ライフサイエンスコーパス: depression

1 ns in response to the induction of long-term depression.

2 tial target for the treatment of anxiety and depression.

3 sk of developing epilepsy following incident depression.

4 tmortem dorsolateral PFC of individuals with depression.

5 P = NS), except for proxy-reports of sadness/depression.

6 campal volume loss is a hallmark of clinical depression.

7 quality of life and increased prevalence of depression.

8 like morphine, can be limited by respiratory depression.

9 port a role of the amygdala in recovery from depression.

10 to an important role of this phosphatase in depression.

11 le clustering defects and increased synaptic depression.

12 Inflammatory illness is associated with depression.

13 gy in this sample of patients with late-life depression.

14 al dopaminergic indices in suicide and major depression.

15 ty to reward loss/gain consistent with human depression.

16 rease in ventilation followed by a secondary depression.

17 apid antidepressant effects in patients with depression.

18 sent the majority of those affected by major depression.

19 ographics, medical comorbidities, and active depression.

20 raumatic stress disorder (PTSD) and probable depression.

21 ructure known to be involved in both OCD and depression.

22 for patients with mild to moderate severity depression.

23 easures of posttraumatic stress disorder and depression.

24 fiber sprouting, but exhibited less synaptic depression.

25 50% for pain/discomfort, and 41% for anxiety/depression.

26 sponse rates in participants with bipolar II depression.

27 nisms through which RCL1 may be relevant for depression.

28 ds at levels not seen since before the Great Depression.

29 an array of disorders, including anxiety and depression.

30 with venlafaxine in older adults with major depression.

31 ed to dramatic and long-lasting remission of depression.

32 of psychiatric diseases, such as anxiety and depression.

33 ns abolishes NMDA-induced chemical long-term depression.

34 rong predictor for suicidality in males with depression.

35 ow brain reward networks contribute to youth depression.

36 or people with intellectual disabilities and depression.

37 a role in explaining the protection against depression.

38 hy; and symptoms of fatigue, sleepiness, and depression.

39 ry was positive for hypercholesterolemia and depression.

40 e, effective, and ethical use of ketamine in depression.

41 bioenergetic function in subjects with major depression.

42 entral striatum [nucleus accumbens (NAc)] in depression.

43 obesity, dysfunctional breathing and anxiety/depression.

44 e of HCM over the development of anxiety and depression.

45 ious anhedonia, pure anhedonia, and resolved depression.

46 derstand the molecular and cellular basis of depression.

47 or women with previous hospital contacts for depression.

48 ion control) in individuals with symptoms of depression.

49 D patients with depression and those without depression.

50 ovascular disease (1.20; 95% CI, 1.06-1.36), depression (1.72; 95% CI, 1.55-1.90), and low educationa

51 nt), gastroesophageal reflux (+1 point), and depression (+1 point) was predictive of the "persistentl

52 ortality in comparison with patients without depression (10.8% versus 6.1%; adjusted hazard ratio, 1.

53 etal pain (303 [38%]), headache (278 [35%]), depression (124 [17%] of 713 responses), abdominal pain

54 115482041) in the RCL1 gene segregating with depression across multiple generations.

55 ); (2) treated depression; and (3) untreated depression adjusting for demographics, AMI severity, and

56 However, little is known about whether depression affects individuals' valuation of potential r

57 Since depression affects multiple brain regions, and the role

58 major (beta = -0.193, pcorrected = 0.025) in depression (all betas standardised).

59 In depression, altered genes include humanin-like-8 (MTRNRL

60 we found uneven benefit of NDVI on incident depression among our study participants.

61 The rate of depression among the patients in this study was comparab

62 nerating long-term synaptic potentiation and depression, AMPARs are the main fast transduction elemen

63 759 (18.7%) patients met PHQ-9 criteria for depression and 231 (30.4%) were treated.

64 ment Network of whom 229164 (2.2%) developed depression and 97177 (0.9%) developed epilepsy.

65 diseases, such as autism spectrum disorder, depression and Alzheimer's disease.

66 renal (HPA) axis has been linked to risk for depression and antidepressant response.

67 The risk ratio of depression and anxiety 3 years after admission to ICU wa

68 ed to identify genetic mechanisms underlying depression and anxiety after traumatic experiences.

69 i-inflammatory effects and risk of new-onset depression and anxiety among adult patients admitted to

70 een in the internalizing conditions of major depression and anxiety disorders, risk was associated wi

71 Depression and anxiety frequently accompany the motor ma

72 one may be potential therapeutic targets for depression and anxiety in traditionally treatment-resist

73 Mean Hamilton depression and anxiety scores were highest in AN (p<0.00

74 Baseline HRQoL, depression and BMI should be systematically assessed bef

75 tory cytokine production, in turn leading to depression and cognitive deficits.

76 support for interactions between inbreeding depression and environmental variation compared with exp

77 ically relevant phenotypes including anxious depression and episodic recurrence.

78 l increase in equitable contact coverage for depression and improved mental health literacy.

79 connected limbic brain regions implicated in depression and its treatment with imipramine or ketamine

80 individuals experience recurrent episodes of depression and mania, disrupting normal life and increas

81 vary by level of childhood disadvantage for depression and metabolic syndrome in young adulthood, ac

82 d parameters supports an association between depression and momentary mood fluctuations during cognit

83 ine in behavioral symptoms using the Anxiety Depression and Mood Scale (ADAMS) total score.

84 At baseline, both groups had moderate depression and no hypomanic or manic symptoms.

85 identify RCL1 as a novel candidate gene for depression and offer insights into mechanisms through wh

86 xygen consumption rates indicating metabolic depression and pointing to particular sensitivity of E.

87 y mediated the effect of the intervention on depression and PTSD at 6 months post-transplant.

88 Associations between previous treatment of depression and risk of receiving nonguideline treatment

89 d transporter, in nucleus accumbens (NAc) in depression and stress susceptibility.

90 Depression and suicidal ideation improved equally with b

91 k of negative mental health outcomes such as depression and suicide.

92 leukocyte populations from PD patients with depression and those without depression.

93 t have shown a negative relationship between depression and ToM.

94 Depression and use of antidepressant medications are bot

95 5 patients (35.7%) were classified as having depression, and 32 patients (20.8%) had borderline depre

96 ns of self-care, usual care, and anxiety and depression, and a lower EuroQol visual analog scale scor

97 ported lower sleep disturbance, anxiety, and depression, and better cognitive function than younger p

98 Maternal stress, depression, and childhood wheezing episodes were assesse

99 % CI = 2.9-5.4) after adjusting for anxiety, depression, and healthcare utilization.

100 on and interferon-alpha, patients with major depression, and healthy controls).

101 Excellence clinical guidelines for anxiety, depression, and OA and was supported by a brief training

102 orbid with migraine include asthma, anxiety, depression, and other chronic pain conditions, and these

103 ocin receptor expression in both suicide and depression, and provisional evidence for altered DNA-dep

104 reater benefits in quality of life, anxiety, depression, and spiritual well-being compared with UC al

105 tion and development of new therapeutics for depression, and the next steps that need to be made to f

106 epression (PHQ-9<10; reference); (2) treated depression; and (3) untreated depression adjusting for d

107 of Perceived Social Support (MSPSS), (2) The Depression Anxiety Stress Scales (DASS-21), (3) the Live

108 r dominant phenotype, autonomic dysfunction, depression, anxiety and probable behaviour disorder, but

109 High levels of depression, anxiety and social anxiety occurred in all g

110 isorders (schizophrenia, bipolar or unipolar depression, anxiety disorders, and substance use disorde

111 study was to assess the association between depression, anxiety, and AD in adults and examine the ri

112 jects had few symptoms, that is, sleepiness, depression, anxiety, and cognitive deficits.

113 associated with higher reported symptoms of depression, anxiety, and post-traumatic stress disorder

114 requency of clinically significant levels of depression, anxiety, and posttraumatic stress among pati

115 c conditions (posttraumatic stress disorder, depression, anxiety, and substance abuse) on this associ

116 Depression, anxiety, and suicidal ideation are more comm

117 ychiatric symptoms to compare prevalences of depression, anxiety, suicidal ideation, and anxiety atta

118 severe anxious depression, moderate anxious depression, anxious anhedonia, pure anhedonia, and resol

119 s response, neural processing of reward, and depression are related in very young children.

120 The etiologic factors of late-life depression are still poorly understood.

121 circadian rhythms that resemble features of depression as it appears in humans.

122 ry outcomes included indicators of grief and depression as reported by adolescents and behavioural pr

123 Imaging study participants who had undergone depression assessments.

124 JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synap

125 Intervention patients also reported lower depression at week 24, controlling for baseline scores (

126 chiatric disorders, including schizophrenia, depression, attention-deficit hyperactivity disorder and

127 oaggregation between them and schizophrenia, depression, attention-deficit/hyperactivity disorder, ea

128 Synaptic depression attenuates the sensitivity to DCS from 1.1% p

129 to better QOL (B = 2.61; P < .001) and less depression (B = -0.78; P < .001) among patients who repo

130 ith better QOL (B = 3.50; P < .001) and less depression (B = -1.01; P < .001) among patients who ackn

131 cted by contemporary theoretical accounts of depression based on findings in animal models.

132 atients who have a diagnosis of self-harm or depression before surgery.

133 eus accumbens MSN subtypes in stress-related depression behavior and speculates on how currently unde

134 ore >9) who sought treatment for symptoms of depression between the baseline and the 18 month survey

135 est possible differences in the aetiology of depression between women and men.

136 re is the source of the sample, with greater depression burden prevalent in clinic-based samples.

137 levels and show no clear signs of anxiety or depression, but do show clear signs of reduced motivatio

138 We investigated evidence for inbreeding depression by environment interactions in nine traits in

139 (n = 1,188), we show here that patients with depression can be subdivided into four neurophysiologica

140 nt in the Guaymas Basin, a young extensional depression, causes mass production and discharge of reac

141 ed with the Center for Epidemiologic Studies Depression (CES-D) scale; LTL (years 15, 20, 25) and mtD

142 esistance may benefit patients with atypical depression characterized by obesity-related metabolic al

143 vation, which allowed us to examine both the depression component (Dc-ODP) and potentiation component

144 Perinatal depression comprises a heterogeneous group of clinical s

145 predicts presynaptic expression of long-term depression, consistent with experimental observations.

146 Conclusion Women previously treated for depression constitute a large subgroup of patients with

147 Cortical spreading depression (CSD) is likely the underlying phenomenon of

148 geminovascular neurons by cortical spreading depression (CSD).

149 ngulate deep brain stimulation (SCC DBS) for depression demonstrated the common impact of the electri

150 e matter was associated with greater anxiety/depression during late childhood.

151 t the hypothesis that maternal stress and/or depression during pregnancy and early life are associate

152 s for Epidemiologic Studies Depression Scale depression, education, and health-related quality of lif

153 hat antidepressant effects of amisulpride in depression emerged after sustained administration.

154 health-related quality of life, anxiety and depression, employment status, and use of analgesics and

155 In order to estimate the variance in depression explained by the genetic vulnerability, the s

156 t genetic factors influence vulnerability to depression following stress.

157 f 66.6 (standard deviation, 7.6) years, were depression-free in 1996, and were followed through 2008.

158 Logistic regression explored predictors of depression from among individual and clinical characteri

159 ng the relationship between inflammation and depression from this evolutionary perspective yields a n

160 In contrast, the 528 patients with untreated depression had higher 1-year mortality in comparison wit

161 l hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with sev

162 d 14 items from the clinician-rated Hamilton Depression (HAM-D) rating scale.

163 Twitter data and details of depression history were collected from 204 individuals (

164 tion of the biological mechanisms underlying depression, however, its complex etiology has proved to

165 After further adjustment for active depression, however, risk for subjective memory impairme

166 In bipolar depression imaging studies show increased dopamine trans

167 vironment in potentially countering incident depression in a nationally representative survey in Sout

168 as a direct measure of the vulnerability for depression in a sample of 5221 individuals from 3083 fam

169 nctional MRI (fMRI), to predict the onset of depression in adolescents.

170 gate biopsychological mechanisms of comorbid depression in OCD, we examined effective connectivity an

171 depressive symptoms and prevent more severe depression in older people.

172 terferon-alpha, a widely used model to mimic depression in the context of inflammation.

173 gs have been obtained in patients developing depression in the context of treatment with interferon-a

174 ine the rationale of why certain features of depression including its environmental and genetic risk

175 l vasodilation appears caused by respiratory depression-induced hypoxia and a subsequent rise in CO2

176 ons between profiles and intrapersonal (e.g. depression), interpersonal (e.g. empathy), and emotion r

177 sted for age, condomless receptive anal sex, depression, interpersonal stigma, law enforcement stigma

178 tomatology-Self Report [QIDS-SR] or the Beck Depression Inventory [BDI]), obtained for up to 1 week a

179 ation, serum samples were taken and the Beck Depression Inventory II was completed to assess depressi

180 = 0.81) and moderately correlates with Beck Depression Inventory-Second Edition (r = 0.293; p < 0.00

181 cortex on the posterior cingulate cortex in depression is a neural correlate of the disturbed self-a

182 of brexanolone in patients with post-partum depression is in progress.

183 st-surgery self-harm and hospitalization for depression is mainly attributable to patients who have a

184 Like other neuropsychiatric disorders, depression is not a unitary disease, but rather a hetero

185 dispose individuals to increased anxiety and depression later in life.

186 care-induced phenotype, including diminished depression-like and anxiety-like behaviors.

187 , decreased anxiety-like behavior, decreased depression-like behavior and increased preference for re

188 Of interest, increased depression-like behavior in the forced swim test was obs

189 tor decreased vocalizations and anxiety- and depression-like behaviors and increased sensory threshol

190 mothers consistently displayed anxiety- and depression-like behaviors under acute stress.

191 only aged HCM females displayed anxiety- and depression-like behaviors.

192 tment with either GLO1 inhibitor blocked the depression-like effects induced by CMS on the FST and co

193 area (VTA)-a brain reward region-to be in a depression-like state.

194 ays fewer side effects, such as sedation and depression-like symptoms, than other dopamine receptor a

195 h wealth, income, subjective wellbeing, less depression, low social isolation and loneliness, more cl

196 this pathway in activity-dependent long-term depression (LTD) at hippocampal Schaffer collateral (SC)

197 t that activation of mGlu3 induces long-term depression (LTD) of excitatory transmission in the PFC a

198 timulation-induced NMDAR-dependent long-term depression (LTD).

199 Alcohol dependence (AD) and major depression (MD) are leading causes of disability that of

200 ention patients experienced less anxiety and depression (median Hospital Anxiety and Depression Scale

201 to chronic social defeat stress, a validated depression model, and used RNA sequencing to analyze tra

202 ypes of perinatal depression: severe anxious depression, moderate anxious depression, anxious anhedon

203 trast to younger patients, older adults with depression more commonly have several concurrent medical

204 depression (PMD) and with nonpsychotic major depression (NPMD) and healthy controls (HC) were studied

205 Major depression occurs in 2% of adults aged 55 years or older

206 al stimulation, but, surprisingly, decreased depression of dendritic IPSCs isolated after blocking GA

207 OF increased depression of inhibitory postsynaptic currents (IPSCs) a

208 bumin interneurons (PV-IPSCs), but decreased depression of IPSCs from dendritically projecting somato

209 uent optogenetic analyses revealed increased depression of IPSCs originating from perisomatically pro

210 ebellar output mediated in-part by long-term depression of parallel fiber-Purkinje cell synapse and i

211 d C-X-C motif chemokine 10, in parallel with depression of serum markers of the myeloid cell activati

212 increases in global network excitability or depression of the conditioned pair.

213 Indeed, depression often precedes cognitive deficits in patients

214 rs screened with moderately severe to severe depression on the Patient Health Questionnaire 9 (PHQ-9)

215 To determine the effect of depression on the risk of epilepsy and seizure outcomes.

216 e psychiatric outcomes, the association with depression onset has not, to our knowledge, been previou

217 sk ratio of new-onset psychiatrist-diagnosed depression or anxiety or prescriptions for antidepressan

218 sm with internalizing psychopathology (e.g., depression or anxiety).

219 e of these studies adequately controlled for depression or other psychiatric disorders that may be li

220 tic violence, and those diagnosed with major depression or psychotic disorders were excluded.

221 ifference in negative aspects of caregiving, depression, or anxiety.

222 2.29; diabetes: OR 1.56; hepatitis: OR 1.30; depression: OR 1.47; hearing impairment: OR 1.91) (all P

223 It was lower in subjects reporting depression (P = .0414).

224 st-stroke anxiety (P = 0.04) and post-stroke depression (P = 0.02).

225 rences in disease activity indices, anxiety, depression, perceived stress, and quality-of-life scores

226 A broad depression phenotype including both phenotypes has not b

227 erence in the proportion of individuals with depression (PHQ-9 score >9) who sought treatment for sym

228 red between patients with AMI having: (1) no depression (PHQ-9<10; reference); (2) treated depression

229 s with major depression with psychotic major depression (PMD) and with nonpsychotic major depression

230 ICD-positive patients had more severe depression, poorer sleep quality and reduced quality of

231 study was to determine whether a history of depression predicted incident back pain in a population

232 Neither CMD nor depression predicted intake changes.

233 Observations: Depression presents with the same symptoms in older adul

234 olfactory bulb is subject to strong synaptic depression, presumably truncating the postsynaptic respo

235 ternal smoking during pregnancy in offspring depression, rather observed associations may reflect res

236 ression Rating Scale [MADRS] or the Hamilton Depression Rating Scale [HAM-D]) and self-report scales

237 linician-administered (the Montgomery-Asberg Depression Rating Scale [MADRS] or the Hamilton Depressi

238 were moderately depressed (Montgomery-Asberg Depression Rating Scale=30+/-6) and about half were trea

239 Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated wit

240 cription factor FoxO3a, previously linked to depression-related behavior and shown to be regulated in

241 that REDD1 in cacna1c HET mice may influence depression-related behavior via regulation of the FoxO3a

242 en-eleven translocation protein 1 (TET1), in depression-related behavioral abnormalities.

243 pact on weight, activity levels, anxiety, or depression-related behaviors.

244 In contrast to the cocaine- and depression-related phenotypes, GluA1/A2 AMPARs in the NA

245 ected functional connectivity paths within a depression-relevant network were characterized using Gro

246 (eg, region A influences region B) within a depression-relevant network were characterized using Gro

247 eports implicating SRF and MEF2 in long-term depression (required for Dc-ODP), and CREB in long-term

248 ression symptoms on the Hospital Anxiety and Depression Scale and Patient Health Questionnaire (adjus

249 ptoms, and QOL with the Hospital Anxiety and Depression Scale and Patient Health Questionnaire, PTSD

250 psychological distress (Hospital Anxiety and Depression Scale anxiety and depressive symptoms and Glo

251 isability, Centers for Epidemiologic Studies Depression Scale depression, education, and health-relat

252 ompleted the Center of Epidemiologic Studies Depression scale in 1993.

253 and depression (median Hospital Anxiety and Depression Scale score: 6 versus 9; P=0.015) and better

254 have small short-term beneficial effects on depression scores and quality of life in patients with i

255 To evaluate the diagnostic accuracy of depression screening instruments and to compare safety a

256 e 10 included studies showed that a range of depression screening instruments produces acceptable lev

257 , on Earth, are characterized by bowl-shaped depressions several tens of centimetres across, whose ed

258 entified five distinct subtypes of perinatal depression: severe anxious depression, moderate anxious

259 Parent-reported child depression severity and child cortisol response followin

260 ing a stressor was associated with increased depression severity and reduced amygdala reactivity to s

261 se (defined as a 40% or greater reduction in depression severity from baseline) averaged over months

262 or, functional brain activity to reward, and depression severity in children 4 to 6 years old.

263 ady related to increased cortisol output and depression severity in preschoolers.

264 aged 6 to 12 years; and emotional awareness, depression severity, and general health outcomes in chil

265 the severity of suicidality independent from depression severity.

266 Patients with depression show blunted amygdala hemodynamic activity to

267 However, participants with depression showed an intact association between RPEs and

268 One-tenth of antidepressant initiators with depression simultaneously initiated benzodiazepine thera

269 be associated with relapse or recurrence of depression, so the patient should be closely observed.

270 timing-dependent long-term potentiation and depression (st-LTP and st-LTD) were confined to a +/-25

271 nitive performance differed as a function of depression subtype.

272 A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and started w

273 increment, aOR = 1.49, 95% CI: 1.12, 2.00), depression symptoms (aOR = 3.13, 95% CI: 1.05, 9.36), an

274 vity was associated with greater anxiety and depression symptoms during early adulthood, while increa

275 nt, intervention participants reported lower depression symptoms on the Hospital Anxiety and Depressi

276 Rates of elevated depression symptoms were higher during the postpartum pe

277 hifted from spike-timing-dependent long-term depression (tLTD), the predominant form of plasticity in

278 health they ranged from 1.61 (1.51-1.72) for depression to 1.92 (1.79-2.04) for anxiety; for illicit

279 manner that is known to cause switches from depression to mania.

280 s and to compare safety and effectiveness of depression treatments in adults within 3 months of an AC

281 Industry-sponsored child and adolescent depression trials suffer from a number of implementation

282 expression profiling studies of suicide and depression using oligonucleotide microarrays have often

283 Prior depression was a statistically-significant predictor of

284 22.1%) ERMs were mild and thin and a foveal depression was present.

285 The contact coverage for current depression was six-times higher in the 18 month survey p

286 Change in depression was unrelated to change in neuropsychological

287 risk factors (obesity, sleep complaints, and depression) was predicted by a large number of indicator

288 riority trial involving adults with unipolar depression, we randomly assigned patients to receive tDC

289 Symptoms of psychosis and depression were established using questions from the Men

290 teristics associated with medication use for depression were largely consistent with those for anxiet

291 age 17 years, the odds of reporting clinical depression were more than seven times higher in individu

292 Adults aged 18-65 with treatment-naive major depression were randomly assigned with equal likelihood

293 tual disabilities and clinically significant depression were recruited from health and social care se

294 rection opposite to the changes described in depression, when performance is maintained.

295 ctivation of these synapses leads to initial depression, which is followed by steady-state responses

296 have been associated with opiate respiratory depression, which may have clinical applications.

297 CBT, for adolescents with moderate to severe depression who are attending routine specialist CAMHS cl

298 rescribed for short periods to patients with depression who are beginning antidepressant therapy to i

299 an increase in the proportion of people with depression who sought treatment (contact coverage).

300 Patients with major depression with psychotic major depression (PMD) and wit