ライフサイエンスコーパス: deoxyribonucleotide

1 rocarbon linkers, and a ganciclovir-modified deoxyribonucleotide.

2 ge of the glycosidic linkage in a pyrimidine deoxyribonucleotide.

3 e for RR in the formation of 8-oxodG-derived deoxyribonucleotides.

4 ing the formamidopyrimidines opposite native deoxyribonucleotides.

5 A synthesis by converting ribonucleotides to deoxyribonucleotides.

6 Fapy*dG excision opposite all four native 2'-deoxyribonucleotides.

7 als in DNA, guanine deoxyribonucleosides and deoxyribonucleotides.

8 is restrained by the limited availability of deoxyribonucleotides.

9 catalyze the reduction of ribonucleotides to deoxyribonucleotides.

10 doxin 3, thus restoring an effective pool of deoxyribonucleotides.

11 higher affinity for ribonucleotides than for deoxyribonucleotides.

12 cal for the conversion of ribonucleotides to deoxyribonucleotides.

13 meet the demand of the replication forks for deoxyribonucleotides.

14 thesis or the polymerization of the first 26 deoxyribonucleotides.

15 to both single-stranded and double-stranded deoxyribonucleotides.

16 oligonucleotides that include both ribo- and deoxyribonucleotides.

17 m bRT-catalyzed misincorporation of standard deoxyribonucleotides.

18 talyzes the conversion of ribonucleotides to deoxyribonucleotides.

19 e, thereby blocking the de novo synthesis of deoxyribonucleotides.

20 r ribonucleotides was comparable to that for deoxyribonucleotides.

21 and C2'-endo conformations are found in the deoxyribonucleotides.

22 A, it binds cooperatively to single stranded deoxyribonucleotides.

23 tial function of reducing ribonucleotides to deoxyribonucleotides.

24 ductases, which convert ribonucleotides into deoxyribonucleotides.

25 h their strong selectivity against mispaired deoxyribonucleotides.

26 to initiate reduction of ribonucleotides to deoxyribonucleotides.

27 present at much higher levels compared with deoxyribonucleotides.

28 ucleotide reductases supply cells with their deoxyribonucleotides.

29 incorporates rNTPs almost as efficiently as deoxyribonucleotides.

30 atalyzes the reduction of ribonucleotides to deoxyribonucleotides.

31 ncing with fluorescent reversible terminator deoxyribonucleotides.

32 to discriminate between ribonucleotides and deoxyribonucleotides.

33 e reductase (RNR) catalyzes the formation of deoxyribonucleotides, a rate limiting step in DNA synthe

34 reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for D

35 talyzes the conversion of ribonucleotides to deoxyribonucleotides, an essential step in DNA biosynthe

36 s unique in family X pols, the design of CXY deoxyribonucleotide analogues to enhance interaction is

37 dition of two molecules of the complementary deoxyribonucleotide analyte.

38 more rapidly than the corresponding correct deoxyribonucleotide and incorrect nucleotides are added

39 tion of ribonucleotides to the corresponding deoxyribonucleotides and is an essential enzyme for DNA

40 erent ribonucleotides to their corresponding deoxyribonucleotides and is the rate-limiting enzyme in

41 nto replicating DNA due to the similarity of deoxyribonucleotides and ribonucleotides, the high conce

42 ld with a heterogeneous mixture of ribo- and deoxyribonucleotides and sequences, while suggesting an

43 polymerases effectively discriminate against deoxyribonucleotides and specifically recognize ribonucl

44 ed ribonucleotides are superior to activated deoxyribonucleotides and that RNA templates are superior

45 cient enzymes that reduce ribonucleotides to deoxyribonucleotides and thus prime DNA synthesis.

46 dependent incorporation of the four natural deoxyribonucleotides and thus, significantly expand the

47 ribonucleotides despite their preference for deoxyribonucleotides, and analysis of cultured cells ind

48 ive site, has a role in the interaction with deoxyribonucleotides, and regulates DNA replication fide

49 atalyze the conversion of ribonucleotides to deoxyribonucleotides, and represent the only de novo pat

50 led region, irrespective of whether ribo- or deoxyribonucleotides are at the cleavage site.

51 tide reductase (RNR)-catalyzed production of deoxyribonucleotides are provided by glutaredoxin (Grx)

52 It is also not known where deoxyribonucleotides are synthesized in the cell.

53 Ribonucleotides and 2'-deoxyribonucleotides are the basic units for RNA and DNA

54 A comparison of the utilization of ribo- and deoxyribonucleotides as substrates indicates the existen

55 ed by Vmax/Km, c-N-I preferred pyrimidine 2'-deoxyribonucleotides as substrates with thymidine monoph

56 to template-primer in the presence of added deoxyribonucleotides, as seen by gel-shift analysis, but

57 This site discriminates against deoxyribonucleotides at the 3' end, and interactions at

58 has a DNA exonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapp

59 We adapted in two steps a deoxyribonucleotide-based aptamer to signal the recognit

60 New, emerging deoxyribonucleotide-based technologies allow integration

61 2',5'-Linked oligo-3'-deoxyribonucleotides bind selectively to complementary R

62 catalyzes the rate-limiting step in de novo deoxyribonucleotide biosynthesis and is essential in DNA

63 This key enzyme in deoxyribonucleotide biosynthesis is the target of establ

64 two enzymes required for the entire de novo deoxyribonucleotide biosynthesis, and possessed low dNTP

65 report that TMPK and RNR, two key enzymes in deoxyribonucleotide biosynthesis, co-localize to damaged

66 Because of the involvement of NADPH in deoxyribonucleotide biosynthesis, we asked whether mitoc

67 ress through the inhibition of nucleotide or deoxyribonucleotide biosynthesis.

68 reonine metabolism and buffers deficiency in deoxyribonucleotide biosynthesis.

69 ribonucleotide reductase, the key enzyme for deoxyribonucleotide biosynthesis.

70 n dNTP synthetase, a multienzyme complex for deoxyribonucleotide biosynthesis.

71 catalyzes the rate-limiting step in de novo deoxyribonucleotide biosynthesis.

72 DinB2 effectively incorporates deoxyribonucleotides, but not ribonucleotides, opposite

73 se substituents were incorporated into oligo-deoxyribonucleotides by standard phosphoramidite methodo

74 leotide reductases catalyze the formation of deoxyribonucleotides by the reduction of the correspondi

75 f the ribonucleotides to their corresponding deoxyribonucleotides catalysed by ribonucleotide reducta

76 sion of ribonucleotides to the corresponding deoxyribonucleotides catalyzed by the enzyme ribonucleot

77 Most significant deoxyribonucleotide changes were present in the gut and

78 Synthetic deoxyribonucleotide competition studies defined the RNA-

79 chimeras, i.e. tRNA3Lys extended by 5 and 31 deoxyribonucleotides complementary to the viral genome u

80 in nonreplicating cells containing very low deoxyribonucleotide concentrations.

81 suggest that NrdR activity is modulated by a deoxyribonucleotide corepressor.

82 Three sets of semi-self-complementary deoxyribonucleotide decamers with the sequence XX-(5meCG

83 The misincorporation of 2'-deoxyribonucleotides (dNs) into RNA has important implic

84 in macrophages by reducing the intracellular deoxyribonucleotide (dNTP) pool to levels below those re

85 it responsible for normal maintenance of the deoxyribonucleotide (dNTP) pool used for DNA replication

86 affected by the balance and concentration of deoxyribonucleotide (dNTP) pools, which are strictly reg

87 plication stress are alterations in pools of deoxyribonucleotide (dNTP) precursors required for DNA s

88 Cross-linking analogs and radioactive deoxyribonucleotides (dNTPs), followed by normal dNTPs,

89 talyzes the conversion of ribonucleotides to deoxyribonucleotides (dNTPs), which are necessary for bo

90 ation of DNA requires a sufficient supply of deoxyribonucleotides (dNTPs), which are produced by ribo

91 When a synthesized deoxyribonucleotide duplex, 5'-CCATCGCTACC-3'.5'-GGTAGCG

92 le to incorporate ribonucleotides as well as deoxyribonucleotides during polymerization and is resist

93 vides the only de novo means of synthesizing deoxyribonucleotides, essential precursors for DNA repli

94 pucker and conformational flexibility of the deoxyribonucleotide exhibited cleavage rates comparable

95 In mammals thymidine kinase supplies deoxyribonucleotides for DNA replication and DNA repair,

96 reductase (RnR) is a key enzyme synthesizing deoxyribonucleotides for DNA replication and repair.

97 eductase activity is required for generating deoxyribonucleotides for DNA replication.

98 ich catalyzes the rate-limiting synthesis of deoxyribonucleotides for DNA replication.

99 Production of deoxyribonucleotides for DNA synthesis is an essential a

100 diphosphates, ensuring a balanced supply of deoxyribonucleotides for DNA synthesis.

101 s I ribonucleotide reductases (RRs) generate deoxyribonucleotides for DNA synthesis.

102 ase to convert imported ribonucleotides into deoxyribonucleotides for DNA synthesis.

103 apable of utilising both ribonucleotides and deoxyribonucleotides for primer synthesis in the presenc

104 atalyzes the reduction of ribonucleotides to deoxyribonucleotides for use in DNA synthesis.

105 e the rate-limiting step in the synthesis of deoxyribonucleotides from the corresponding ribonucleoti

106 cycle of the ribonucleotide opposing the TFI deoxyribonucleotide had no effect on the human RNase H1

107 base pair formed between a template adenine deoxyribonucleotide in the syn conformation and a deoxyt

108 atalyze the conversion of ribonucleotides to deoxyribonucleotides in all organisms.

109 o induce DNA damage and hydroxyurea to limit deoxyribonucleotides in cells deprived of DBF4 function

110 n of (2)H(2)O into the deoxyribose moiety of deoxyribonucleotides in dividing cells.

111 O into the deoxyribose (dR) moiety of purine deoxyribonucleotides in dividing cells.

112 H(2)O) into the deoxyribose moiety of purine deoxyribonucleotides in DNA of dividing cells, by use of

113 H(2)O) into the deoxyribose moiety of purine deoxyribonucleotides in DNA of dividing cells.

114 r data identify a previously unknown role of deoxyribonucleotides in regulation of OIS.

115 phosphate disclose the novel binding mode of deoxyribonucleotides in the active site.

116 folding with the incorporation of 2'-methoxy deoxyribonucleotides in the capture sequences.

117 We demonstrate that deoxyribonucleotides in the guide strand overhang of siR

118 sonably close to the proportions of the four deoxyribonucleotides in the vaccinia virus genome, but o

119 ain, synthetic U6 RNAs were constructed with deoxyribonucleotides incorporated site specifically.

120 omopolymeric templates indicate that initial deoxyribonucleotide incorporation is complementary to th

121 r substituted 1,2,3-triazolyl phosphonate-2'-deoxyribonucleotide internucleotide linkage.

122 Multiple substitutions of deoxyribonucleotides into RNA stem-loops in one case (dG

123 -hydrogen bonding base modifications, abasic deoxyribonucleotides, intranucleotide hydrocarbon linker

124 oxidized adenine [A(-H)*] in dAdo and its 2'-deoxyribonucleotides leads to formation of deoxyribose s

125 The control of deoxyribonucleotide levels is essential for DNA synthesi

126 cleotide reductase and reduces intracellular deoxyribonucleotide levels, these results suggest that N

127 ality that is rescued by increasing cellular deoxyribonucleotide levels.

128 v1 discriminates between ribonucleotides and deoxyribonucleotides mainly by reducing the rate of inco

129 Furthermore, activated 2'-deoxyribonucleotides maintain a C2'-endo sugar pucker in

130 The absence of the 2'-hydroxyl group of the deoxyribonucleotide may destabilize binding of the ligan

131 At the same time, aspects of deoxyribonucleotide metabolism have been shown to be cri

132 es a rate-limiting step in the production of deoxyribonucleotides needed for DNA replication and repa

133 ze the only pathway for de novo synthesis of deoxyribonucleotides needed for DNA replication and repa

134 i fragment consisted of five ribo- and seven deoxyribonucleotides on the hybrid strand, together with

135 Y122*), which is essential for production of deoxyribonucleotides on the larger R1 subunit.

136 l preference for the incorporation of either deoxyribonucleotides or ribonucleotides during chain elo

137 ses exhibit a high degree of selectivity for deoxyribonucleotides over ribo- or dideoxynucleotides.

138 yeast have surprisingly low selectivity for deoxyribonucleotides over their analogous ribonucleotide

139 Class II AP endonuclease, deoxyribonucleotide phosphate (dRP) lyase, DNA synthesis

140 t cells display both a mutator phenotype and deoxyribonucleotide pool abnormalities.

141 ase genes, and measurements of intracellular deoxyribonucleotide pool concentrations.

142 Ribonucleotide reductase maintains cellular deoxyribonucleotide pools and is thus tightly regulated

143 ragilis NrdAB may have a role in maintaining deoxyribonucleotide pools for DNA repair and growth reco

144 on and repair requires adequate and balanced deoxyribonucleotide pools that are maintained primarily

145 R function to avoid inadequate or unbalanced deoxyribonucleotide pools that cause DNA damage and geno

146 on of RNR genes and to decrease the cellular deoxyribonucleotide pools.

147 efore, 5-azaC causes a major perturbation of deoxyribonucleotide pools.

148 as precursors for DNA repair and to balance deoxyribonucleotides pools.

149 ying DNA synthesis with isotopically labeled deoxyribonucleotide precursors.

150 , which catalyzes the rate-limiting step for deoxyribonucleotide production required for DNA synthesi

151 on of ribonucleotides to their corresponding deoxyribonucleotides, providing a balanced supply of pre

152 ucleotides are found in great abundance over deoxyribonucleotides, raising the possibility that ribon

153 a 25-nt homology domain comprised of a five-deoxyribonucleotide region (harboring a single base mism

154 2 subunits, RRM1 and RRM2, that provides the deoxyribonucleotides required for DNA synthesis/repair.

155 tion of a 2'-deoxyribo- or 2',2'-difluoro-2'-deoxyribonucleotide resulted in strong chain termination

156 e, 2'-methoxyethyl nucleotide, or mismatched deoxyribonucleotide resulted in the ablation of the 5'-m

157 port a method to hydrolyze RNA to release 2'-deoxyribonucleotide-ribonucleotide pairs (dNrN) that are

158 rential screening as a new PET probe for the deoxyribonucleotide salvage pathway.

159 the RNase H activation property of the 3'-5'-deoxyribonucleotide segment adjacent to the modification

160 ides (MBOs) containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments.

161 ster bond on the 5' side of a ribonucleotide-deoxyribonucleotide sequence in substrates mimicking RNA

162 erved for Okazaki-like substrates containing deoxyribonucleotide substitutions at the 3' pole of the

163 the loss of discrimination between ribo- and deoxyribonucleotide substrates as well as to defects in

164 against incorporation of ribonucleotides, 3'-deoxyribonucleotides (such as cordycepin) and 2',3'-dide

165 n to mimic the carbohydrate components of 2'-deoxyribonucleotides suggest that 2'-deoxy-5-methyleneur

166 crease in the concentration of intracellular deoxyribonucleotides, suggesting that one effect of the

167 und in many biochemical processes, including deoxyribonucleotide synthesis and oxidative DNA damage.

168 iae, many genes encoding enzymes involved in deoxyribonucleotide synthesis are expressed preferential

169 ngation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity

170 d higher concentrations of the inhibitors of deoxyribonucleotide synthesis FUdR, methotrexate and hyd

171 sential iron-dependent enzyme that catalyzes deoxyribonucleotide synthesis in eukaryotes.

172 ) reductase and further supply electrons for deoxyribonucleotide synthesis, antioxidant defense, and

173 ide reductase subunit M2 (RRM2), involved in deoxyribonucleotide synthesis, drives the chemoresistanc

174 lic processes, including electron transport, deoxyribonucleotide synthesis, oxygen transport and many

175 ctions in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively dam

176 coordinating DNA replication with increased deoxyribonucleotide synthesis.

177 etween the initiation of DNA replication and deoxyribonucleotide synthesis.

178 ls by controlling the rate-limiting step for deoxyribonucleotide synthesis.

179 either DNA damaging agents or inhibitors of deoxyribonucleotide synthesis.

180 A-binding protein in organizing a complex of deoxyribonucleotide-synthesizing enzymes at the replicat

181 These experiments showed several deoxyribonucleotide-synthesizing enzymes to be present i

182 Thus, the induction of deoxyribonucleotide-synthesizing genes at G1/S was fully

183 The relationship between the induction of deoxyribonucleotide-synthesizing genes, deoxyribonucleos

184 hosphate accumulation, like the induction of deoxyribonucleotide-synthesizing genes, was not dependen

185 required for normal cell cycle regulation of deoxyribonucleotide-synthesizing genes.

186 003W94, a 15-base phosphorothioate antisense deoxyribonucleotide that is currently under preclinical

187 yuridylate, which results in an imbalance of deoxyribonucleotide that may lead to excessive uracil mi

188 beling the deoxyribose (dR) moiety of purine deoxyribonucleotides through the de novo nucleotide synt

189 t involves the covalent linkage of the first deoxyribonucleotide to the polymerase polypeptide.

190 The LigD2 POL domain adds ribonucleotides or deoxyribonucleotides to a DNA primer-template, with rNTP

191 se module (POL) that adds ribonucleotides or deoxyribonucleotides to DSB ends and primer-templates.

192 retaining its normal ability to incorporate deoxyribonucleotides to form DNA.

193 talyzes the conversion of ribonucleotides to deoxyribonucleotides to provide the monomeric building b

194 further confirmed by DNA ladder and terminal deoxyribonucleotide transferase-mediated dUTP nick end l

195 Terminal deoxyribonucleotide transferase-mediated dUTP nick-end l

196 ll nuclear antigen), and apoptosis (terminal deoxyribonucleotide transferase-mediated nick-end labeli

197 cell nuclear antigen) / apoptosis (terminal deoxyribonucleotide transferase-mediated nick-end labeli

198 LC25A19, also called DNC, is a mitochondrial deoxyribonucleotide transporter.

199 er catalytic efficiency for rNTP relative to deoxyribonucleotide triphosphate (dNTP) incorporation, r

200 in the incorporation efficiency of a correct deoxyribonucleotide triphosphate (dNTP) relative to wild

201 hrough enhancement of LVDr changes in the RT deoxyribonucleotide triphosphate (dNTP)-binding pocket.

202 coordinately regulated to ensure appropriate deoxyribonucleotide triphosphate levels.

203 Thus, the coordinate repression of deoxyribonucleotide triphosphate metabolic enzymes is de

204 wever, we find that DinB incorporates the tC deoxyribonucleotide triphosphate opposite template G and

205 a limited, "fine-tuning" role in regulating deoxyribonucleotide triphosphate pools produced by the d

206 s high ratios of ribonucleotide triphosphate:deoxyribonucleotide triphosphate pools result in approxi

207 hen forks stall because of DNA damage or low deoxyribonucleotide triphosphate pools.

208 rdgB gene encodes a protein homologous to a deoxyribonucleotide triphosphate pyrophosphatase from Me

209 a molybdoenzyme, thought to detoxify HAP, a deoxyribonucleotide triphosphate pyrophosphatase that re

210 SAMHD1 forms tetramers that possess deoxyribonucleotide triphosphate triphosphohydrolase (dN

211 ination of free energy released during dNTP (deoxyribonucleotide triphosphate) hydrolysis and thermal

212 ribonucleotide triphosphates (NTPs) but not deoxyribonucleotide triphosphates (dNTPs) and instead us

213 lyzes an essential step in the production of deoxyribonucleotide triphosphates (dNTPs) in cells.

214 Viral DNA replication requires deoxyribonucleotide triphosphates (dNTPs).

215 only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs).

216 te pyrophosphatase that removes noncanonical deoxyribonucleotide triphosphates from replication precu

217 not discriminate between ribonucleotide and deoxyribonucleotide triphosphates, and it unwinds duplex

218 A trend in signal intensity for deoxyribonucleotide triphosphates, oligonucleotides, and

219 triphosphates (rNTPs) is higher than that of deoxyribonucleotide triphosphates.

220 n which diaminopurine (DAP) replaced adenine deoxyribonucleotide triphosphates.

221 orporation of both ribonucleotide- (NTP) and deoxyribonucleotide-triphosphates (dNTPs) using spCSR.

222 The deoxyribonucleotide triphosphohydrolase SAMHD1 restricts

223 tion of ribonucleotides to the corresponding deoxyribonucleotides, used in DNA synthesis and repair.

224 reductases (RNRs) convert ribonucleotides to deoxyribonucleotides via radical-based chemistry.

225 he apparent affinity of Glu-297 3Dpol for 2'-deoxyribonucleotides was decreased by 6-fold relative to

226 t molecular beacons synthesized from natural deoxyribonucleotides were not suitable, because they are

227 roposed to act as the selectivity switch for deoxyribonucleotide, which is supported by comparison to

228 tion of ribonucleotides to the corresponding deoxyribonucleotides, which are used as building blocks

229 Ribonucleotides are the natural analogs of deoxyribonucleotides, which can be misinserted by DNA po

230 , preventing elimination of oxidized guanine deoxyribonucleotides, which was achieved by suppressing

231 ess than 1/150000, and incorporation of a 2'-deoxyribonucleotide with a correct base should occur at

232 reported that DNA base pairs formed between deoxyribonucleotides with large aromatic, predominantly

233 A series of oligo-2'-deoxyribonucleotides with parallel (ps) and antiparallel