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1 e than the relative time that the channel is depolarized.
2 when resting membrane potential was slightly depolarized.
3 ion curve of somatic A-type K(+) current was depolarized.
4 ective foci, and in 54.5% the foci were also depolarizing.
5 in [Ca(2+) ]i in cells that were moderately depolarized (11-20 mV) by elevation of [KCl]o (12-20 mm)
7 old, the membrane voltage will automatically depolarize above the INa threshold due to the large nega
9 data suggest that GABA acquires a transient depolarizing action during recovery from UVN, which pote
10 ly suggesting that GABA acquires a transient depolarizing action in the VN during the recovery period
16 The loss of Cdc42 resulted in a shift to depolarized AML cells that is associated with a decrease
18 ia in C452F mouse embryonic fibroblasts were depolarized and had reduced calcium uptake with impaired
19 ss, the inner mitochondrial membrane becomes depolarized and permeable to osmolytes, proposedly due t
21 ree cycles), occurred when PVs and PYRs were depolarizing and entrained their membrane potential dyna
24 ionally control the membrane potential using depolarizing and hyperpolarizing opsins; the ability to
25 ctance increased stepwise and gradually with depolarizing and hyperpolarizing pulses, respectively.
26 expressing G77R and G83V were significantly depolarized as compared with WTKir4.1, whereas cells exp
27 nhanced ENaC current contributed to the more depolarized basal membrane potential observed in VP neur
28 elease by closing ATP-sensitive K+ channels, depolarizing beta cells, and opening voltage-dependent C
29 ues molecular pathology at the photoreceptor-depolarizing bipolar cell (photoreceptor-DBC) synapse an
35 Surprisingly, dentate PV interneurons are depolarized by GABA signaling, which is in sharp contras
38 ls only activate in spines that are strongly depolarized by their synaptic input, a process requiring
39 ochondrial membrane potential (Deltapsimito) depolarized; Ca(2+) was released from the endoplasmic re
40 endered them responsive to C12: Deltapsimito depolarized, Cacyto increased, and caspase 3/7 activated
41 , released from efferent terminals, directly depolarizes calyceal endings by activating nicotinic ACh
42 faced particle photothermally induces a cell-depolarizing capacitive current, and predicts that deliv
43 coded by the SCN5A gene, conducts the inward depolarizing cardiac Na(+) current (INa) and is vital fo
44 iomyocyte gap junctional coupling, TGF-beta1 depolarized cardiomyocytes coupled to myofibroblasts by
45 ffect mediated by the emergence of a rapidly depolarizing cell population, and the expression of hERG
47 d CaMKII had enhanced persistent current and depolarized channel inactivation resembling the properti
48 ur voltage-clamp analysis showed that R1279P depolarizes channel activation, a change that was suppor
49 be searched, when decoherence is modelled by depolarizing channels' deleterious effects imposed on th
50 internal reflectivity, presence of internal depolarizing characteristics, and presence of overlying
51 leotide-gated (CNG) channel and stimulates a depolarizing chloride current by opening the olfactory C
53 er direct control, we used densely-expressed depolarizing (ChR2) or hyperpolarizing (eArch3.0, eNpHR3
57 holds that optimal states exhibit tonically depolarized cortical neurons with enhanced spiking activ
58 e-type releaser at DAT that evoked an inward depolarizing current and calcium influx, whereas other a
59 ts due to a severe reduction of a muscarinic depolarizing current and M1 receptor internalization.
60 activation might cause a sharp escalation in depolarizing current and underlie the steep initial rise
61 the number of action potentials evoked by a depolarizing current at 2X rheobase in neurons from CCD
62 s can fire single action potentials (APs) to depolarizing current commands, but are unable to dischar
63 es the action potential waveform by reducing depolarizing current during the plateau phase of the act
64 e sodium current (INa) that provides a rapid depolarizing current during the upstroke of the action p
65 re quiescent or made to fire at low rates by depolarizing current injection, light-induced activation
67 The magnitude of [Ca(2+)]i reduction during depolarizing current injections correlated with the ampl
69 e majority of cells preset at -80 mV, 500 ms depolarizing current injections to cells led to a brief
70 y quantifying the impact of an infinitesimal depolarizing current pulse on the time of occurrence of
73 esponse increased indefinitely with injected depolarizing current, but reached saturation with chemic
74 tion of an M1-coupled, pirenzepine-sensitive depolarizing current, which appeared to be, at least in
76 sponses to hyperpolarizing (P < 0.00007) and depolarizing currents (P < 0.001) in threshold electroto
77 edictions and experimental results: net soma depolarizing currents increased choice hysteresis, while
79 exhibit no K(+) conductance, have a markedly depolarized DeltaPsi and little sensitivity to changes i
82 nels only becomes important when the cell is depolarized (e.g. by a high external K(+) concentration)
83 patch-clamp recordings demonstrated that the depolarizing effect of 5-HT on PVINs was mediated by 5-H
87 ommon spectroscopic characteristics, such as depolarized emission, viscosity-dependent radiationless
88 ells equilibrated with FMP-Red-Dye exhibited depolarized equilibrium membrane potentials compared wit
89 de bifurcation, the system can automatically depolarize even in the absence of INa to voltages higher
90 ic ventral posterior medial neurons and with depolarizing events in the posterior nucleus neurons.
91 1632G mutation hyperpolarizes activation and depolarizes fast-inactivation, both gain-of-function att
94 ur findings show that early post-SE abnormal depolarizing GABA and p75(NTR) signaling fosters a long-
95 s of the K(+)/Cl(-) cotransporter KCC2 and a depolarizing GABAA receptor-mediated synaptic component
98 increase in glutamatergic input and requires depolarizing GABAergic transmission and NMDA receptor ac
99 fuse intracerebrally a specific inhibitor of depolarizing GABAergic transmission as well as a functio
100 vivo also change the type of excitability: a depolarized gamma-Aminobutyric acid receptor (GABAR) rev
101 rewiring of excitatory circuits, an abnormal depolarizing gamma-aminobutyric acidergic (GABAergic) dr
102 ent individual principal cells from strongly depolarizing granule cells, which likely discharge in re
103 ation (EDH) characteristic of arteries, LECs depolarized (>15 mV) to either ACh or TRPV4 channel acti
104 13R expression is uniquely associated with a depolarizing, HCO3(-) independent, Cl(-) -conductance in
105 expressed ligand-gated Na(+) channel, which depolarizes horizontal cells, causes synaptic acidificat
106 h release depolarized VIP BCs whereas PV BCs depolarized, hyperpolarized or produced biphasic respons
107 abilization could also be elicited by single depolarizing/hyperpolarizing pulses of very high field s
109 how that BK/Kv are activated as glomus cells depolarize in response to hypoxia, which then limits the
113 that the reversal potential for GABA is more depolarized in mutant mice, but is restored by applicati
115 and miR-34c, which subsequently targeted key depolarizing (INa) and repolarizing (Ito) currents alter
116 ed with larger persistent sodium current and depolarized inactivation in neurons from F1.Q54 animals.
118 ounted for largely by granule cells, receive depolarizing input from M/T dendrites and in turn inhibi
120 rt in brain slices that activation of nAChRs depolarizes LHb cells and robustly increases firing, and
122 atrial cardiomyocyte monolayers expressing a depolarizing light-gated ion channel (Ca(2+)-translocati
124 citatory and inhibitory synaptic inputs that depolarize many neurons to spike threshold before return
125 al of 30.5% of the drusen exhibited internal depolarizing material; 0.3% presented overlying hyperref
127 leads to reduced Kv7.4 membrane abundance, a depolarized membrane potential and an augmented response
128 leads to reduced Kv7.4 membrane abundance, a depolarized membrane potential and an augmented response
129 flufenamic acid, an agent that restores the depolarized membrane potential of SCA1 Purkinje neurons
130 lular calcium ([Ca(2+)]i) and recovered with depolarized membrane potentials or elevated [Ca(2+)]i Co
131 ing K(+) channels conduct greater current at depolarized membrane potentials, whereas inward rectifie
132 us Ca release activates inward current which depolarizes membrane potential (Vm) and can trigger acti
133 rrent clamp, block of BKCa current increased depolarizing membrane potential excursions, raising the
134 amped horizontal cells, BKCa channels subdue depolarizing membrane potential excursions, reduce the a
136 nction pharmacologically or by gene knockout depolarizes microglia, which decreases microglial ramifi
138 and 2-deoxyglucose, a glycolytic inhibitor, depolarized mitochondria after respiratory inhibition, w
141 not its E3 ligase-deficient mutants, reduces depolarized mitochondria and rescues cell death in neona
143 was shown to bind, ubiquitinate, and target depolarized mitochondria for destruction by autophagy.
144 ubiquitin ligase and mitophagy effector, on depolarized mitochondria in neonatal rat cardiac myocyte
145 l shRNA transduction induces accumulation of depolarized mitochondria in resting neonatal rat cardiac
147 intracellular oxidative stress by targeting depolarized mitochondria to the plasma membrane via arre
148 activation by PINK1, parkin is recruited to depolarized mitochondria where it ubiquitinates outer mi
153 bioenergetics in MTC cells, as indicated by depolarized mitochondrial membrane, decreased oxygen con
154 by potent inhalation anesthetics and/or the depolarizing muscle relaxant succinylcholine in malignan
155 Basolateral membranes of DCT cells were depolarized, nearly devoid of conductive potassium trans
157 dullary respiratory networks that is able to depolarize neurons of the parafacial respiratory group d
158 d extracellular nTS glutamate concentration, depolarized neurons and enhanced spontaneous EPSCs.
162 bative: e.g., by intentionally polarizing or depolarizing one spin species while detecting the respon
163 ience research through their use as membrane-depolarizing optogenetic tools for targeted photoactivat
164 oporation) that occurs while the membrane is depolarized or hyperpolarized to voltages beyond so-call
166 manipulated the activity of CI1 by injecting depolarizing or hyperpolarizing current or killing the c
167 post-trial activity decay through simulated depolarizing or hyperpolarizing network stimulation.
169 e potassium in the synaptic cleft, and would depolarize other hair cells enveloped by the same neurit
173 odium (Nav) channels are responsible for the depolarizing phase of the action potential in most nerve
174 on of cytosolic Ca(2+) concentration and the depolarized PM drive the efflux of K(+) from the cell, r
175 may hold even greater potential as tools for depolarizing political debates and resolving policy disp
177 polarized resting membrane potentials; these depolarized potentials cause cardiac arrhythmia; however
179 A735V shifted DII-VSD voltage dependence to depolarized potentials, whereas G752R significantly slow
185 this activity is observed in vitro as giant depolarizing potentials (GDPs) during the first postnata
186 ting in synergy with glutamate, drives giant depolarizing potentials (GDPs) in the hippocampal networ
188 ated nicotinic ACh receptor (nAChR)-mediated depolarizing potentials and muscarinic ACh receptor (mAC
190 rticocallosal neurons lacking mAChR-mediated depolarizing potentials did not show persistent firing.
192 rons, ACh generated prolonged mAChR-mediated depolarizing potentials in corticocollicular neurons.
193 re hyperexcitable and generated long-lasting depolarizing potentials with bursts of action potentials
197 When UV was applied at progressively more depolarized preopen holding potentials, cross-linking of
200 time course of recovery from short and long depolarizing prepulses, which, under drug-free condition
203 entries using Grover's QSA at an aggressive depolarizing probability of 10(-3), the success probabil
206 -VSD deactivation kinetics were modulated by depolarizing pulses with durations in the intermediate t
208 ptical Kerr-effect spectroscopy to study the depolarized Raman spectra of lysozyme and its complex wi
211 allenged mice displayed a significantly more depolarized resting membrane potential, decreased rheoba
212 er hyperpolarization-activated current (Ih), depolarized resting membrane potential, faster action po
213 gs showed significantly decreased amplitude, depolarized resting membrane potential, increased durati
214 ent-clamp experiments small neurons had more depolarized resting membrane potentials, and required sm
215 rbil IHCs (~0.3 kHz) have significantly more depolarized resting membrane potentials, faster kinetics
216 cardiomyocytes show both hyperpolarized and depolarized resting membrane potentials; these depolariz
217 d Go-opsin1 coexpressed with two r-opsins in depolarizing rhabdomeric photoreceptor cells in the pigm
220 Application of VU0463271 caused a reversible depolarizing shift in E(GABA) values and increased spiki
222 uced membrane hyperpolarization and caused a depolarizing shift in GABA reversal potential of dorsal
223 physically distinct K(+) currents revealed a depolarizing shift in the activation of a rapidly inacti
225 fter spinal cord injury (SCI) resulting in a depolarizing shift of the chloride equilibrium potential
226 d with loss-of-function effects, including a depolarizing shift of voltage-dependent activation or a
227 isolated from ST3Gal4(-/-) mice demonstrated depolarizing shifts in activation gating of the transien
229 lts in inward transient cation currents that depolarize smooth muscle cells, leading to vasoconstrict
231 hat glucose-stimulated beta cells spent in a depolarized state with high cytosolic Ca(2+) concentrati
232 ty, in the form of recurring self-maintained depolarized states (Up states), which allows us to exami
233 cells demonstrated that R1279P significantly depolarizes steady-state fast-, slow-, and closed-state
234 ulse potentiation," in which activation by a depolarizing step facilitates activation in a subsequent
235 reported that the K current in response to a depolarizing step to ENa was delayed if the step was pre
237 ion, rather than to the timing of subsequent depolarizing steps, suggesting that cholinergic signal t
238 CO2/H+ changes), in the absence of external depolarizing stimulation, showed no signs of postinhibit
240 ormally governs cortical neuron responses to depolarizing stimuli by opposing prolonged discharges an
241 porting persistent firing modes triggered by depolarizing stimuli following cholinergic receptor acti
242 T-channels switched burst firing with lower depolarizing stimuli to regular spiking, and fully aboli
244 ted modest transient electrical responses to depolarizing stimuli, revealing the potential for circad
247 il current of up to 8 s duration following a depolarizing stimulus in both tsA-201 cells and male rat
251 n scheme, including the presence of internal depolarizing structures and associated depolarizing foci
254 n contrast, PID ripples were associated with depolarizing synaptic inputs frequently reaching the thr
255 lexiform layers after glutamatergic synapses depolarize TH cell dendrites in the inner plexiform laye
256 harge transfer, allows presynaptic AMPARs to depolarize the bouton membrane sufficiently to modulate
257 glucose metabolism alone is insufficient to depolarize the cell and evoke GLP-1 secretion in the mod
259 single motoneuron inputs were sufficient to depolarize the Renshaw cell beyond threshold for firing.
262 sed the GluN1/GluN3A equilibrium current and depolarized the membrane in a glycine concentration-depe
263 The elevated potassium concentration also depolarized the postsynaptic neuron by altering ion perm
266 f quanta released, elevates [K(+) ]cleft and depolarizes the afferent to potentials at which smaller
267 tores activates inward membrane currents and depolarizes the beta cell to the threshold for VDCC acti
268 Blocking K(ATP) channels pharmacologically depolarizes the beta-cell plasma membrane and terminates
269 ducing a flux of Na(+) and/or K(+) ions that depolarizes the cell, thus modulating cellular Ca(2+) en
271 tials in response to a current stimulus that depolarizes the membrane above an excitation threshold.
272 In addition, we also found that shizukaol F depolarizes the mitochondrial membrane and inhibits resp
274 ide-gated (HCN) channels, and contributes to depolarizing the afferent to potentials where a single E
275 y of ENaCs, which augments synaptic drive by depolarizing the basal membrane potential close to the a
276 to heat, which changes membrane capacitance, depolarizing the cell and eliciting action potentials.
279 oss-linked 300 kDa increased excitability by depolarizing the resting membrane potential, and decreas
280 l enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upo
281 here transduction currents are sufficient to depolarize them to voltages necessary for calcium influx
283 cted selectively to increase their activity, depolarizing these neurons and increasing their firing r
285 ts transiently switched their direction from depolarizing to hyperpolarizing as a result of neuronal
287 ons display synchronized transitions between depolarized Up states and hyperpolarized Down states.
289 lf-maximal Kv11.3 channel activation to more depolarized values and reduced its voltage sensitivity.
291 sponses in V1 to a stationary scene, 2) that depolarized VIP cells enhance V1 responses to moving obj
294 y describes one physiological form of KCNQ1, depolarized voltage sensors with a closed pore in the ab
295 ed that strong hyperpolarization preceding a depolarizing voltage-clamp pulse delayed the rise of the
296 s study observed residual STOC production at depolarized voltages that was independent of CaV 1.2 and
300 is not dependent on the level of maturation (depolarizing vs. hyperpolarizing) of postsynaptic GABAA
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