ライフサイエンスコーパス: depolarization

1 in excitable cells following plasma membrane depolarization.

2 s to K(+)-mediated mitochondrial bulging and depolarization.

3 ion, but not elimination, of the TA-mediated depolarization.

4 he latency of action potentials triggered by depolarization.

5 +) and Na(+) through TRPV4 channels to evoke depolarization.

6 t increased intracellular Ca(2+) with robust depolarization.

7 calcium-current traces elicited by membrane depolarization.

8 xaggerate the passive propagation of somatic depolarization.

9 not directly affect BK, but activated BK via depolarization.

10 to 1, while its Rayleigh scattering has zero depolarization.

11 PINK1 in cells independent of mitochondrial depolarization.

12 itially coincident with action potentials or depolarization.

13 e antibody uptake occurred at rest or during depolarization.

14 clooxygenase-2 in the cortex after spreading depolarization.

15 nduction, growth arrest, and plasma membrane depolarization.

16 o voltage sensor stabilization upon membrane depolarization.

17 t, allowing neurons to extend their level of depolarization.

18 chanisms of both abnormal repolarization and depolarization.

19 a process that was preceded by mitochondrial depolarization.

20 action induced membrane permeabilization and depolarization.

21 duced PH and correlated with plasma-membrane depolarization.

22 honon-assisted intervalley scattering causes depolarization.

23 be altered in acetaminophen-induced hepatic depolarization.

24 resent a typical light-sensitive current and depolarization.

25 apping that captures supra- and subthreshold depolarization.

26 polarization is a wave of neuronal and glial depolarization.

27 racellular Ca(2+) equilibrium, and caused Vm depolarization.

28 ablation of the P2x7 gene inhibits spreading depolarization.

29 were mostly closed at rest and activated by depolarization.

30 sensory neurons released GABA in response to depolarization.

31 h and its modulation by subthreshold somatic depolarization.

32 orphology, and cause membrane permeation and depolarization.

33 creased coupling and allowed Ca wave-induced depolarizations.

34 g away from the ganglion activated at weaker depolarizations.

35 rough LVA channels following GABAAR-mediated depolarizations.

36 significantly more likely to have spreading depolarizations (6/7 and 10/12, respectively) than those

37 ques, including a unique model that assesses depolarization (a marker of sensory nerve activation) of

38 to increase mEJP rate in response to spaced depolarization, a type of activity-dependent plasticity

39 ral RV progression was associated with prior depolarization abnormalities, whereas LV progression is

40 lar toxicity and vasoconstrictive effects of depolarizations act in synergy with direct ischaemic eff

41 g repetitive firing; (ii) enhanced the after-depolarization (ADP); (iii) reduced fast and medium afte

42 efficiency of the passive spread of membrane depolarization along TATS.

43 transport and dumps the transport-associated depolarization along the astrocyte processes.

44 thways are strongly induced by mitochondrial depolarization, although a direct link between loss of m

45 atory neurotransmitters to sustain spreading depolarization and activate neuroinflammation.

46 of the fluorophore SSF, ORF, and scattering depolarization and anisotropy using a combination of flu

47 efect in the early response to mitochondrial depolarization and autophagosome formation.

48 Because mitochondrial membrane depolarization and calcium are known to activate iPLA2ga

49 Depolarization and cAMP signals induce preferential tran

50 89771 exhibits a slow onset of block that is depolarization and concentration dependent, with a simil

51 aphic QRS duration, a measure of ventricular depolarization and conduction, is associated with cardio

52 ivity, corresponding to upstates of neuronal depolarization and downstates of hyperpolarization.

53 osing the conduction pathway during membrane depolarization and dynamically regulating neuronal activ

54 been implicated as modulators of spontaneous depolarization and electrical conduction that may be inv

55 Changes in plasma membrane depolarization and elevated intracellular Na(+), which c

56 day (P) 2-P15 mice, photostimulation caused depolarization and excitation of interneurons and evoked

57 ed by cyclophilin D and led to mitochondrial depolarization and fragmentation.

58 g a ubiquitous promoter resulted in cellular depolarization and ganglion cell action potential firing

59 n peroxide, contributes to cellular membrane depolarization and HPV.

60 cell body to shorten and elongate upon cell depolarization and hyperpolarization, respectively.

61 ERG currents, leading to membrane potential depolarization and increased input resistance, two criti

62 face membrane of neurons can induce membrane depolarization and initiate an action potential.

63 ed mitochondrial integrity, leading to rapid depolarization and massive CLL cell death.

64 -cell coupling in intact hearts limits local depolarization and may protect hearts from this arrhythm

65 We identify a deterministic relation between depolarization and nanoparticle concentration.

66 ction region (LIR) domain upon mitochondrial depolarization and proteasome-dependent outer membrane r

67 Apamin also slowed diastolic depolarization and reduced pacemaker rate in isolated SA

68 activation puts a ceiling on horizontal cell depolarization and regulates the temporal responsivity o

69 id, and Bax; and 3) subsequent mitochondrial depolarization and release of apoptosis-inducing factor

70 mmarizing the evidence that both the initial depolarization and repolarization phases of the cardiac

71 to sensory input stimulation with decreased depolarization and spiking following resident-intruder e

72 astatin 4 (TRPM4) channels to cause membrane depolarization and vasoconstriction.

73 etween ON periods, characterized by membrane depolarization and wake-like tonic firing, and OFF perio

74 lting in a decrease in the rate of diastolic depolarization and, consequently, the heart rate, a mech

75 ases the quantity of glutamate released upon depolarization and, in turn, limits the positive-feedbac

76 /fissures are sufficient to induce spreading depolarizations and acute infarction in adjacent cortex.

77 neurons, menthol application induced larger depolarizations and generation of APs with frequencies s

78 iation and propagation of cortical spreading depolarizations and the role of astrocytes in maintainin

79 root apex, (2) greater salt-induced membrane depolarization, and (3) a higher reactive oxygen species

80 istension, induces channel opening, membrane depolarization, and initiation of pain signaling.

81 n2(-/-) mice with the exception of a rebound depolarization, and non-mGluR-mediated long-term potenti

82 Treg cell induction in vitro, mitochondrial depolarization, and recruitment of PTEN to the immunolog

83 evate the electrical threshold for spreading depolarization, and reduce spreading depolarization freq

84 pairing mAChR stimulation with subthreshold depolarization ( approximately 10 mV from RMPs) initiate

85 capacitance changes immediately after strong depolarization are also different between control and cK

86 2, SR Ca(2+) leak and mitochondrial membrane depolarization are critically involved in the apoptotic

87 round suppression, the functions of VIP cell depolarization are not fully understood.

88 re unknown, although mass cortical spreading depolarizations are hypothesized as a requisite mechanis

89 cal spreading depression and terminal anoxic depolarization arose preferentially in the whisker barre

90 ne integrity (electroporation) and resulting depolarization as an intermediate step.

91 Results further validate spreading depolarizations as a clinical marker of early brain inju

92 ents of TRPV4-expressing Xenopus oocyte upon depolarizations as well as phenotypes of expressing yeas

93 c coupling between soma and axon, the >25 mV depolarization associated with the plateau could propaga

94 (yellow and green) that were associated with depolarization at a false discovery rate of </=0.05.

95 RPE migration was defined by the presence of depolarization at intraretinal hyperreflective foci on P

96 cripta elegans, either sex) evoked by steady depolarization at rest is replaced by irregular firing d

97 ation at the first zero-current potential to depolarization at the third zero-current potential, agai

98 tional model predicts a higher threshold for depolarization block in the variant, particularly at 40

99 The range of most M1s is limited by depolarization block, which is generally considered path

100 ents cell death from excessive mitochondrial depolarization but also activates AMPK signaling and inc

101 M1 allowed mitochondrial depolarization but blocked procaspase-9 processing, sugg

102 Vpr are highly susceptible to mitochondrial depolarization, but develop resistance following stimula

103 antagonizes norepinephrine-induced membrane depolarization by promoting potassium efflux in brown ad

104 ect was due to strong attenuation of plateau depolarizations by axonal K(+) channels, allowing full a

105 ormal Na+ conductance, resulting in membrane depolarization, calcium influx, aldosterone production,

106 regulator neurogenin3 but requires membrane depolarization, calcium influx, and calcineurin signalin

107 tinal polypeptide positive (VIP) interneuron depolarization can account for the reduction of surround

108 We report on how depolarization can be exploited as a strategy to visuali

109 tations that evoke small degrees of membrane depolarization cause hyperexcitability and familial epis

110 thy, while mutations evoking larger membrane depolarizations cause hypoexcitability and insensitivity

111 Interestingly, only depolarization caused significant changes in the relativ

112 arized radiation intensity, including linear depolarization, circular depolarization, cross-polarizat

113 er finding is that the fluorophore ORF has a depolarization close to 1, while its Rayleigh scattering

114 Spreading depolarization clusters were associated with formation o

115 polarizing potentials, but not upon membrane depolarization compared with wild-type channels.

116 (</=2.5 ng/mL), causes substantial membrane depolarization concomitant with a several-fold increase

117 n potential firing in response to subsequent depolarization, consistent with the increased intrinsic

118 cortical sulci caused clusters of spreading depolarizations (count range: 12-34) in 7/17 animals in

119 rogression of RV disease was associated with depolarization criteria at baseline (odds ratio [OR], 9.

120 y, including linear depolarization, circular depolarization, cross-polarization, directional birefrin

121 d mitochondrial fragmentation, mitochondrial depolarization, cytochrome c release, reactive oxygen sp

122 henyl hydrazone (CCCP)-induced mitochondrial depolarization decreased mitochondrial mass and Mfn2 lev

123 eotides determines a singular and very large depolarization depending on the concerted effects of ext

124 Repetitive bipolar cell depolarizations, designed to maintain the same amount of

125 Depolarization did not increase the resting open probabi

126 However, membrane depolarization did not induce an increase in intracellul

127 nd urethane anesthesia demonstrated that the depolarizations did not propagate from a subcortical sou

128 , organelle damage manifest by mitochondrial depolarization, disordered autophagy, and pathological e

129 ther, these data suggest that in response to depolarization, dopamine vesicles utilize a cascade of v

130 G protein-coupled receptor-promoted neuronal depolarization downstream of Galphaq in the mouse prefro

131 Progressive increase in step depolarization duration slowed voltage-sensor return in

132 aptide) increased coupling and suppressed Vm depolarization during Ca waves.

133 lucidate the potential functions of VIP cell depolarization during locomotion.

134 lation of dendritic sectors to prevent their depolarization during non-preferred motion, yet enables

135 We find that the subthreshold depolarization during ripples is uncorrelated with the n

136 ional structural constraint on lattice-scale depolarization dynamics; whereas Smax in relaxor and nor

137 This depolarization enabled the afferent to reliably generate

138 These somatic depolarizations enhanced somatic excitability by increas

139 ects on insulin secretion, including reduced depolarization-evoked Ca(2+)-influx and beta-cell exocyt

140 The G100V/C103V mutation nearly abolishes depolarization-evoked exocytosis (measured by membrane c

141 The reduction of depolarization-evoked exocytosis in du/du IHCs reflected

142 te normal intracellular Ca(2+) signaling and depolarization-evoked exocytosis.

143 As in muscle, depolarization evokes Ca(2+) transients independent of e

144 on itself is not voltage-sensitive, but that depolarization facilitates rapid cycling of extracellula

145 ype structures are formed that are driven by depolarization fields occurring in such systems.

146 reading depolarization, and reduce spreading depolarization frequency and amplitude.

147 onstrates backpropagation of GABAAR-mediated depolarizations from MNTB axon terminals to the soma, so

148 g firing at high rates; (ii) enhancing after-depolarizations; (iii) reducing the fast and medium afte

149 the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K(+)]

150 h mouse OHCs and HEI-OC1 cells and generated depolarization in both cell types.

151 decreased hypoxia-induced cellular membrane depolarization in Cox4i2(-/-) PASMCs compared with wild-

152 produced mitochondrial swelling and membrane depolarization in FRD-WT mice but not in FRD-S2814A mice

153 e local intercellular coupling in Ca-induced depolarization in intact hearts, using confocal microsco

154 revealed cell membrane permeabilization and depolarization in M bovis BCG.

155 e P2X7-PANX1 pore complex inhibits spreading depolarization in mice carrying the human familial hemip

156 ustic phonons, which is essential for valley depolarization in MoS2.

157 Furthermore, we found that membrane depolarization in murine heart mitochondria was sensitiz

158 The time constant of depolarization in OHCs, 1.45 ms, is 10 times faster than

159 a single Ca(2+) occupancy requires membrane depolarization in order to open (C.J.P. et al., manuscri

160 al trafficking correlated with mitochondrial depolarization in palmitate-treated DRG neurons.

161 ane potential of CA1 interneurons but caused depolarization in pyramidal cells.

162 reading depression (CSD), a wave of neuronal depolarization in the cerebral cortex following traumati

163 rgy density generated in the crystals during depolarization in the high voltage mode is four times hi

164 ng current into the myocardium and recording depolarization in the scar through optical mapping.

165 FRD produced mitochondrial membrane depolarization in WT mice but not in S2814A mice, in whi

166 clotted blood into a sulcus caused spreading depolarizations in 5/6 animals (count range: 4-20 in 6 h

167 ER was associated with a trend toward late depolarization, in general was suppressed with exercise

168 Simulated depolarization increased baseline firing rates of pyrami

169 This leads to depolarization, increased input resistance, enhanced spi

170 we defined the mechanisms by which membrane depolarization increases Ca(2+) sparks and subsequent ST

171 m in which lowering extracellular calcium or depolarization increases P(open).

172 We show that cell depolarization increases synaptic vesicle dopamine conte

173 With increased stimulation, hair cell depolarization increases the frequency of quanta release

174 As fluid flow increases, depolarization increases to activate voltage-gated Ca(2+

175 The latter would enhance depolarization-induced alkalinization of astrocytes, and

176 be, which previously allowed us to resolve a depolarization-induced Ca(2+)-dependent close-to-open tr

177 milar to those present in the SR lumen after depolarization-induced calcium release cause the dissoci

178 This potentiation of depolarization-induced calcium transients was blocked by

179 lcholine receptor (M2R) was found to exhibit depolarization-induced charge movement-associated curren

180 Remarkably, both depolarization-induced dopamine vesicle hyperacidificati

181 K(+) (Kv) channel Kv2.1 (KCNB1) facilitates depolarization-induced exocytosis in INS 832/13 cells an

182 This depolarization-induced hyperacidification is mediated by

183 ouse cortical neurons, we observed increased depolarization-induced mitochondrial calcium uptake.

184 sm of inhibitory channels and a mechanism of depolarization-induced neurite outgrowth.

185 K(+) depolarization-induced PKC translocation entirely mirror

186 tes retrograde synaptic depression including depolarization-induced suppression of excitation (DSE) a

187 CB1-mediated depolarization-induced suppression of synaptic inhibitio

188 male DRG neurons, IP3 (100 mum) potentiated depolarization-induced transients produced by extracellu

189 While strong depolarization-induced uptake of HRP suppressed evoked r

190 vealed no evidence of postinhibitory rebound depolarization inherent to coincidence models of duratio

191 t palmitate induces DRG neuron mitochondrial depolarization, inhibiting axonal mitochondrial traffick

192 oupling that reliably convert brief membrane depolarization into precisely timed intracellular signal

193 mined which neurons converted choice-related depolarization into spiking.

194 onduct ions between CMs, triggering membrane depolarization, intracellular calcium release, and actom

195 Spreading depolarization is a wave of neuronal and glial depolariz

196 We have shown that Vpr-induced mitochondrial depolarization is mediated by TNFR-associated factor-1 (

197 ormational change in the domain IV VSD after depolarization is necessary and sufficient to reveal a h

198 During long depolarizations, lacosamide slowly (over seconds) put ch

199 Myocardial depolarization leading to cardiac muscle contraction is

200 Depolarization leads to the opening of voltage-gated Na(

201 at are altered in these cells in response to depolarization (linear models at false discovery rate </

202 ce of this signalling pathway with effective depolarization may promote rapid conduction of contracti

203 sitive picosecond time-resolved fluorescence depolarization measurements that allowed us to discern t

204 C. difficile growth in vitro via a membrane depolarization mechanism.

205 nism underlying analog-digital modulation is depolarization-mediated inactivation of presynaptic Kv1-

206 a similar abrupt transition of degranulation/depolarization near sites of keratin deposition, as well

207 ion facilitates spiking by focusing synaptic depolarization near threshold for action potentials.

208 egenerative dendritic events can provide the depolarization necessary for Hebbian potentiation, these

209 leakage and may explain the gradual membrane depolarization observed with daptomycin.

210 ) channel activation indicates that membrane depolarization occurs.

211 nal complex likely is attributable to direct depolarization of acid-sensitive trigeminal nerve fibers

212 Depolarization of cultured mouse cortical neurons upregu

213 Kir2 antagonist caused depolarization of freshly dispersed ICC and colonic smoo

214 emonstrated that chemogenetic or optogenetic depolarization of GABAergic dorsal root ganglion neurons

215 an SB-705498 at inhibiting capsaicin-induced depolarization of guinea pig and human isolated vagus ne

216 DEP-OE) and not the cleaned particles evoked depolarization of guinea pig and human vagus, and this w

217 steocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons.

218 Under current clamp, ML-133 caused the depolarization of isolated ICC and also that of cells im

219 Absence of EDH with effective depolarization of LECs may promote the rapid conduction

220 Depolarization of MECII impaired spatial memory and elic

221 V4 ligands and hypo-osmotic solutions caused depolarization of murine, guinea pig, and human vagus an

222 on (SD) is a slow propagating wave of strong depolarization of neural cells, implicated in several ne

223 als was observed together with the prolonged depolarization of neurons induced by pharmacological man

224 n response to odors, triggering long lasting depolarization of olfactory glomeruli.

225 etinal photoreceptors, and the b-wave is the depolarization of ON-bipolar cells.

226 The process is associated with depolarization of paternal mitochondria and additionally

227 blockade slows repolarization and subsequent depolarization of SAN cells.

228 This is driven in part by depolarization of senescent cell plasma membrane, which

229 The method may be used to detect membrane depolarization of sympathetic nerve fibres in human pati

230 h a transient, fast block established by the depolarization of the egg membrane within milliseconds a

231 functional role of BKCa current in limiting depolarization of the horizontal cell membrane potential

232 DAN activation produces a slow depolarization of the MBON in these DAN>MBON synapses an

233 IKs channels open in response to depolarization of the membrane voltage during the cardia

234 in intracellular reactive oxygen species or depolarization of the mitochondrial membrane potential.

235 rmination is due to ChR2-mediated transmural depolarization of the myocardium, which causes a block o

236 Depolarization of the postsynaptic afferent could also e

237 t is activated by the AMPA receptor-mediated depolarization of the spine and thus will contribute to

238 oride conductance, resulting in diuresis and depolarization of the transepithelial potential.

239 y of ENaC which resulted in the steady state depolarization of VP neurons.

240 pid N-type channel inactivation during short depolarizations of the plasma membrane.

241 expression of L1302F and L811P evoked large depolarizations of the resting membrane potential and im

242 on biased the timing but not the location of depolarization onset.

243 Ca(2+) release in response to K(+)-membrane depolarization or caffeine stimulation, suggesting a red

244 K(+) channels occurs upon sustained membrane depolarization or channel opening and then recovers duri

245 g potential, but instead exhibit a period of depolarization or hyperpolarization referred to as an af

246 Loss of DeltaPsi with either pharmacologic depolarization or LPS leads to Ca(2+)-dependent mitochon

247 posed by fatiguing stimulation, long-lasting depolarization, or low drug concentrations).

248 m governing such resistance to mitochondrial depolarization, our results show that prior stimulation

249 tically induced ATP depletion, mitochondrial depolarization, oxidative stress, and necrotic death als

250 Primary afferent depolarization (PAD) normally mediates inhibition via so

251 inward current to flow during the diastolic depolarization phase under cholinergic activation.

252 In these areas, detrimental peri-infarct depolarizations (PIDs) contribute to secondary infarct g

253 itated dendritic propagation of postsynaptic depolarization, potentially improving coincidental activ

254 ter ACh application, but not by subthreshold depolarization preceding mAChR stimulation.

255 ter for presenting a unifying picture of the depolarization process.

256 e and persistent changes, including membrane depolarization, prolonged elevation of intracellular Ca(

257 rites in the inner plexiform layer and these depolarizations propagate to the varicosities.

258 of the threshold potential and the diastolic depolarization rate that is independent of the maximum u

259 mpanied by alterations in the tissue optical depolarization rate, allowing tissue polarimetry to guid

260 the membrane potential such as the diastolic depolarization rate.

261 operties, such as the lidar backscatter, the depolarization ratio and the optical depth, sharply decr

262 teristic resonant behaviour, shape-dependent depolarization ratio, and mass-dependent line shape.

263 nel inhibitor chromanol 293B caused membrane depolarization, redistribution of beta-catenin into the

264 eishmania donovani (Ld) causes mitochondrial depolarization, reduces mitochondrial dynamics, and rest

265 (++) , that interferes with normal cycles of depolarization-repolarization.

266 ficient to produce the critical postsynaptic depolarization required for associative LTP in CA3 pyram

267 tion, rescue of SK responses by subthreshold depolarization required the presence of extracellular ca

268 TGF-beta1-dependent cardiomyocyte depolarization resulted from electrotonic crosstalk with

269 ificantly lowers the threshold for spreading depolarization (SD) in dorsal medulla, leading to cardio

270 Spreading depolarization (SD) is a slow propagating wave of strong

271 Furthermore, the incidence of spreading depolarization (SD) is markedly reduced in the absence o

272 tial changes during the passage of spreading depolarization (SD) waves.

273 lutamate uptake in the dynamics of spreading depolarization (SD)-the electrophysiological event under

274 Spreading depolarizations (SDs) are recognized as actors in neurol

275 ed that calcium influx is induced by voltage depolarizations, similar to metazoan action potentials.

276 ading depression (CSD) is a wave of neuronal depolarization spreading through the cortex and is assoc

277 Optical measurements reveal that a sustained depolarization strongly potentiates the inhibitory effec

278 uppress downstream consequences of spreading depolarization such as upregulation of interleukin-1 bet

279 oxo-M washout, and not relieved by a strong depolarization, suggesting a voltage-insensitive mechani

280 d genes, is closely correlated with membrane depolarization, suggesting their use as markers for an i

281 mplex is a critical determinant of spreading depolarization susceptibility and its downstream consequ

282 mplex is a critical determinant of spreading depolarization susceptibility with important consequence

283 the current passed in response to premature depolarizations that normally helps protect against the

284 tion enabled the generation of low-threshold depolarizations that occurred in an all-or-none or grade

285 ists also abolished SWs as well as transient depolarizations that persisted after addition of CavL an

286 e-spine activation produced large spine head depolarizations that severely distorted measurements and

287 Within minutes after spreading depolarization, the neuronal hemichannel pannexin 1 (PAN

288 IAP-2 may prevent Vpr-mediated mitochondrial depolarization through stabilizing TRAF-1/2 expression a

289 concentration during a train of long-lasting depolarizations to a maximally activating voltage was mo

290 function decreased, suggesting that membrane depolarization uncouples WNK kinases from NCC.

291 minals of primary afferent fibers experience depolarization upon activation of GABAA receptors (GABAA

292 complete fusion with spontaneous ventricular depolarization using temporary electrodes.

293 This depolarization was facilitated by the absence of Ca(2+)

294 e reduction in current amplitude during step depolarizations was a consequence of both decreased CaV1

295 er not coincident with atrial or ventricular depolarization were analyzed on the recording system.

296 Only following this centromere depolarization were homologous chromosome arms connected

297 fluorescence in D411N, V535A, and K538Q upon depolarization, whereas [2-(trimethyl ammonium) ethyl] m

298 ion (CSD) is a propagating event of neuronal depolarization, which is considered as the cellular corr

299 Depolarization with high extracellular potassium evokes

300 The association of spreading depolarizations with early brain injury was then investi