ライフサイエンスコーパス: deoxynucleoside

1 xy-2'-deoxyguanosine and 8,5'-cyclopurine-2'-deoxynucleosides.

2 riction by SAMHD1 was rescued by addition of deoxynucleosides.

3 tics and product profile of QM reaction with deoxynucleosides.

4 e and thus explaining the specificity for 2'-deoxynucleosides.

5 and class II enzymes are highly specific for deoxynucleosides.

6 ing deoxynucleoside triphosphates (dNTPs) to deoxynucleosides.

7 partially overcome by addition of exogenous deoxynucleosides.

8 was alleviated by the addition of exogenous deoxynucleosides.

9 (4)-epsilon-Cyt)] and their corresponding 2'-deoxynucleosides.

10 ates for oxidation than the corresponding 2'-deoxynucleosides.

11 The deoxynucleosides 1 and 2 demonstrate that the chemical d

12 thase inhibitor 5-fluorouracil (5-FU) or its deoxynucleoside, 2'-deoxy-5-fluorouridine.

13 tudies carried out on the AFB-FAPY bases and deoxynucleoside 3',5'-dibutyrates now establish that the

14 8-dihydrodiol-9,10-epoxide (B[a]PDE) with 2'-deoxynucleoside 3'-monophosphates.

15 ith these modifications, coupling of each 2'-deoxynucleoside 3'-phosphoramidite to the growing oligod

16 eaction, boron-modified nucleotides, i.e. 2'-deoxynucleoside 5'-alpha-[P-borano]-triphosphates, are i

17 Synthesis entails preparation of 2'-deoxynucleoside 5'-diphosphate precursors, followed by a

18 (RNR) converts nucleoside 5'-diphosphates to deoxynucleoside 5'-diphosphates and is expressed under i

19 cleoside 5'-diphosphate substrates (S) to 2'-deoxynucleoside 5'-diphosphates.

20 Reaction of 11 with 2'-deoxynucleoside 5'-monophosphates or a nucleoside 5'-mon

21 ting CD4(+) T cells by reducing the cellular deoxynucleoside 5'-triphosphate (dNTP) concentration to

22 onding distance to the bases of the incoming deoxynucleoside 5'-triphosphate (dNTP), the terminal pri

23 Deoxynucleoside 5'-triphosphate analogues in which the b

24 at manganese increases the rate constant for deoxynucleoside 5'-triphosphate insertion compared to ma

25 ns required for the reaction of the incoming deoxynucleoside 5'-triphosphate with the 3'-hydroxyl in

26 duction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates and uses coenzyme B12,

27 mer extension reaction utilizing 5'-amino-5'-deoxynucleoside 5'-triphosphates generates polynucleotid

28 Two modified 2'-deoxynucleoside 5'-triphosphates have been used for the

29 on, deoxynucleotides in DNA are converted to deoxynucleoside 5'-triphosphates.

30 he incorporation of benzimidazole-derived 2'-deoxynucleoside-5'-O-triphosphates ( BENZI: TP and BIM:

31 total six crystal structures of modified 2'-deoxynucleoside-5'-O-triphosphates (dNTPs) carrying modi

32 sized base-modified benzimidazole-derived 2'-deoxynucleoside-5'-O-triphosphates on DNA polymerases wh

33 iphosphate (dSpTP) and guanidinohydantoin-2'-deoxynucleoside-5'-triphosphate (dGhTP) are reported.

34 riphosphate lesions spiroiminodihydantoin-2'-deoxynucleoside-5'-triphosphate (dSpTP) and guanidinohyd

35 back regulatory control by the physiological deoxynucleoside-5'-triphosphate dTTP, we examined the ef

36 ) plays a critical role in the production of deoxynucleoside-5'-triphosphates (dNTPs), the building b

37 conversion of nucleoside-5'-diphosphates to deoxynucleosides-5'-diphosphates.

38 ant increases in the oxidatively damaged DNA deoxynucleoside 8-hydroxydeoxyguanosine, with the degree

39 chromatographic analysis of DNA digested to deoxynucleosides, about 60% of the Wilms tumors were fou

40 rly, Vpx-containing virus-like particles and deoxynucleosides added to the cells more than 24 h posti

41 Thus, deoxynucleoside addition partially overcomes the restric

42 ionic acid (BODIPY FL) was used to label the deoxynucleoside adducts N-(2'-deoxyguanosine-8-yl)-4-ami

43 The 2'-deoxynucleoside adducts, 1,N(2)-epsilon-dG and 1,N(6)-ep

44 linked DNA returned primarily the unmodified deoxynucleosides, along with 1-[N3-deoxycytidyl]-2-[N1-d

45 e recently reported that in the last step, L-deoxynucleoside analog diphosphates are phosphorylated b

46 ts attributed favorable phosphorylation of L-deoxynucleoside analog diphosphates by PGK to difference

47 mutations on the phosphorylation of L- and D-deoxynucleoside analog diphosphates was different from t

48 ted by 3-phosphoglycerate kinase, whereas, D-deoxynucleoside analog diphosphates were phosphorylated

49 explain the preference of PGK for L- over D-deoxynucleoside analog diphosphates, the kinetics of the

50 Among these pyrimidine deoxynucleoside analog monophosphates, D-FMAU monophosph

51 fluorescence of a set of four benzo-expanded deoxynucleoside analogs (xDNA) that maintain Watson-Cric

52 We evaluated deoxynucleoside analogs for lack of toxicity to human ce

53 "lethal mutagenesis" driven by the class of deoxynucleoside analogs represented by 5-OH-dC could pro

54 y, several L- and D-configuration pyrimidine deoxynucleoside analogs were found to be potent antivira

55 Fd4C, L-FMAU, and L-ddC were compared with D-deoxynucleoside analogs, AraC, dFdC, and D-FMAU, and D-d

56 Studies with deoxynucleoside analogues indicated that 3'-azido-3'deox

57 e in DMSO/THF gave the respective 2'- and 3'-deoxynucleoside analogues with beta-D-threo configuratio

58 ry of potent antiviral agents based on novel deoxynucleoside analogues with unusual bicyclic base moi

59 es of this enzyme and to study the effect of deoxynucleoside analogues, we have isolated and partiall

60 w furo[2,3-d]pyrimidin-2(3H)-one (FuPyrm) 2'-deoxynucleoside analogues.

61 ynucleoside triphosphates to the constituent deoxynucleoside and inorganic triphosphate.

62 catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively

63 he results define the acidity of oxopropenyl deoxynucleosides and highlight its importance to their r

64 n products from millimolar concentrations of deoxynucleosides and oligomers.

65 aced incorporation of (15)N into tryptophan, deoxynucleosides and pheophytin derived from chlorophyll

66 6-[chloro (5, 63%) or bromo (6, 80%)]purine deoxynucleosides, and 2',3',5'-tri-O-acetyladenosine (8)

67 8,5'-Cyclopurine 2'-deoxynucleosides are among the major lesions in DNA that

68 The 8,5'-cyclopurine-2'-deoxynucleosides are quite stable lesions and are valid

69 ivation parameters for the degradation of 2'-deoxynucleosides at 25 degrees C were determined by extr

70 '-deoxyadenosine, 4-methylbenzimidazole beta-deoxynucleoside (B), and 9-methyl-1H-imidazo[4,5-b]pyrid

71 4'-C-ethynyl-2'-deoxynucleosides belong to a novel class of nucleoside a

72 As free deoxynucleosides, both dyT and dyC displayed robust fluo

73 We have focused our attention on the use of deoxynucleoside building blocks bearing non-natural base

74 specificity of the class I enzyme for purine deoxynucleosides can be traced to a loop (residues 48-62

75 es, which accept either purine or pyrimidine deoxynucleosides, class I enzymes are specific for purin

76 e incorporating the low energy C2'-endo/anti deoxynucleoside conformation.

77 ase pairing, base stacking, or C2'-endo/anti deoxynucleoside conformations are perturbed significantl

78 uggest no significant changes in backbone or deoxynucleoside conformations.

79 The 2'-deoxynucleoside containing the synthetic base 1-[(2R,4S,

80 Diastereomeric 8,5'-cyclopurine 2'-deoxynucleosides, containing a covalent bond between the

81 minishes quickly as the concentration of the deoxynucleoside decreases.

82 d 1,N(2)-propanoguanine (PGua)] and their 2'-deoxynucleoside derivatives were not oxidized.

83 sugar chloride in a nonpolar solvent give 2'-deoxynucleoside derivatives with N9 regiochemistry and e

84 des, 3'-O-methyl-substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-C-azido substituti

85 and GTP and donates it to all nucleoside and deoxynucleoside diphosphate acceptors tested.

86 RB69 DNA polymerase and have shown that the deoxynucleoside diphosphate can be incorporated, in cont

87 talyzes nucleoside diphosphate conversion to deoxynucleoside diphosphate.

88 the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs).

89 of all the NTPs, has a low affinity for the deoxynucleoside diphosphates and cannot generate the dNT

90 le for converting nucleoside diphosphates to deoxynucleoside diphosphates, ensuring a balanced supply

91 the conversion of nucleoside diphosphates to deoxynucleoside diphosphates.

92 the conversion of nucleoside diphosphates to deoxynucleoside diphosphates.

93 conversion of nucleoside diphosphates to 2'-deoxynucleoside diphosphates.

94 Mutations that reduce the efficiency of deoxynucleoside (dN) triphosphate (dNTP) substrate utili

95 and in vivo, CpG DNA containing unnatural 3'-deoxynucleoside either within the CpG-dinucleotide or ad

96 Here we show that addition of deoxynucleosides enhanced integration and 2LTR formation

97 The 2'-fluoro-2'-deoxynucleosides examined here are valuable probes of th

98 f thymidines in A5 tracts by difluorotoluene deoxynucleoside (F), a non-polar molecule of the same si

99 e critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleos

100 lication on encountering these pro-mutagenic deoxynucleosides four steps ahead of the primer-template

101 act in a concerted manner to excise oxidized deoxynucleosides from duplex DNA.

102 The syntheses of the desired deoxynucleoside generally proceed in three steps from a

103 Supplementation by deoxynucleosides improved DNA repair.

104 Interestingly, substitution of a 3'-deoxynucleoside in the 5'-flanking sequence distal to th

105 8,5'-cyclopurine-2'-deoxynucleosides in DNA are repaired by nucleotide-excis

106 ence properties of the purine and pyrimidine deoxynucleosides in organic solvents in the presence of

107 The covalent 2'-deoxynucleoside inactivators of CD38 are powerful inhibi

108 effect of 3'-deoxy-2'-5'-ribonucleoside (3'-deoxynucleoside) incorporation into CpG DNA on the immun

109 RCA1 mutations to repair 8,5'-cyclopurine-2'-deoxynucleosides indicates the involvement of BRCA1 in n

110 Adenine deoxynucleosides induce apoptosis in quiescent lymphocyt

111 yields of the N9 isomers of beta-anomeric 2'-deoxynucleoside intermediates.

112 of the C-C and C-N bond-forming reactions of deoxynucleosides is also reported.

113 Two nonpolar deoxynucleoside isosteres containing 2,4-difluorotoluene

114 DNA shuffling of Drosophila melanogaster 2'-deoxynucleoside kinase, followed by FACS analysis, yield

115 ating that Cryptosporidium possesses another deoxynucleoside kinase.

116 Our work reveals that multiple deoxynucleoside kinases are involved in the phosphorylat

117 Three of the four deoxynucleoside kinases required for growth of Lactobaci

118 in T cells may be dependent on the levels of deoxynucleoside kinases.

119 n the binding of carboranyl nucleosides with deoxynucleoside kinases.

120 s potential terminators: 4-methylindole beta-deoxynucleoside (M), 1-naphthyl alpha-deoxynucleoside (N

121 The capacity of adenine deoxynucleoside metabolites to activate the apoptosome p

122 eoxycytidine (dC), we hypothesized that: (1) deoxynucleosides might be the major active agents and (2

123 etailed investigations of this procedure for deoxynucleoside modification.

124 on of an array of endogenously generated DNA deoxynucleosides modifications.

125 is of all of the products indicated that the deoxynucleoside monophosphate incorporated "opposite" Pd

126 slippage and dNTP stabilization followed by deoxynucleoside monophosphate incorporation and extensio

127 it is also found that transcripts containing deoxynucleoside monophosphates (dNMPs) are more poorly e

128 Because we observed rapid catabolism of the deoxynucleoside monophosphates to deoxythymidine (dT) an

129 e beta-deoxynucleoside (M), 1-naphthyl alpha-deoxynucleoside (N) and 1-pyrenyl alpha-deoxynucleoside

130 ent and hydrolysis of the modified DNA to 2'-deoxynucleosides, N(2)-BPDE-dG adducts formed at the [(1

131 Derivatives of the 2'-deoxynucleoside of furo[2,3-d]pyrimidin-2(3H)-one with l

132 The oxidized lesions observed include the 2'-deoxynucleosides of 8-oxo-7,8-dihydroguanine (dOG), spir

133 nst varicella-zoster virus (VZV) shown by 2'-deoxynucleosides of furo[2,3-d]pyrimidin-2(3H)-one and r

134 Surprisingly, deoxynucleosides of the packaged DNA genome of Pf3 adopt

135 lpha-deoxynucleoside (N) and 1-pyrenyl alpha-deoxynucleoside (P).

136 thesized and used in the preparation of four deoxynucleoside phosphoramidites 28 and 65-67, plus the

137 A triester method for the synthesis of deoxynucleoside phosphorodithioate dimers is described.

138 ch of seven contiguous 3',5'-linked oligo-2'-deoxynucleoside phosphorothioate linkages in the center

139 thioate linkages gives 2',5'-linked oligo-3'-deoxynucleoside phosphorothioate ODNs that exhibit signi

140 roviruses/cell in memory or naive cells, and deoxynucleoside pools were equally limiting.

141 Fluorescent deoxynucleosides possessing the modified bases 6-(2-benz

142 able reactions at the C-2 position of purine deoxynucleosides proceed with less sensitivity to the li

143 its dA N1 adduct yield a similar profile of deoxynucleoside products when treated with an equimolar

144 nversion, for which this fluorine-labeled 2'-deoxynucleoside proved to be a powerful sensor.

145 and 9-methyl-1H-imidazo[4,5-b]pyridine beta-deoxynucleoside (Q), were used to examine the importance

146 oxycytidine kinase (dCK) is to phosphorylate deoxynucleosides required for DNA synthesis, with the ex

147 he 3'-hydroxyl group from potent anti-VZV 2'-deoxynucleosides results in loss of the VZV activity, bu

148 Incorporation of 3'-deoxynucleosides results in the formation of 2'-5'-inter

149 Long-chain derivatives at C6 in the 2'-deoxynucleoside series showed virus-encoded nucleoside k

150 e NO.-induced deamination rate constants for deoxynucleosides, single- and double-stranded oligonucle

151 substrate, were more modestly affected by 2'-deoxynucleoside substitution.

152 INTERPRETATION: Our studies demonstrate that deoxynucleoside substrate enhancement is a novel therapy

153 Adenine deoxynucleosides, such as 2-chloro-2'-deoxyadenosine (2C

154 Adenine deoxynucleosides, such as 2-chlorodeoxyadenosine (2CdA)

155 Both pyrimidine and purine deoxynucleoside sugar puckers are perturbed by the phena

156 (ii) Ethidium binding converts deoxynucleoside sugar puckers from the C2'-endo to the C

157 The stability of dX as a 2'-deoxynucleoside (t(1/2) = 3.7 min at pH 2; 1104 h at pH

158 modified bases including 8,5'-cyclopurine-2'-deoxynucleoside tandem lesions were identified and quant

159 The other adenine deoxynucleosides tested displayed comparable DNA-damagin

160 beta was completely antagonized by providing deoxynucleosides to bypass the block in ribonucleotide r

161 dation of any hydrocarbon with the purine 2'-deoxynucleosides to date.

162 hosphorolysis in 6-oxypurine nucleosides and deoxynucleosides to form purine and alpha-D-phosphorylat

163 Addition of deoxynucleosides to the medium increased intracellular d

164 ly protected 5'-O-(4, 4'-dimethoxytrityl)-2'-deoxynucleosides to yield 3'-O-phosphinoamidite reactive

165 ed oligomers were 5 times more reactive than deoxynucleosides toward N2O3.

166 the 110-to-115 loop region, which may affect deoxynucleoside triphosphate (dNTP) binding and polymera

167 upport catalysis, and Ca(2+), which supports deoxynucleoside triphosphate (dNTP) binding but not cata

168 Residue 272 is located within the deoxynucleoside triphosphate (dNTP) binding pocket of DN

169 er of the HBV reverse transcriptase (RT)-DNA-deoxynucleoside triphosphate (dNTP) complex, based on th

170 This advantage was maintained as deoxynucleoside triphosphate (dNTP) concentrations were

171 onocytic cells by reducing the intracellular deoxynucleoside triphosphate (dNTP) concentrations.

172 Analogues were examined both as incoming deoxynucleoside triphosphate (dNTP) derivatives and as t

173 f methionine synthase activity, resulting in deoxynucleoside triphosphate (dNTP) imbalance, increased

174 ate of misincorporation is high because of a deoxynucleoside triphosphate (dNTP) imbalance.

175 dTTP is the most abundant deoxynucleoside triphosphate (dNTP) in the cell despite

176 Here, we investigated the pre-steady-state deoxynucleoside triphosphate (dNTP) incorporation kineti

177 can be explained by decreased sensitivity to deoxynucleoside triphosphate (dNTP) inhibition of the nu

178 Samhd1(-/-) cells have elevated deoxynucleoside triphosphate (dNTP) levels but, surprisi

179 alleviated by SML1 deletion, which increases deoxynucleoside triphosphate (dNTP) pools.

180 ble interaction between SOS and the cellular deoxynucleoside triphosphate (dNTP) pools.

181 anscriptase (RT) mutants or limited cellular deoxynucleoside triphosphate (dNTP) pools.

182 The presence of complementary 2'-deoxynucleoside triphosphate (dNTP) shifts the equilibri

183 not contact the DNA template or the incoming deoxynucleoside triphosphate (dNTP) substrate, is locate

184 I (KF) as a function of the concentration of deoxynucleoside triphosphate (dNTP) substrate.

185 zing the template-directed polymerization of deoxynucleoside triphosphate (dNTP) substrates onto the

186 SAMHD1 is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase

187 anscriptase with a DNA template:primer and a deoxynucleoside triphosphate (dNTP), and the crystal str

188 a dideoxy-terminated primer and an incoming deoxynucleoside triphosphate (dNTP), does not form the c

189 Moreover, we show that binding of a deoxynucleoside triphosphate (dNTP), in the absence of a

190 h the catalytic residues of RT, the incoming deoxynucleoside triphosphate (dNTP), or the primer-templ

191 in reverse transcriptase (RT) that alter the deoxynucleoside triphosphate (dNTP)-binding pocket, incl

192 ast to previous suggestions that Dpo4 uses a deoxynucleoside triphosphate (dNTP)-stabilized misalignm

193 he presence or in the absence of an incoming deoxynucleoside triphosphate (dNTP).

194 ents associated with binding of the incoming deoxynucleoside triphosphate (dNTP).

195 metal exchange-inert Rh(III) derivative of a deoxynucleoside triphosphate (Rh.dTTP).

196 ts of the purine substrates ADP and GDP, the deoxynucleoside triphosphate allosteric effectors dGTP a

197 radical-containing (R2) enzyme subunits and deoxynucleoside triphosphate allosteric effectors.

198 f S phase by transcribing genes required for deoxynucleoside triphosphate and DNA synthesis.

199 m our laboratory have shown that the natural deoxynucleoside triphosphate and the NNRTI can simultane

200 constants of transitions that lead to strong deoxynucleoside triphosphate binding prior to chemistry.

201 e effect of mutations in the YXDD motif, the deoxynucleoside triphosphate binding site, the thumb dom

202 ismatched nucleotides from the ternary E.DNA.deoxynucleoside triphosphate complex and by the use of s

203 ccur in a fully assembled DNA polymerase-DNA-deoxynucleoside triphosphate complex with two canonical

204 relatively inactive except when the cellular deoxynucleoside triphosphate concentrations are high, as

205 Thus, rather large increases in fidelity of deoxynucleoside triphosphate insertion and mispair exten

206 previously shown to increase the fidelity of deoxynucleoside triphosphate insertion.

207 r results suggest that motif B influences RT-deoxynucleoside triphosphate interactions at multiple st

208 PCR was performed with a deoxynucleoside triphosphate mixture which resulted in t

209 d by the direct interaction of CD81 with the deoxynucleoside triphosphate phosphohydrolase SAMHD1.

210 Taken together, these findings support deoxynucleoside triphosphate pool depletion as the prima

211 ponse to genotoxic stress by maintaining the deoxynucleoside triphosphate pools necessary for error-p

212 Quantification of deoxynucleoside triphosphate pools showed that hydroxyur

213 DNA stability is by modulating mitochondrial deoxynucleoside triphosphate pools.

214 repair of DNA require equilibrated pools of deoxynucleoside triphosphate precursors.

215 ion by the lentivirus vector was improved by deoxynucleoside triphosphate pretreatment of the vector

216 oredoxin, a primer-template, and an incoming deoxynucleoside triphosphate reveals a putative hydrogen

217 ring the balance between DNA replication and deoxynucleoside triphosphate synthesis in the case of nd

218 than the Exo mutants, converted the incoming deoxynucleoside triphosphate to its monophosphate, indic

219 1 has been identified as the first mammalian deoxynucleoside triphosphate triphosphohydrolase (dNTPas

220 A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPas

221 SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase and a n

222 The deoxynucleoside triphosphate triphosphohydrolase SAMHD1

223 Upon binding a correct deoxynucleoside triphosphate, alpha-helix N of DNA polym

224 e on the side of O-helix facing the incoming deoxynucleoside triphosphate, as determined by x-ray ana

225 tion resulted when uracil was present as the deoxynucleoside triphosphate, dUTP.

226 , potentially involving rearrangement of the deoxynucleoside triphosphate-binding pocket residues.

227 titutions near the polymerase active site or deoxynucleoside triphosphate-binding site of HIV-1 RT in

228 omplex formation in the presence of the next deoxynucleoside triphosphate.

229 P, XTP, dXTP, or 6-hydroxylaminopurine (HAP) deoxynucleoside triphosphate] into nucleic acids is prev

230 catalyzes the hydrolysis of nucleoside- and deoxynucleoside-triphosphate (NTP) substrates by nucleop

231 d expression, decreasing the availability of deoxynucleoside triphosphates (dNTP) and thus HIV-1 reve

232 large number of nucleoside analogues and 2'-deoxynucleoside triphosphates (dNTP) have been synthesiz

233 ave functional roles in the interaction with deoxynucleoside triphosphates (dNTPs) and DNA.

234 cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and inhibits the a

235 4), NL4-3 virions, incubated with or without deoxynucleoside triphosphates (dNTPs) and/or the polyami

236 Normal deoxynucleoside triphosphates (dNTPs) could still be inc

237 Synthesis of deoxynucleoside triphosphates (dNTPs) is required for bo

238 The deoxynucleoside triphosphates (dNTPs) of these bases are

239 t cell type contains a very low level of the deoxynucleoside triphosphates (dNTPs) required for provi

240 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleoside

241 apped DNA 5.5-fold, and increases the Km for deoxynucleoside triphosphates (dNTPs) twofold.

242 icted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their co

243 , is impaired due to limited availability of deoxynucleoside triphosphates (dNTPs), which are needed

244 emplating base from a pool of four different deoxynucleoside triphosphates (dNTPs).

245 reactions lacking one of four complementary deoxynucleoside triphosphates (dNTPs).

246 of a 13/20mer primer/template (D) to detect deoxynucleoside triphosphates (N)-dependent conformation

247 bility of the enzyme to discriminate between deoxynucleoside triphosphates and nucleoside analog RT i

248 erize efficiently with low concentrations of deoxynucleoside triphosphates and seems to be able to ex

249 d d4TMP, even when relatively high levels of deoxynucleoside triphosphates are present in the reactio

250 work by depleting the pool of intracellular deoxynucleoside triphosphates but has also been reported

251 , suggesting that demethylation of alkylated deoxynucleoside triphosphates by AlkB could have biologi

252 Other deoxynucleoside triphosphates could also inhibit the upt

253 Other nucleoside triphosphates or deoxynucleoside triphosphates could not substitute for A

254 he capacity to synthesize dTTP and the other deoxynucleoside triphosphates essential for viral replic

255 vels of dNTPs to maintain a balanced pool of deoxynucleoside triphosphates in the cell.

256 NA polymerases catalyze the incorporation of deoxynucleoside triphosphates into a growing DNA chain u

257 racellular enzyme that specifically degrades deoxynucleoside triphosphates into component nucleoside

258 e (RNAP) for ribonucleoside triphosphates vs deoxynucleoside triphosphates inverted question mark(kca

259 magnesium, potassium, sodium, Tris ions, and deoxynucleoside triphosphates on melting profiles of dup

260 2 microM, had no detectable activity against deoxynucleoside triphosphates or other typical Nudix hyd

261 y with different primers and compositions of deoxynucleoside triphosphates to differentially monitor

262 stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent deoxynu

263 re, the addition of DNA polymerase alpha and deoxynucleoside triphosphates to the excision reaction f

264 converting ribonucleoside triphosphates and deoxynucleoside triphosphates to their respective diphos

265 drolyze all eight of the canonical ribo- and deoxynucleoside triphosphates to their respective monoph

266 The Km of deoxynucleoside triphosphates was determined with a modi

267 m wild-type enzyme under conditions in which deoxynucleoside triphosphates were not limiting.

268 g sequences, under conditions where primers, deoxynucleoside triphosphates, and enzyme are not limiti

269 th various triggers, including S100 cytosol, deoxynucleoside triphosphates, detergents, NaCl, and buf

270 in the presence of a normal concentration of deoxynucleoside triphosphates, leading to a high toxicit

271 hydrolase that depletes the cellular pool of deoxynucleoside triphosphates, thereby preventing revers

272 leoside triphosphatase preferring pyrimidine deoxynucleoside triphosphates.

273 The drugs directly or indirectly decrease deoxynucleoside triphosphates.

274 osine polyphosphates, sugar nucleotides, and deoxynucleoside triphosphates.

275 nt for the binding of nucleoside analogs and deoxynucleoside triphosphates.

276 -based approach with 15N- and/or 13C-labeled deoxynucleoside triphosphates.

277 he conversion of nucleoside triphosphates to deoxynucleoside triphosphates.

278 eration of a wide variety of nucleoside (and deoxynucleoside) triphosphates (NTPs) from their cognate

279 een proposed that SAMHD1 is a dGTP-dependent deoxynucleoside triphosphohydrolase (dNTPase) that restr

280 The deoxynucleoside triphosphohydrolase SAMHD1 restricts ret

281 HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the r

282 inoquinoline- and 2-aminoquinazoline-based C-deoxynucleosides (TRIPsides) that are designed to be inc

283 en condensed with appropriately protected 2'-deoxynucleosides using 4,5-dicyanoimidazole to yield the

284 Ts catalyze N-glycosidic bond cleavage of 2'-deoxynucleosides via a covalent 2-deoxyribosyl-enzyme in

285 Substitution of G620 with a 2'-deoxynucleoside was expected to inhibit the reaction, in

286 group of solid phase-supported 2'-fluoro-2'-deoxynucleoside was used as an acceptor and 5'-diisoprop

287 ion of lipophilic alkyl furano pyrimidine 2'-deoxynucleosides, we now report that 2',3'-dideoxy sugar

288 Sites of derivatization of adduct deoxynucleosides were established primarily by nuclear m

289 Suitably protected versions of the deoxynucleosides were prepared for oligonucleotide synth

290 the expanded adenine, we tested a formamide deoxynucleoside, which Leonard proposed as a shortened t

291 Pretreatment of HLFs with deoxynucleosides, which increase cellular dNTP pools, en