ライフサイエンスコーパス: deoxyribonucleoside

1 se with the exception of UTP opposite purine deoxyribonucleoside.

2 amino-catechol PAH derivative with a halo-2'-deoxyribonucleoside.

3 of a halo-PAH catechol derivative with a 2'-deoxyribonucleoside.

4 pes and enzymatically hydrolyzed to the free deoxyribonucleosides.

5 iption process following the addition of the deoxyribonucleosides.

6 species/genus retains the ability to salvage deoxyribonucleosides.

7 -step' protocol for the hydrolysis of DNA to deoxyribonucleosides.

8 converts a terminal ribonucleoside 3'-PO4 or deoxyribonucleoside 3'-PO4 of a primer-template to a 3'-

9 -BgCDEs with calf thymus DNA and with purine deoxyribonucleoside-3'-phosphates in vitro.

10 t ecto-5'-nucleotidase activity on ribo- and deoxyribonucleoside 5'-mono- and 5'-diphosphates with a

11 the N-glycosidic bond cleavage of purine 2'-deoxyribonucleoside 5'-monophosphates, a novel enzymatic

12 an be used to identify ribonucleoside and 2'-deoxyribonucleoside 5'-monophosphates, thereby taking a

13 the N-glycosidic bond cleavage of purine 2'-deoxyribonucleoside 5'-monophosphates.

14 7-deazaadenine, and 7-iodo-7-deazaguanine 2'-deoxyribonucleoside 5'-O-monophosphates (dNMPs) and 5'-O

15 e relative concentrations of the 4 canonical deoxyribonucleoside 5'-triphosphates (dNTPs) at the repl

16 eat-sensitive 3'-protected derivatives of 2'-deoxyribonucleoside 5'-triphosphates (dNTPs) have been s

17 cies of different RNA polymerases against 2'-deoxyribonucleoside 5'-triphosphates (dNTPs).

18 rporation of fluorescently labeled dNTPs (2'-deoxyribonucleoside 5'-triphosphates) and by terminal tr

19 te-primer and noncompetitive with respect to deoxyribonucleoside 5'-triphosphates.

20 sphates (NRTI-TP) compete with endogenous 2'-deoxyribonucleosides-5'-triphosphates (dNTP) for incorpo

21 (pyrazolo[3,4-d]pyrimidin- 4-amine) N(8)-(2'deoxyribonucleoside), a deoxyadenosine analog (UB), pair

22 The most abundant 2'-deoxyribonucleoside adducts cross-linked by glyoxal are

23 rometry has been applied to the detection of deoxyribonucleoside adducts of the food-derived mutagen

24 Notably, the generally more labile 2'-deoxyribonucleosides also undergo reaction.

25 ed O6-benzyl-2'-deoxyguanosine (dBG), the 2'-deoxyribonucleoside analogue of BG, for its ability to i

26 low prediction of the mutagenic potential of deoxyribonucleoside analogues.

27 ed nucleoside derivatives, 6-fluoropurine 2'-deoxyribonucleoside and 2-fluoro-2'-deoxyinosine, by the

28 thesis of 3',5'-di-O-acetyl-6-bromopurine-2'-deoxyribonucleoside and its reaction with an arylamine i

29 aminopurine ribonucleoside, reduction to the deoxyribonucleoside and standard preparation of the 5'-0

30 f deoxyribose sugar radicals in DNA, guanine deoxyribonucleosides and deoxyribonucleotides.

31 rolase that cleaves physiological dNTPs into deoxyribonucleosides and inorganic triphosphate.

32 ith respect to environmental availability of deoxyribonucleosides and metabolic processes generating

33 well as 5-substituted uracil and cytosine 2'-deoxyribonucleosides and mono- and triphosphates were sy

34 When mixed with deoxyribonucleosides and N-protected 2'-deoxyribonucleos

35 drolase (dNTPase), converting dNTPs into the deoxyribonucleosides and triphosphate.

36 triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.

37 steres of cytosine (2-fluoro-4-methylbenzene deoxyribonucleoside) and thymine (2,4-difluoro-5-methylb

38 stable UVA photoproduct of free 6-TG, its 2'-deoxyribonucleoside, and DNA 6-TG.

39 nomic DNA, hydrolyzing enzymatically to free deoxyribonucleosides, and derivatizing for GC-MS analysi

40 ty is labeled; purine rather than pyrimidine deoxyribonucleosides are analyzed; and stable isotopes r

41 electron affinities in eV for each of the 2'-deoxyribonucleosides are as follows: 0.06, dA; 0.09, dG;

42 been evaluated for 5'-hydroxyl protection of deoxyribonucleosides as carbonates and for potential use

43 arly promising for 5'-hydroxyl protection of deoxyribonucleosides as thermolytic carbonates.

44 f 8-fluoro derivatives were obtained with 2'-deoxyribonucleosides, as compared to ribonucleosides.

45 ng sequences by replacing one or two natural deoxyribonucleosides at various positions with one or mo

46 approach, we show that depletion of a single deoxyribonucleoside causes reversible arrest of cells in

47 e of the glucitol (GutR), fucose (FucR), and deoxyribonucleoside (DeoR) systems of E. coli, as well a

48 The purine deoxyribonucleoside, deoxyadenosine (dA), is directly is

49 hymidine can also transport other pyrimidine deoxyribonucleosides (deoxycytidine) and pyrimidine ribo

50 ides a class of stable, isolable ribo and 2'-deoxyribonucleoside derivatives that possess excellent r

51 This is the first synthesis of 8-fluoro-2'-deoxyribonucleoside derivatives.

52 The structure of the deoxyribonucleoside derived from N 6-methoxy-2, 6-diamin

53 for the quantitative analysis of the native deoxyribonucleoside dG, and MS-MS was used for the deter

54 2'-Deoxyribonucleoside dimers connected by a five-atom link

55 RNRs) are Fe-dependent enzymes that catalyze deoxyribonucleoside diphosphate (dNDP) synthesis.

56 sion of ribonucleoside diphosphates (NDP) to deoxyribonucleoside diphosphates (dNDP) and thereby prov

57 iphosphates (rNDPs) that can be converted to deoxyribonucleoside diphosphates (dNDPs) by ribonucleoti

58 eotide reductase catalyzes the production of deoxyribonucleoside diphosphates, the precursors of deox

59 ersion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential fo

60 CK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an importan

61 The diastereomeric spiroiminodihydantoin-2'-deoxyribonucleoside (dSp) lesions resulting from 2'-deox

62 a set of thermodynamically stable endcapped deoxyribonucleoside duplexes as a tool to elucidate the

63 es of C-6 azidopurine ribonucleosides and 2'-deoxyribonucleosides have been developed.

64 ns using high-level ab initio methods on the deoxyribonucleosides have been performed to investigate

65 The deoxyribonucleosides have been studied to determine the

66 from lactobacilli and a 5'-monophosphate-2'-deoxyribonucleoside hydrolase from rat.

67 the neutral and anionic forms of the four 2'-deoxyribonucleosides in DNA: 2'-deoxyriboadenosine (dA),

68 Deoxyribonucleoside kinases (dNKs) are important to DNA

69 In antiviral and cancer therapy, deoxyribonucleoside kinases (dNKs) are often the rate-li

70 Deoxyribonucleoside kinases (dNKs) carry out the rate-de

71 r inefficient activation through cellular 2'-deoxyribonucleoside kinases (dNKs).

72 ut independent calculations for complexes of deoxyribonucleoside kinases with various cognate ligands

73 oothly with the silyl-protected ribo- and 2'-deoxyribonucleosides, leading to the C-6 triazolyl produ

74 the point of having nicks with a 3'OH and 5'deoxyribonucleoside monophosphate during S phase.

75 d NDP kinase, but not dCMP hydroxymethylase, deoxyribonucleoside monophosphate kinase, or DHF reducta

76 s: dihydrofolate reductase, dCTPase-dUTPase, deoxyribonucleoside monophosphokinase, ribonucleotide re

77 escribe the preparation and structure of the deoxyribonucleoside of 4-fluoro-6-methylbenzimidazole, a

78 reliable means for the formation of novel 2'-deoxyribonucleosides of novel structural type from these

79 Product characterization identified the 2'-deoxyribonucleosides of spiroiminodihydantoin, 5-guanidi

80 ted electrochemically or chemically) with 2'-deoxyribonucleosides or the corresponding purine bases.

81 with deoxyribonucleosides and N-protected 2'-deoxyribonucleosides or with a model phosphorothioate di

82 achieved through incorporation of activated deoxyribonucleoside phosphoramidite 8b into the oligonuc

83 rt-butylcarboxamido)-1-propyl group into the deoxyribonucleoside phosphoramidites 1a-d is achieved us

84 pyridyl)]aminoethanol were incorporated into deoxyribonucleoside phosphoramidites 7a-d and 9, which w

85 Deoxyribonucleoside phosphoramidites functionalized with

86 hich were found as efficient as 2-cyanoethyl deoxyribonucleoside phosphoramidites in solid-phase olig

87 potential 5'-hydroxyl protecting groups for deoxyribonucleoside phosphoramidites to improve the synt

88 ficiently as that achieved with 2-cyanoethyl deoxyribonucleoside phosphoramidites.

89 omparable to that of commercial 2-cyanoethyl deoxyribonucleoside phosphoramidites.

90 coupling efficiencies comparable to those of deoxyribonucleoside phosphoramidites.

91 Here, we report that down-regulation of deoxyribonucleoside pools is another endogenous source o

92 Since this assay was selective for deoxyribonucleosides, potential interference from methyl

93 g 6-methylpyrrolo[2,3-d]pyrimidine-2(3H) one deoxyribonucleoside (pyrrolo dC), which pairs with G, wa

94 oesters, comprised of butenyl-functionalized deoxyribonucleoside repeat units, connected via 3',5'-ba

95 kinase (dCK), a rate-limiting enzyme in the deoxyribonucleoside salvage metabolism and in gemcitabin

96 ively expressed, mitochondrial enzyme of the deoxyribonucleoside salvage pathway.

97 xycytidine kinase (dCK), a key enzyme in the deoxyribonucleoside salvage pathway.

98 mphocyte development critically requires the deoxyribonucleoside salvage pathway.

99 ne kinase (dCK) is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that re

100 ((F)iCd, (F)iGd and fluorinated canonical 2'-deoxyribonucleosides) stabilize double-stranded DNA, RNA

101 pic coexpression of TS and RR or addition of deoxyribonucleosides substantially suppressed DNA damage

102 23 altered substrates, each with a single 2'-deoxyribonucleoside substitution, were synthesised and t

103 ctive centers of the enzymes responsible for deoxyribonucleoside synthesis and transfer RNA modificat

104 trityl) derivatives of 3'-(carboxymethyl)-3'-deoxyribonucleosides that are effective precursors for s

105 A charges, which show that in the neutral 2'-deoxyribonucleosides the sum of NPA charges for every ba

106 n of 5-methyl-2'-deoxycytidine from the four deoxyribonucleosides, the four ribonucleosides, and 5-me

107 blood-brain barrier (BBB) for the pyrimidine deoxyribonucleoside, thymidine, was demonstrated.

108 reductase was bypassed, by adding exogenous deoxyribonucleosides to highly purified T cells in the G

109 Adding deoxyribonucleosides to restore dNTP pools transiently p

110 inally, dun1Delta mutants display defects in deoxyribonucleoside triphosphate (dNTP) biosynthesis und

111 tso2 mutants had reduced deoxyribonucleoside triphosphate (dNTP) levels and exhib

112 ecombination phenotype correlates with lower deoxyribonucleoside triphosphate (dNTP) levels, compared

113 t result from mutations affecting enzymes of deoxyribonucleoside triphosphate (dNTP) metabolism.

114 Deoxyribonucleoside triphosphate (dNTP) pool imbalances

115 that contributes to the control of cellular deoxyribonucleoside triphosphate (dNTP) pool sizes throu

116 Because mitochondrial and nuclear deoxyribonucleoside triphosphate (dNTP) pools are physic

117 the basis for marked natural asymmetries in deoxyribonucleoside triphosphate (dNTP) pools in mammali

118 Our laboratory has reported that deoxyribonucleoside triphosphate (dNTP) pools in rat tis

119 that this generates imbalanced mitochondrial deoxyribonucleoside triphosphate (dNTP) pools, which in

120 a in a pos5 deletion mutant contain abnormal deoxyribonucleoside triphosphate (dNTP) pools.

121 ions, each with a single fluorescein-labeled deoxyribonucleoside triphosphate (dNTP) species.

122 ine leukemia virus (MLV) RT that contact the deoxyribonucleoside triphosphate (dNTP) substrate are im

123 titive inhibitor of HIV-1 RT with respect to deoxyribonucleoside triphosphate (dNTP) substrate, where

124 each catalytic cycle, DNA polymerases select deoxyribonucleoside triphosphate (dNTP) substrates compl

125 s form a multienzyme complex that we call T4 deoxyribonucleoside triphosphate (dNTP) synthetase.

126 to common antibiotics, is a homo-tetrameric deoxyribonucleoside triphosphate (dNTP) triphosphohydrol

127 SAMHD1, a dGTP-regulated deoxyribonucleoside triphosphate (dNTP) triphosphohydrol

128 NA, replacing the error with the appropriate deoxyribonucleoside triphosphate (dNTP).

129 Deoxyribonucleoside triphosphate accumulation at G1/S wa

130 Thus, deoxyribonucleoside triphosphate accumulation, like the

131 hange that occurs after binding a correct 2'-deoxyribonucleoside triphosphate and, in the present wor

132 ibonucleotides, mainly due to its defects in deoxyribonucleoside triphosphate binding, and is also a

133 in, with well defined functions in ribo- and deoxyribonucleoside triphosphate biosynthesis and more r

134 nfection of Escherichia coli, the enzymes of deoxyribonucleoside triphosphate biosynthesis form a mul

135 e level and requires a divalent cation and a deoxyribonucleoside triphosphate effector.

136 e brain but also in the small intestine, and deoxyribonucleoside triphosphate imbalance was observed

137 Deoxyribonucleoside triphosphate levels increased severa

138 n of deoxyribonucleotide-synthesizing genes, deoxyribonucleoside triphosphate levels, and replication

139 animals have normal mitochondrial ribo- and deoxyribonucleoside triphosphate levels, suggesting that

140 vated levels of nucleotides cause unbalanced deoxyribonucleoside triphosphate pools and, in turn, pat

141 Deoxyribonucleoside triphosphate pools in mammalian mito

142 hway increases mtDNA copy number by altering deoxyribonucleoside triphosphate pools through the activ

143 causes a differential depletion of the four deoxyribonucleoside triphosphate pools, suggesting that

144 Balanced pools of deoxyribonucleoside triphosphate precursors are required

145 ces cerevisiae, mouse, and human all possess deoxyribonucleoside triphosphate pyrophosphohydrolase ac

146 ductase, the rate-limiting enzyme in de novo deoxyribonucleoside triphosphate synthesis.

147 tate domain-containing protein 1 (SAMHD1), a deoxyribonucleoside triphosphate triphosphohydrolase tha

148 SAMHD1 is a nuclear deoxyribonucleoside triphosphate triphosphohydrolase tha

149 Enzymatic synthesis of the azole carboxamide deoxyribonucleoside triphosphate was based on ATP as the

150 oportion, rather than the absolute amount of deoxyribonucleoside triphosphate, was critical for mitoc

151 y of ribonucleotides in DNA is determined by deoxyribonucleoside triphosphate/ribonucleoside triphosp

152 Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are closely re

153 When ERT was driven by addition of deoxyribonucleoside triphosphates (dNTPs) at high concen

154 rature-shift and release, and starvation for deoxyribonucleoside triphosphates (dNTPs) by treatment w

155 The synthesis of 2'-deoxyribonucleoside triphosphates (dNTPs) either by clas

156 Current methods for measuring deoxyribonucleoside triphosphates (dNTPs) employ reagent

157 zymes required to maintain adequate pools of deoxyribonucleoside triphosphates (dNTPs) for DNA synthe

158 the rate-limiting step in the production of deoxyribonucleoside triphosphates (dNTPs) for DNA synthe

159 ses (RNRs) are required for the synthesis of deoxyribonucleoside triphosphates (dNTPs) from ribonucle

160 ynthesis of ribonucleoside triphosphates and deoxyribonucleoside triphosphates (dNTPs) from the corre

161 the rate-limiting step in the production of deoxyribonucleoside triphosphates (dNTPs) required for r

162 transcriptase called telomerase, which uses deoxyribonucleoside triphosphates (dNTPs) to extend telo

163 os requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)).

164 lls is far greater than the concentration of deoxyribonucleoside triphosphates (dNTPs), and this pool

165 xhibit a surprising tolerance for analogs of deoxyribonucleoside triphosphates (dNTPs), despite the e

166 ailability of adequate and balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building

167 g four distinguishable fluorescently labeled deoxyribonucleoside triphosphates (dNTPs).

168 When all deoxyribonucleoside triphosphates and a template bearing

169 The NTPase activity with deoxyribonucleoside triphosphates as substrate is higher

170 enzymatic degradation of excess primers and deoxyribonucleoside triphosphates before the primer exte

171 bonucleoside diphosphates, the precursors of deoxyribonucleoside triphosphates for DNA synthesis.

172 talyzes ATP-dependent synthesis of ribo- and deoxyribonucleoside triphosphates from the cognate dipho

173 in vivo ATP-dependent synthesis of ribo- and deoxyribonucleoside triphosphates from the corresponding

174 been developed to measure concentrations of deoxyribonucleoside triphosphates in individual, day 14

175 gene 32 protein helps to recruit enzymes of deoxyribonucleoside triphosphates synthesis to DNA repli

176 that adenylate kinase can meet a demand for deoxyribonucleoside triphosphates that increases by up t

177 hydrolysis of all eight canonical ribo- and deoxyribonucleoside triphosphates to their corresponding

178 Finally, 3' deoxyribonucleoside triphosphates were able to inhibit R

179 -limiting enzyme in the de novo synthesis of deoxyribonucleoside triphosphates, and control of mitoch

180 dGTP is the best substrate among the deoxyribonucleoside triphosphates, and GTP is the best a

181 oside triphosphates almost as efficiently as deoxyribonucleoside triphosphates, and, unlike analogous

182 In addition, nonphysiological deoxyribonucleoside triphosphates, such as 3'-azido-3'-d

183 atural permeability of the HIV-1 envelope to deoxyribonucleoside triphosphates, the substrates for DN

184 ase active on all of the canonical ribo- and deoxyribonucleoside triphosphates.

185 reduction of ribonucleoside triphosphates to deoxyribonucleoside triphosphates.

186 iscriminate between ribo-, dideoxyribo-, and deoxyribonucleoside triphosphates.

187 the presence of calf thymus DNA and the four deoxyribonucleoside triphosphates.

188 extracellular milieu, such as polyamines and deoxyribonucleoside triphosphates.

189 ted endothelial cell stores of aspartate and deoxyribonucleoside triphosphates.

190 Hydrolysis of the oligonucleotide to its 2'-deoxyribonucleosides upon exposure to snake venom phosph

191 The imidazole (Im) deoxyribonucleoside was chosen as a highly Ag(I) -specif

192 one metabolites of carcinogenic PAHs with 2'-deoxyribonucleosides were investigated and compared.

193 Base-modified ribo- and 2'-deoxyribonucleosides were potent inhibitors of T8.

194 e) and thymine (2,4-difluoro-5-methylbenzene deoxyribonucleoside) were synthesized and hybridized to

195 gives similar recoveries for all five major deoxyribonucleosides when compared to the older protocol

196 rystal structure of TbTUT4 with the bound 2' deoxyribonucleoside, which provides the structural basis

197 Substitution of deoxyribonucleosides with a C3 or C4 alkyl-linker was fo

198 orientation incorporating 2'-fluorinated 2'-deoxyribonucleosides with canonical nucleobases or 2'-de