ライフサイエンスコーパス: deoxyinosine

1 observed except in the case of a 3'-terminal deoxyinosine.

2 ng deoxyuridine compared with DNA containing deoxyinosine.

3 Deoxyinosine (22), a natural analog which has found exte

4 Endonuclease V (deoxyinosine 3' endonuclease), the product of the nfi ge

5 and pseudo-Y DNA structures, suggesting that deoxyinosine 3'-endonuclease is a bacterial functional h

6 These biochemical properties suggest that deoxyinosine 3'-endonuclease might be important in the r

7 Endonuclease V is a deoxyinosine 3'-endonuclease which initiates removal of

8 Deoxyinosine 3'-endonuclease, an Escherichia coli repair

9 zyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine (3).

10 uilding block, the O6-(benzotriazol-1-yl)-2'-deoxyinosine 5'-O-DMT 3'-O-phosphoramidite, has been pre

11 amidite monomer of N1-(2,4-dinitrophenyl)-2'-deoxyinosine 9 was prepared from 2'-deoxyinosine in four

12 ure of the N1-(1-hydroxy-3-buten-2(S)-yl)-2'-deoxyinosine adduct arising from the alkylation of adeni

13 Rotation of the N1 deoxyinosine adduct into the high syn conformation may f

14 ded a plausible hypothesis as to why this N1 deoxyinosine adduct strongly coded for the incorporation

15 '-deoxynebularine analogues) and C-2 aryl 2'-deoxyinosine analogues can be conveniently prepared via

16 transformed to the desired N1-substituted 2'-deoxyinosine analogues.

17 e that recognizes and cleaves DNA containing deoxyinosine and base mismatches, can cleave heteroduple

18 tially high synthetic utility of 2-chloro-2'-deoxyinosine and in many instances this derivative can s

19 gPNP has kcat values of 54 and 41 s-1 for 2'-deoxyinosine and inosine, its preferred substrates, and

20 containing 2-fluoro-O(6)-trimethylsilylethyl deoxyinosines and the appropriate diamine (ethylenediami

21 in the repair of deaminated deoxyadenosine (deoxyinosine) and abasic sites in DNA, but there was no

22 (I is 2'-deoxyinosine), and 5'-...CG*C....

23 Deoxyguanosine is a weaker substrate than deoxyinosine, and DADMe-Immucillin-G is less tightly bou

24 ever, levels of the DNA deamination product, deoxyinosine, and the numbers of apurinic/apyrimidinic (

25 ivity is similar between the double-stranded deoxyinosine- and deoxyxanthosine-containing DNA.

26 The enzyme is also active on single-stranded deoxyinosine- and deoxyxanthosine-containing DNA.

27 e purified from an overproducing strain, the deoxyinosine- and mismatch-specific activities of endonu

28 e V exhibits limited turnover on cleavage of deoxyinosine- and xanthosine-containing DNA.

29 es the conversion of 5'-deoxyadenosine to 5'-deoxyinosine as its major product but will also deaminat

30 ent syntheses of 2-chloro- and 2-tosyloxy-2'-deoxyinosine as their tert-butyldimethylsilyl ethers are

31 CR primers containing mixed-base residues or deoxyinosine at positions of codon degeneracy.

32 rms two stable complexes with DNA containing deoxyinosine, but not with DNA containing base mismatche

33 iation, recognition, and dissociation of the deoxyinosine by the endo V, were determined at 5.9, 14.5

34 urine 2'-deoxyribonucleoside and 2-fluoro-2'-deoxyinosine, by the amino triol then yielded diastereom

35 In addition to deoxyinosine-containing DNA, the enzyme cleaves DNA cont

36 V in a catalytic cycle using a substrate of deoxyinosine-containing single-stranded DNA (ssDNA).

37 BcPh amino tribenzoates with the 2-bromo-2'-deoxyinosine derivative proceeded in comparable yields.

38 nthesized from the O6-(benzotriazol-1-yl)-2'-deoxyinosine derivative.

39 equisite O6-(benzotriazol-1-yl)inosine or 2'-deoxyinosine derivatives.

40 -dihydro-8-oxo-2'-deoxyguanosine (OxodG), 2'-deoxyinosine (dI) and 2'-deoxyguanosine (dG) in otherwis

41 and deoxycytidine (dC) were substituted with deoxyinosine (dI) and 3-(2'-deoxy-beta-D-ribofuranosyl)p

42 Deoxyinosine (dI) and deoxyxanthosine (dX) are both form

43 ing 7-deaza-2'-deoxyguanosine (dc(7)G) or 2'-deoxyinosine (dI) in place of dG support oligoribonucleo

44 Replacement of dG at 5'-d(CG) with 2'-deoxyinosine (dI), which lacks the exocyclic C2 amino gr

45 : 2'-deoxyuridine, 2'-deoxyxanthosine and 2'-deoxyinosine from nitrosative deamination; 8-oxo-2'-deox

46 l endonuclease, which cleaves the 5' side of deoxyinosine, from the hyperthermophilic archaeon, Pyroc

47 bolished in the 5'-...CIG*C...duplex (the 2'-deoxyinosine group, I, lacks this amino group).

48 ic efficiencies: thymidine > deoxyuridine >> deoxyinosine > deoxyguanosine.

49 of structurally disparate lesions, including deoxyinosine (I), which results from the spontaneous oxi

50 donuclease V (endo V) recognizes and cleaves deoxyinosine in deaminated DNA.

51 enyl)-2'-deoxyinosine 9 was prepared from 2'-deoxyinosine in four steps and incorporated into oligome

52 e, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used

53 ugar-protected or -unprotected inosine or 2'-deoxyinosine nucleosides and 1H-benzotriazol-1-yloxy-tri

54 rates are not affected by bases opposite the deoxyinosine or deoxyxanthosine lesions.

55 (dA) was substituted with adenosine (A), 2'-deoxyinosine, or 2'-deoxyuridine, toxin-dependent signal

56 nd in replication using 7,8-dihydro-8-oxo-2'-deoxyinosine (OxodI).

57 In contrast, the process of deoxyinosine recognition appeared little affected by the

58 to the 2-fluoro-O(6)-(2-trimethylsilylethyl)deoxyinosine residue of the 12-mer oligonucleotide.

59 oliovirus PCR primers contain mixed-base and deoxyinosine residues to compensate for the high degener

60 The primers contain mixed-base and deoxyinosine residues to compensate for the high rate of

61 l shift (1.3 ppm), indicating that C-6 of 2'-deoxyinosine retains its sp2 hybridization after binding

62 e-ImmH) is a transition-state mimic for a 2'-deoxyinosine ribocation with a fully dissociated N-ribos

63 eater than 20-fold higher for DNA containing deoxyinosine than deoxynebularine or base mismatches.

64 n of dCTP via Hoogsteen-type templating with deoxyinosine, thus generating A-to-G mutations.

65 with half-times ranging from 4 years for 2'-deoxyinosine to 40 years for 2'-deoxycytidine (37 degree

66 ding 2'-deoxyuridine triphosphate (dUTP), 2'-deoxyinosine triphosphate (dITP), and 7-deaza-2'-deoxygu

67 omologs have high specificity for dHAPTP and deoxyinosine triphosphate compared with the four canonic

68 varation, filtering out data collected with deoxyinosine triphosphate during primer extension, gave

69 aminopurine triphosphate (dHAPTP) as well as deoxyinosine triphosphate.

70 otide mutagenesis with reversibly terminated deoxyinosine triphosphates (rtITP).

71 '-bis-O-(tert-butyldimethylsilyl)-2-bromo-2'-deoxyinosine, using a (+/-)-BINAP-Pd complex and Cs2CO3.

72 2'-deoxyinosine was converted into an N1-2,4-dinitrophenyl

73 ts yielded a structure in which the modified deoxyinosine was in the high syn conformation about the

74 ne epoxide (BDO), followed by deamination to deoxyinosine, was determined, in the oligodeoxynucleotid

75 osine, formycin A, adenosine, inosine, or 2'-deoxyinosine were determined by x-ray crystallography wi

76 c parameters of the 'universal pairing base' deoxyinosine were determined for the pairs I.C, I.A, I.T

77 bound inosine in a different way, we labeled deoxyinosine with 13C, excepting an upfield shift of 70-

78 ...CIG*C... sequences, which contain "I" (2'-deoxyinosine), with hydrogen replacing the amino group i