ライフサイエンスコーパス: deoxyribonuclease

1 mediated conversion from a ribonuclease to a deoxyribonuclease.

2 digestion of linear DNA by an ATP-dependent deoxyribonuclease.

3 s cleaved the inhibitor of caspase-activated deoxyribonuclease.

4 encode human and murine DNase II, the acidic deoxyribonuclease.

5 idate protein family that includes ribo- and deoxyribonucleases.

6 dtB, was shown to exhibit features of type I deoxyribonucleases.

7 tested the hypothesis that recombinant human deoxyribonuclease 1 (rhDNase) reduces airflow obstructio

8 ctive chromatin configuration as analyzed by deoxyribonuclease 1 sensitivity.

9 Recombinant deoxyribonuclease accelerated the lysis of coronary thro

10 Coronary NET burden and deoxyribonuclease activity are predictors of ST-segment

11 vely with ST-segment resolution, whereas CLS deoxyribonuclease activity correlated negatively with in

12 A simple colorimetric assay for deoxyribonuclease activity employing a DNA-methyl green

13 f the UL12.5 protein prevented its potential deoxyribonuclease activity from being assayed in infecte

14 spase to generate a C-terminal fragment with deoxyribonuclease activity, which produced 3' hydroxyl D

15 I forms a very tight complex with actin, and deoxyribonuclease affinity columns have been utilized to

16 TREX2 structure is the first of a dimeric 3'-deoxyribonuclease and indicates how this highly efficien

17 ne can cleave inhibitor of caspase-activated deoxyribonuclease and lead to DNA fragmentation, thus pr

18 ccal antibodies, antistreptolysin O and anti-deoxyribonuclease B.

19 nuclease II (DNase II) is also known as acid deoxyribonuclease because it has optimal activity at the

20 agmentation factor (DFF, a caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD)), is ca

21 in a homolog cDNA encoding caspase-activated deoxyribonuclease (CAD)/DNA fragmentation factor 40 (DFF

22 for catalysis or magnesium binding in type I deoxyribonucleases did not cause chromatin disruption.

23 Deoxyribonuclease digestion of the capped fragments left

24 Mutations in a DNA helicase/deoxyribonuclease (dna2-1) or in two RNase H activities

25 Deoxyribonuclease (DNase) I has been implicated in the i

26 Additionally, deoxyribonuclease (DNase) I sensitivity mapping defined

27 Several deoxyribonuclease (DNase) I-hypersensitive sites (HS) ha

28 Deoxyribonuclease (DNase) II, which was discovered more

29 uclease degradation was tested by means of a deoxyribonuclease (DNase) protection assay.

30 We expressed neurotrophin-3 (NT3), deoxyribonuclease (DNase), or vascular endothelial growt

31 icancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl)

32 phisms (SNPs) were functionally enriched for deoxyribonuclease (DNase)-hypersensitivity sites, expres

33 ons and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sp

34 activity of human TREX2-catalyzed 3' --> 5'-deoxyribonuclease has been analyzed in steady-state and

35 inding site that is located near a region of deoxyribonuclease hypersensitivity.

36 Employing deoxyribonuclease I (DNase I) as a model enzyme template

37 are concentrated in regulatory DNA marked by deoxyribonuclease I (DNase I) hypersensitive sites (DHSs

38 It was demonstrated previously that deoxyribonuclease I (DNase I) is a highly active renal e

39 Bovine pancreatic deoxyribonuclease I (DNase I) is a nuclease of relativel

40 Bovine pancreatic deoxyribonuclease I (DNase I) is a well characterised en

41 Recombinant human deoxyribonuclease I (DNase I) is an important clinical a

42 Deoxyribonuclease I (DNase I) is an important enzyme tha

43 Although deoxyribonuclease I (DNase I) was used to probe the stru

44 Human deoxyribonuclease I (DNase I), an enzyme recently approv

45 Human deoxyribonuclease I (DNase I), an enzyme used to treat c

46 ty (71 and 63% similarity), respectively, to deoxyribonuclease I (DNase I).

47 Deoxyribonuclease I (DNaseI) hypersensitivity analyses i

48 selective serine 3 cofilin kinase binds to a deoxyribonuclease I affinity column, whereas the nonspec

49 odified 3'-phosphate of oligonucleotides and deoxyribonuclease I and ribonuclease H cleavages.

50 A deoxyribonuclease I binding assay shows that the number

51 Detection of pointed ends in situ using deoxyribonuclease I binding demonstrates that this incre

52 reated wild-type MLEC were hypersensitive to deoxyribonuclease I compared with wild-type cells, demon

53 Deoxyribonuclease I footprint analysis of the minimal pr

54 tituted in vitro transcription reactions and deoxyribonuclease I footprinting assays confirmed the ab

55 Deoxyribonuclease I footprinting identified a specific s

56 We used genomic deoxyribonuclease I footprinting to map nucleotide resol

57 Deoxyribonuclease I footprinting was used to identify a

58 Deoxyribonuclease I forms a very tight complex with acti

59 The identification of a tissue-specific deoxyribonuclease I hypersensitive site approximately 3k

60 portant transcriptional regulatory elements, deoxyribonuclease I hypersensitive site mapping studies

61 Colon-specific deoxyribonuclease I hypersensitive sites (DHS) have been

62 d single nucleotide polymorphisms (SNPs) and deoxyribonuclease I hypersensitive sites (DHSs) from 112

63 locus control region (LCR) composed of five deoxyribonuclease I hypersensitive sites (HSs).

64 Analysis of transcription factor motifs in deoxyribonuclease I hypersensitive sites at cell-type-sp

65 A 3.5-kb fragment containing one of these deoxyribonuclease I hypersensitive sites, located -14 kb

66 ility as detected by histone acetylation and deoxyribonuclease I hypersensitivity.

67 Deoxyribonuclease I protection assays confirmed the pres

68 iple histone marks and Pol II, as well as in deoxyribonuclease I sensitivity and nucleosome positioni

69 lease A) and six acidic proteins (myoglobin, deoxyribonuclease I, beta-lactoglobulin A, beta-lactoglo

70 nalised with dornase alfa (recombinant human deoxyribonuclease I, DNase), demonstrating DNA degradati

71 They belong to nine different proteins (deoxyribonuclease I, enolase, hen egg-white lysozyme, hu

72 i to digestion with micrococcal nuclease and deoxyribonuclease I, indicating that chromatin structure

73 ous ATP-actin structures from complexes with deoxyribonuclease I, profilin, and gelsolin, monomeric A

74 However, removal of SWI/SNF left a deoxyribonuclease I-hypersensitive site specifically at

75 cs of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mo

76 l protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1beta (IL1B);

77 markers acetyl-H4 and H4K20m, and regions of deoxyribonuclease I-sensitive chromatin compared with co

78 Gel-shift and deoxyribonuclease-I footprinting assays revealed four DN

79 Myeloid-cell-specific, deoxyribonuclease-I-hypersensitive sites localized to th

80 a, which was abrogated by preincubation with deoxyribonuclease-I.

81 acute liver failure plasma with and without deoxyribonuclease-I.

82 We have previously implicated deoxyribonuclease II (DNase II) as an endonuclease respo

83 Deoxyribonuclease II (DNase II) has been implicated in d

84 Deoxyribonuclease II (DNase II) is also known as acid de

85 previously cloned and ubiquitously expressed deoxyribonuclease II (DNase II).

86 Acid endonucleases of the deoxyribonuclease II (DNase II, EC 3.1.22.1) family have

87 of a highly positively charged enzyme, acid deoxyribonuclease II (EC 3.1.22.1), by glycosaminoglycan

88 not exhibit the approximately 100-base pair deoxyribonuclease II repeat characteristic of condensed

89 Deoxyribonuclease IIalpha (DNase IIalpha) is an acidic e

90 ibes the cloning of this cDNA, which we term deoxyribonuclease IIbeta (DNase IIbeta) and comparison o

91 e active site is structurally congruent to a deoxyribonuclease, making an unexpected link in the evol

92 a mutation in the RTH1/RAD27 gene encoding a deoxyribonuclease needed for removal of excess nucleotid

93 nes encoding IgA proteases, mitogenic factor deoxyribonucleases, nickel/cobalt uptake and cobalamin b

94 e I was originally identified as a 5' --> 3' deoxyribonuclease present in fractionated extracts of Sc

95 letal integrity and DNA repair, and activate deoxyribonucleases, producing cell death with morphologi

96 p), a subunit of RNA polymerase II, Rad2p, a deoxyribonuclease required in DNA repair, and Rnt1p (RNa

97 Daily recombinant human deoxyribonuclease (rhDNase) is an established but expens

98 terase preparation is free of any detectable deoxyribonuclease, ribonuclease, and nucleotidase activi

99 triggers of NETosis, activity of endogenous deoxyribonuclease, ST-segment resolution, and infarct si

100 Amino acid similarity analyses of known GAS deoxyribonucleases suggest that Sda1 may be a chimeric p

101 r analogous to the PB1 and caspase-activated deoxyribonuclease superfamily of protein interaction dom

102 ase-3 target caspase-activated DNase (CAD, a deoxyribonuclease that catalyzes DNA fragmentation) to a

103 TREX1 is a 3'-deoxyribonuclease that degrades single- and double-stran

104 erpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alka

105 erpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alka

106 Trex2 is a keratinocyte-specific 3'-deoxyribonuclease that participates in the maintenance o

107 pe II restriction endonucleases (REases) are deoxyribonucleases that cleave DNA sequences with remark

108 ntrapleural tissue plasminogen activator and deoxyribonuclease therapy can potentially improve outcom

109 n of the actin filament destabilising agents deoxyribonuclease type 1 (DNase 1; 50 microg ml-1) or cy