 8-oxo-7,8-dihydro-2'-deoxyguanosine, which is found both in DNA (8-oxo-G) and

296 through its ability to provide intracellular deoxyguanosine, which is readily converted by the DeoD p

297 e template base (dG) or 7,8-dihydro-8-oxo-2'-deoxyguanosine with a significant propeller twist.

298 t Cr-PdG adducts could be formed by reacting deoxyguanosine with muM concentrations of AA in the pres

299 a DNA adduct arising from the reaction of 2-deoxyguanosine with the lipid peroxidation product, malo

300 The DNA adduct 1,N(2)-etheno-2'-deoxyguanosine, with a larger stacking surface than cano