ライフサイエンスコーパス: depot

1 therapy used (prednisolone or tetracosactide depot).

2 tion of preadipocytes and adipocytes in each depot.

3 lar hydrogel injections acting as a delivery depot.

4 lean mice, especially in the epididymal fat depot.

5 taken up by macrophages associated with the depot.

6 y temperature, thereby forming an injectable depot.

7 only CD14 monocytes (MNs) retained an HBsAg depot.

8 y temperature, thereby forming an injectable depot.

9 tribution, possibly by serving as a cytokine depot.

10 an induction of T-cell proliferation in that depot.

11 tified the drug content primarily within the depot.

12 r 2 was only indirectly involved as a supply depot.

13 and was related to percent body fat in each depot.

14 f the GR to its target gene promoters in fat depots.

15 bly due to interactions with cellular copper depots.

16 gulatory mechanisms operate in different WAT depots.

17 itoneal white adipose tissue (IWAT and RWAT) depots.

18 laterally in supraclavicular and gluteal fat depots.

19 in vivo CN recruits iron from intracellular depots.

20 nd oxygen consumption in beige and white fat depots.

21 s well as on the level of several individual depots.

22 ssion of the thermogenic gene program in fat depots.

23 nied by weight gain and expansion of adipose depots.

24 is and activity in both these adipose tissue depots.

25 ncreased immune cell infiltration within the depots.

26 best of both classes of injectable polymeric depots.

27 heterogeneity within various adipose tissue depots.

28 o the metabolic and immune nature of adipose depots.

29 y were lean because of reduced white adipose depots.

30 llapses the GTPase into enlarged perinuclear depots.

31 subcutaneous than in internal adipose tissue depots.

32 ked microparticles, or thermally coacervated depots.

33 hen %body fat was replaced with fat in other depots.

34 e that develops in coordination with adipose depots.

35 n milky spots, rather than in peritoneal fat depots.

36 oting the formation of rBAT within white fat depots.

37 take or increased vessel density in targeted depots.

38 pressed in visceral and subcutaneous adipose depots.

39 ences in adipogenic potential in various fat depots.

40 kcal/d in subjects with relatively large BAT depots.

41 increasing mitochondrial density across all depots.

42 tigens, depending on the dose of drug in the depots.

43 differentially affect specific body adipose depots.

44 white adipose tissue (WAT) in different body depots.

45 ulation and gradual release from subcellular depots.

46 factor present in brown adipocytes found in depots.

47 adipocytes within multiple visceral adipose depots.

48 effects on atherogenic and diabetogenic fat depots.

49 ly higher in the liver compared with adipose depots.

50 ed on volume and intensity of individual BAT depots.

51 to serve as prolonged gastric resident drug depots.

52 must be boosted to establish long-acting ARV depots.

53 ophysiological contributions of visceral fat depots.

54 times a day or intramuscular tetracosactide depot 0.5 mg (40 IU) on alternate days with or without v

55 f newly synthesized lipids in adipose tissue depots, accompanied by weight gain and expansion of adip

56 Here we report that iron depots accumulate in human atherosclerotic plaque areas

57 The (131)I-ELP depots achieved >95% tumor regression in the prostate tu

58 e signaling molecule found in adipose tissue depots, acts on adenosine receptors.

59 We find that deletion of ERK5 in adipose depots (adipo-ERK5(-/-)) increases adiposity, in part, d

60 nutritionally, decreasing in adipose tissue depots after high-fat feeding.

61 ling protein 1 (UCP1) in both adipose tissue depots, although these effects are much more pronounced

62 s ATBF, most strikingly in the gluteofemoral depot, an effect further augmented in the postprandial s

63 In the current study, a polymeric drug depot-anchoring hydrogel scaffold was developed for the

64 was released relatively quickly from the oil depot and its carbamate bond was too stable to be used a

65 ansion of the subcutaneous abdominal adipose depot and the development of insulin resistance.

66 s to the exacerbated IL-6 production in this depot and the low-grade systemic inflammation typically

67 nd are sensitive to levels of liver-stage Ag depot and they express CD44(hi)CD62L(lo) markers indicat

68 erides serve as the principal energy storage depot and, where vascular systems exist, as a means of e

69 al and molecular differences between adipose depots and depot-specific cellular mechanisms of adipose

70 the relationship between DEXA-quantified fat depots and diabetes/cardiovascular risk factors in a hea

71 Brown adipocytes are located in dedicated depots and express constitutively high levels of thermog

72 ate inflammation and immunity within adipose depots and foster the generation of an unexpected pool o

73 n mesenteric and subcutaneous adipose tissue depots and genes previously shown to be targets of procy

74 omote migration of immune cells into adipose depots and impede further angiogenesis.

75 test the association between individual fat depots and incident hypertension, adjusting for age, sex

76 re produced transgenerational effects on fat depots and induced a phenotype resembling nonalcoholic f

77 Peripheral and central fat depots and lean mass were measured using standardized an

78 ion of interleukin (IL)-12 in adipose tissue depots and led to the selective proliferation and accumu

79 n progressive lipodystrophy of white adipose depots and metabolic dysfunction.

80 the selective enlargement of epididymal fat depots and suppresses energy expenditure in a nutritiona

81 he relative mass of different adipose tissue depots and thus insulin sensitivity in obesity, and it s

82 ed the formation of DERE-involved regulatory depots and transcription inactivation of candidate tumor

83 that of preadipocytes in the scABD and scFEM depots and was related to percent body fat in each depot

84 We measured heart, liver, adipose (three depots), and muscle (truncal postural and thigh locomoti

85 e (VAT) has been identified as a harmful fat depot, and sex and race differences in VAT have been rep

86 ent effects, depending on the adipose tissue depot, and whether these effects show a relation to the

87 orting vaccines from national to subnational depots, and 8 of 48 vaccine carriers (17%) used in outre

88 e MED/LC diet mobilizes specific ectopic fat depots, and exercise has an independent contribution to

89 ulin-mediated (18)F-FDG influx rates, tissue depots, and M value.

90 ere obtained from subcutaneous abdominal fat depots, and preadipocytes were isolated and cultured.

91 up-regulated in brown and inguinal white fat depots, and that midage Foxa3-null mice have increased w

92 luorodeoxyglucose (FDG) influx rates, tissue depots, and whole-body insulin sensitivity (referred to

93 ow) preadipocytes and adipocytes in the same depot are more oxidative and less glycolytic.

94 pose-derived stem cells (ASCs) from visceral depots are compromised compared with those of ASCs from

95 aptations to cold of brown and beige adipose depots are examined using quantitative mitochondrial pro

96 tablished, but how these differences between depots are regulated at the molecular level remains larg

97 ther uncovered that ERalpha-bound regulatory depots are tethered to heterochromatin protein 1 (HP1) f

98 Injectable depots are typically prepared by encapsulation of the dr

99 sing method under real-world conditions at a depot area and on the normal route of bus line 24 in Hel

100 At the depot area the emission factors were in the range of 0.3

101 ver PPT and demonstrate the promise of a gel depot as an IP drug delivery system.

102 zation usually results in the formation of a depot at the site of injection (SOI), which hinders the

103 in mildly acidic conditions, form insoluble depots at neutral pH, efficiently release soluble protei

104 une function, the inflammatory response, fat depot blood flow, and insulin sensitivity.

105 sue (WAT) in both epidydmal and subcutaneous depots but not in interscapular brown adipose tissue (BA

106 ompared with those of ASCs from subcutaneous depots, but little is known about the underlying mechani

107 e associated with the vasculature of adipose depots, but not in mature adipocytes.

108 ta-emissions of (131)I further stabilize the depot by introducing crosslinks within the ELP depot ove

109 The effect of local depot C6' or C6 was evaluated in mice with a priapic phe

110 These data show that persisting vaccine depots can induce specific T cell sequestration, dysfunc

111 gression analysis demonstrated that the drug depot characteristics including volume, surface area, an

112 f drug-loaded polymer islands acting as drug depots colocalized with adherent cells are surrounded by

113 afts was unchanged by treatment with fat/PGZ depots compared to no treatment.

114 d, sequence-targeted refilling of a delivery depot consisting of intratumor hydrogels completely abro

115 developed an in-situ crosslinkable hydrogel depot containing paclitaxel (PTX) nanocrystals (PNC).

116 rporation in fat and to determine if fat/PGZ depots could decrease vascular hyperplasia development i

117 s MMP14 promotes the generation of white fat depots crucial for energy storage, MMP15 differentially

118 cantly less than that of the unmodified drug depots (DDs).

119 skeletal muscle, kidneys, heart, and all fat depots decreased.

120 rther followed the dynamics of different fat depots (deep and superficial subcutaneous, liver, perica

121 loss-of-function studies in inguinal adipose depots demonstrated a cell-autonomous function for Foxa3

122 265744 LAP administration, while the Vehicle depot did not suggesting that the active drug substance

123 d rehydration from patterned reagent storage depots directly within the paper membrane.

124 een believed that brown adipose tissue (BAT) depots disappear shortly after the perinatal period in h

125 of global thermogenic metabolism in adipose depots during acute cold exposure.

126 In both depots, energy-generating metabolic genes were negativel

127 d, resulting in a large subcutaneous insulin depot, estimated to be 450 units of regular insulin.

128 r related particle was a key driver for drug depot evolution.

129 Fat depots exhibit diverse responsiveness and are differenti

130 Upper- and lower-body fat depots exhibit opposing associations with obesity-relate

131 The depot expansion was associated with an increase in macro

132 are often found or are intercepted in grain depots, flour mills, and entry-exit ports, etc.

133 for use of the megakaryocytes/platelets as a depot for efficient production, delivery, and effective

134 ke polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat

135 ids, converting the lysosome into a cellular depot for them.

136 are internalized into vesicles that serve as depots for delivery back to the cell surface, allowing f

137 on of low-cost controlled-release injectable depots for leuprolide and related peptides.

138 and hence the importance of alternate lipid depots for meeting the energetic demands of the migratio

139 chaperone pairs, PQC E3 ligases, and storage depots for misfolded proteins.

140 at late and recycling endosomes can serve as depots for nanoATV.

141 opment of injectable PLGA controlled-release depots for peptides and proteins, and then use this info

142 The amphiphilic beads act as depots for sustained drug release that is integrated int

143 0q13 DEREs were mobilized to form regulatory depots for synchronized gene expression of target loci.

144 The study suggests that amyloids may act as depots for the native form of the protein and therefore

145 sues impeding greater widespread use of PLGA depots for this class of drugs.

146 ymers capable of thermally-triggered in situ depot formation that have been successfully employed as

147 or RA-producing enzymes, on sex-specific fat depot formation.

148 Significantly, a single injection of depot forming GLP-1-ELP fusions reduced blood glucose le

149 2 diabetes drug, and a thermally responsive, depot-forming elastin-like-polypeptide that undergoes a

150 Development of in-situ depot-forming gel systems for intratumoral delivery of i

151 The results support the use of this depot formulation for treatment initiation and stabiliza

152 Lastly, injectable hydrogels as depot formulation were formed by stereocomplexation, and

153 a novel, weekly, subcutaneous buprenorphine depot formulation, CAM2038, to block euphorigenic opioid

154 Biodegradable, injectable depot formulations for long-term controlled drug release

155 essons learned from: (i) microparticle-based depot formulations, (ii) nanoparticle-based cancer drugs

156 f-regulated drug delivery systems, long-term depot formulations, and nanotechnology-based delivery sy

157 DEs thus accumulated represent a contaminant depot from which they may be slowly released to the syst

158 n the stromal vascular cells of visceral fat depots from mice.

159 ubdomains called foci, which likely serve as depots from where SV40 gains access to the cytosol.

160 Visceral and subcutaneous adipose depots have different metabolic roles that may be involv

161 Local drug delivery depots have significant clinical utility, but there is c

162 thods, we show that even within a single WAT depot, high Tbx15 expression is restricted to a subset o

163 entially secreted from the different adipose depots; however, their paracrine and autocrine effects o

164 ive and soluble insulin is released from the depot in a well behaved, first order fashion.

165 hite adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating wh

166 The variation in gene expression among fat depots in both human and rodent has been an extensively

167 ected to have applications in refilling drug depots in cancer therapy, wound healing, and drug-elutin

168 can be used to identify brown adipose tissue depots in mice by whole-body near-infrared fluorescence

169 to cold exposure in multiple adipose tissue depots in mice.

170 aP2-lineage progenitors give rise to adipose depots in recipient mice.

171 ed that Foxa3 levels are elevated in adipose depots in response to high-fat diet regimens and during

172 The major WAT depots in the body are found in the visceral cavity (vWA

173 mized to establish functional brown fat-like depots in vivo.

174 ing a CE, whereas the LC-forming MEs formed 'depots' in water.

175 PGZ was detected in the fat depot, in the external jugular vein wall and in adjacent

176 found outside classical brown adipose tissue depots, in adipocytes that are termed 'brite' (brown-in-

177 r, kidney masses, and several adipose tissue depots increased except for visceral adipose tissue (VAT

178 For example, twice-a-year depot injections with leuprolide are available compared

179 ergo temperature-mediated assembly to form a depot inside the lacrimal gland.

180 understood phenomenon in controlled-release depots involves the strong interaction between common ca

181 tide (Autogel [known in the United States as Depot], Ipsen) at a dose of 120 mg (101 patients) or pla

182 ite this negative feedback, the expanded BAT depot is sufficient to prevent both genetic and high-fat

183 onship of marrow adipose tissue to other fat depots is complex and might play very distinct parts in

184 el, and methotrexate) from membrane-enclosed depots is described.

185 for disability, but risk of specific adipose depots is not completely understood.

186 f glucose metabolism, and in susceptible WAT depots, it can cause browning.

187 al differences in responsiveness between BAT depots, it is likely that BAT will be shown to have much

188 Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles th

189 t the decentralized local biomass processing depots lead to lower profitability but better environmen

190 aging approach was used to identify the drug depot location and volumetric/physiologic changes in bot

191 , and the greater metabolic activity of this depot makes its lipid composition more dependent on LpL-

192 ch they approach ideality for photoactivated depot materials.

193 treatment by an implanted oxygen-generating depot may enhance the cytotoxicity of DOX against malign

194 unt of adipose tissue in abdominal and thigh depots may also convey risk beyond BMI.

195 While expansion of UCP1-expressing adipose depots may be achieved in rodents via genetic and pharma

196 ions in violent crime were also recorded for depot medication (HR adjusted for concomitant oral medic

197 among black people, and the effectiveness of depot medications.

198 Increasing evidence suggests depot medroxyprogesterone acetate (DMPA) and intravagina

199 Depot medroxyprogesterone acetate (DMPA) has been linked

200 To address this discrepancy, we developed a Depot medroxyprogesterone acetate (DMPA)-treated cotton

201 sion levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the le

202 n increase in HIV risk in the ten studies of depot medroxyprogesterone acetate (pooled hazard ratio [

203 our study would merit complete withdrawal of depot medroxyprogesterone acetate needs to be balanced a

204 Depot medroxyprogesterone acetate use associated with in

205 In women using depot medroxyprogesterone acetate, adjusted pregnancy in

206 risk of HIV acquisition for all women using depot medroxyprogesterone acetate, with a smaller increa

207 Studies that assessed the use of depot-medroxyprogesterone acetate (DMPA) or non-specifie

208 ceptives (COCs) or the injectable progestins depot-medroxyprogesterone acetate (DMPA) or norethistero

209 intramuscular (IM) or subcutaneous (SC) drug depot morphology and distribution kinetics with plasma p

210 es with 56 populations and 29 adipose tissue depots/obesity indices were included in the meta-analysi

211 ned associations of different adipose tissue depots/obesity indices with insulin resistance, as measu

212 n insulin resistance and most adipose tissue depots/obesity indices, and the strongest association is

213 id a study of the efficacy of pazopanib with depot octreotide in patients with advanced NETs.

214 e implanted into the inguinal adipose tissue depot of C57BL6 mice.

215 llus species is release of the spores' large depot of dipicolinic acid (DPA).

216 ores' IM through which the spore core's huge depot of dipicolinic acid is released during germination

217 ically delivered drugs, MDD systems act as a depot of drug localized to the treatment site, which can

218 ious observations of the size of the colonic depot of folate and its potential for manipulation by di

219 Additionally, the presence of a depot of large tubular organelles in the cytoplasm sugge

220 ession (AS; two injections of every-3-months depot of luteinizing hormone-releasing hormone agonist)

221 eciprocally regulated in white and brown fat depots of diet-induced obesity and leptin-deficient ob/o

222 we create materials that form photoactivated depots of insulin without the need for polymers, by link

223 e polarization in the subcutaneous white fat depots of microbiota-depleted animals.

224 ncreases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthesis and secret

225 trast, sustained local delivery via hydrogel depots of required axon-specific growth factors not pres

226 ipocytes are located mainly in dedicated BAT depots of rodents and infants, beige adipocytes sporadic

227 the vasculature of brown adipose tissue-like depots of subcutaneous white adipose tissue.

228 Wnt6, a known anti-adipogenic factor, in fat depots of the mouse.

229 iferase emission was detected from major fat depots of transplanted mice.

230 mones or treatments with chemicals, specific depots of WAT undergo a browning process, characterized

231 o assess the effect of different ectopic fat depots on left ventricular (LV) function in subjects wit

232 r vein was used to assess effects of PGZ/fat depots on vascular hyperplasia development.

233 We previously described the photoactivated depot or PAD approach that allows for the light control

234 er, associations of different adipose tissue depots or/and obesity indices with insulin resistance ha

235 pot by introducing crosslinks within the ELP depot over 24h.

236 een non-reactive secretory protein molecular depots patterned at the plasma membrane.

237 used to examine the association of each fat depot (per 1 SD increment) with the risk of incident car

238 rough charge-charge interaction, and 2) this depot platform enabled long-term, controlled release ove

239 Here we present a novel nanoparticle depot platform for on-demand drug delivery using a far u

240 in-releasing hormone analogues, danazol, and depot progestagens are associated with a higher incidenc

241 umans have active brown adipose tissue (BAT) depots, raising the question of whether activation and r

242 propose that these foci act as mRNA storage depots rather than mRNA decay facilities.

243 lf-assembling peptide (RADA16)-modified drug depots (RDDs) were prepared and anchored to a RADA16 hyd

244 on close to the tumor, the oxygen-generating depot reacts with the interstitial medium to produce oxy

245 eous compartment rather than to the visceral depot, reduced AT inflammation associated with reduced T

246 age infiltration and edema in and around the depot region and was correlated to plasma drug concentra

247 macrophages were shown to be present in the depot region of the GSK1265744 LAP injected gastrocnemiu

248 ytes had higher formation rates in the scFEM depot relative to the scABD.

249 rdial fat compared with other adipose tissue depots remains uncertain.

250 id fluxes in the abdominal and gluteofemoral depot, resulting in the fat distribution changes associa

251 The ELP depots retained greater than 52% and 70% of their radioa

252 rafficking to the GSK1265744 LAP and Vehicle depot sites.

253 ) during bariatric surgery and characterized depot-specific adipose tissue angiogenic capacity using

254 and blood parameters did not affect total or depot-specific BAT activity.

255 cular differences between adipose depots and depot-specific cellular mechanisms of adipose expansion.

256 tivity, enhanced energy expenditure, and fat depot-specific cellular remodeling toward lowered energy

257 in AMPK activity and SIRT1 gene expression, depot-specific changes in inflammatory, mitochondrial an

258 accumulation and metabolic disease risk and depot-specific differences is well established, but how

259 Mechanisms for sex- and depot-specific fat formation are unclear.

260 rown adipogenesis in iBAT and further define depot-specific mechanisms of BA recruitment.

261 Depot-specific responses might lead to differential fatt

262 d adipose tissue on systemic metabolism, and depot-specific responses to exercise training.

263 Isolated preadipocytes retained a depot-specific transcriptional "memory" of embryonic dev

264 This finding might point to depot specificity of glucocorticoid responses and insuli

265 highway, an immune sanctuary, and a storage depot supporting tumor growth and drug resistance.

266 When loading MK2i, 1) the HT depot surface gained high MK2i-loading efficiency throug

267 mic multi-tRNA synthetase complex (MSC) is a depot system that regulates non-translational cellular f

268 med using the "smile-and-fill," fanning, and depot technique with an optional touch-up at the 2-week

269 onse reveals that TAMs serve as a local drug depot that accumulates significant vehicle from which DN

270 presents the first long-term, drug-releasing depot that can be administered as a traditional eye drop

271 Marrow adipose tissue is a dynamic depot that probably exists as both constitutive and regu

272 ransition, leading to in situ formation of a depot that released curcumin over 4days post-injection a

273 ), was encapsulated in RDDs (V-RDDs) as drug depot that was then anchored to the hydrogel.

274 tion by engineering cells with intracellular depots that continuously release phenotype-altering agen

275 nd secretion from white adipose tissue (WAT) depots, the induction of LCN2 varied among different ins

276 ulations or the transplantation of brown fat depots, these methods are difficult to use for human cli

277 Adipose tissue is distributed in depots throughout the body with specialized roles in ene

278 regulatory factors are secreted from adipose depots to control appetite and cellular homeostasis.

279 (21%) transporting vaccine from subnational depots to health facilities and 14 of 48 vaccine carrier

280 cine model, pharmacokinetics of PGZ from fat depots transplanted perivascular to jugular vein were as

281 were observed to significantly change in WAT depots up to 6 hours post exposure.

282 visceral fat is only one of many ectopic fat depots used when the subcutaneous adipose tissue cannot

283 om the abdominal (scABD) and femoral (scFEM) depots using an 8-week incorporation of deuterium ((2)H)

284 d the two alpha-isoforms of AMPK showed more depot variation.

285 e of 50.2 years) underwent assessment of fat depots (visceral adipose tissue, pericardial adipose tis

286 The GSK1265744 LAP depot volume increased rapidly by day 2 in the IM inject

287 The IM depot volume increased rapidly to a maximum volume at 2d

288 Interestingly, the released OVA from amyloid depot was found to exhibit biophysical characteristics o

289 ssed by HPLC/MS/MS, and retention of the fat depot was monitored by MRI.

290 ng-based method for quantification of tissue depots was feasible for determining adipose tissue volum

291 sceral and subcutaneous white adipose tissue depots was unchanged upon cold acclimation.

292 flammatory responses in Reverbalpha(-/-) WAT depots were associated with tonic elevation of A20 prote

293 Small losses of AT from all depots were observed after 24 weeks of telmisartan thera

294 Tissue depots were quantified by using water-fat separated MR i

295 ficiently release soluble protein from these depots when irradiated, and leave behind only small easi

296 wn fat-like cells in remaining white adipose depots, which express markers of brown and beige fat suc

297 Central to these pathologies is the fat depot: white adipose tissue (WAT) stores excess calories

298 hours) in both BAT and the subcutaneous WAT depots, with the most striking change being observed in

299 ovel effect of nanoART that facilitates drug depots within intracellular compartments at or adjacent

300 ccurately target the inguinal adipose tissue depot without damaging the probe.