ライフサイエンスコーパス: depressant

1 ession attenuated cocaine reward and was pro-depressant.

2 ate (GHB) is a potent central nervous system depressant.

3 quite similar to those mediated by other CNS depressants.

4 l differences in the response to common anti-depressants.

5 e appears to be non-specific in blocking the depressant action of 2-Me-5-HT, gamma-aminobutyric acid

6 Recently, we showed that the baroreflex depressant action of ANG II in the NTS is mediated by ac

7 concentration-response relationship for the depressant action of CADO on the EPSPm more closely para

8 Although the motor-depressant action of diazepam is suppressed in alpha1(H1

9 The network depressant action of midazolam at low concentrations was

10 closely paralleled that for its presynaptic depressant action on glutamate-mediated EPSPs than that

11 The depressant action on the evoked IPSC was reduced, but no

12 The depressant actions of ethanol on central nervous system

13 but show normal sensitivity to its locomotor-depressant actions.

14 pha and IL-1beta as well as serum with known depressant activity from five patients with acute septic

15 by TNF-alpha, IL-1beta, and serum with known depressant activity from patients with septic shock.

16 Myocardial depressant activity was found to be heat stable, protein

17 Myocardial depressant activity was measured by using isolated rat l

18 e change in the mode of action of LqhIT5 (no depressant activity) by substitutions of a few amino aci

19 resulted in elimination of serum myocardial depressant activity.

20 ere evaluated for the presence of myocardial depressant activity.

21 ts with meningococcal disease had myocardial depressant activity.

22 a fast contraction paralysis occurs without depressant activity.

23 cally associated with central nervous system-depressant agents, including motor incoordination, anxio

24 xins (LqhIT2, LqqIT2), and Buthotus judaicus depressant anti-insect toxin (BjIT2).

25 ect toxin 4 (AaIT4), Leiurus quinquestriatus depressant anti-insect toxins (LqhIT2, LqqIT2), and Buth

26 neuroactive drugs, including trycyclic anti-depressants, anti-convulsants, and opiates.

27 ker gene expression that correlate with anti-depressant, antipsychotic and opioid drug action on prim

28 ally unapproved formulations for NSAID, anti-depressant/benzodiazepine, and anti-psychotic FDCs were

29 decreased for metformin (100%/75%) and anti-depressants/benzodiazepines (20%/18%), and the overall p

30 abetes (metformin), depression/anxiety (anti-depressants/benzodiazepines), and psychosis (anti-psycho

31 napproved formulations were as follows: anti-depressants/benzodiazepines, 69%; anti-psychotics, 43%;

32 (80%) approved, five (20%) unapproved; anti-depressants/benzodiazepines: 16 formulations, three (19%

33 of a highly potent insect-selective scorpion depressant beta-toxin, Lqh-dprIT(3), from Leiurus quinqu

34 The fact that anti-depressants, cocaine and amphetamines can have such prof

35 nutes) of variable direction, stimulatory or depressant, depending on the ambient physiologic milieu

36 Because the tricyclic anti-depressant desipramine has been found to be effective in

37 parison of different chemical classes of CNS depressant drugs on NMDA-gated currents.

38 Some have speculated that the depressant effect is related to long-term depression (LT

39 nodal myocytes, elevated [K+]o, augments the depressant effect of adenosine on AV nodal conduction.

40 The depressant effect of capsaicin on gustatory transmission

41 The depressant effect of high glucose was rapidly (minutes)

42 Tolerance developed to the respiratory depressant effect of morphine but at a slower rate than

43 elative lack of tolerance to the respiratory depressant effect of opioids.

44 The depressant effect of Waglerin-1 was greater at negative

45 (10 and 30muM) and Flupirtine (30muM) had a depressant effect on 4-AP-induced excitation in SG such

46 ggest that in addition to its well-described depressant effect on NMDA receptor-mediated synaptic tra

47 n 2 and 7 hours of exposure; this myocardial depressant effect persisted at 25 hours.

48 The depressant effect was due mostly to anoxic activation of

49 anding of molecular mechanisms of the mGluR4 depressant effect, we decided to identify the proteins i

50 edating patients, which can have respiratory depressant effects and reduce patient mobility.

51 Similarly, depressant effects caused by synergistic concentrations

52 ist CGP 55845A (1 microM) fully reversed the depressant effects of (-)-baclofen (5-10 microM) such th

53 These results suggest that the depressant effects of A2a receptor activation are due to

54 thine (DPCPX; 0.2 microM) fully reversed the depressant effects of both adenosine (100 microM) and CA

55 Antagonism of GABAA receptors blocked the depressant effects of CGS 21680 on neuronal firing; was

56 ed bursting frequency, and acid reversed the depressant effects of halothane, consistent with modulat

57 ical effects of the VSD patch and myocardial depressant effects of ischemia and reperfusion during su

58 increased behavioral arousal and reduced the depressant effects of isoflurane on barrel cortex somato

59 If these depressant effects of L-Phe take place in the PKU brain,

60 Consistent with the depressant effects of L-Phe, expression of NMDA receptor

61 We found that the anxiolytic and anti-depressant effects of NPS are enhanced in acute ethanol

62 ethanol reduced tolerance to the respiratory depressant effects of opioids.

63 hesis sensitizes the heart to the myocardial depressant effects of PPA and increases the risk for ven

64 erm potentiation (LTP) was enhanced, and the depressant effects of the metabotropic glutamate recepto

65 test also mirror the antidepressant and pro-depressant effects of these drugs in patients suggesting

66 Thus, after fluid loading, the cardiac-depressant effects of TNF and L-NMMA given together beca

67 Of note was that the cardiac-depressant effects of TNF and L-NMMA given together were

68 sed in the brain during hypoxia has critical depressant effects on breathing in fetal and newborn mam

69 in these analyses is consistent with strong depressant effects that account for the "zombielike" beh

70 ioral changes, such as stimulant followed by depressant effects, and (2) chronic changes in behavior,

71 gamma-hydroxybutyrate, a drug of abuse with depressant effects, primarily on the central nervous sys

72 by which PACAP exerts its anxiogenic and pro-depressant effects, via the recruitment of the central C

73 tides AQEE-30 and TLQP-62 in dHc induced pro-depressant effects.

74 in septic shock are known to have myocardial depressant effects.

75 in mice with profound central nervous system depressant effects.

76 tOH), has stimulant, anxiolytic, ataxic, and depressant effects.

77 his neuropeptide has anti-rewarding (ie, pro-depressant) effects.

78 protein augmented the release of myocardial depressant factor by peripheral blood mononuclear cells

79 Nitric oxide is a myocardial depressant factor candidate.

80 wed that interleukin 6 is a major myocardial depressant factor in children with meningococcal septice

81 Further characterization of the myocardial depressant factor was undertaken by using cell culture s

82 tein products had properties of a myocardial depressant factor--specifically a 12-25 kDa heat-stable

83 size and had characteristics of a myocardial depressant factor.

84 Myocardial depressant factors are also released when whole blood or

85 Myocardial depressant factors are thought to cause myocyte dysfunct

86 ification and characterization of myocardial depressant factors present in meningococcal septicemia.

87 s mediated in part by circulating myocardial depressant factors.

88 stimulators could serve as fast-acting anti-depressants in some forms of depressive and stress-relat

89 Volatile hydrocarbon based CNS depressants including short chain alcohols and anestheti

90 A receptor (GABA(A)R) is the target of many depressants, including benzodiazepines, anesthetics, and

91 nment, dietary restriction, running and anti-depressants increase proliferation, however, stress and

92 The scorpion venom-derived excitatory and depressant insect-selective polypeptide neurotoxins modi

93 y a significant increase in anxiety-like and depressant-like behaviors relative to wild type.

94 tration into mPFC mimics the anxiogenic- and depressant-like effects of social stress.

95 of MDD, and (ii) clinical remission to anti-depressant medications (ADMs).

96 Glucose (Tg = 30 degreesC), a very effective depressant of the phase transition temperature of freeze

97 dorsal hippocampus (dHc) or NAc, led to pro-depressant or antidepressant behaviors, respectively, wh

98 Unlike other presynaptic depressants, partial NaCh blockade increases paired-puls

99 -alcohols increase in central nervous system depressant potency with increasing chain length until a

100 de variety of volatile hydrocarbon based CNS depressants produce a similar inhibition of NMDA-gated c

101 recently leptin has been shown to have anti-depressant properties.

102 ice, although they showed a normal locomotor depressant response to the dopamine D1 antagonist SCH-23

103 otic effects of propofol without the cardiac depressant side-effects.

104 sychological states, including stimulant and depressant states.

105 ith the presence of a circulating myocardial depressant substance with physical characteristics consi

106 anesthetics (GAs) are central nervous system depressants that render patients unresponsive to externa

107 307/rs14259 (E197G-A>G) plays a role in anti-depressant therapy response, depression and schizophreni

108 itatory toxins in its mode of action and the depressant toxins in its primary structure.

109 Sequence comparison of LqhIT5 and known depressant toxins shows a high degree of similarity amon

110 thin hippocampus produced by stress and anti-depressant treatment that may open an avenue of understa

111 Onset kinetics for the CNS depressants was similar with tau values near 100 ms.

112 dogmatic view that BK channels act as neural depressants, we show that drug-induced slo expression en

113 fects have not been obtained with other anti-depressants which also block neonatal AS.