ライフサイエンスコーパス: depalmitoylation

1 APTs are the only enzymes known to promote depalmitoylation.

2 L115R mutation and were depleted by chemical depalmitoylation.

3 ntity to APT1, that also controls BK channel depalmitoylation.

4 almitoylation-dependent fashion and promotes depalmitoylation.

5 ate the import of R7BP into the nucleus upon depalmitoylation.

6 ma membrane to the Golgi as a consequence of depalmitoylation.

7 Equally important is the mechanism of depalmitoylation.

8 he enzyme more susceptible to APT1-catalyzed depalmitoylation.

9 protein thioesterase 1 (APT1) regulates eNOS depalmitoylation.

10 tate inactivation and ablates sensitivity to depalmitoylation.

11 -Jun N-terminal kinase, resulting in Galphai depalmitoylation and enhanced receptor-Galphai associati

12 aspanin palmitoylation, and underscoring how depalmitoylation and EWI-2 association may collaborate t

13 ation switch, and ligand engagement leads to depalmitoylation and lysosomal degradation.

14 receptors through the combined processes of depalmitoylation and palmitoylation.

15 D17 catalytic activity is required for N-Ras depalmitoylation and re-localization to internal cellula

16 We propose that a cycle of depalmitoylation and repalmitoylation regulates the time

17 rt a role for APT1 in the regulation of eNOS depalmitoylation and suggest that Ca(2+)-CaM activation

18 ts such as bradykinin, which promotes enzyme depalmitoylation and translocation from caveolae.

19 Depalmitoylation and translocation of eNOS modulate the

20 s likely to mediate receptor-induced alpha s depalmitoylation and translocation of the protein to cyt

21 thways that regulate eNOS palmitoylation and depalmitoylation are poorly understood.

22 namics in cells and confirms enzyme-mediated depalmitoylation as a critical regulatory mechanism for

23 X6 recruitment and oxidation-induced Galphai depalmitoylation as an additional mechanism of Galphai-G

24 mitoylating enzyme APT1 blocks Wnt5a-induced depalmitoylation, asymmetric MCAM localization, and cell

25 nstrate that APT1 not only catalyzes its own depalmitoylation but also that of APT2 promoting dynamic

26 alpha s, but not alpha s-GTP[gamma S], from depalmitoylation by a recombinant esterase.

27 brain proteins are highly palmitoylated and depalmitoylation by PPT is essential for their effective

28 transferases zDHHC9/14/18 and is followed by depalmitoylation by the plasma membrane-localized acyl-p

29 including peptide palmitoylation by PAT(s), depalmitoylation by thioesterases, and evaluation of pot

30 The palmitoylation/depalmitoylation cycle of posttranslational processing i

31 e of this modification is the palmitoylation-depalmitoylation cycle that regulates the subcellular tr

32 Interestingly, however, depalmitoylation does not release NMNAT2 from membranes.

33 erases APT1 and APT2 and that palmitoylation/depalmitoylation dynamics are on a time scale similar to

34 Our findings indicate that the family of depalmitoylation enzymes may be substantially broader th

35 However, palmitoylated proteins require depalmitoylation for recycling.

36 dification, these proteins must also undergo depalmitoylation for their degradation by lysosomal prot

37 acyl thioesterases that control ion channel depalmitoylation have not been identified.

38 Depalmitoylation inhibition caused R7BP to redistribute

39 ese data support the clinical development of depalmitoylation inhibitors as a novel class of rational

40 rendered GIRK channel closure insensitive to depalmitoylation inhibitors.

41 In contrast, depalmitoylation is controlled by the cytosolic thioeste

42 g to plasmalemmal caveolae; agonist-promoted depalmitoylation leads to eNOS translocation.

43 Inhibiting R7BP depalmitoylation may provide a means of enhancing GIRK a

44 Depalmitoylation occurred slowly (t(1/2) approximately 2

45 ted with the sequential S-palmitoylation and depalmitoylation of a previously undescribed site of mod

46 One model declares that depalmitoylation of alpha, which accompanies activation

47 This dissociation may involve depalmitoylation of an amino-terminal cysteine residue.

48 PT1 overexpression appears to accelerate the depalmitoylation of eNOS in COS-7 cells cotransfected wi

49 n-eNOS complex, rather than agonist-promoted depalmitoylation of eNOS, relieves caveolin's tonic inhi

50 r of Ras signaling through its modulation of depalmitoylation of H-Ras and its recycling from plasma

51 A cycle of palmitoylation/depalmitoylation of H-Ras mediates bidirectional traffic

52 kdown or inhibition of APT1 and APT2 blocked depalmitoylation of Huntingtin, but did not affect palmi

53 and APT2 are cytosolic enzymes that catalyze depalmitoylation of membrane-anchored, palmitoylated H-R

54 Depalmitoylation of membrane-bound GAP-43 did not releas

55 More important, the APT1-catalyzed depalmitoylation of palmitoyl-eNOS is potentiated by Ca(

56 toyl protein thioesterase(s) responsible for depalmitoylation of plasma membrane-associated signaling

57 iated AMPA receptor internalization requires depalmitoylation of PSD-95.

58 Depalmitoylation of R7BP translocates R7BP-R7-Gbeta5 com

59 Depalmitoylation of Rho at Cys322 and Cys323 altered the

60 -kDa isoform, although it did not accelerate depalmitoylation of sarcolemmal eNOS, as determined by p

61 In contrast, APT1-catalyzed depalmitoylation of the G protein Galpha(s) is unaffecte

62 Our results show that Wnt5a promotes depalmitoylation of the melanoma cell adhesion molecule

63 Moreover, depalmitoylation of the receptor is regulated by activat

64 oting dynamic palmitoylation (palmitoylation-depalmitoylation) of both thioesterases.

65 ced spine removal of AKAP79/150 required its depalmitoylation on two Cys residues within the N-termin

66 hat the mutants either have a faster rate of depalmitoylation or that they are consumed in a time-dep

67 Selective inhibition of PRDX6 blocks Galphai depalmitoylation, prevents the enhanced receptor G-prote

68 Depalmitoylation produced a weakened interaction with ei

69 The identification of the depalmitoylation reaction of CD95 by APTs as a microRNA

70 Further, chemical depalmitoylation reduces the casein phosphorylation acti

71 Inhibition of depalmitoylation reveals that S-palmitoylation of Cys-26

72 Additional results show that blockade of depalmitoylation slows the degradation of ARL13b that oc

73 gation of the CSPalpha mutants, and chemical depalmitoylation solubilized the aggregates, demonstrati

74 P12 regulates H-Ras trafficking by promoting depalmitoylation through cis-trans isomerization of a pe

75 Ts to directly interact with CD95 to promote depalmitoylation, thus impairing apoptosis mediated thro

76 cilitate GAP action by (i) promoting Gialpha depalmitoylation to create optimal GAP substrates, and (

77 mal GAP substrates, and (ii) inhibiting R7BP depalmitoylation to stabilize membrane association of R7

78 lipid rafts by pharmacological inhibition of depalmitoylation virtually abolished CD44-ezrin interact

79 Notably, such LTD-induced depalmitoylation was also blocked by CaMKII inhibition.

80 nucleus; and G(i/o) signaling inhibits R7BP depalmitoylation whereas G(i/o) inactivation induces nuc

81 provide evidence that Wnt5a induces protein depalmitoylation, which promotes polarized protein local

82 ential mechanism, perhaps involving receptor depalmitoylation, with phosphorylation at Thr(318) being