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1 ent status (never, currently, and previously deployed).
2 re costly, not versatile or are difficult to deploy.
3 so sensitive to how the other's attention is deployed.
4 s that estimate how that technology might be deployed.
5 s need to be discovered, employed and widely deployed.
6                               The experiment deployed 17 Argo floats in an anticyclonic eddy (AC) wit
7     In January 2012, April 2013 and 2014, we deployed 34 popup satellite archival tags on sailfish in
8 98 assigned to intervention had cell salvage deployed (50.8% had salvaged blood returned; mean 259.9
9              Data from a deep sediment trap, deployed 7.4 km SW of the well between August 2010 and O
10 itis elegans, the AWC neurons are thought to deploy a cGMP signaling cascade in the detection of and
11                                   Herein, we deploy a genetic system to starve cells of an essential
12 cell with dozens of diguanylate cyclases can deploy a given subset of them to produce a desired pheno
13 vent this response, phytopathogenic bacteria deploy a repertoire of effector proteins to perturb immu
14 sed the statistical outcomes from testing to deploy a semi-automatic workflow able to classify and la
15 nce of factors before determining whether to deploy a service member, creating a nonignorable exposur
16                          To address this, we deploy a three-tiered transcriptomic meta-analysis that
17                             To test this, we deployed a cell-mixing approach to evaluate the contribu
18                                           We deployed a submersible, animal-borne electrocardiograph-
19     We report on recent experimental results deploying a continuous cryogenic hydrogen jet as a debri
20                                           By deploying a genetic screen for suppressors of cell death
21 zed, the variables involved in designing and deploying a genomic testing program for cancer can be re
22  describe their experience of developing and deploying a large-scale rabies surveillance system based
23  and metabolic pathways), and developing and deploying a modern interface.
24                                           By deploying a multi-cation binary electrolyte in concert w
25                                              Deploying a range of computational tools, we obtain four
26                   The STS programme annually deploys a grid of 60,000-100,000 pheromone-baited traps,
27 of Cell Host & Microbe, show that Legionella deploys a novel form of ubiquitylation to generate its r
28  that, at least in certain legumes, the host deploys a number of antimicrobial peptides, called nodul
29 tbreak, it is therefore vital to develop and deploy accurate diagnostic tests that can determine whet
30 ome of a single plant to the plant varieties deployed across a region.
31 sting that pathway-targeted therapies can be deployed across diverse cancers.
32 and estimated the effects of the most widely-deployed ACT, artemether-lumefantrine (AL), relative to
33 nology offers unprecedented opportunities to deploy advanced implantable monitoring systems that elim
34 le, safe, and effective platform that can be deployed against a broad range of tumors.
35 nsible platform for developers to create and deploy all-new visualizations of genomic data.
36                 Insects and plants primarily deploy AMPs as an antibiotic to protect against potentia
37  Wirion Embolic Protection System is used to deploy an independent distal filter using any 0.014'' gu
38                                           We deployed an animal-borne camera on gentoo penguins (Pygo
39                                           We deployed an efficient framework for partitioning complex
40                                      We have deployed an efficient secondary electrospray ionization
41                                           We deployed an in vitro co-culture system based on direct c
42                                              Deploying an approach in Saccharomyces cerevisiae that s
43 tiologic agent of African Sleeping Sickness, deploys an RNA pol II that contains a non-canonical CTD
44 ticipants, of whom 18 (15%) were potentially deployed and 102 (85%) were non-deployed, to receive hig
45 imum packages vary when control measures are deployed and assessed at national, subnational first adm
46 astes--both established and novel--should be deployed and integrated (or not) to meet the requirement
47 a physical presence in Syria, either through deployed and locally employed staff, were asked to parti
48 line covariates for the 2 comparison groups (deployed and nondeployed), followed by a variable-orient
49                    Fc-SEMSs were successfuly deployed and removed in all of the cases.
50           All stent-grafts were successfully deployed, and endoleaks were clearly depicted in the las
51                   Skin and mucosal epithelia deploy antimicrobial peptides (AMPs) to eliminate harmfu
52                                              Deploying antimicrobial surfaces in hospital wards could
53 red in seagrass meadows [2], where fishermen deploy artificial shelters for the lobsters to supplemen
54            The FabI inhibitor, AFN-1252, was deployed as a chemical biology tool to determine whether
55 Mini-Autonomous Underwater Explorer (M-AUE), deployed as a swarm of 16 independent vehicles whose 3D
56                              P-MartCancer is deployed as a web service, alternatively available via D
57                             TiO2 is commonly deployed as an efficient energy transfer electrode in dy
58            Male circumcision is being widely deployed as an HIV prevention strategy in countries with
59                         All the services are deployed as containers and the user-facing interfaces as
60                                              Deployed as part of the Public Health England solution f
61       Enantiopure 4-formyl-beta-lactams were deployed as synthons for the diastereoselective formatio
62 antified using ion-exchange resin collectors deployed at 23 locations, over 1-6 years.
63                                Samplers were deployed at five depths covering 26-2535 m in the northe
64 Ts containing 0.3, 3, and 10 g of resin were deployed at four different coastal areas in France and a
65                 These results show EG can be deployed at specified locations throughout the sequence
66                                           If deployed at the bedside in the clinical context, such ne
67                              Mammalian cells deploy autophagy to defend their cytosol against bacteri
68 ly sulphate aerosol geoengineering should be deployed, but suggests that both detection methods could
69                   We also discuss strategies deployed by adapted microbes to manipulate these pathway
70                       Pore-forming proteins, deployed by both hosts and pathogens alike, breach this
71 ecretion system (T6SS) is a versatile weapon deployed by many bacterial species to target either host
72 inding that similar molecular strategies are deployed by symbionts and pathogens to dampen immune res
73 o GTPase signaling pathway (T48/Fog) that is deployed by the developmental regulatory genes twist and
74                           The CdiA-CT(EC536) deployed by uropathogenic Escherichia coli 536 (EC536) i
75               The tetrapods were efficiently deployed by wedging them in reef crevices, in 1.5 to 7%
76 ing new guidance for PPE, a rapid system for deploying CDC staff to assist hospitals ("Ebola Response
77 0) in the acute to subacute stage and combat-deployed control individuals (n = 44) in Afghanistan or
78 ations, in contrast with only 5 of 44 combat-deployed controls (11%).
79 th concussive blast TBI compared with combat-deployed controls, whereas performance on cognitive meas
80                                           We deploy cooperation theory and a novel synthetic system i
81                             Moreover, merely deploying covert attention within the same temporal inte
82                                     Here, we deploy CRISPR/Cas9 technology to demonstrate a variety o
83 empt suicide with a firearm than those never deployed (currently deployed: OR, 4.0; 95% CI, 2.9-5.6;
84           These data showed that the rapidly deployed CX3CR1(+) cell-based mechanism of immune exclus
85 mind if society is to make rapid progress in deploying DAC as a means of mitigating climate change.
86 pathogens indicates that microbial pathogens deploy deamidases or enzyme-deficient homologues (pseudo
87 n be improved using chemogenetic approach by deploying designer receptors exclusively activated by de
88 pes, are one of the most powerful and widely deployed diagnostics for these studies.
89 isk was correctly identified, the mitigation deployed did not avert the risk.
90 e, engage in diverse trophic lifestyles, and deploy different infection strategies.
91                                       Plants deploy distinct secondary metabolisms to cope with envir
92                      Here we report that Hfq deploys dual mechanisms to control mutS expression.
93 s and processes that may differ from what is deployed during online language processing.
94   With this improvement comes the ability to deploy E-AB sensors directly in situ in the veins of liv
95 on the nature of the transgenic manipulation deployed (e.g., whether vector population reduction or r
96                               Pathogens also deploy effectors in a spatial and temporal manner, depen
97              We also describe the process of deploying ePlant as an "app" on Araport.
98  of gout diagnosis, reduce costs, and can be deployed even at the point-of-care and in resource-limit
99 rected behavior, but can also be costly when deployed excessively, necessitating a mechanism that reg
100 cross the visual field (foveated vision) and deploy eye movements to actively sample regions of inter
101                                              Deploying FABP and MPO specific scFvs as receptor molecu
102         Between 2005 and 2013, the number of deployed facility and community-based health-care profes
103 uctured N-terminal tail (NTT) of yeast eIF1A deploys five basic residues to contact tRNAi, mRNA, or 1
104 d test supported "3omega" sensors on in vivo deployed focal therapy probe surfaces (i.e. balloons or
105 g field testing, the sensor was continuously deployed for 9 weeks in a chalk stream, revealing comple
106 These artificial muscles might eventually be deployed for a host of applications, from robotics to pe
107 is new device concept is scalable and easily deployed for a range of modular alternating-current-powe
108  or relative quantification, but can also be deployed for absolute quantification if appropriate cali
109 actor S-adenosyl methionine have been widely deployed for alkyl-diversification and bioorthogonal lab
110 nd serve as models for uncovering strategies deployed for allosteric signal transduction.
111 te dehydrogenase (PfLDH) antigens are widely deployed for detection of P. falciparum infection; howev
112 s imaging probe of just 30 nm in size can be deployed for direct electrochemical and topographical im
113 und technologies have only been designed and deployed for short-stature crops.
114 rst demonstrated, the method has been widely deployed for targeted lipid structure elucidation but it
115                       Combination therapy is deployed for the treatment of multidrug-resistant Acinet
116 e confidence ratings, it must be voluntarily deployed for this increase to take place.
117                        Passive samplers were deployed for week-long intervals in triplicate and coloc
118 previous three quarters; 1.14 [1.06-1.23] if deployed four or more quarters ago).
119    XAD-resin-based passive air samplers were deployed from May to September 2011 at six sites along a
120                                     Here, we deployed genome-scale CRISPR-Cas9 screening of MYCN-ampl
121 ions, highlighting studies that have already deployed GEVIs for biological discovery.
122 es and placebo, but were pooled with the non-deployed group to compare immunogenicity.
123 e Runx3-CBFbeta transcription factor complex deployed H3K27me3 to Bcl6 and Tcf7 genes to suppress the
124 Compared with service members who were never deployed, hazard rates of suicide (which represent the p
125 ious quarter) were lower among the currently deployed (HR 0.50, 95% CI 0.40-0.61) but significantly h
126  substituted by murine counterparts, here we deploy human-specific expression profiling of CRC PDXs t
127 id, and protein cargo signals in the cell to deploy in a site-specific manner.
128 eloping specific chemical functionalities to deploy in biological environments for targeted enzyme in
129 d even nanoparticles, which are difficult to deploy in harsh reservoir conditions and where failures
130 were engaged, of whom 92% were strategically deployed in 11 states classified as high risk on the bas
131 ting with classic pulmonary TB symptoms were deployed in 3 provinces of China in July 2015.
132            Oral cholera vaccination could be deployed in a diverse range of situations from cholera-e
133 stimation of LSM and CAP can be successfully deployed in a multicenter setting with low failure (3.2%
134 al health impacts, passive air samplers were deployed in a rural community heavily affected by the na
135 multiplexed, dual purpose standards, readily deployed in a single workflow, supporting seamless quant
136                                    A vaccine deployed in areas of high prevalence might reduce the in
137 -based emergency mapping is most intensively deployed in Asia and Europe and follows well the geograp
138 ed that public TCRbeta may be preferentially deployed in autoimmunity.
139                         Fathead minnows were deployed in cages for 2, 4, or 8 days at three locations
140 ered skin equivalents have been successfully deployed in clinical applications, and skin epidermal st
141 dopants have been developed and successfully deployed in devices in the past decade, air-stable molec
142 ying how substituted [3]dendralenes could be deployed in diversity-oriented synthesis with high selec
143 domisation lists for individuals potentially deployed in endemic areas and those not deployed, to rec
144           Surface elevation change pins were deployed in four locations, Scotland, Kenya, Tanzania an
145 mory can strongly influence how attention is deployed in future encounters.
146      Our affordable device ( euro200) can be deployed in growth chambers or greenhouse to acquire opt
147                    The application was first deployed in Guinea, when the West Africa Ebola epidemic
148  doses are limited, these would be optimally deployed in highly populated urban centers and in high-p
149 uggest that RNase A-like toxins are commonly deployed in inter-bacterial competition.
150 ncluded in the study were 601892 US veterans deployed in Iraq or Afghanistan who separated from the m
151 s a major CMD resistance locus that has been deployed in many cassava cultivars through large-scale b
152               The MVH tool could be feasibly deployed in many conflict areas.
153 oughput settings using instruments currently deployed in NBS laboratories.
154 ect sensors (Microsoft, Beijing, China) were deployed in one ICU room to collect continuous patient m
155 ectrometry (imaging) has become increasingly deployed in preclinical and clinical research due to its
156  primarily on murine models, that are widely deployed in preclinical breast cancer research.
157  short periodic shaking of a passive sampler deployed in static sediment enhances the rate of mass tr
158 and attempted suicide among 273,591 veterans deployed in support of Operation Enduring Freedom, Opera
159 usion An absorbable IVC filter can be safely deployed in swine and resorbs gradually over the 32-week
160             Innovative molecular diagnostics deployed in the clinic enable new ways to stratify patie
161 cal challenges to be solved before it can be deployed in the competitive fuel market.
162 urrents and poor signal-to-noise ratios when deployed in the complex, fluctuating environments found
163  demonstrate that the TFN can be conformally deployed in the curved blood vessel of a swine model wit
164 s process relies on signals spatiotemporally deployed in the extra-embryonic tissues that locate the
165 ing first deployment (HR 1.51 [1.17-1.96] if deployed in the previous three quarters; 1.14 [1.06-1.23
166 standing of how these spatial regulators are deployed in the proper temporal order, however, has rema
167  urgency for understanding how each could be deployed in the real world and the potential impacts of
168 wever, from often-severe baseline drift when deployed in undiluted whole blood either in vitro or in
169          The developed passive samplers were deployed in wastewater-dominated reaches of the Grand Ri
170 to most stem rust resistance genes currently deployed in wheat and poses a threat to global wheat pro
171                          Such substrates are deployed in, for example, integrated circuits for synthe
172 in (SF) concentrations are the most commonly deployed indicator for determining ID, and low SF concen
173  may last 5 years while the two insecticides deployed individually may last 3 and 4 years giving an o
174  indoors and polypropylene deposition plates deployed indoors.
175                               Feasibility of deploying inhaler sensors to identify the impacts of env
176                                    The diver-deployed instrument permits studies of both spatial and
177 ng orthopedic surgery where a bone graft was deployed intraoperatively.
178     As decomposers or plant pathogens, fungi deploy invasive growth and powerful carbohydrate active
179                                  Endothelial-deployed jagged-2 triggered Notch2/Hey1, while tempering
180                              CDI(+) bacteria deploy large CdiA effector proteins, which carry variabl
181 ofection, a non-viral gene transfer approach deploying magnetic nanoparticles and DNA with magnetic f
182 agents, the equipment not being installed or deployed, maintenance, and staff training requirements.
183  and discuss some general considerations for deploying mass cytometry in the context of vaccine devel
184 he peptide-loading machinery and the ERC for deploying MHC-I molecules that alert CD8 T cells of infe
185 f blood transfusion capability after 2012 to deployed military medical evacuation (MEDEVAC) units ena
186 nfection at accession among younger recently deployed military personnel born after 1965 was 0.98/100
187 mine the trajectories of PTSD symptoms among deployed military personnel with and without combat expo
188 a, will be critical to determine how best to deploy MRD testing in routine practice and whether MRD a
189 s demonstrate how the synergistic effects of deploying multiple chemical mitigation strategies couple
190        Maciej F. Boni and colleagues propose deploying multiple first-line combination therapies agai
191 0.4% of enlisted soldiers who had never been deployed (n = 12421294 person-months) accounted for 61.1
192 reasingly have immunotherapy as the control, deploy new biomarker-enrichment strategies, and likely e
193                              Configuring and deploying new Hadoop clusters can be done in minutes.
194 cably intertwined with perception, and it is deployed not only to spatial regions, but also to sensor
195      Little is known about why organizations deploy NPs differently.
196 69 to 3349 m) of the NEMO Phase 2 prototype, deployed offshore Capo Passero (Sicily) at the KM3NeT-It
197 s by digital acoustic recording tags (DTAGs) deployed on 20 individual whales off Cape Hatteras, Nort
198                  Seventy satellite tags were deployed on basking sharks over four years (2012-2015) o
199 Management System (LIMS) which can be easily deployed on local servers for any genome research labora
200                            This tool is then deployed on novel experimental data as a proof of concep
201 e change in signal upon target binding) when deployed on these shrink electrodes.
202 he newly developed software, called rTLC, is deployed online, and instructions for direct use as a we
203 ch BioResource Rare-Diseases, in particular, deploying open-source for Computational Biology (OpenCB)
204       The objective of the DDM was to timely deploy operational funds at the field level and directly
205                                  A new study deploys optogenetics to induce the yeast bud on demand,
206 ployed: OR, 3.4; 95% CI, 3.0-4.0; previously deployed: OR, 1.5; 95% CI, 1.4-1.7; and never deployed:
207 in their first 2 years of service (currently deployed: OR, 1.9; 95% CI, 1.5-2.3; previously deployed:
208 oyed: OR, 22.2; 95% CI, 20.1-24.4; and never deployed: OR, 15.0; 95% CI, 14.2-16.0).
209 ployed: OR, 1.9; 95% CI, 1.5-2.3; previously deployed: OR, 2.2; 95% CI, 1.9-2.7; and never deployed:
210 eployed: OR, 1.5; 95% CI, 1.4-1.7; and never deployed: OR, 2.4; 95% CI, 2.3-2.6), in their first 2 ye
211 ployed: OR, 4.0; 95% CI, 2.9-5.6; previously deployed: OR, 2.7; 95% CI, 1.8-3.9).
212 yed: OR, 29.8; 95% CI, 25.0-35.5; previously deployed: OR, 22.2; 95% CI, 20.1-24.4; and never deploye
213 h diagnosis in the previous month (currently deployed: OR, 29.8; 95% CI, 25.0-35.5; previously deploy
214 eployed: OR, 2.2; 95% CI, 1.9-2.7; and never deployed: OR, 3.1; 95% CI, 2.7-3.6), and had a recently
215 ely among soldiers who were women (currently deployed: OR, 3.4; 95% CI, 3.0-4.0; previously deployed:
216 firearm than those never deployed (currently deployed: OR, 4.0; 95% CI, 2.9-5.6; previously deployed:
217 he approach to treatment of cattle sheds, or deploying other tactics that target zoophilic behavior.
218 luded polyurethane foam passive air samplers deployed outdoors and indoors and polypropylene depositi
219                                              Deployed participants were allocated to only the vaccine
220 ty evaluation was not masked for potentially deployed participants, who were therefore not included i
221 lacement, but other mechanisms could also be deployed, particularly in situations of high stress.
222                                          The deployed pellet is then discarded to regain the fresh ba
223 oronary intervention with 2.7 +/- 2.0 stents deployed per patient.
224   There is pressing need for a tool that can deploy population structure analysis on high performance
225 ng for the potential delay in the effects of deploying public health strategies on long-term disease
226 lete transmurality and contiguity within the deployed radiofrequency circle.
227  both lesion depth and contiguity within the deployed radiofrequency circle.
228                                      Here we deployed rapid genome-wide physical maps combined with h
229 es to develop recommendations to effectively deploy registered nurses in primary care needed to assur
230 95% CI, 46.4%-49.1%) and Afghanistan mission-deployed Reserve Forces (49.4%; 95% CI, 46.3%-51.5%) com
231                              Existing widely deployed resistance to G. rostochiensis is an important
232                         For those previously deployed, risk was highest at 5 months after return (40
233                                           We deployed RNA nanoparticle technology to create a vaccine
234                                       Plants deploy salicylic acid (SA)-mediated defences against bio
235                                  Finally, we deployed SANDPUMA in a systematic investigation of 7635
236                                           We deploy SELFA secretomics to predict the inflammatory pot
237                                   All of the deployed separation methods rely on thermodynamic proper
238 Clavulanic acid and avibactam are clinically deployed serine beta-lactamase inhibitors, important as
239              Across all trajectories, combat-deployed service members diverged from non-combat-deploy
240 yed service members diverged from non-combat-deployed service members, even after a single deployment
241                          We show that humans deploy several mechanisms to limit expression of functio
242 rganic chemical integrative samplers (POCIS) deployed simultaneously.
243                     Currently and previously deployed soldiers were more likely to attempt suicide wi
244 gement of illness, across organisations that deploy staff to outbreaks.
245    The complex three-dimensional geometry of deployed stents together with the combination of diffusi
246   Because this approach will be difficult to deploy, strategies for secondary prevention aimed at lat
247                                           We deployed SUMs in an effectiveness study of 6 ICSs in 45
248 elated behaviors identified using clinically deployed surveys may hold value for public health survei
249                               Developing and deploying systems of care that address barriers related
250  designs, targeting tumor heterogeneity, and deploying technologies beyond DNA sequencing, among othe
251 for survival, while mesenchymal cancer cells deploy the PI3K-independent mTORC2-AKT axis in response
252 ors and the number of angiograms required to deploy the stent graft, thereby reducing delays.
253                                           We deployed the DNA-encapsulated QDs for real-time imaging
254 in laser-forward direction are observed when deploying the planar jet as compared to the cylindrical
255                        The hepatitis B virus deploys the hepatitis B virus X protein (HBx) as a suppr
256 i et al. (2016) reveal how mTORC1 activation deploys the ribosomal serine/threonine kinase S6K1 and P
257 es are specialized secretory organelles that deploy their contents at the apical tip of apicomplexan
258 s and diagnostics rather than developing and deploying them separately.
259                                      We then deploy these techniques to identify previously immeasura
260                                           We deploy this approach to show that the binding of cGMP to
261 s, demonstrating that it will be possible to deploy this strategy in large urban areas.
262 eat reactions, whereas CBT may target slowly deployed threat responses.
263                     We developed, tested and deployed three solutions.
264       Once their virtual machine instance is deployed through iPlant's Atmosphere cloud services, use
265 plex flow patterns, our study indicates that deployed THV geometry may have implications on the occur
266 er and how spatial management actions can be deployed to ameliorate future impacts.
267              Second, the patient models were deployed to assess the patient-specific organ dose as a
268                    Three separate lenses are deployed to correct the defocus and astigmatism.
269 or platform technologies that can be quickly deployed to develop therapeutics needed to contain the o
270 A hyperactive PB (hyPB) transposase was then deployed to enable transposition of the large-size PB tr
271              Advanced cooling systems can be deployed to enhance the resilience of thermoelectric pow
272 ed with amyloid pathology but have also been deployed to forecast the clinical course.
273 s in incidence, but how these methods can be deployed to have the best effect on the heterogeneous la
274 itary veterans (89.3% male; 71.4% white) who deployed to Iraq, Afghanistan, or both.
275 etic replacements for IVIG therapy, which is deployed to manage many diseases and conditions but is e
276 erence laboratories, and it could be readily deployed to national and subnational laboratories on a w
277 ple of Florida National Guard members (1,443 deployed to Operation Enduring Freedom/Operation Iraqi F
278 here the different ACTs could be selectively deployed to optimize treatment based on regional differe
279       A Delphi method involving 3 stages was deployed to refine a list of HCT outcomes.
280                                    Personnel deployed to remote areas during infectious disease outbr
281 hat the language of ethics can fruitfully be deployed to shed new light on policies that have repercu
282 owever, until now this approach has not been deployed to study large cohorts of unrelated participant
283                           The instrument was deployed to support canine training in the field, detect
284                         RNA-seq approach was deployed to understand the host-pathogen interaction by
285 ally deployed in endemic areas and those not deployed, to receive a single intramuscular dose of high
286  potentially deployed and 102 (85%) were non-deployed, to receive high-dose vaccine (n=49), low-dose
287 tion through a disruption of contralaterally deployed top-down attention.
288 s of semiochemical stimuli paired with field-deployed traps in Europe (Greece, Hungary, Italy, and Sw
289                                           We deployed two levels of bladderwort presence (functional
290 espiratory pathogen Streptococcus pneumoniae deploys type IV pili to take up DNA during transformatio
291 ance and micro-architectural stability while deployed under long-term mechanical strain.
292  Our work will further efforts to define and deploy useful microbes to enhance plant performance.
293 y highlights the necessity of validating and deploying vector control measures targeting outdoor expo
294  filters made from polydioxanone suture were deployed via a catheter in the IVC of 11 swine.
295 alized on kleptoparasitic fly pollinators by deploying volatiles linked to the flies' food source, i.
296 e Marines (66,286 deployers and 42,644 never deployed) were followed for 467,857 person-years of acti
297 reedom/Operation Iraqi Freedom and 1,655 not deployed) who completed an online survey during the peri
298                           This method can be deployed with as low as 10 nM enzyme to determine activi
299 construct size versus conventional plasmids) deployed with magnetofection achieve the highest, safe n
300  Three different statistical approaches were deployed with male age considered both as a categorical

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