ライフサイエンスコーパス: dependency

1 ber alterations (copy-number associated gene dependencies).

2 cer and modulate competitive fitness and MEK dependency.

3 ndowed with adaptive scalability and context dependency.

4 tions follow the same trend toward IL-1alpha dependency.

5 cause these patients rapidly develop insulin dependency.

6 ard recently seen stimuli: a positive serial dependency.

7 apeutically targetable mechanism for GOF p53 dependency.

8 -ERG-positive prostate cancer cells from ERG dependency.

9 h similar effects but with only partial IL-6 dependency.

10 iversity, and low precursor ion charge-state dependency.

11 organisms without the need for engineered co-dependency.

12 ate global warming and to reduce fossil fuel dependency.

13 ype SF3B1 as a novel, non-driver cancer gene dependency.

14 ualize and interactively explore intra-motif dependencies.

15 d diversity but also display the intra-motif dependencies.

16 y expressed with tissue- and disease-subtype-dependencies.

17 enomic data to identify differential genetic dependencies.

18 e time and low oxygen-, temperature- and pH- dependencies.

19 ualization using improved navigation without dependencies.

20 ld identify clinically actionable metastatic dependencies.

21 eps of HCV life cycle and related viral host dependencies.

22 [1.8-3.1] for women) and increases with high dependency (0.9 years [0.2-1.7] for men and 1.3 years [0

23 es in years lived from age 65 years with low dependency (1.7 years [95% CI 1.0-2.4] for men and 2.4 y

24 estimates of dependency in four states: high dependency (24-h care), medium dependency (daily care),

25 e were spent independent (36.3%) or with low dependency (36.3%) whereas for women the majority were s

26 We found predictive models for 426 dependencies (55%) by nonlinear regression modeling cons

27 s for women the majority were spent with low dependency (58.0%), and only 4.8% were independent.

28 EDDY (Evaluation of Differential DependencY), a statistical test to detect differential s

29 rimination and predict a negative perceptual dependency: a contrastive relationship that enhances sen

30 proach, which explicitly models gene-centric dependencies across multiple and distinct genomic platfo

31 ole of advanced age on survival and dialysis dependency after initiation of renal replacement therapy

32 ns to be modelled as propagating conditional dependencies among species' presences.

33 Moreover, the dependency among genes should be taken into account in o

34 olkits require large libraries with multiple dependencies and are not well suited for custom MS data

35 ell metabolic phenotypes reflect biochemical dependencies and highlights evidence that both the metab

36 ide a catalog of copy-number associated gene dependencies and identify partial copy-loss of wild-type

37 demonstrated its ability to show intra-motif dependencies and intuitively reveal biomolecular structu

38 However, the nature of these evolutionary dependencies and their impact remain unclear.

39 ce logo is unable to display the intra-motif dependencies and therefore is insufficient to fully char

40 patients is evident: it prolongs ventilator dependency and increases morbidity, duration of hospital

41 ated with a higher risk of subsequent opioid dependency and overdose.

42 i and C. albicans displayed differential MR1 dependency and TCR beta-chain bias, consistent with poss

43 Thus, identifying the basis for Nrp1 dependency and the key drivers of Treg fragility could h

44 This suggests a dose dependency and threshold for the CD74 NTF-associated imp

45 actors as one set of in vivo-specific cancer dependencies, and determined that these factors are nece

46 large number of associated software/hardware dependencies, and the detailed expertise required to per

47 vision, near activities, role difficulties, dependency, and color vision, with correlations ranging

48 alysis implicates splicing in cellular PRMT5 dependency, and we identify a biomarker that predicts se

49 motion, suggesting that positive perceptual dependencies are pervasive.

50 communication is successful, close temporal dependencies arise between adult speakers' and listeners

51 y different markers and transcription factor dependencies as compared with conventional NK cells.

52 ssion displayed cell type-specific HIF1/HIF2-dependencies as well as dysregulation of several pathway

53 d metabolism translate into distinct pathway dependencies, as genetic disruption of the enzymes respo

54 nally explains observed non-linear intensity dependencies, as well as self-limited growth of iodide-r

55 ns of PKCdelta also segregate based on K-Ras dependency, as K-Ras-independent cells are more sensitiv

56 mor types, we constructed a map of oncogenic dependencies associated with cellular pathways, transcri

57 d nucleation by investigating the delay time dependency at various voltages and temperatures.

58 h very little data, and (c) bridge long-term dependencies between actions and rewards.

59 The mutual dependencies between chromatin organization and patterns

60 The BNs found strong dependencies between functionality and system type and a

61 f mutations that explicitly captures residue dependencies between positions.

62 d structural analyses were done to track the dependencies between the process of FeS2 dissolution and

63 lts living with and without HIV, and examine dependency between causes of comorbidities.

64 We specifically aim at estimating the dependency between oxygen dynamics and hydrologic condit

65 plifying assumptions that often break up the dependency between the four processes, or are tailored t

66 , they have very little effect on wavelength-dependency beyond the expected monotonic fall.

67 e been developed to quantify the intra-motif dependencies, but fewer tools are available for visualiz

68 isk and the incremental influence of insulin dependency by examining short- and long-term adverse out

69 s of epidermal growth factor receptor (EGFR) dependency by performing CRISPR, shRNA, and expression s

70 rations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulate

71 he acceptor organic molecule, volcano-shaped dependencies, characteristic of the Marcus inverted regi

72 ynamics and filament turnover, and how these dependencies combine to determine overall rates of corti

73 Both dependencies combined linearly to determine perception,

74 on K-Ras and PKCdelta co-segregate, and that dependency correlates with a more epithelial-like phenot

75 states: high dependency (24-h care), medium dependency (daily care), low dependency (less than daily

76 A weighted linear sum of the separate dependencies described the original cubic pattern well.

77 ence, 17.3; 95% CI, 8.0-26.6; P < .001), and dependency (difference, 5.6; 95% CI, 0.5-10.8; P = .03)

78 es an explanation for many of the wavelength-dependency discrepancies in the published literature.

79 n is the consequence of a decreased template dependency during NHEJ, which renders the error-rate of

80 e deficit and elevation; and that these same dependencies emerge from an independent analysis of empi

81 ng of cancer evolution shows that alteration dependencies emerge only under conditional selection.

82 nstrate that accounting for the gene-centric dependencies enables leveraging information from multi-o

83 r and together explained most of the spatial dependency exhibited by this zoonosis.

84 rapeutic potential of CHK1's role in GOF p53 dependency, experiments in cell culture and mouse xenogr

85 Overall, these findings identify a dependency factor in acute leukaemia and suggest a mecha

86 coreceptor signaling, which activates a host dependency factor, cofilin, and its kinase, the LIM doma

87 To identify host dependency factors resulting from these EBV+, B cell-tra

88 Many dependencies fall into a limited number of classes, and

89 Together, our data highlight distinct CSC dependencies for primary versus metastasic tumour growth

90 ational studies reported reductions in shunt dependency for a combined treatment approach of IVF plus

91 tween seawater and sea-ice showed a compound-dependency for Arctic samples not evident with those fro

92 gnificantly reduces rates of permanent shunt dependency for aresorptive hydrocephalus post-ICH.

93 assive sensitization +/- omalizumab showed a dependency for basophil-bound IgE, substantiated by a re

94 veloped to fully take into account the local dependency for differential analysis, in which different

95 piratory failure (RF), defined as ventilator dependency for more than 48 hours or unplanned reintubat

96 omponents and isolated a positive perceptual dependency for motion and a negative dependency for orie

97 The positive dependency for motion shows an integrative perceptual ef

98 We found a clear positive dependency for motion, suggesting that positive perceptu

99 ng, and consistent with this, we demonstrate dependency for one of the miRNA mutants on the NF-kappaB

100 so found a concurrent negative (contrastive) dependency for orientation.

101 ceptual dependency for motion and a negative dependency for orientation.

102 sets in mice and reveal a hierarchy of STAT5 dependency for populating lymphoid and nonlymphoid tissu

103 most intractable human cancers and establish dependency for tumor maintenance and progression.

104 nder an open source license and bundled in a dependency-free container for wide distribution.

105 The outcome was independence measured in dependency-free life-years (DFLYs) to 65 years of age.

106 vantages over existing MS viewers, such as a dependency-free, browser-based, one click, cross-platfor

107 llele of PTEN is sufficient to shift isoform dependency from p110alpha to p110beta in vivo.

108 eased miR-15a/16-1, shifting their oncogenic dependency from the BCL-2 to the ERK signaling pathway.

109 this screen, outlining the classes of cancer dependency genes and their relationships to genetic, exp

110 utations alone cannot explain the JAK1/STAT3 dependency, given that wild-type JAK1 or STAT3 was suffi

111 tein complexes we learn a sparse conditional dependency graph from approximately 3,000 CF-MS experime

112 e most prevalent in upland rivers, with flow dependency, greater age and length at maturity, isolatio

113 However, a comprehensive mapping of cancer dependencies has lagged behind and the discovery of ther

114 Exploiting this spin dependency holds promise for artificial photosynthetic s

115 those recruited from intensive care or high dependency hospital units were excluded.

116 rate was the only one predictor of dialysis dependency identified.

117 community that exhibits arbitrary inter-taxa dependencies; (ii) localize lineages on the taxonomic tr

118 selective for stable attributes by examining dependencies in motion perception.

119 Current models of dependencies in NoN inspired by the power grid express i

120 logies that encapsulate all binary and other dependencies in one convenient package.

121 While dose dependencies in pharmacokinetics and clearance are often

122 ing RNA (siRNA) screens and compared genetic dependencies in SS tumor cells with those in >130 non-SS

123 identify therapeutically actionable genetic dependencies in SS, we performed a series of parallel, h

124 sis provides tools for understanding complex dependencies in the collision probabilities of multiple

125 idue correlations and coevolutionary residue dependencies in the construction of allosteric interacti

126 (ICH) and is associated with permanent shunt dependency in a substantial proportion of patients post-

127 oth studies provided prevalence estimates of dependency in four states: high dependency (24-h care),

128 e and identify the causal miRNAs for alcohol-dependency in patients which were validated by the phase

129 atalyst that includes an inverse first-order dependency in pyridine.

130 h, then fell, possibly indicative of taurine dependency in seals, and progressive depletion of matern

131 ase (MELK) has been reported to be a genetic dependency in several cancer types.

132 e same period, suggesting some temporal/data dependency in the analysis.

133 nd the incremental risk conferred by insulin dependency in the performance of TAVR.

134 position specific information and long-range dependency in the sequence.

135 n the cell surface of neuroblastoma and is a dependency in this disease.

136 ne set, which also accounts for the temporal dependency in time-course data.

137 ring the body-fixed task, demonstrating task dependency in vestibular control of the upper limb.

138 g derivative of proline, shows relaxed eIF5A dependency, indicating that the structural rigidity of p

139 Despite dependencies inherent in the fact that nearby agents may

140 Understanding these dependencies is fundamental to assess future change in b

141 This positive serial dependency is a kind of temporal averaging that exploits

142 Specifically, the local dependency is modeled by Leroux conditional autoregressi

143 nnervation, yet the molecular nature of this dependency is unknown.

144 ical test to detect differential statistical dependencies, is one method that leverages genomic data

145 h care), medium dependency (daily care), low dependency (less than daily), and independent.

146 RES, a computational method to estimate gene-dependency levels from CRISPR-Cas9 essentiality screens

147 gion on networks with different fractions of dependency links and find that the density of final reco

148 l recovered nodes increases as the number of dependency links is increased.

149 n be decreased by increasing the fraction of dependency links or the number of initially-adopted node

150 nterdependent spatial networks with abundant dependency links, increasing the fraction of initial ado

151 In networks with a small number of dependency links, the phase transition remains second-or

152 and find that as we increase the fraction of dependency links, the phase transition switches from sec

153 We explored the dose-dependency (low, medium, high) of these interventions on

154 In our efforts to define a cancer dependency map, we performed genome-scale CRISPR-Cas9 es

155 functions at multiple scales and that causal dependencies may be best inferred with perturbation tool

156 Identifying pathways that support K-Ras dependency may define clinically relevant KRAS subgroups

157 This Ca(2+)-dependency membrane ordering was not observed with influ

158 e gained into leukemic stem cell (LSC) niche dependencies might be exploited to devise novel therapeu

159 tality (safety outcome) and 3-month death or dependency (modified Rankin Scale (mRs) >/=3;efficacy ou

160 screening to identify new classes of 'cancer dependencies' not identified by previous in vitro approa

161 To validate the in vivo relevance of genetic dependencies observed in human cell lines, we performed

162 These individual dependencies of active stress and effective viscosity de

163 othesis (5,6) predicts specific quantitative dependencies of chi on temperature, vapour pressure defi

164 mes are shorter than both tauc and taum, the dependencies of effective viscosity and steady state str

165 to be the main source of sharp polyQ length dependencies of HD.

166 The genetic dependencies of human cancers widely vary.

167 nnel data-based IP3R model, we establish the dependencies of lambda and xi on two important IP3R mode

168 ons in this lethal malignancy, the metabolic dependencies of obesity-associated PDA remain unknown.

169 embrane by extrapolating the linearized time dependencies of selectivity coefficients determined by t

170 The dependencies of temperature target overshoot's propertie

171 n RSA, the unequal variances and statistical dependencies of the dissimilarity estimates need to be t

172 rofluidic channels to resolve the positional dependencies of the resistive pulses.

173 Dependencies of thermal conductivity coefficient of coat

174 e hERG channel and show stronger reverse use dependency of action potential prolongation.

175 inetic parameters, and observe an increasing dependency of activation energy on the reaction progress

176 not account for the experimentally observed dependency of angiogenic network evolution on growth-ind

177 wever, because of the complexity and context dependency of both pathways, little is known about HH an

178 These findings reveal the dependency of bread production on the unsustainable use

179 Most notably, our analysis reveals the co-dependency of BRG1 and CHD7 at distal regions on regulat

180 nd first step towards eliminating the ribose dependency of Cas9 to develop a XNA-programmable endonuc

181 the inter-trial intervals (ITI), and history dependency of choice is affected by PPC inactivation dur

182 and PPC inactivation diminishes the history dependency of choice.

183 tures provides better insight on temperature dependency of diffusivity.

184 ties on non-Fickian transport and saturation-dependency of dispersion are discussed, which highlight

185 can produce large changes in the wavelength-dependency of epi-generated SHG.

186 These results suggest that the environmental dependency of epistasis can profoundly influence the res

187 rrent and by positively shifting the voltage dependency of gating.

188 Hence, the dependency of gbM on a CMT most likely extends to all an

189 conducted to validate and determine the dose-dependency of identified modulators.

190 lls, induced a positive shift in the voltage dependency of K(+) current activation, and slowed its ki

191 nsor platform simultaneously exploits the pH dependency of liquid-gated graphene-based transistors an

192 These results confirm widespread dependency of masting on temperature and lend robustness

193 ux conditional autoregressive structure; the dependency of methylation changes is modeled by a discre

194 ies of multisensory integration, such as the dependency of multisensory products on the temporal alig

195 The strong age dependency of neonatal systemic infection with Escherich

196 litative and quantitative description of the dependency of OCTA on thresholding level.

197 eements between orthology calls, the context dependency of orthology definitions, special challenges

198 The negative impact of OM on the SL dependency of pCa50, c, and ktr was also observed in 3.0

199 long SL, suggesting that OM abolished the SL dependency of pCa50.

200 The specific dependency of PDA on ARG2 rather than the principal hepa

201 This sensitivity can be explained by the dependency of pol delta mutants on Chk1 activation for s

202 g the minimal-depth concept, and the partial dependency of predicted risk on the continuous variables

203 Furthermore, the SL dependency of rate constants of cross-bridge distortion

204 ntain episodic-like accuracy and hippocampus dependency of remote memory.

205 The dependency of self-reported sensations of satiation on t

206 From validating the CI-MPR dependency of SNX1/2-SNX5/6 tubular profile formation, w

207 ast, we reveal pronounced differences in the dependency of TF activity on chromatin and classify TFs

208 PS measurements, the frequency and amplitude dependency of the cell stiffness is investigated and sta

209 In further experiments, the dependency of the development of irreversible lesions on

210 different array geometries revealed a strong dependency of the image quality on the source location p

211 Analysis of the tilt-angle dependency of the intensities associated with atomic-res

212 ower HER activity, indicating a strong boron-dependency of these borides for the HER.

213 rs, to HeV spillovers to explore the spatial dependency of this zoonosis.

214 provides novel insights into the saturation-dependency of transport and mixing in porous media.

215 ith p53-null cancer cells, the mechanism for dependency of tumor growth on mutant p53 is unknown.

216 We derive the dependency of wintertime runoff on this warming effect i

217 typic subgroups characterized by exploitable dependencies on BCR, mTOR, or MEK signaling and associat

218 Calibration equations did not capture dependencies on body mass index.

219 osome-mediated RNA decay, albeit with unique dependencies on elements within the nuclear exosome.

220 The dependencies on energy state and [ADP] near the threshol

221 rates for these processes followed expected dependencies on Mn(II) concentration and temperature, bu

222 herapeutic opportunities by targeting tumour dependencies on NMD-elicit mutations.

223 utually exclusive properties due to opposing dependencies on spin-orbit interactions.

224 trix proteins display surprisingly different dependencies on the Deltapsi.

225 s nanoplatelet formation as well as observed dependencies on time and temperature.

226 osteosarcomas and other cancers that exhibit dependencies on translation stress response.

227 enhanced adherence properties, and increased dependency on adhesion for viability in vitro Overall, o

228 ctin-degrading phenotype, we demonstrate its dependency on an extracellular bacterium housed in speci

229 The exquisite dependency on CRAF kinase in KRAS mutant tumors has been

230 of histones and the major phosphatase PP2A, dependency on cysteine, and sensitivity to oxidative str

231 se or human cancer cells, leads to increased dependency on exogenous glutamine through increased cons

232 ified neuroblastoma and found a preferential dependency on genes encoding the polycomb repressive com

233 Dependency on GPX4 was found to exist across diverse the

234 e demonstrate that persister cells acquire a dependency on GPX4.

235 ion of transplant tolerance to eliminate the dependency on immunosuppression is ideal, but remains ch

236 We show that functional dependency on K-Ras and PKCdelta co-segregate, and that

237 Finally, our data also suggest that T-cell dependency on Kv1.3 or KCa3.1 might be irreversibly modu

238 power of bioinformatic work is shaped by its dependency on life science work, which combined with the

239 Marked dependency on linker length was observed for BET-degradi

240 house-gas emissions, and decrease the energy dependency on oil sources.

241 previous studies to reduce exacerbations and dependency on oral corticosteroids compared with placebo

242 end has been completely redesigned to reduce dependency on outdated browser technologies, and the dat

243 This lipid metabolism creates a dependency on pathways converging on the phospholipid gl

244 ding led us to propose general mechanisms of dependency on plastid organelles in eukaryotes that have

245 ed as K-Ras-dependent or -independent for co-dependency on protein kinase C delta (PKCdelta).

246 mutated bladder cancer model alleviates the dependency on STAG1.

247 MC-SSS showed a slight dependency on the mu-map used, with a difference of 2% o

248 The dependency on the polycomb repressive complex (PRC2) and

249 in this study, do not replicate the observed dependency on the relative positions of functional group

250 Findings also suggest that there is no dependency on the surrogate L chain, and thus the authen

251 ated factors as MLL fusion partners belies a dependency on transcription control.

252 , suggesting that CRPC possesses an enhanced dependency on TRX1.

253 ermethylation of the UBB ubiquitin gene to a dependency on UBC.

254 were hemodynamic instability, hypoxemia, and dependency on venovenous extracorporeal membrane oxygena

255 after ESS were pre-operative corticosteroid dependency (P = 0.011) and change in total SNOT-22 score

256 to "general vision," "distance activities," "dependency," "peripheral vision," "self-image," "daily l

257 ence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic

258 ho values and of their field and temperature dependencies provides evidence of motions on at least tw

259 tion using a disparate dataset that also has dependencies: real-world prediction precision for the gl

260 Dependency relationships between transcription factors w

261 NA screens in 17 AML cell lines and analyzed dependencies relative to parallel screens in 199 cell li

262 teins that are being identified as key tumor dependencies represent poor pharmacological targets or l

263 The different solvent dependencies reveal that the dynamics of the allene buil

264 r an association with lower 3-month death or dependency risk compared with standard treatment (OR: 0.

265 We propose that PCNA and ATP-dependency serve as a multi-layered regulatory mechanism

266 Meta-analyses on shunt dependency showed an absolute risk reduction of 24% for

267 iscoveries into the clinic including context dependency, signalling plasticity, and tumour heterogene

268 in can calculate contrastive and integrative dependencies simultaneously from recent stimulus history

269 nds for social care, the proportions in each dependency state (by age group and sex) were applied to

270 Years in each dependency state were calculated by Sullivan's method.

271 e aimed to estimate years lived in different dependency states at age 65 years in 1991 and 2011, and

272 Little is known about how the proportions of dependency states have changed between generational coho

273 This shift in voltage dependency strongly and specifically bypasses the behavi

274 ng model for syntactic structure is enriched dependency structure, as in Word Grammar.

275 nce of water availability in driving context dependency suggests that as water limitation increases u

276 tated in human cancers leading to epigenetic dependencies that are therapeutically targetable.

277 le kinetics, chemosensitivity, and molecular dependencies that may be exploited to potentiate treatme

278 forebrain cholinergic neurons decreases the dependency that is commonly observed between signal and

279 d by the visual system through global serial dependencies: the appearance of scene gist is sequential

280 eavage confounds such measurement of genetic dependency, thereby leading to false-positive results in

281 a small package that requires minimal python dependencies to function.

282 y applied resistance included the power-time dependencies under flow cell conditions, the sensors per

283 bidity (22% vs 39%, P = 0.001), shorter High Dependency Unit (2 vs. 6 days, P = 0.001), and total hos

284 s in an intensive care unit (ICU) and a high-dependency unit (HDU) where standard infection control m

285 its in octogenarians except for a lower High Dependency Unit stay.

286 onvective layers of stars and have a complex dependency upon stellar rotation rate.

287 We bound the strength of these dependencies using local mixing properties of the underl

288 Dialysis dependency was more frequent among survivors 80 years ol

289 An administered volume dependency was observed with a 15-mL volume, resulting i

290 Transfusion dependency was the only clinical variable associated wit

291 To systematically identify cancer dependencies, we analyzed 501 genome-scale loss-of-funct

292 To systematically characterize AML's genetic dependencies, we conducted genome-scale short hairpin RN

293 nd post acute kidney injury chronic dialysis dependency were assessed at hospital discharge according

294 d be stratified according to their oncogenic dependencies when treated with PI3K and AKT inhibitors.

295 therapy is associated with risks, including dependency, which may take only a few weeks to develop.

296 del that partially accounts for this context dependency while preserving independence of sites during

297 gly, our data showed a cubic-like pattern of dependencies with positive and negative components.

298 tterns known from cell survival studies, LET-dependencies with pronounced maxima around 100-200 keV/m

299 gnostic test characteristics, including time dependency with increasing follow-up time.

300 ed significant change in genetic statistical dependencies within annotated pathways between drug sens