ライフサイエンスコーパス: deoxyribose

1 6.0473 Da, attributed to the neutral loss of deoxyribose.

2 ts this enzyme to distinguish ribose from 2'-deoxyribose.

3 n species (ROS) damage to membrane lipids or deoxyribose.

4 precursor with a dihydrofuran derivative of deoxyribose.

5 o increased by thymidine phosphorylase and 2-deoxyribose.

6 se and subsequent extracellular release of 2-deoxyribose.

7 ce that effectively replaces the ribose with deoxyribose.

8 A and causes sequence-selective oxidation of deoxyribose.

9 lecule for nucleophilic attack at C1' of the deoxyribose.

10 ns whereupon it was partially converted to 2-deoxyribose.

11 e synthesis resin in which Cy3B is linked to deoxyribose.

12 tic patch that appears selective for binding deoxyriboses.

13 .07, G; 0.03, C; 0.20, T) and the isolated 2-deoxyribose (-0.38) at the same level of theory.

14 rsenate with thymidine to form thymine and 2-deoxyribose 1-arsenate, which rapidly decomposes to 2-de

15 orming thymine and the chemically unstable 2-deoxyribose 1-arsenate.

16 ribose 1-phosphate (or 2'-deoxyuridine to 2'-deoxyribose 1-phosphate).

17 s phosphorolysis of thymidine to thymine and deoxyribose 1-phosphate.

18 cleosides to the free base and ribose (or 2'-deoxyribose) 1-phosphate.

19 dine were duplicated by the TP metabolite, 2-deoxyribose-1-phosphate (dR-1-P), and 10-fold more poten

20 ow that cleavage of thymidine to thymine and deoxyribose-1-phosphate by the host thymidine phosphoryl

21 ernative yjjG (dUMP phosphatase) pathway for deoxyribose-1-phosphate generation greatly exacerbated t

22 s suggest that the dgt-dependent pathway for deoxyribose-1-phosphate generation may operate under var

23 adily converted by the DeoD phosphorylase to deoxyribose-1-phosphate, the critical intermediate that

24 ore potently by its subsequent metabolite, 2-deoxyribose (2dR).

25 ct hydrogen-atom abstraction reaction of the deoxyribose 4'-H by ABLM.

26 A, and with base propenals also derived from deoxyribose 4'-oxidation.

27 eated with oxidizing agents known to produce deoxyribose 4'-oxidation.

28 patches (1-5 nt) in damaged DNA and removing deoxyribose 5'-phosphate from the 5'-side of damaged DNA

29 A oligomers, that surrounds and includes the deoxyribose 5'-phosphate lyase active site region.

30 The deoxyribose 5'-phosphate lyase catalytic residues that i

31 s) of backbone motion to the DNA binding and deoxyribose 5'-phosphate lyase function of this domain.

32 five-carbon phosphorylated monosaccharide, 2-deoxyribose 5-phosphate (2dR5P), as an alternate substra

33 tose 1,6-bisphosphate (F16BP) aldolase and 2-deoxyribose 5-phosphate (dR5P) aldolase (DERA).

34 o create nicks flanked by 3'-hydroxyl and 5'-deoxyribose 5-phosphate (dRP) termini.

35 n-natural nucleoside, 5-cyclohexylindolyl-2'-deoxyribose (5-CHInd), behaves as a P-gp inhibitor.

36 er binding affinity of 5-phenyl-1-indolyl-2'-deoxyribose-5'-triphosphate and suggests that the polyme

37 ously demonstrated that 5-nitro-1-indolyl-2'-deoxyribose-5'-triphosphate, a nonnatural nucleobase pos

38 -terminal abasic sites are excised by the 5'-deoxyribose-5-phosphate (5'-dRP) lyase activity of DNA p

39 ution structures of wild-type and mutant d-2-deoxyribose-5-phosphate (DRP) aldolase complexes with DR

40 yed an average seven-fold acceleration, with deoxyribose-5-phosphate aldolase (DERA) achieving an ave

41 f the bacterial (Escherichia coli) class I 2-deoxyribose-5-phosphate aldolase (DERA) has been determi

42 one-pot tandem aldol reaction catalyzed by a deoxyribose-5-phosphate aldolase (DERA) to form a 6-carb

43 repair synthesis and excision of the abasic deoxyribose-5-phosphate by polymerase beta.

44 (BER) process requires removal of an abasic deoxyribose-5-phosphate group, a catalytic activity that

45 moiety of the downstream strand by the 5'-2-deoxyribose-5-phosphate lyase activity of either DNA pol

46 a, but not pol mu, pol IV has intrinsic 5'-2-deoxyribose-5-phosphate lyase activity.

47 mage, because Pol lambda has intrinsic 5',2'-deoxyribose-5-phosphate lyase activity.

48 The mechanism of the 5'-2-deoxyribose-5-phosphate lyase reaction catalyzed by mamm

49 tivities, including DNA polymerase and 5',2'-deoxyribose-5-phosphate lyase.

50 demonstrate that although this 5'-terminal 2-deoxyribose-5-phosphate mimic does not affect the fideli

51 a 1,2-dideoxyribose-5-phosphate moiety, a 2-deoxyribose-5-phosphate mimic, we measured the incorpora

52 sion repair, the excision of a 5'-terminal 2-deoxyribose-5-phosphate moiety of the downstream strand

53 Yet the effects of this 5'-terminal 2-deoxyribose-5-phosphate moiety on the polymerase activit

54 cent 3' base pair and to be inhibited when 2-deoxyribose-5-phosphate, rather than phosphate, constitu

55 ta-pol was covalently cross-linked to a 5'-2-deoxyribose-5-phosphate-containing DNA substrate by sodi

56 pairs, puckering differences between A and T deoxyriboses, a narrow minor groove, and a stable water

57 components of thymidine phosphorylase and 2-deoxyribose action.

58 tative cross-link remnant 9b composed of a 2-deoxyribose adduct attached to the exocyclic N(2)-amino

59 The transition state model predicts that deoxyribose adopts a mild 3'-endo conformation during nu

60 Here, a stabilized 2'-fluoro-2'-deoxyribose analog of N(2),3-epsilonG was used to quanti

61 The ribose analogues were converted to deoxyribose analogues by replacement of a 3''-OH group b

62 ay, using magnetic particles bearing 21-mer, deoxyribose analogues of the complement to microRNA-143

63 eavage of the glycosidic bond between the 2'-deoxyribose and base, corresponding to B[a]PDE adducts o

64 se 1-arsenate, which rapidly decomposes to 2-deoxyribose and inorganic arsenate.

65 dyad related molecules form four consecutive deoxyribose and ribose zipper hydrogen bonds in the mino

66 isotope analogs of dGuo revealed the loss of deoxyribose and secondarily the loss of a series of stab

67 ides, containing a covalent bond between the deoxyribose and the purine base, represent an important

68 muM), which contain one or two 2'-fluoro-2'-deoxyriboses and/or bis-phosphorothioate linkages, are m

69 Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkag

70 was constructed by reattaching uracil to the deoxyribose, and both complexes were studied by molecula

71 cai (Euterpe oleracea) genotypes using ABTS, deoxyribose, and glutathione oxidation assays, as well a

72 ses A, G, C, T, and U, the sugars ribose and deoxyribose, and the phosphate backbone were determined

73 2-deoxyribonolactone (L) and 2-deoxyribose (AP) are abasic sites that are produced by i

74 The 8,5'-cyclopurine-2'-deoxyriboses are suspected to play a role in the etiolog

75 d stability, reactivity, and solubility of 2-deoxyribose as compared to ribose.

76 blocks using readily available O-1-methyl-2-deoxyribose as starting material.

77 Furthermore, the deoxyribose assay with 19b demonstrated potent antioxida

78 ence in the antioxidant activity by ABTS and deoxyribose assays.

79 2 to 100-fold, similar to that observed with deoxyribose at position -5.

80 sembly, because an siRNA strand bearing a 2'-deoxyribose at this position can inhibit the cognate str

81 s are a DNA/RNA mimic in which the phosphate deoxyribose backbone has been replaced by uncharged link

82 structures suggested that the DNA phosphate-deoxyribose backbone is recognized by RAGE through well-

83 ic bleomycin causes two major lesions in the deoxyribose backbone of DNA: formation of 4'-keto abasic

84 s in the nucleotide bases and phosphodiester-deoxyribose backbone, as reflected in a substantial (34%

85 tiated by hydrogen atom abstraction from the deoxyribose backbone.

86 base interactions and changes in the phospho-deoxyribose backbone.

87 esses an AP lyase activity that cleaves at a deoxyribose but not at a THF residue.

88 Further, thymidine phosphorylase and 2-deoxyribose, but not VEGF, increased the association of

89 mation of a Schiff base adduct of the abasic deoxyribose C-1' with a lysine residue (K312 in the case

90 d cleavage of DNA through abstraction of the deoxyribose C4'-H.

91 y be active, depending on orientation of the deoxyribose C4'-H.

92 radical attack on the C1', C3' and C4' of 2-deoxyribose can give rise to epimeric 2-deoxyribose lesi

93 study shows that structural features of the deoxyribose carbons reporting on the sugar pucker are st

94 ry base is the same, -0.28 with the sum of 2-deoxyribose charges being positive, +0.28.

95 The latter was used as a model for the 2-deoxyribose component of DNA.

96 that an anti glycosidic torsion with C1'-exo deoxyribose conformation allows AAF-dG to be Watson-Cric

97 The transition state model predicts a deoxyribose conformation with a 2'-endo ring geometry.

98 ' and C5', considered to be key reporters of deoxyribose conformation, fall near or beyond the edges

99 anded helix with all nucleotides in anti, 2'-deoxyribose conformations within the C2'-endo/C1'-exo ra

100 s been crystallized with a cationic 1-aza-2'-deoxyribose-containing DNA that mimics the ultimate tran

101 However, the complexity of nucleobase and 2-deoxyribose damage caused by strong oxidants such as ion

102 C4' radical contributes little to the total deoxyribose damage via the direct effect.

103 except hexane, were effective in preventing deoxyribose degradation, and the inhibition was increase

104 orted here by using three different methods: deoxyribose degradation, hydroxylation of benzoate and h

105 nd 2-methyltetrahydrofuran, simple models of deoxyribose, do not reflect differences in reaction exot

106 on the metabolism of [U-(13)C(6)]glucose to deoxyribose (DR) and then incorporation of [U-(13)C(5)]D

107 The loss of the deoxyribose (dR) from the protonated DNA adducts ([M + H

108 ed on the incorporation of (2)H(2)O into the deoxyribose (dR) moiety of purine deoxyribonucleotides i

109 for measuring DNA synthesis by labeling the deoxyribose (dR) moiety of purine deoxyribonucleotides t

110 epyrimidination of dT yielding thymine and 2-deoxyribose (dRib).

111 The positions of the phosphate and deoxyribose equilibria provide a quantitative measure of

112 The S-cdG deoxyribose exhibited the O4'-exo (west) pseudorotation.

113 bond provide nucleobase and/or ribose or 2'-deoxyribose fragment ions and fragments thereof.

114 However, the repair of oxidized deoxyribose fragments at the 5' terminus after strand br

115 By contrast, a deoxyribose G5 variant that can undergo only the first o

116 ee radical attack on the C1' position of DNA deoxyribose generates the oxidized abasic (AP) site 2-de

117 conformational exchange of the phosphate and deoxyribose groups of the DNA oligomers d(GCGTACGC)(2) a

118 Both form covalently attached deoxyribose groups to the catalytic site nucleophile.

119 aluating D4GTP (the planar 2',3'-unsaturated deoxyribose guanosine analogue that is complementary to

120 s between the 1,N(2)-epsilondG imidazole and deoxyribose H1' protons and between the 1,N(2)-epsilondG

121 evisiae revealed that the model lesion and 2-deoxyribose have distinct in vivo effects.

122 These include the phosphate group, the deoxyribose hydroxyl group, and various functional group

123 oligonucleotide containing a cationic 1-aza-deoxyribose (I) oxacarbenium ion mimic is a potent inhib

124 nucleotide (AIA) containing a cationic 1-aza-deoxyribose (I) residue designed to be a stable mimic of

125 The oxidation of 2-deoxyribose in DNA has emerged as a critical determinant

126 both lipid peroxidation and 4'-oxidation of deoxyribose in DNA, and with base propenals also derived

127 minant of hydroxyl radical reactivity with 2-deoxyribose in DNA, but the large differences between ga

128 sphate residues arising from 5'-oxidation of deoxyribose in DNA, caused by the enediyne neocarzinosta

129 f UDG enforces distortions of the uracil and deoxyribose in the flipped-out nucleotide substrate that

130 o DNA, followed by abstraction of C4'-H from deoxyribose in the rate-limiting step for DNA degradatio

131 The deoxyribose in the thymidine comes from dUMP, which must

132 3',5'-cyclic phosphoester ring derived from deoxyribose indicated strain energies at least 5.4 kcal/

133 Thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylatio

134 Pentoses, such as arabinose, ribose, and deoxyribose, inhibit the interaction between SP-D and ma

135 anomer of X is observed, and the abasic site deoxyribose is largely intrahelical.

136 helical and well-stacked and the abasic site deoxyribose is predominantly extrahelical, consistent wi

137 The terminal deoxyribose is responsible for retarding the rate of inh

138 present mechanistic studies revealing the 2'-deoxyribose isomerization and subsequent deglycosylation

139 raniloyl modification at the 3'-OH of the 2'-deoxyribose leads to ligands (mant-deoxy-ATP [dATP], man

140 Owing to the instability of 2-deoxyribose lesions (AP), a chemically stable tetrahydro

141 ctive oxygen species produce oxidized bases, deoxyribose lesions and DNA strand breaks in mammalian c

142 of 2-deoxyribose can give rise to epimeric 2-deoxyribose lesions, for which the in vivo occurrence an

143 incorporated into oligonucleotides through a deoxyribose linkage.

144 xyguanosine, pyrimido[1,2-a]purin-10(3H)-one deoxyribose (M(1)dG), and 1,N(2)-propanodeoxyguanosine i

145 adduct, pyrimido[1,2-alpha]purin-10(3H)-one-deoxyribose (M(1)GdR) in urine.

146 The mechanisms by which 2-deoxyribose might mediate thymidine phosphorylase-induce

147 from entering holo-RISC; in contrast, the 2'-deoxyribose-modified strand has enhanced activity in the

148 erturbation of specific vibrational modes of deoxyribose moieties and presumably reflect desolvation

149 noncomplementary bases or ribo- instead of a deoxyribose moieties.

150 a the abstraction of H1' and/or H5' from the deoxyribose moiety and by base modification, resulting i

151 s located close to the 2'-carbon atom of the deoxyribose moiety and is proposed to act as the selecti

152 cling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabol

153 based on incorporation of (2)H(2)O into the deoxyribose moiety of deoxyribonucleotides in dividing c

154 entified a series of modifications of the 2'-deoxyribose moiety of DNA arising from the exposure of i

155 y for 84 days, and 2H incorporation into the deoxyribose moiety of DNA of newly divided B-CLL cells w

156 ((2)H) from heavy water ((2)H(2)O) into the deoxyribose moiety of purine deoxyribonucleotides in DNA

157 ((2)H) from heavy water ((2)H(2)O) into the deoxyribose moiety of purine deoxyribonucleotides in DNA

158 raction from the 4'- and 5'-positions of the deoxyribose moiety of the backbone of DNA.

159 e primer terminus and the ring oxygen of the deoxyribose moiety of the incoming dNTP to align the 3'-

160 riginal methodology's neutral loss of the 2'-deoxyribose moiety to allow for the detection of all DNA

161 e activities that nick the DNA strand at the deoxyribose moiety via a beta- or beta,delta-elimination

162 alog of dUTP in which the ring oxygen of the deoxyribose moiety was replaced by a methylene group.

163 sidic orientation, an S conformation for the deoxyribose moiety, and quite close shape mimicry of gua

164 after C4' hydrogen atom abstraction from the deoxyribose moiety.

165 oncomitant nucleophilic attack on C1' of the deoxyribose moiety.

166 DNA polymerase yeast pol eta inserts pyrene deoxyribose monophosphate (dPMP) in preference to A oppo

167 resulting in the formation of normal product deoxyribose monophosphate (dR5P) or methoylated-dR5P.

168 enzymes to switch nucleobases attached to a deoxyribose monophosphate.

169 ee energy perturbation simulations of ribose-deoxyribose mutations in a single-strand dodecamer and i

170 n phosphate B(I) and B(II) conformations and deoxyribose N and S conformations was expressed as perce

171 e calculate binding free energies for a free deoxyribose nucleotide triphosphate, dATP or dGTP, to Po

172 by proton transfer from the terminal primer deoxyribose O3' to Asp-256.

173 o transfer damage from the nucleobase to the deoxyribose of an adjacent nucleotide in DNA under hypox

174 upling constants for adjacent protons of the deoxyribose of both the alpha and beta anomers of the ab

175 e native C2'-endo/C3'-exo form of B-DNA, the deoxyribose of the 5'-nucleoside always adopts the C2'-e

176 Glu-710, whose side chain interacts with the deoxyribose of the incoming dNTP.

177 mical-specific cleavage at the C-4' H of the deoxyribose of the pyrimidine has remained controversial

178 Using duplex 2'-deoxyribose oligonucleotides containing an abasic (AP) s

179 rect effect of thymidine phosphorylase and 2-deoxyribose on signaling pathways associated with endoth

180 However, RNA molecules with deoxyribose or dideoxyribose residues at their 3' termin

181 and quencher (methyl red) attached either to deoxyribose or to the 5 position of dU.

182 ed previously, using 2'-OH (ribose) to 2'-H (deoxyribose) or 2'-O-methyl substitutions in the stem 2

183 The deoxyribose orientation shifts to become parallel to the

184 ted to 40% and 35%, respectively, of total 2-deoxyribose oxidation as measured by a plasmid nicking a

185 Further, the well-defined 2-deoxyribose oxidation chemistry of the enediyne antibiot

186 However, deoxyribose oxidation produces strand breaks and abasic

187 reaction of aldehyde- and ketone-containing deoxyribose oxidation products and abasic sites with [(1

188 ensitive method to quantify abasic sites and deoxyribose oxidation products arising in damaged DNA.

189 The proportions of the various 2-deoxyribose oxidation products generated by gamma-radiat

190 r the rigorous quantification of two major 2-deoxyribose oxidation products: the 2-deoxyribonolactone

191 -deoxyribonolactone at 7% and 24% of total 2-deoxyribose oxidation, respectively, with frequencies of

192 NA damage induced by free radical attack and deoxyribose oxidation.

193 excision involves protonation of O(8) or the deoxyribose oxygen moiety.

194 /pi interactions between AlkD and the lesion deoxyribose participate in catalysis of glycosidic bond

195 ver, the O4'-exo pseudorotation of the S-cdG deoxyribose perturbed the helical twist and base pair st

196 air intermediates containing a 5'-adenylated-deoxyribose phosphate (5'-AMP-dRP) group.

197 iates containing the 5'-AMP or 5'-adenylated-deoxyribose phosphate (5'-AMP-dRP) lesions may accumulat

198 Here, we uncovered a weak 5'-deoxyribose phosphate (5'-dRP) lyase activity in mouse R

199 ere, we show that Pol theta has intrinsic 5'-deoxyribose phosphate (5'-dRP) lyase activity that is in

200 ovalent Schiff base intermediate with the 5'-deoxyribose phosphate (5'-dRP) residue that results from

201 l gamma acts to catalyze the removal of a 5'-deoxyribose phosphate (dRP) group in addition to playing

202 lso has a dRP lyase activity that cleaves 5'-deoxyribose phosphate (dRP) groups from DNA, thus contri

203 In single-nucleotide BER, the deoxyribose phosphate (dRP) in the abasic site is remove

204 ) exhibits apurinic/apyrimidinic (AP) and 5'-deoxyribose phosphate (dRP) lyase activities.

205 We found earlier that human pol iota has deoxyribose phosphate (dRP) lyase activity and unusual s

206 here that human pol iota has an intrinsic 5'-deoxyribose phosphate (dRP) lyase activity.

207 filling DNA synthesis and removal of the 5'-deoxyribose phosphate (dRP) of the abasic site, whereas

208 Deoxyribose phosphate (dRP) removal by DNA polymerase be

209 of the repair patch and lyase removal of 5'-deoxyribose phosphate (dRP).

210 A 28-kDa protein identified as deoxyribose phosphate aldolase also contained bound sele

211 y the abstraction of hydrogen atoms from the deoxyribose phosphate backbone of duplex DNA, but exact

212 pair involves cleavage on the 5' side of the deoxyribose phosphate by AP endonuclease.

213 w that the excision of the characteristic 5'-deoxyribose phosphate containing oligonucleotide (dRP-ol

214 This domain catalyzes the removal of deoxyribose phosphate during short patch base excision r

215 fically at BER intermediates containing a 5'-deoxyribose phosphate group.

216 epair of dUs, including an abasic site and a deoxyribose phosphate group.

217 hat LCA suppresses the DNA polymerase and 5'-deoxyribose phosphate lyase activities of DNA pol beta b

218 helix-4, which provides the DNA binding and deoxyribose phosphate lyase activities of the enzyme.

219 er Pol beta gap-filling and much stronger 5'-deoxyribose phosphate lyase activities than was observed

220 (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase activities that are integral

221 (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase activities.

222 BER activity by inhibiting Pol-beta-directed deoxyribose phosphate lyase activity.

223 cterized and found to be an inhibitor of the deoxyribose phosphate lyase and DNA polymerase activitie

224 The enzyme has deoxyribose phosphate lyase and polymerase activity, but

225 mbinantly, are active as DNA polymerases and deoxyribose phosphate lyases, but their polymerase activ

226 It is the loss of beta-pol-mediated 5'-deoxyribose phosphate removal that renders mouse fibrobl

227 ding to [(B[a]Ptriol+phosphate)-H]- and [(2'-deoxyribose+phosphate+B[a]Ptriol)-H]-, respectively.

228 polymerase active site yet functional for 5'-deoxyribose-phosphate (5'dRP) lyase activity.

229 the apparent equilibrium constant K' for the deoxyribose-phosphate aldolase reaction makes it possibl

230 -aminoethyl)glycine backbone in place of the deoxyribose phosphates.

231 Consistent with the important role that deoxyribose plays in strand exchange, oligonucleotides w

232 oupling of iodinated base derivatives with a deoxyribose precursor.

233 A newly designed 1'-methylenedisulfide deoxyribose probe can efficiently cross-link to DNA cyto

234 single-strand breaks (SSBs) with 5'-blocking deoxyribose products generated directly or as repair int

235 the C(18) and T(19) H1', H2', H2' ', and H3' deoxyribose protons were shifted upfield.

236 n-Drew dodecamer was used to re-evaluate the deoxyribose pseudorotation profile and the Lennard-Jones

237 umes a very steep distance-dependent form, a deoxyribose pseudorotation profile with reduced energy b

238 No C3'-endo deoxyribose pucker and no significant roll are observed

239 /6.682(2)/36.02(2) A, Z = 4) shows C2'- endo deoxyribose puckering, and the base is found in the anti

240 bond and formation of the corresponding C3'-deoxyribose radical.

241 The resulting 4'-deoxyribose radicals can be trapped by O2 and ultimately

242 ) are believed to involve the formation of 2-deoxyribose radicals.

243 to creation of an abasic (AP) site leaving a deoxyribose residue in the strand, is a frequent lesion

244 articipates in a tight interaction with a 2'-deoxyribose residue of the 5'-terminal G of a neighborin

245 nant 6 in which the anomeric carbon of the 2-deoxyribose residue was connected to the exocyclic N(6)-

246 eters indicate that the conformations of the deoxyribose residues of each strand are dynamically coup

247 How ever, some DNA lesions that render deoxyribose resistant to beta-elimination are removed th

248 tion, these crosspeak resonances and several deoxyribose resonances are multiply split, presumably th

249 s showed that substitution of ribose -5 with deoxyribose resulted in a 24-fold decrease in binding af

250 e radicals also abstract hydrogen atoms from deoxyribose, resulting in the formation of apurinic/apyr

251 e correlated with the %S and C1' S(2) of the deoxyribose ring 5' of the phosphates.

252 At the transition state, the deoxyribose ring exhibits significant oxocarbenium ion c

253 y associated with the conformation of the 2'-deoxyribose ring is the value of the C-N torsion angle c

254 groups of spins both in the bases and in the deoxyribose ring of the DNA backbone.

255 The puckering of the deoxyribose ring plays an important role in determining

256 atom abstraction from the 4'-position of the deoxyribose ring rather than redox-induced base oxidatio

257 The A6 deoxyribose ring showed an increased percentage of the C

258 2',3'-unsaturation in its planar carbocyclic deoxyribose ring that acts on HIV-1 reverse transcriptas

259 o the isosteric replacement of oxygen in the deoxyribose ring with carbon.

260 ydrogen atom abstraction from the respective deoxyribose ring, and that 2-deoxyribonolactone formatio

261 e that self-catalyzes the elimination at the deoxyribose ring.

262 ely on the 3'- and 5'-hydroxyl groups of the deoxyribose ring.

263 ucleoside with 2'-endo sugar puckers for the deoxyribose ring.

264 formational preferences of HSV-tk for the 2'-deoxyribose ring.

265 broken and the timing of the opening of the deoxyribose ring.

266 ing a benzyl group at the 2' position of the deoxyribose rings in the backbone, we observed that the

267 show that both thymidine phosphorylase and 2-deoxyribose stimulated the formation of focal adhesions

268 2'-Deoxyribose substitution leads to folding with reduced m

269 ty among YNMG loops was further supported by deoxyribose substitution, CD, and NMR experiments.

270 tide-RNA interface are largely unaffected by deoxyribose substitution.

271 the magnitude of the free energy change for deoxyribose substitutions is determined to a larger exte

272 639 provides discrimination of ribose versus deoxyribose substrates.

273 ine of its N-terminal proline) on C1' of the deoxyribose sugar at a damaged base, which results in th

274 hydrogen-atom abstraction from the C-4' of a deoxyribose sugar moiety.

275 d structure for accommodating the additional deoxyribose sugar moiety.

276 ne radical cations results in high yields of deoxyribose sugar radicals in DNA, guanine deoxyribonucl

277 '-deoxyribonucleotides leads to formation of deoxyribose sugar radicals in remarkably high yields.

278 Furthermore, deoxyribose sugar repuckering is accompanied by increase

279 These analogs contain substitutions on the deoxyribose sugar ring at the 4' carbon (4'C-methyl dT a

280 e nucleophile to attack C1' on the ring-open deoxyribose sugar to form a transient peptide-DNA imino

281 abstraction of the C-4' hydrogen atom of the deoxyribose sugar unit.

282 osidic bond between the crosslinked base and deoxyribose sugar.

283 r the terminal adenine base and the terminal deoxyribose sugar.

284 ules and choose substrates with the correct (deoxyribose) sugar.

285 modification preorganizes the ribose and 2'-deoxyribose sugars for a C3'-endo conformation, and stab

286 east hindered (C4' and C5') positions of the deoxyribose sugars in the double helix.

287 In particular, the deoxyribose sugars of the DNA strand show strong evidenc

288 tive damage to the nucleic acid bases and/or deoxyribose sugars.

289 than that in bulk water and that attached to deoxyribose, suggesting a unique role for the dynamics o

290 e source of selectivity in silyl-protected 2-deoxyribose systems.

291 e AlkD active site interacts with the lesion deoxyribose through a series of C-H/pi interactions.

292 -glycosylic bond between the uracil base and deoxyribose to initiate the uracil-DNA base excision rep

293 phosphoramidite monomers with Cy3B linked to deoxyribose, to the 5-position of thymine, and to a hexy

294 precedented activity was further extended to deoxyribose triphosphate, and in vitro biosyntheses coul

295 ss tC on the template strand and incorporate deoxyribose-triphosphate-tC into the growing primer term

296 zing several unique 5-substituted indolyl 2'-deoxyribose triphosphates and defining their kinetic par

297 hibit Fenton induced hydroxyl degradation of deoxyribose was observed.

298 e 2-chloro pharmacophore, rather than the 2'-deoxyribose was responsible for the reduced 2CdA uptake

299 BCNA) 6-pentylphenylfuro[2,3-d]pyrimidine-2'-deoxyribose was synthesized using carbocyclic 2'-deoxyur

300 etermine the properties of combinations of 2-deoxyribose with each of the isolated DNA bases for both