ライフサイエンスコーパス: depress

1 Yet many exposed individuals do not become depressed.

2 ess belonging support were more likely to be depressed.

3 ased with Ni exposure and calcium influx was depressed.

4 the 13 subjects were severely anxious and/or depressed.

5 ch and sucrose metabolisms were dramatically depressed.

6 pecially at night when net calcification was depressed ~78% compared to ambient pCO2 .

7 eas the hypoxic ventilatory reflex was still depressed (95.3%) and hypoxia no longer evoked sighs.

8 ory were collected from 204 individuals (105 depressed, 99 healthy).

9 Along with OATP2B1 depressed, a main reduction was found for each of morphi

10 NBS indicated that, compared with controls, depressed adolescents exhibited reduced connectivity (p<

11 rk using seed-based approaches indicate that depressed adolescents show limited task-evoked vs restin

12 Relative to controls, depressed adolescents were characterized by inflexibilit

13 reduced MyBP-C phosphorylation may underlie depressed adrenergic reserve in heart failure.

14 recall and depressive symptoms in currently depressed adults and two vulnerable populations: individ

15 METHOD: The study enrolled depressed adults with bipolar I or II disorder who were

16 resting-state field potentials and CBF were depressed after cocaine administration (19.8+/-4.7% and

17 Norepinephrine depresses aggrecans expression but stimulates MMP-3, MMP

18 Reductions in lake mixing have depressed algal production and shrunk the oxygenated ben

19 g phosphorylation-incompetent RyR2 displayed depressed AM sarcomere shortening and reduced in vivo at

20 periods of postsynaptic bursting selectively depressed AMPA receptor (R) synaptic transmission, or si

21 Accordingly, increasing MAP1B-LC expression depresses AMPAR-mediated synaptic transmission.

22 However, studies investigating depressed and bipolar populations have found that scopol

23 ng models successfully discriminated between depressed and healthy content, and compared favorably to

24 nectivity to reveal subgroups present across depressed and healthy individuals during positive proces

25 would be overlooked in group comparisons of depressed and healthy participants, and tracks with clin

26 t mGluR5-specific treatments may aid in both depressed and manic mood states.

27 but not within the same class, were markedly depressing and were more powerful to sculpt activity of

28 Depressed anti-HER2 Th1 response is a novel immune corre

29 treated with trastuzumab and chemotherapy), depressed anti-HER2 Th1 responsivity (recurrence, 2 of 2

30 units are generally located in economically depressed areas and can contribute up to 87% of hourly m

31 Platelets were slightly depressed at 121,000 muL, and alpha-fetoprotein level wa

32 than in service users who had been similarly depressed at baseline (adjusted odds ratio 7.38, 1.73-31

33 excitation of BA interneurons (INs) that was depressed at higher frequencies.

34 d with LS neurons, ES neurons had strong and depressing autapses, which enhanced spike-timing precisi

35 Increased ROS also depress autonomic ganglion synaptic transmission by oxid

36 A depressed autophagy has previously been reported in cyst

37 wborns with brain injury demonstrate similar depressed background activity and loss of bursts in the

38 Patients reported more withdrawn/depressed behavior (z score = -0.47 [0.54]; p = 0.02), s

39 social ethological context and associate the depressed behavioral phenotype with significant serum me

40 ncreased in schizophrenia, euthymic (but not depressed) bipolar disorder and MDD compared with contro

41 apses, whereas more prolonged (24 hr) firing depressed both AMPAR and NMDAR EPSCs and eliminated spin

42 enetics to demonstrate that ethanol potently depresses both MSN- and fast-spiking interneuron (FSI)-M

43 D1LRs whereas pallidal inputs to the EP were depressed by D2LRs.

44 Given that reproductive success is not depressed by disease prevalence, density-dependent recru

45 temperature of tetragonal FeS was gradually depressed by pressure, different from the case in tetrag

46 on of MF origin, MF GABAergic responses were depressed by the activation of metabotropic glutamate re

47 agonist SKF 38393 concentration-dependently depressed C-fiber-evoked potentials in rats receiving sp

48 lycerol (</=15 mol %) in C1P source vesicles depressed C1P intermembrane transfer.

49 her action potential propagation failure nor depressed Ca(2+) influx explained loss of evoked synapti

50 Isoflurane and propofol are known to depress cardiac contraction, but the molecular mechanism

51 uced by ischaemia-reperfusion (IR), restores depressed cardiac function and contraction, reduces infa

52 und debridement, increased infarct size, and depressed cardiac function, newly implicating MerTK in c

53 ith higher ventricular filling pressures and depressed cardiac output reserve (both p < 0.0001).

54 to reduced postischemic cardiac function and depressed cardiomyocyte contractility caused by myofilam

55 r, functional-group Lewis basicity typically depresses catalytic activity and co-monomer incorporatio

56 nthesis, decreased amino acid metabolism and depressed cell growth were related to RS consumption.

57 In addition, the L273D mutation depressed channel activity equally regardless of which O

58 s, the biological children (generation 3) of depressed compared with nondepressed parents (generation

59 evidence that net community calcification is depressed compared with values expected for pre-industri

60 ted with SMIC included Kudo pit pattern V, a depressed component (0-IIc), rectosigmoid location, 0-Is

61 Longer duration of illness, depressed consciousness, and peripheral blood eosinophil

62 individuals (68 depressed patients, 24 never-depressed control subjects) completed a sustained positi

63 es such as interferon-alpha to otherwise non-depressed controls increased glutamate in the basal gang

64 For example, we compute that temperature depresses current U.S. maize yields by ~48%, warming sin

65 Importantly, elevated CXCR7 and depressed CXCL12 expression levels were prominent featur

66 NSAH depresses dGTP and dATP levels in the dNTP pool causing

67 in cTnI C terminus impacts heart function by depressing diastolic function at baseline and limiting s

68 Maintenance of EGFR activity in these cells depresses dSRF levels in the neighboring anterior crossv

69 Synapses often become depressed during spontaneous presynaptic activity, and t

70 In control participants, vagal tone remained depressed during sustained hypoglycemia.

71 Why is social bias and its depressing effects on low-status or low-performing group

72 iscontinued after 10.3 months as a result of depressed ejection fraction.

73 ase (phase 2) of the Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy a

74 The Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy o

75 Astrocytes depressed excitatory synapses from basolateral amygdala

76 modeling that occurs in prefrontal cortex of depressed females.

77 venous thrombosis is dominated by stasis or depressed flows, endothelial inflammation, white blood c

78 ctate whether NMDAR function is augmented or depressed following M1R stimulation.

79 oth propofol and isoflurane dose dependently depressed force from low doses (propofol, 27 +/- 6 muM;

80 Bath applied Delta(9)-tetrahydrocannabinol depressed GABA cell activity, therefore downstream dopam

81 medication compared with medication alone in depressed geriatric patients after a successful course o

82 ng and highly effective treatment option for depressed geriatric patients, with excellent safety and

83 Among grandchildren without a depressed grandparent, those with (n = 14) vs without (n

84 erable groups showed activity similar to the depressed group, while amygdala hypoactivity during posi

85 ect on the posterior cingulate cortex in the depressed group, with self-appraisal causing significant

86 ancholic and 30 nonmelancholic) and 39 never-depressed healthy controls (HC) underwent resting-state

87 ibition on Morbidity, Mortality, and Mood in Depressed Heart Failure Patients (MOOD-HF) study was a d

88 Depressed heart rate variability is a well-established r

89 biological offspring (mean age=47 years) of depressed (high-risk) and nondepressed (low-risk) parent

90 gulated in nucleus accumbens (NAc) (male) in depressed human subjects and in mice subjected to chroni

91 en males and females, an effect seen in both depressed humans and stressed mice.

92 globulin G against C. difficile toxin A were depressed in aged mice, and vancomycin treatment reduced

93 ns to maintain health, but its functions are depressed in aging and obesity.

94 nce and sarcoplasmic reticulum Ca uptake are depressed in both sarcomere mutation-positive and -negat

95 low-affinity binding motifs is significantly depressed in sea urchins compared with sea star, but bot

96 es intracellular calcium recycling, was also depressed in SSc-PAH (0.32+/-0.05 versus 0.50+/-0.05; P=

97 the hypothesis that RV functional reserve is depressed in SSc-PAH patients.

98 RV contractile reserve is depressed in SSc-PAH versus IPAH subjects, associated wi

99 ion of purinergic receptors is significantly depressed in subjects with sporadic as well as rare synd

100 contents of both LHCI and LHCII were equally depressed in the cpSRP43-deficient mutant (chaos).

101 ng and burst firing patterns were profoundly depressed in the mouse with global deletion of CaV 3.1 i

102 ofilament-Ca(2)(+) responsiveness, which was depressed in untreated Tm-E54K mice.

103 dence of RA was higher in depressed than non-depressed individuals (2.07 vs. 1.21 per 1,000 PYs), wit

104 nd white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590

105 d corticostriatal functional connectivity in depressed individuals but had no behavioral effects.

106 c markers in major depressive disorder: some depressed individuals manifest increased appetite, while

107 wards predicted better reward learning among depressed individuals receiving amisulpride as well as a

108 olumes, significant reductions were found in depressed individuals versus controls in global white ma

109 Depressed individuals versus healthy control subjects, s

110 The human samples were from depressed individuals who died by suicide, with (N=27) o

111 Groups were constituted of depressed individuals who died by suicide, with or witho

112 regions involved in win/loss anticipation in depressed individuals with bipolar disorder (BDD) versus

113 sed impulsivity and risk for mania, however, depressed individuals with bipolar disorder may differ f

114 dividuals with bipolar disorder (BDD) versus depressed individuals with major depressive disorder (MD

115 y control subjects, 45 unmedicated currently depressed individuals, 25 unmedicated remitted depressed

116 pressed individuals, 25 unmedicated remitted depressed individuals, and 30 individuals at high famili

117 In both populations, depressed individuals, especially those with new onset,

118 heart disease and persistent pain states) in depressed individuals.

119 uring the hypercholinergic state observed in depressed individuals.

120 ative events, while the opposite is found in depressed individuals.

121 ses to reward and improve reward learning in depressed individuals.

122 levels are reduced in postmortem tissue from depressed individuals; however, p11 has not yet been inv

123 logical functions that impact health through depressing inflammation.

124 s correlated with improvements of previously depressed interhemispheric FC across attention, sensory,

125 auses only a subset of individuals to become depressed is critical to understanding depression on a b

126 ncy firing "wakes up" silent Ib synapses and depresses Is synapses.

127 c performance through either a significantly depressed lattice thermal conductivity down to its theor

128 eatment caused loss of myocardial tissue and depressed left ventricular function in WT mice.

129 JAK kinase inhibitors have depressed leukemic T cell line proliferation.

130 eversible encephalopathy syndrome, seizures, depressed level of consciousness, methotrexate-related s

131 filtration, and mucus production, as well as depressed levels of CCL2 chemokine and Th2 cytokines.

132 n of CK2alpha in the PFC show a robust 'anti-depressed-like' phenotype and display an enhanced respon

133 e mPFC to generate mice with a similar 'anti-depressed-like' phenotype.

134 Ketamine depressed local field potentials evoked in the OFC by ex

135 E-stress) in 2 mouse models with genetically depressed macrophage numbers and compared them to their

136 kinned preparations, propofol and isoflurane depressed maximum Ca(2+)-activated force and increased t

137 zed MyBPC(PKA-) and DBL(PKA-) mice displayed depressed maximum systolic pressure in response to dobut

138 Unmedicated and currently depressed MDD patients (N=25, aged 18-52 years) and heal

139 failure (64% versus 78%, P<0.001), had less-depressed mean left ventricular fractional shortening z

140 dicated cows consuming RS diets may have had depressed milk protein synthesis because these animals h

141 in alcoholic animals is also associated with depressed mitochondrial fusion.

142 pproximately 0.6 nS, approximately 7 ms) and depressed moderately.

143 Patients were moderately depressed (Montgomery-Asberg Depression Rating Scale=30+

144 voidance behaviors, hyperarousal, as well as depressed mood and anxiety.

145 search by exploring the relationship between depressed mood and cognitive ToM, specifically visual pe

146 dietary supplement reduces vulnerability to depressed mood at postpartum day 5, the typical peak of

147 d MAO-A activity eliminates vulnerability to depressed mood during the peak of PPB.

148 ing the MIP, there was a robust induction of depressed mood in the control group, but no effect in th

149 severity was quantitated by the elevation in depressed mood on a visual analog scale following the sa

150 o the EPDS dimensions that reflect states of depressed mood, anhedonia, and anxiety.

151 Participants included mothers with depressed mood, anhedonia, or depression history but who

152 underlying dimensions measured by the EPDS: depressed mood, anxiety, and anhedonia.

153 factors known to predict adherence, such as depressed mood, social support, and disease severity lev

154 Although evidence shows depressed moods enhance risk for somatic diseases, molec

155 of depressive behavior and human studies of depressed moods.

156 Depressed mothers with high anxious distress and irritab

157 eNpHR or Arch in ChAT(+) or Isl1(+) neurons, depressed motoneuron discharge, transiently decreased th

158 urane decrease force development by directly depressing myofilament Ca(2+) responsiveness and have bi

159 BP and either a current hypomanic (n=30) or depressed (n=30) episode and 30 closely age/sex-matched

160 Remitted depressed (n=48) and healthy volunteers (n=48) were rand

161 l cranio-facial dysmorphisms (hypertelorism, depressed nasal bridge, frontal bossing), and postaxial

162 srupt plant-RFS mutualisms can significantly depress native plant fitness.

163 The depressed neuromuscular transmission in R6/2 muscle may

164 Midazolam depressed neuronal activity at a low concentration of 5

165 en midazolam concentration was increased, it depressed neuronal discharge rates in a biphasic manner.

166 on by M1R stimulation requires IP3Rs and can depress NMDA-evoked currents with modest intracellular C

167 cinal leech), endocannabinoids were found to depress nociceptive synapses, but enhance non-nociceptiv

168 and decrease of PBL height, and thus further depressing of aerosol and water vapour in a very shallow

169 ta sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched he

170 ta sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched he

171 porter (SLC6A4, SERT) genes and remission in depressed older adults treated with venlafaxine.

172 to exclusions of persons who were previously depressed or had a history of cancer or cardiovascular d

173 ty-seven offspring of moderately to severely depressed or nondepressed parents selected from the same

174 ned bone structure, increased bone turnover, depressed osteoblastogenesis (Runx2, Sparc), and increas

175 cross-sectional study of 50 medication-free, depressed outpatients using single-voxel MRS, to measure

176 napses maintain the ability to potentiate or depress over a wide frequency range, but it remains unkn

177 e Purkinje cells, evoking complex spikes and depressing parallel fibre synapses.

178 depression status: grandchildren with both a depressed parent and grandparent (n = 38) were at highes

179 t, those with (n = 14) vs without (n = 74) a depressed parent had overall poorer functioning (F = 6.3

180 ychopathology in the biological offspring of depressed parents has been widely replicated, the long-t

181 April 2007 to March 2011) among offspring of depressed parents in the general community.

182 risk of major depression in the offspring of depressed parents is well known.

183 The offspring of depressed parents remain at high risk for depression, mo

184 of major depression seen in the offspring of depressed parents was not offset by later first onsets i

185 nd placebo-controlled design, 46 unmedicated depressed participants and 43 healthy control participan

186 nd placebo-controlled design, 46 unmedicated depressed participants and 43 healthy control participan

187 tivity compared with the other groups, while depressed participants exhibited increased amygdala conn

188 During positive recall, depressed participants exhibited significantly decreased

189 control participants receiving amisulpride), depressed participants receiving amisulpride exhibited i

190 Relative to depressed participants receiving placebo (and control pa

191 Depressed participants selected previously rewarded stim

192 High and low depressed participants were eye-tracked as they complete

193 Within putative reward regions, depressed participants with increased appetites exhibite

194 correlated with food pleasantness ratings of depressed participants with increased appetites, and its

195 In depressed participants, left amygdala activity during po

196 uggests that increasing O-GlcNAcylation will depress pathological hyperexcitability.

197 Although the average depressed patient benefits moderately from cognitive-beh

198 led an atypical pattern of connectivity in a depressed patient subset that would be overlooked in gro

199 tamen, pallidum, and nucleus accumbens in 53 depressed patients (mean age: 44.1 years, 13.8 SD; 52% f

200 In 65 unmedicated depressed patients 15-min resting-state EEGs were record

201 ine whether symptoms experienced by formerly depressed patients after at least 8 weeks of remission c

202 orphometric MRI analysis was conducted in 73 depressed patients and 73 matched comparison subjects wi

203 ontal pole volume was first compared between depressed patients and comparison subjects by subdivisio

204 d subdivisions of human frontal pole between depressed patients and comparison subjects using both un

205 -13 produces rapid antidepressant actions in depressed patients and in preclinical rodent models.

206 ants offer therapeutic benefit, about 35% of depressed patients are not adequately treated, creating

207 al connectivity to reveal subgroups among 80 depressed patients completing resting state fMRI.

208 The sparse comorbidity map confirmed that depressed patients frequently suffer from both psychiatr

209 nal connection in stress, many (but not all) depressed patients have alterations in the components of

210 ive function including executive function in depressed patients in randomised placebo-controlled clin

211 arison of the functional connectivity in 185 depressed patients not receiving medication and 182 pati

212 across DMN nodes, as previously reported in depressed patients on average.

213 In phase 1, depressed patients received high-dose ECT (at six times

214 al magnetic stimulation (rTMS) in bipolar II depressed patients remain unclear.

215 Depressed patients show abnormalities in brain connectiv

216 ty in the left medial frontal pole volume in depressed patients was demonstrated.

217 In this study, thirty-eight bipolar II depressed patients were randomly assigned into three gro

218 der risk, and impaired emotion regulation in depressed patients with a history of suicide attempts.

219 Forty-five depressed patients with a suicide attempt history, 47 no

220 self-reported work productivity improved in depressed patients with antidepressant treatment even af

221 glutamate may be preferentially effective in depressed patients with increased inflammation as measur

222 , brain activity was compared in unmedicated depressed patients with increased or decreased appetite

223 ring the neural responses to food stimuli of depressed patients with increased versus decreased appet

224 kg(-1) intravenously) was administered to 11 depressed patients with MDD.

225 oughts, within 1 day and for up to 1 week in depressed patients with suicidal ideation.

226 clinically significant suicidal ideation in depressed patients within 24 hours compared with midazol

227 Ninety-two individuals (68 depressed patients, 24 never-depressed control subjects)

228 itively correlated with loss aversion in the depressed patients, also implicating impairment in regul

229 th a suicide attempt history, 47 nonsuicidal depressed patients, and 75 healthy controls participated

230 Among currently depressed patients, higher leptin was associated with ke

231 irments in Theory of Mind (ToM) abilities in depressed patients, particularly in relation to tasks in

232 d TPI identified an increased BTP in midlife depressed patients, suggesting early and subtle vascular

233 s aversion correlated with each other in the depressed patients, suggesting that a common pathophysio

234 the North of England, we recruited severely depressed patients, who were diagnosed as having unipola

235 eable, better informed, and less anxious and depressed patients, with a better mental well-being.

236 significantly smaller medial frontal pole in depressed patients, with a negative correlation of disea

237 effects of psilocybin, and are the first in depressed patients.

238 LDN5 expression was also decreased in NAc of depressed patients.

239 tive protein (CRP)) are reliably elevated in depressed patients.

240 nitive measures over 8 weeks of treatment in depressed patients.

241 y defined medial area of the frontal pole in depressed patients.

242 Orexins are altered in anxious and depressed patients.

243 Our model suggests that in depressed people with high ELS, the likelihood of remiss

244 social connections, were connected to other depressed people, or were connected to people who had le

245 of the GAL system in postmortem brains from depressed persons who had committed suicide and controls

246 ption of inflammatory genes and consistently depressed phagocytosis of amyloid-beta1-42 (Abeta) by mo

247 oratory strain of Enterococcus faecalis, but depressed photoinactivation of sewage-sourced enterococc

248 t cocaine and the expectancy of cocaine each depresses plasma leptin levels.

249 ricular filling pressures with exercise, and depressed pulmonary artery vasodilator reserve.

250 All new analogues show depressed pyrogenicity in both free (micellar) state and

251 nhibition of oxidative phosphorylation alone depressed recovery from vesicle depletion.

252 roteomic differences as a function of state (depressed/remitted) or number of previous episodes.

253 ow dose of ethanol (0.3 mg/kg) alone did not depress respiration but in prolonged morphine-treated an

254 luoxetine and a dopamine transporter blocker depress reuptake in striatum.

255 ercise, lower pulmonary arterial compliance, depressed right ventricular ejection fraction, and short

256 aARs in young mice (noradrenaline; 10(-9) m) depressed ROV most effectively in FA and 1A.

257 The mutation induces Ca(2+) imbalance by depressing RyR2 channel activity during excitation-contr

258 It is suggested that a deceivingly depressed selectivity (1 < kappaobs < kA/kB), caused by

259 th others, because high-efficiency terminals depress significantly during episodic bursts of activity

260 f electrons and holes are always enhanced or depressed simultaneously in electric fields.

261 d midline shift (OR, 6.8; 95% CI, 3.4-13.8), depressed skull fracture (OR, 6.5; 95% CI, 3.7-11.4), an

262 Lower GCS score, midline shift, depressed skull fracture, and epidural hematoma are key

263 rvival through multiple mechanisms including depressing stroke volume, increasing fluid loss into the

264 Trains of EPSCs (5 Hz) depressed strongly throughout development, whereas conve

265 ors of cognition across the entire sample of depressed subjects and HR.

266 is increasingly localized to lipid rafts in depressed subjects and that chronic antidepressant treat

267 In contrast, depressed subjects experiencing appetite loss exhibited

268 dered for treatment of insulin resistance in depressed subjects.

269 um) and block by the peptide inhibitor blood depressing substance I (BDS-I).

270 l spinal neurons, blockade of Kv3.4 by blood depressing substance II suppresses axon growth via an in

271 udy, we examined miRNA networks in the LC of depressed suicide completers and healthy controls.

272 These effects were absent in the depressed suicide completers with no history of child ab

273 were pairwise correlated specifically in the depressed suicide group, but not in the control group.

274 vels are increased in the post-mortem PFC of depressed suicide subjects relative to matched controls.

275 nal connectivity, and this is related to the depressed symptoms.

276 litation would be present at these and other depressing synapses.

277 NTD exhibit increased mobility in synapses, depress synaptic transmission and are unable to sustain

278 cause of its widely characterized ability to depress synaptic transmission on short- and long-term sc

279 tivation of presynaptic GABABRs specifically depresses synaptic transmission from the AOC to OB inhib

280 The incidence of RA was higher in depressed than non-depressed individuals (2.07 vs. 1.21

281 ns between the fungal species can trigger or depress the biocontrol activity.

282 In comparison, 1-hydroxymidazolam did not depress the cortical network activity at low nanomolar c

283 The simulations indicate that fluctuations depress the freezing efficiency of monolayers of alcohol

284 enough in atmospheric particles to strongly depress the surface tension until activation, and (2) th

285 ne evoked respiratory response and partially depressed the cardiovascular response in one participant

286 erial CO2 tension: approximately 46.3 mmHg), depressed the CMRO2 ( approximately 17%, P = 0.04, Cohen

287 Bath-applied Abeta (1 mum) depressed the IPSCs on average to 60% of control, wherea

288 addition, PNE increased the TRPV1 currents, depressed the slow delayed rectifier potassium currents,

289 eron (IFN), a major antiviral mediator, also depresses the cholesterol synthesis pathway.

290 and increased N2 O flux, while significantly depressing the Q10 for CO2 , and having no effect on the

291 wild-type and mutant neuromuscular junctions depress to steady-state response levels, but the latter

292 ways connecting phytoplankton and fish, (ii) depresses trophic transfer efficiencies in the tropics a

293 f schizophrenia or schizoaffective disorder, depressed type.

294 fically in cardiomyocytes, we found severely depressed ventricular function in the Gata4-ablated mice

295 .96 events per 1000 person-years among those depressed versus nondepressed, multiadjusted hazard rati

296 s demonstrate that simulated future climates depress viability and fecundity components of fitness fo

297 Participants with depressed visual field sensitivity reported lower visual

298 c silencing of natural GAD65LH cell activity depresses voluntary locomotion, and that GAD65LH cell ov

299 In depressed volunteers, changes in IL-18 were more pronoun

300 ss drove a phase shift to high mortality and depressed zoobenthic immobilized carbon stocks, which ha