ライフサイエンスコーパス: deoxynucleotide

1 formation with the phosphate group of the 2'-deoxynucleotide.

2 n kinetics for incorporation of an incorrect deoxynucleotide.

3 dducts by B[a]PDE following reaction with 2'-deoxynucleotides.

4 catalyzes the reduction of nucleotides to 2'-deoxynucleotides.

5 says demonstrate that both NH2Y-alpha2s make deoxynucleotides.

6 the equilibrium of allosteric activation by deoxynucleotides.

7 tracellular dGTP without any effect on other deoxynucleotides.

8 , catalyzes the conversion of nucleotides to deoxynucleotides.

9 14 microg/ml, whereas M1dG fell to 1.4/10(7) deoxynucleotides.

10 oration and removal of natural and unnatural deoxynucleotides.

11 ophosphates and PP(i), with a preference for deoxynucleotides.

12 xynucleotides were not the same as for the D-deoxynucleotides.

13 s) catalyze the conversion of nucleotides to deoxynucleotides.

14 reductase (RNR) converts ribonucleotides to deoxynucleotides.

15 e ribonucleotide embedded within a series of deoxynucleotides.

16 A biosynthesis: conversion of nucleotides to deoxynucleotides.

17 e >200-fold more rapidly than other ribo- or deoxynucleotides.

18 s) catalyze the conversion of nucleotides to deoxynucleotides.

19 catalyzing the conversion of nucleotides to deoxynucleotides.

20 2 have significantly reduced ability to make deoxynucleotides.

21 hetic oligonucleotides containing 4'-thio-2'-deoxynucleotides.

22 cytosine guanine dinucleotide-enriched oligo-deoxynucleotides.

23 ol alpha), which extends the RNA primer with deoxynucleotides.

24 NA template and extending an RNA primer with deoxynucleotides.

25 el pathway for the prebiotic synthesis of 2'-deoxynucleotides.

26 ency vary inversely with the accumulation of deoxynucleotides.

27 nd can generate products containing up to 32 deoxynucleotides.

28 s of magnitude less efficiently than natural deoxynucleotides.

29 emplate duplexes with 3'-deoxynucleotide, 3'-deoxynucleotide 3'-phosphate, or 3' ribonucleotide termi

30 presence of primer-template duplexes with 3'-deoxynucleotide, 3'-deoxynucleotide 3'-phosphate, or 3'

31 2'-Deoxynucleotide 5'-tetraphosphates in which a fluorescen

32 sion of nucleoside diphosphates (NDPs) to 2'-deoxynucleotides, a critical step in DNA replication and

33 ) catalyzes the conversion of nucleotides to deoxynucleotides, a process that requires long-range rad

34 n cognate and near-cognate tRNAs, we made 2'-deoxynucleotide and 2'-fluoro substituted mRNAs, which d

35 cluding MDA, as compared with 3.8 M1dG/10(7) deoxynucleotides and 0.07 microg/ml lipid peroxidation p

36 in cancer cells to fuel the biosynthesis of deoxynucleotides and antioxidants and to sustain stress-

37 s) catalyze the conversion of nucleotides to deoxynucleotides and are composed of alpha- and beta-sub

38 es catalyze the conversion of nucleotides to deoxynucleotides and are composed of two subunits: R1 an

39 , enzymes that convert nucleotides (NDPs) to deoxynucleotides and are essential for DNA replication a

40 This enzyme contains approximately 30 deoxynucleotides and can cleave almost any RNA substrate

41 for counting efficiencies of labeled DNA and deoxynucleotides and illustrate the generality of this e

42 he conversion of nucleoside triphosphates to deoxynucleotides and is 100% inactivated by 1 equiv of 2

43 i catalyzes the conversion of nucleotides to deoxynucleotides and is composed of two homodimeric subu

44 ) catalyzes the conversion of nucleotides to deoxynucleotides and is composed of two subunits: alpha2

45 uction of nucleoside 5'-diphosphates into 2'-deoxynucleotides and is composed of two subunits: alpha2

46 ) catalyzes the conversion of nucleotides to deoxynucleotides and is essential in all organisms.

47 he conversion of nucleoside triphosphates to deoxynucleotides and is rapidly (<30 s) inactivated by 1

48 h 18:0/stearic acid) produced 6.5 M1dG/10(7) deoxynucleotides and no detectable lipid peroxidation pr

49 the availability of pure, well-characterized deoxynucleotides and not a sequence-specific pure DNA st

50 s) catalyze the conversion of nucleotides to deoxynucleotides and require dinuclear metal clusters fo

51 ficient at adding templated and nontemplated deoxynucleotides and ribonucleotides to DNA ends in vitr

52 The antisense deoxynucleotides and siRNA approach acts via removal of

53 encing in GBM cells reduced levels of NADPH, deoxynucleotides, and glutathione and increased their se

54 acteriophage-encoded RNA polymerase using 3'-deoxynucleotides as chain terminators.

55 results suggest that the potency of adenine deoxynucleotides as co-factors for APAF-1-dependent casp

56 Incorporation of site-specific 2'-deoxynucleotides, as well as phosphorothioate and methyl

57 as documented by more rapid incorporation of deoxynucleotides, associated with earlier increases in c

58 ozyme bound to an inhibitor RNA containing a deoxynucleotide at the cleavage site.

59 A polymerase Pol iota, which misincorporates deoxynucleotides at a high rate.

60 thesis of a series of derivatives containing deoxynucleotides at each position along the D5 strand.

61 The introduction of 3 deoxynucleotides at the 5' terminus of the 2'-methoxy an

62 binds nucleoside diphosphate substrates and deoxynucleotide/ATP allosteric effectors and is the site

63 that phage-augmented NADPH production fuels deoxynucleotide biosynthesis for phage replication, and

64 phage genes involved in the light reactions, deoxynucleotide biosynthesis, and the PPP, including a t

65 A protein, termed mitochondrial deoxynucleotide carrier (DNC), based on its ability to t

66 25A19, which encodes a nuclear mitochondrial deoxynucleotide carrier (DNC), contains a substitution t

67 The lack of deoxynucleotides causes replicative stress leading to ac

68 will only occur if the gap is filled with a deoxynucleotide complementary to the wild-type or mutant

69 triphosphate (TP) levels similar to cellular deoxynucleotide concentrations can induce multilog killi

70 Bypass efficiency was proportional to deoxynucleotide concentrations equivalent to those found

71 /z 399 and 497 were observed for all four 2'-deoxynucleotides, corresponding to [(B[a]Ptriol+phosphat

72 efficient than the second, and among natural deoxynucleotides, dATP was the preferred substrate due t

73 vestigate allosteric activation of SAMHD1 by deoxynucleotide-dependent tetramerization and measure ho

74 Collectively, our data suggest that deoxynucleotide-dependent tetramerization contributes to

75 y, RTEL1 deficiency induces tolerance to the deoxynucleotide-depleting drug hydroxyurea, which could

76 tional Xrs2p complex leads to sensitivity to deoxynucleotide depletion and to an inability to efficie

77 However, under conditions of deoxynucleotide depletion produced by hydroxyurea treatm

78 he half-life of the assembled tetramer after deoxynucleotide depletion varies from minutes to hours d

79 ntrols the balance and level of the cellular deoxynucleotide diphosphate pools that are critical for

80 conversion of nucleoside 5'-diphosphates to deoxynucleotides (dNDPs).

81 n of nucleoside 5'-diphosphates (NDPs) to 2'-deoxynucleotides (dNDPs).

82 sion of nucleoside 5'-diphosphates (NDPs) to deoxynucleotides (dNDPs).

83 over saturation kinetics for all 16 possible deoxynucleotide (dNTP) incorporations and for four match

84 overed that incorporation of a complementary deoxynucleotide (dNTP) into a self-primed single-strande

85 phosphorylation, differential effects on 2'-deoxynucleotide (dNTP) pools, and differences in the aff

86 ) catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis.

87 which subsequently catalyzed the addition of deoxynucleotides (dNTP) containing biotinlated 2'-deoxya

88 es were to analyze pharmacodynamic effect on deoxynucleotides (dNTPs) and to seek relationships betwe

89 se that catalyzes the sequential addition of deoxynucleotides (dNTPs) at the 3'-OH group of an oligon

90 tion of a mixture of natural and fluorescent deoxynucleotides (dNTPs) at the 3'-OH of an RNA-DNA hybr

91 preparation of the corresponding fluorinated deoxynucleotides (dNTPs).

92 strate-recognition domains of seven to eight deoxynucleotides each.

93 Terminal deoxynucleotide end-labeling (TUNEL) assays performed on

94 Terminal nick deoxynucleotide end-labeling-positive apoptotic cells (1

95 yl radical (Fe(III)2-Y*) cofactor to produce deoxynucleotides essential for DNA replication and repai

96 hen this initiation complex is supplied with deoxynucleotides, essentially all of the tRNA is used as

97 yme is comprised of a catalytic domain of 15 deoxynucleotides, flanked by two substrate-recognition d

98 s reveal a preference for guanosine/cytosine deoxynucleotides flanking the cognate CpG.

99 o RNase A pretreatment and requires all four deoxynucleotides for optimal polymerization.

100 tion of large bDNA combs containing all four deoxynucleotides for use as signal amplifiers in nucleic

101 osyl radical (Y122.) cofactor that initiates deoxynucleotide formation.

102 nt of Y731 of R2 with phenylalanine prevents deoxynucleotide formation.

103 with DNA polymerases, can excise mismatched deoxynucleotides from DNA.

104 se containing ribose; purine nucleotides and deoxynucleotides gave more methylglyoxal than did the py

105 The deoxynucleotide generated depends on the presence of all

106 double-stranded target derived from standard deoxynucleotides (i.e. beta-anomers).

107 reaks, incorporates both ribonucleotides and deoxynucleotides in a template-directed manner.

108 The presence of chloride and deoxynucleotides in a total concentration above 10 micro

109 ch catalyze the conversion of nucleotides to deoxynucleotides in all organisms, are an exemplar of ra

110 s) catalyze the conversion of nucleotides to deoxynucleotides in all organisms, providing the monomer

111 s) catalyze the conversion of nucleotides to deoxynucleotides in all organisms.

112 s) catalyze the conversion of nucleotides to deoxynucleotides in all organisms.

113 s) catalyze the conversion of nucleotides to deoxynucleotides in all organisms.

114 e radical chemistry to reduce nucleotides to deoxynucleotides in all organisms.

115 to several other clinically relevant adenine deoxynucleotides in B-chronic lymphocytic leukemia extra

116 ggest that site-specific incorporation of 3'-deoxynucleotides in CpG DNA modulates immunostimulatory

117 his reversal of the polymerization reaction, deoxynucleotides in DNA are converted to deoxynucleoside

118 The duplex donor DNAs are approximately 300 deoxynucleotides in length and contain only 15 bp of the

119 s, thereby maintaining the proper balance of deoxynucleotides in the cell.

120 A pre-steady-state burst of deoxynucleotide incorporation (k(obsd) = 1.0 s(-)(1)) in

121 y for the enzymatic reaction during a single deoxynucleotide incorporation event.

122 Steady-state kinetic analyses of deoxynucleotide incorporation indicate that pol eta has

123 re is a hyperbolic dependence of the rate of deoxynucleotide incorporation on the concentration of dC

124 ved with a DNA template, the rate of correct deoxynucleotide incorporation was reduced 25-fold (5.5+/

125 Endogenous levels of deoxynucleotides increased 24 hours after ara-C infusion

126 merases are defined as such because they use deoxynucleotides instead of ribonucleotides with high sp

127 The misincorporation of non-complementary deoxynucleotides into DNA by pol alpha was substantially

128 on helix was evaluated by introducing single deoxynucleotides into each of the six positions in the h

129 epair in response to the misincorporation of deoxynucleotides into newly synthesized DNA, long before

130 f ribonucleotide 5'-diphosphates to their 2'-deoxynucleotides, is modulated by levels of its M2 subun

131 tion in a viral strategy to control cellular deoxynucleotide levels for efficient replication.

132 tetramerization contributes to regulation of deoxynucleotide levels in cycling cells, whereas in non-

133 h defects in genes involved in mitochondrial deoxynucleotide metabolism or utilization, such as mutat

134 thanol-induced alterations in methionine and deoxynucleotide metabolism.

135 atically digested to its constituent monomer-deoxynucleotide monophosphates (dNMPs), of which there a

136 media (pH 2.2-5.3) than the parent oligo-2'-deoxynucleotide N3'-->P5' phosphoramidates.

137 ase upon Q deprivation is due to the lack of deoxynucleotides needed for DNA synthesis.

138 d (either on the base or phosphate group) 2'-deoxynucleotides of guanine, adenine, cytosine and thymi

139 Interestingly, deoxynucleotides of Pf1 DNA exhibit sugars in the C2'-en

140 Using the drug-containing and normal deoxynucleotide oligomers (21-base) annealed to M13mp18(

141 Substitution of a 3'-deoxynucleotide on the scissile strand at position -6 en

142 e DNA lesions, but readily extends from such deoxynucleotides once they have been inserted.

143 We report that LigD POL can add a deoxynucleotide opposite an abasic lesion in the templat

144 ases act sequentially: Pol iota incorporates deoxynucleotides opposite DNA lesions, and Pol zeta func

145 Pol zeta is very inefficient in inserting deoxynucleotides opposite DNA lesions, but readily exten

146 s damage, Pol iota specifically incorporates deoxynucleotides opposite highly distorting or non-instr

147 polymerase I selects its natural substrates, deoxynucleotides, over ribonucleotides by several thousa

148 s specifically insert the hydrophobic pyrene deoxynucleotide (P) opposite tetrahydrofuran (F), an sta

149 g protein-1 (SAMHD1) is a recently described deoxynucleotide phosphohydrolase controlling the size of

150 ation) and the subsequent addition of 2 or 3 deoxynucleotides (polymerization).

151 or the construction of high molecular weight deoxynucleotide polymers.

152 nvolved DNA sequencing of two closely spaced deoxynucleotide polymorphisms.

153 Also, disturbances in bacterial deoxynucleotide pools amplify 5-FU-induced autophagy and

154 Hydroxyurea also depleted deoxynucleotide pools and increased the incorporation of

155 Deoxynucleotide pools were depressed after incubation of

156 hibit ribonucleotide reductase and decreased deoxynucleotide pools, were incorporated mainly within r

157 , there was a decline in the cellular purine deoxynucleotide pools.

158 the incorporation of matched and mismatched deoxynucleotides probably reflects the differences in th

159 It controls cell proliferation through deoxynucleotide production and metastatic propensity thr

160 The pH rate profiles of deoxynucleotide production by these F(n)()Y(356)-R2s are

161 metabolism including energy transduction and deoxynucleotide production catalyzed by ribonucleotide r

162 up a functional unit involved in energy and deoxynucleotide production for phage replication in reso

163 he possibility of an abiotic route to the 2'-deoxynucleotides provides a new perspective on the evolu

164 ) catalyzes the conversion of nucleotides to deoxynucleotides, providing the building blocks for DNA

165 s) catalyze the conversion of nucleotides to deoxynucleotides, providing the monomeric precursors req

166 The B[a]PDE plus 2'-deoxynucleotide reaction mixtures were purified using so

167 ication that is independent of checkpoint or deoxynucleotide regulation is proposed.

168 For deoxynucleotide removal it could be stimulatory, neutral

169 V-1 RT manifested itself during ATP-mediated deoxynucleotide removal.

170 *) enzymes that provide the balanced pool of deoxynucleotides required for DNA synthesis and repair i

171 wn for its antiviral activity of hydrolysing deoxynucleotides required for virus replication.

172 igomers containing 2-aminoquinazolin-5-yl 2'-deoxynucleotide residues are reported.

173 s they did for substrates composed solely of deoxynucleotide residues.

174 r DNA replication, but 2) upon addition of a deoxynucleotide results in the conversion of the incorpo

175 oside diphosphate reductase with 2'-azido-2'-deoxynucleotides results in appearance of EPR signals fo

176 ric oligonucleotides composed of a five-base deoxynucleotide sequence flanked by chemically modified

177 nse oligonucleotides composed of a five-base deoxynucleotide sequence flanked on either side by chemi

178 e, PCR competent and able to copy repetitive deoxynucleotide sequences six to seven times more faithf

179 t of each nucleotide in the tetraloop with a deoxynucleotide showed a 16-fold increase in k(cat) for

180 The method provides deoxynucleotide-specific detection, accurate measurement

181 restores A site binding, it appears that the deoxynucleotide substituted complexes are impaired in th

182 fects in tRNA selection with the multiple 2'-deoxynucleotide substituted mRNA.

183 A set of deoxynucleotide substituted versions of this tRNA has be

184 expanded set of misacylated tRNAs and two 2'-deoxynucleotide-substituted mRNAs are used to demonstrat

185 45 different tRNAs, each containing a single deoxynucleotide substitution covering the upper half of

186 Only four individual deoxynucleotide substitutions blocked splicing activity:

187 ertiary stabilization is increased by single deoxynucleotide substitutions in the exon mimic at every

188 Our results show that multiple 2'-deoxynucleotide substitutions in the mRNA substantially

189 without significantly affecting affinity for deoxynucleotide substrate (K(d)(-dNTP)).

190 ining juxtaposed dC and 5'-phosphorylated dT deoxynucleotides (substrate 1) yielded kcat and kcat/Km

191 '-substituted terminators and compared to 2'-deoxynucleotide substrates (dNTPs).

192 transferase activity, HP could use all four deoxynucleotide substrates, but TTP was clearly favored

193 ings with other nucleoside analogs or normal deoxynucleotides such as dGTP.

194 leoside 5'-diphosphates to the corresponding deoxynucleotides supplying the dNTPs required for DNA re

195 n of replication origin firing, promotion of deoxynucleotide synthesis and replication fork restart,

196 at the sample solution components (chloride, deoxynucleotides, template DNA) and injection conditions

197 -5-fold greater for removal of a 3'-terminal deoxynucleotide than for cleavage of a dFdCMP molecule.

198 P (residues 283-341) bound to a 21-base pair deoxynucleotide that encompasses the canonical 8-base pa

199 ymphoid development and aberrant pools of 2'-deoxynucleotides that are substrates for TdT in lymphoid

200 NR) catalyze the reduction of nucleotides to deoxynucleotides through a mechanism involving an essent

201 ditions that permitted polymerization of one deoxynucleotide to primers containing either 3'-penultim

202 ct stages, i.e., the attachment of the first deoxynucleotide to RT (initiation) and the subsequent ad

203 NA-DNA junction (formed upon attachment of a deoxynucleotide to the RNA primer).

204 ic DNA polymerase alpha, adding a stretch of deoxynucleotides to the RNA primer before handoff to Pol

205 arious time points using an in situ terminal deoxynucleotide tranferase-mediated dUTP nick-end labeli

206 Pancreata were analyzed by terminal deoxynucleotide tranferase-mediated dUTP nick-end labeli

207 gly, Dpo1 also displays a competing terminal deoxynucleotide transferase (TdT) activity unlike any ot

208 Cell apoptosis was evaluated by terminal deoxynucleotide transferase dUTP nick end labeling stain

209 was obtained by double staining for terminal deoxynucleotide transferase nick end labeling (TUNEL) an

210 tion assay using biotin-16-dUTP and terminal deoxynucleotide transferase showed that TopoIIbeta media

211 human V(D)J recombination, whereas terminal deoxynucleotide transferase, Artemis, and DNA-dependent

212 GATA-3, but did not express Pax-5, terminal deoxynucleotide transferase, or CD3epsilon.

213 situ end-labeling of nicked DNA by terminal deoxynucleotide transferase, with measurements of cellul

214 ating hepatocyte apoptosis with the terminal deoxynucleotide transferase-mediated deoxyuridine tripho

215 e aminotransferase levels, positive terminal deoxynucleotide transferase-mediated deoxyuridine tripho

216 histological injury, the number of terminal deoxynucleotide transferase-mediated deoxyuridine tripho

217 grammed cell death, demonstrated by terminal deoxynucleotide transferase-mediated deoxyuridine tripho

218 Positive TUNEL (in situ terminal deoxynucleotide transferase-mediated dUTP nick end label

219 Terminal deoxynucleotide transferase-mediated dUTP nick end label

220 ssessed by activation of caspase-3, terminal deoxynucleotide transferase-mediated dUTP nick end-label

221 Positive terminal deoxynucleotide transferase-mediated dUTP nick end-label

222 ng areas of infarcted myocardium by terminal deoxynucleotide transferase-mediated dUTP nick end-label

223 s their apoptosis was quantified by terminal deoxynucleotide transferase-mediated dUTP nick-end label

224 Apoptosis assessed by terminal deoxynucleotide transferase-mediated dUTP nick-end label

225 died, and apoptosis was detected by terminal deoxynucleotide transferase-mediated dUTP nick-end label

226 optosis are time-consuming (as with terminal deoxynucleotide transferase-mediated dUTP nick-end label

227 ion, and apoptosis by Annexin V and terminal deoxynucleotide transferase-mediated dUTP nick-end label

228 nohistochemistry), apoptotic rates (terminal deoxynucleotide transferase-mediated dUTP nick-end label

229 lografts were examined by using the terminal deoxynucleotide transferase-mediated dUTP nick-end label

230 d interleukin (IL)-10 proteins, and terminal deoxynucleotide transferase-mediated dUTP nick-end label

231 and apoptosis was measured using a terminal deoxynucleotide transferase-mediated dUTP nick-end label

232 Terminal deoxynucleotide transferase-mediated dUTP nick-end label

233 e dead tumor cells were swollen and terminal deoxynucleotide transferase-mediated dUTP nick-end label

234 let cell apoptosis was evaluated by terminal deoxynucleotide transferase-mediated dUTP nick-end label

235 cardiomyocytes determined with the terminal deoxynucleotide transferase-mediated dUTP nick-end label

236 and neoplastic pituitary tissues by terminal deoxynucleotide transferase-mediated dUTP nick-end label

237 activated caspase-3, phiphilux, and terminal deoxynucleotide transferase-mediated dUTP nick-end label

238 Finally, terminal deoxynucleotide transferase-mediated dUTP nick-end label

239 We demonstrate by terminal deoxynucleotide transferase-mediated dUTP-biotin nick-en

240 mal transport activity, implying that failed deoxynucleotide transport across the inner mitochondrial

241 Our data indicate that mitochondrial deoxynucleotide transport may be essential for prenatal

242 tested if the drim2 gene also encodes for a deoxynucleotide transporter in the fruit fly.

243 o acid that lies above the nucleobase of the deoxynucleotide triphosphate (dNTP) and is expected to p

244 RNA template-DNA primer duplex and incoming deoxynucleotide triphosphate (dNTP) at 3.0-A resolution.

245 primer, and DNA template in the presence of deoxynucleotide triphosphate (dNTP) complementary to the

246 Deoxynucleotide triphosphate (dNTP) concentrations have

247 se controlling the size of the intracellular deoxynucleotide triphosphate (dNTP) pool, a limiting fac

248 -121.6-fold lower binding affinity (K(d)) to deoxynucleotide triphosphate (dNTP) substrates than HIV-

249 n Arg668 and the ring oxygen of the incoming deoxynucleotide triphosphate (dNTP) using a combination

250 he 3'-OH on the sugar moiety of the incoming deoxynucleotide triphosphate (dNTP), we examined how thi

251 compounds are competitive inhibitors of the deoxynucleotide triphosphate (dNTP).

252 cation blocker alpha-amanitin, NTPs (but not deoxynucleotide triphosphate [dNTPs]) templated at downs

253 lon nor theta influenced the Km of alpha for deoxynucleotide triphosphate and only slightly decreased

254 ginine 67 are functionally equivalent to the deoxynucleotide triphosphate binding residues arginine 5

255 These agents cause imbalances in deoxynucleotide triphosphate levels and the accumulation

256 whose products supply the mitochondria with deoxynucleotide triphosphate pools needed for DNA replic

257 de reductase and the consequent depletion of deoxynucleotide triphosphate pools result in a cellular

258 r the removal of HAP from purine pools, from deoxynucleotide triphosphate pools, and from DNA, and we

259 lls into S-phase under conditions of altered deoxynucleotide triphosphate pools, particularly an incr

260 Mus81 enables survival of deoxynucleotide triphosphate starvation, UV radiation, a

261 nterococcus faecalis is a distant homolog of deoxynucleotide triphosphate triphosphohydrolases (dNTPa

262 th protonation of the gamma-phosphate of the deoxynucleotide triphosphate(dNTP) via a solvent water m

263 ernary complex of enzyme*gapped DNA*dNTP (2'-deoxynucleotide triphosphate).

264 ed because the reaction lacked the requisite deoxynucleotide triphosphate.

265 nus to the alpha-beta bridging oxygen of the deoxynucleotide triphosphate; this neutralizes the evolv

266 ested to play an important role in supplying deoxynucleotide triphosphates (dNTP) for DNA repair duri

267 Deoxynucleotide triphosphates (dNTPs) are essential for

268 ductase (RNR) supplies the balanced pools of deoxynucleotide triphosphates (dNTPs) necessary for DNA

269 ctively incorporate Watson-Crick base-paired deoxynucleotide triphosphates (dNTPs) over incorrectly p

270 -limiting enzyme in the de novo synthesis of deoxynucleotide triphosphates (dNTPs), is a potential ta

271 etroviral RNA into DNA by depleting cellular deoxynucleotide triphosphates (dNTPs).

272 to detect the template-dependent binding of deoxynucleotide triphosphates by DNA polymerases.

273 ype oligonucleotides were mixed with various deoxynucleotide triphosphates in the presence of Sr(2)(+

274 ent with the high ratio of ribonucleotide to deoxynucleotide triphosphates in tissues, and that riboa

275 bstrate was observed in reactions containing deoxynucleotide triphosphates required to make full-leng

276 in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to a level below that whic

277 novel checkpoint responsive to low levels of deoxynucleotide triphosphates.

278 orrelated with a rapid decrease in available deoxynucleotide triphosphates.

279 e show that SAMHD1 contains a dGTP-regulated deoxynucleotide triphosphohydrolase.

280 to catalyze the conversion of nucleotides to deoxynucleotides under aerobic conditions, and recent st

281 to purine precursors, which would lead to 2'-deoxynucleotides upon desulfurization.

282 reductase (RNR) catalyzes the production of deoxynucleotides using complex radical chemistry.

283 P at the 3'-terminus and the adjacent normal deoxynucleotide was cleaved by DNA polymerase epsilon, t

284 The rate of excision of the 3'-terminal deoxynucleotide was similar, with both primers resulting

285 concentration of salts (chloride and di- and deoxynucleotides) was decreased below 10 microM using ge

286 The deoxynucleotides were characterized via steady-state kin

287 In 2 of 14 mutant integrants sequenced, deoxynucleotides were deleted from either the U5 or U3 t

288 acid determinants of the action of PGK for L-deoxynucleotides were not the same as for the D-deoxynuc

289 ver, 3'-terminal dAMP and subsequently other deoxynucleotides were readily excised from DNA in a dist

290 pol gamma in vitro as efficiently as natural deoxynucleotides, whereas AZT-TP, 3TC-TP, and CBV-TP wer

291 8,5'-Cyclopurine-2'-deoxynucleotides, which are strong blocks to mammalian D

292 Substitution of the 3'-deoxynucleotide with a ribonucleotide, 2'-methoxyethyl n

293 on in DNA indicates that the substitution of deoxynucleotide with ribonucleotide abolishes the need f

294 pol eta has a low fidelity, misincorporating deoxynucleotides with a frequency of about 10(-2) to 10(

295 yses and find that hPoltheta misincorporates deoxynucleotides with a frequency of about 10(-3) to 10(

296 oli can initiate reduction of nucleotides to deoxynucleotides with either a Mn(III)2-tyrosyl radical

297 obes containing 2'-O-methylnucleotides or 2'-deoxynucleotides with regard to their use in assays for

298 e couple the reduction of ribonucleotides to deoxynucleotides with the oxidation of formate to CO2.

299 nalogue-containing primers lost the terminal deoxynucleotide, with a proportional lower incidence of