ライフサイエンスコーパス: deoxyhypusine synthase

1 origin in the duplication of a gene encoding deoxyhypusine synthase.

2 slation elongation factor eIF5A, mediated by deoxyhypusine synthase.

3 were evaluated as donor substrates for human deoxyhypusine synthase.

4 a specific lysine residue (Lys329) in human deoxyhypusine synthase.

5 a) of the conserved lysine residues in human deoxyhypusine synthase.

6 e spermidine biosynthetic pathway but retain deoxyhypusine synthase.

7 Purified human deoxyhypusine synthase also exhibited homospermidine syn

8 endently by duplication of the gene encoding deoxyhypusine synthase, an enzyme involved in the posttr

9 pusine formation by a selective inhibitor of deoxyhypusine synthase and by its depletion with RNA int

10 two sequential enzymatic steps catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DO

11 se models for the hypusine-modifying enzymes deoxyhypusine synthase and deoxyhypusine hydroxylase as

12 The reaction is catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase.

13 Deoxyhypusine synthase and eIF5A are conserved throughou

14 Here, we tested the hypothesis that deoxyhypusine synthase and, secondarily, hypusinated eIF

15 We discovered that homozygous depletion of deoxyhypusine synthase and/or deoxyhypusine hydroxylase

16 Upon depletion of deoxyhypusine synthase, and consequently of eIF-5A, cess

17 ivity, formation of different complexes with deoxyhypusine synthase, and Km values (1.5 +/- 0.2 vs. 8

18 Although both eIF-5A and deoxyhypusine synthase are essential genes for cell surv

19 Inhibition of deoxyhypusine synthase blocked post-transcriptional expr

20 Deoxyhypusine synthase catalyzes the crucial hypusine mo

21 Deoxyhypusine synthase catalyzes the first step in hypus

22 Deoxyhypusine synthase catalyzes the first step in the p

23 Deoxyhypusine synthase catalyzes the first step in the p

24 Deoxyhypusine synthase catalyzes the first step in the t

25 Deoxyhypusine synthase catalyzes the formation of deoxyh

26 In the initial step of this reaction, deoxyhypusine synthase catalyzes the production of NADH

27 The deoxyhypusine synthase competitive inhibitor N(1)-guanyl

28 s catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl

29 sination, which is catalyzed by two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl

30 It was recently shown that the enzyme deoxyhypusine synthase (DHS) promotes early cytokine-ind

31 copies inhibition or knockdown of the enzyme deoxyhypusine synthase (DHS).

32 f eukaryotic initiation factor 5A (eIF5A) by deoxyhypusine synthase, employing spermidine as a butyla

33 SS, we identified sequences encoding HSS and deoxyhypusine synthase from various species of the Convo

34 of transcript levels have shown that HSS and deoxyhypusine synthase have also diverged with respect t

35 s suggest a previously unrecognized role for deoxyhypusine synthase in promoting T cell proliferation

36 5A-1 and -2, respectively) as substrates for deoxyhypusine synthase in vitro.

37 Th17, and Treg), but those treated with the deoxyhypusine synthase inhibitor GC7 showed a dose-depen

38 rwinian selection is sufficient to convert a deoxyhypusine synthase into a HSS.

39 Inhibition of deoxyhypusine synthase may provide a strategy for reduci

40 chain of the deoxyhypusine residue prevents deoxyhypusine synthase-mediated reversal of the modifica

41 xyhypusine residue, was incubated with human deoxyhypusine synthase, NAD, and 1,3-diaminopropane, [3H

42 This first structure of a deoxyhypusine synthase.NAD.inhibitor ternary complex und

43 t here at 2.2 A a new Form II crystal of the deoxyhypusine synthase:NAD holoenzyme grown at low ionic

44 Trypanosoma brucei encodes two deoxyhypusine synthase paralogs, one that is catalytical

45 f previous biochemical investigations of the deoxyhypusine synthase reaction mechanism.

46 ficity of this enzyme and versatility of the deoxyhypusine synthase reaction.

47 tion in the single copy gene, yDHS, encoding deoxyhypusine synthase results in the loss of viability

48 A previous study of human deoxyhypusine synthase revealed four active sites of the

49 of human DOHH along with eIF5A precursor and deoxyhypusine synthase was required for overproduction o

50 nsion of this prozyme paradigm to the enzyme deoxyhypusine synthase, which is required for spermidine