ライフサイエンスコーパス: deoxyhemoglobin

1 is low in areas with high concentrations of deoxyhemoglobin.

2 d as the ratio of oxyhemoglobin to oxy- plus deoxyhemoglobin.

3 shown previously for the reaction of O2 with deoxyhemoglobin.

4 n and cleaved oxyhemoglobin twice as fast as deoxyhemoglobin.

5 ion to NO by reaction with intraerythrocytic deoxyhemoglobin.

6 zymatic disproportionation, and reduction by deoxyhemoglobin.

7 ivity is inferred from local fluctuations in deoxyhemoglobin.

8 signaling can be recapitulated with isolated deoxyhemoglobin.

9 e responsible for the low oxygen affinity of deoxyhemoglobin.

10 the major source of quaternary constraint in deoxyhemoglobin.

11 activated by a nitrite reductase activity of deoxyhemoglobin.

12 o methemoglobin and reduces methemoglobin to deoxyhemoglobin.

13 nitrosonium donor formed in the presence of deoxyhemoglobin.

14 are several published crystal structures for deoxyhemoglobin A (deoxy-Hb A), and it has been reported

15 focal elevations of R2*, suggesting areas of deoxyhemoglobin accumulation.

16 There was also an increase in deoxyhemoglobin after both doses of resveratrol, which s

17 ween the quaternary-T structure of wild-type deoxyhemoglobin and an ensemble of related T-like quater

18 ulted from the nitrite reductase activity of deoxyhemoglobin and deoxygenated erythrocytes.

19 BC O2 content because of competition between deoxyhemoglobin and key EMP enzymes for binding to the c

20 ic model that includes a redox cycle between deoxyhemoglobin and methemoglobin has been forwarded to

21 es have revealed a novel interaction between deoxyhemoglobin and nitrite to generate nitric oxide (NO

22 , nitric oxide (NO)-generating reaction with deoxyhemoglobin and potentially other heme proteins.

23 h few repulsive contact areas in both the T (deoxyhemoglobin) and R (oxyhemoglobin) structures; (2) t

24 determination of fractions of oxyhemoglobin, deoxyhemoglobin, and high-spin and low-spin methemoglobi

25 globin, promoting nitrite reduction to NO by deoxyhemoglobin, and releasing free NO from iron-nitrosy

26 s of proteins, lipids, non-heme tissue iron, deoxyhemoglobin, and their magnetic susceptibilities.

27 These studies suggest a vital role for deoxyhemoglobin- and deoxymyoglobin-dependent nitrite re

28 dilation elicited by aerosolized nitrite was deoxyhemoglobin- and pH-dependent and was associated wit

29 ferrous high-spin (S = 2) deoxymyoglobin and deoxyhemoglobin; and (6) ferric high spin (S = (5)/(2))

30 CO production was detected by using deoxyhemoglobin as a reporter and monitoring the appeara

31 assess tissue oxygen bioavailability, using deoxyhemoglobin as an endogenous contrast agent.

32 hemoglobin to dimers 2500-fold over that of deoxyhemoglobin, as measured by haptoglobin binding.

33 n detail the magnetic properties of oxy- and deoxyhemoglobin, as well as those of closely related com

34 ts suggest that, unlike the expectation from deoxyhemoglobin-based optical imaging studies, the highe

35 s nitrite approximately 36 times faster than deoxyhemoglobin because of its lower heme redox potentia

36 he X-ray crystallographic results from human deoxyhemoglobin, beta 99Asp at the alpha 1 Beta 2 interf

37 ing (MRI), to detect differences in vascular deoxyhemoglobin between tissue compartments following st

38 By exploiting the paramagnetic properties of deoxyhemoglobin, BOLD magnetic resonance imaging can det

39 chrome oxidase CuA redox state and increased deoxyhemoglobin, both PL-arginine and increased by NO bl

40 Because deoxyhemoglobin, but not oxyhemoglobin, binds band 3 rev

41 results with measurements of tissue oxy- and deoxyhemoglobin concentration during oxygen deprivation

42 stroke are likely to reflect differences in deoxyhemoglobin concentration, and therefore differences

43 alert macaque demonstrate that both oxy- and deoxyhemoglobin concentrations in the frontal lobe show

44 Raman difference spectra between ligated and deoxyhemoglobin contain tryptophan and tyrosine signals

45 nsists of a decrease or an increase in local deoxyhemoglobin, corresponding to a positive (adult-like

46 Human deoxyhemoglobin cross-linked with trimesyl tris(3,5-dibr

47 view the interaction of NO with quaternary-T deoxyhemoglobin, crystallographic studies were carried o

48 However, when deoxyhemoglobin crystals are first exposed to air and th

49 The reaction of nitrite with deoxyhemoglobin (deoxyHb) results in the reduction of ni

50 Deoxyhemoglobin (deoxyHb), but not oxyhemoglobin, binds

51 ignal, detected in fMRI, reflects changes in deoxyhemoglobin driven by localized changes in brain blo

52 resonance imaging detects changes in tissue deoxyhemoglobin during maneuvers that affect oxygen cons

53 of rats, signal intensity ratios of oxy- vs. deoxyhemoglobin from sublingual mucosa correlated with c

54 of a targeted fluorescent agent and oxy- and deoxyhemoglobin gave functional information about tumor

55 s lowered the polymer solubility ("Csat") of deoxyhemoglobin (Hb) S, presumably by increasing its act

56 RS) can measure tissue oxyhemoglobin (HbO2), deoxyhemoglobin (Hb), and cytochrome oxidase (Cyt Ox), w

57 The distributions of oxyhemoglobin (HbO), deoxyhemoglobin (Hb), and total hemoglobin (THb) concent

58 Nitrite reductase activity of deoxyhemoglobin (HbA) in the red blood cell has been pro

59 ximately 0.07 Hz) was similar to the LFOs of deoxyhemoglobin (HbR) and oxyhemoglobin (HbO2) in both l

60 ption contrast from oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR), FOG allows label-free imaging.

61 l parameters including oxyhemoglobin (HbO2), deoxyhemoglobin (HbR), oxygen saturation (sO2), blood fl

62 ed at wavelengths absorbed preferentially by deoxyhemoglobin (HbR).

63 ly, changes in cortical oxyhemoglobin (HbO), deoxyhemoglobin (HHb), and total hemoglobin (HbT), infer

64 Nitrite reacts with deoxyhemoglobin in an allosteric reaction that generates

65 , which is directly related to the amount of deoxyhemoglobin in blood and in turn to tissue PO2.

66 lving the reduction of nitrite back to NO by deoxyhemoglobin in RBCs.

67 blood that depends on the volume fraction of deoxyhemoglobin in red blood cells.

68 tion of the percentages of oxyhemoglobin and deoxyhemoglobin in specific skin tissue areas.

69 issue and is not dependent on reactions with deoxyhemoglobin in the pulmonary circulation.

70 The crystal structure of the mutant deoxyhemoglobin in which the beta-globin Val67(E11) has

71 Overall our data suggest that deoxyhemoglobin is the primary erythrocytic nitrite redu

72 Tissue deoxyhemoglobin levels (R(2)*) were measured by blood ox

73 relaxation (R2*) positively correlates with deoxyhemoglobin levels and was therefore used as a surro

74 showed that both 2,3-bisphosphoglycerate and deoxyhemoglobin levels rose following 5'-AMP administrat

75 s (a measure directly proportional to tissue deoxyhemoglobin levels) were significantly higher in nor

76 culate that one signaling mechanism by which deoxyhemoglobin may activate HIF-1 involves NO.

77 radients of intravascular nitric oxide, with deoxyhemoglobin-mediated reduction identified as the dom

78 zymatic disproportionation, and reduction by deoxyhemoglobin, myoglobin, and tissue heme proteins.

79 "inverted" hemodynamic response (increasing deoxyhemoglobin, negative BOLD) with early signs of oxyg

80 ion, a process by which the NO formed in the deoxyhemoglobin-nitrite reaction that binds to other deo

81 In addition to the proposed role of deoxyhemoglobin, our findings suggest that the nitrite r

82 hosphate dehydrogenase, phosphofructokinase, deoxyhemoglobin, p72syk protein tyrosine kinase, and hem

83 in and cytochrome oxidase and an increase in deoxyhemoglobin (PA redox state, PL-arginine did not att

84 cific region and is related to the amount of deoxyhemoglobin present.

85 ounds as well as those of deoxymyoglobin and deoxyhemoglobin, previously studied, have a negative sig

86 monstrated that the reaction of nitrite with deoxyhemoglobin produces a hybrid intermediate with prop

87 Single-kidney deoxyhemoglobin (R2*, reciprocal to blood relaxation) an

88 ive concentrations of both oxyhemoglobin and deoxyhemoglobin, rather than either species alone.

89 hysical and chemical analysis of the nitrite-deoxyhemoglobin reaction has revealed unexpected chemist

90 to the heme groups of crystalline wild-type deoxyhemoglobin ruptures the Fe-proximal histidine bonds

91 We have refined the crystal structure of deoxyhemoglobin S (beta Glu6-->Val) at 2.05 A resolution

92 The deoxyhemoglobin S (deoxy-HbS) double strand is the funda

93 cs of nucleation-dependent polymerization of deoxyhemoglobin S (HbS) are important in governing wheth

94 Polymerization of intraerythrocytic deoxyhemoglobin S (HbS) is the primary molecular event t

95 le cell disease depends on polymerization of deoxyhemoglobin S into rod-like fibers, forming gels tha

96 with nucleation-dependent polymerization of deoxyhemoglobin S into stiff, rodlike fibers that deform

97 x steps related to both the primary event of deoxyhemoglobin S polymerization and the many resultant

98 Although direct chemical inhibition of deoxyhemoglobin S polymerization has proven difficult, s

99 s have been designed to reduce the extent of deoxyhemoglobin S polymerization.

100 Use of deoxyhemoglobin-sensitive MRI sequences enabled visualiz

101 ctral peak height to the sum of the oxy- and deoxyhemoglobin spectral peak heights.

102 he alpha1beta2 interface of the quaternary-T deoxyhemoglobin tetramer.

103 ctural properties and ligand affinity of the deoxyhemoglobin tetramer.

104 d unexpected chemistries between nitrite and deoxyhemoglobin that may contribute to and facilitate hy

105 al activity, and (3) the initial increase in deoxyhemoglobin that precedes an increase in blood volum

106 phic studies were carried out on crystals of deoxyhemoglobin that were exposed to gaseous NO under a

107 acts at a nearly diffusion-limited rate with deoxyhemoglobin to form iron-nitrosyl-hemoglobin, which

108 ing studies reveal that hydroxyurea oxidizes deoxyhemoglobin to methemoglobin and reduces methemoglob

109 eric reaction that generates NO and oxidizes deoxyhemoglobin to methemoglobin.

110 by exposing crystals of wild-type or mutant deoxyhemoglobins to oxygen.

111 rmine tissue concentration of oxyhemoglobin, deoxyhemoglobin, total hemoglobin, tissue hemoglobin oxy

112 Deoxyhemoglobin was generated by predeoxygenation (nitro

113 hat depended on the paramagnetic property of deoxyhemoglobin was used.

114 re absolute concentrations of oxyhemoglobin, deoxyhemoglobin, water, and lipid in tumor and normal br

115 The reaction of deoxyhemoglobin with nitric oxide (NO) or nitrite ions (

116 suggest that the rapid reactions of oxy- and deoxyhemoglobin with nitric oxide are the fundamental ca

117 The reaction of deoxyhemoglobin with nitrite was characterized in the pr

118 ess reveals a higher volume/surface ratio of deoxyhemoglobin, with a positive Delta G(W) also in favo