ライフサイエンスコーパス: deprotection

1 astereoselective hydrogenation, and nitrogen deprotection).

2 ral modification via UV irradiation or basic deprotection.

3 id-catalyzed deprotection, and amine-induced deprotection.

4 rded its 6-phospho analogue (49) after final deprotection.

5 athione could be observed upon the enzymatic deprotection.

6 of synthetic peptides prior to cleavage and deprotection.

7 atalyst, followed by S-alkylation and acetyl deprotection.

8 novel heterocyclic system 4 during attempted deprotection.

9 condensation with symmetrical diamines, and deprotection.

10 roxylation catalyzed by OsO(4) or RuO(4) and deprotection.

11 , followed by solution-phase cyclization and deprotection.

12 egulate telomere length and prevent telomere deprotection.

13 l 12 via the practical Tollens' reaction and deprotection.

14 ecular dynamics contribution to amide proton deprotection.

15 rther elaborated by hydroboration and global deprotection.

16 ct was obtained after macrolactamization and deprotection.

17 eased difficulties in both glycosylation and deprotection.

18 cketed by acetonide formation, and wholesale deprotection.

19 at allows controlled and reversible telomere deprotection.

20 ic phospholane monomers followed by oligomer deprotection.

21 tion with 800 nm light resulted in efficient deprotection.

22 er by a Mitsunobu reaction followed by final deprotection.

23 yl Thermolabile Protecting Groups in thermal deprotection.

24 site-selective syn-1,4-hydroxyamination and deprotection.

25 r promotion of the coupling reaction and for deprotection.

26 residue under basic conditions used for Fmoc deprotection.

27 s well as numerous selective protections and deprotections.

28 (F)iCd is not stable during oligonucleotide deprotection (55 degrees C, aq NH3) and was converted to

29 tion with a fluorescent probe produces, upon deprotection, a transporter-probe conjugate that is show

30 Telomere deprotection activates both ataxia telangiectasia mutate

31 cal caspase pathway, which promotes telomere deprotection, activates DNA damage signalling, and deter

32 uccessive phosphorylation followed by global deprotection afforded bis- and monophosphorylated hexaac

33 rylation of the tertiary hydroxyl and global deprotection afforded novel analogues that retain their

34 Global deprotection afforded the target pentasaccharide to be u

35 Finally, two mild deprotections afforded the target molecules.

36 Subsequent cyclization and global deprotection affords ustiloxin D in six steps from a kno

37 d good stereoselectivities in only one step, deprotection affords water-soluble 2-thio saccharides.

38 Ensuing acetylation and PMB deprotection allowed for the assignment of relative (and

39 It requires shorter reaction times for deprotection and allows us to replace Cu(OTf)(2) by CuCl

40 This approach streamlines selective deprotection and anomeric derivatization steps prior to

41 ubes are mixed, strand displacement-mediated deprotection and binding aligns the nanotubes into cross

42 itotic arrest, resulting in mitotic telomere deprotection and cell death, thereby eliminating precanc

43 Their one-pot deprotection and coupling with 2-thiophene carboxaldehyd

44 Efficient conditions for the subsequent deprotection and cyclization of these intermediates allo

45 ase protected maleimides are used, maleimide deprotection and Diels-Alder cycloaddition can be simult

46 A highly efficient TMSI-mediated deprotection and direct isolation method to obtain zwitt

47 manipulations and a final concomitant -OTBS deprotection and displacement of an -OMs placed next to

48 rmediates was further demonstrated through a deprotection and double-reductive amination sequence to

49 ll aging and tissue-invasiveness to telomere deprotection and heterochromatin unpacking, identifying

50 reacted with (11)C-methyl iodide followed by deprotection and high-performance liquid chromatography

51 Following deprotection and isolation, the Fapy-dG lesion is genera

52 ss of these materials was initiated by allyl deprotection and monitored by the absorbance of the PNP

53 Deprotection and reduction affords the corresponding ter

54 Deprotection and reduction of the resulting acyclic azid

55 ans isomerization of delta-azaproline during deprotection and reprotection is supported by theoretica

56 dules performing N-alkylation and arylation, deprotection, and amidation to install broad molecular d

57 monstrated: thermal cleavage, acid-catalyzed deprotection, and amine-induced deprotection.

58 d resin, followed by the addition of folate, deprotection, and cleavage, resulted in the isolation of

59 fied Stryker reduction of the alkyne, global deprotection, and oxidation of the resulting C1 primary

60 uinoline ring, which upon further amidation, deprotection, and sulfation gave the targeted nonsacchar

61 the addition of K2CO3 in THF ensured a clean deprotection-aromatization sequence to afford the desire

62 bromo-N-arylbenzylamines undergo a one-pot N-deprotection/biaryl coupling followed by oxidation, thus

63 Difficulties with final deprotection by hydrogenation/hydrogenolysis caused by t

64 Exacerbation of mitotic telomere deprotection by partial TRF2 (also known as TERF2) knock

65 bsorbing UVA (lambda >315 nm), photochemical deprotection can be carried out with sunlight in high yi

66 o-oxazine regioisomers showed that selective deprotection can be performed.

67 Its deprotection can be successfully carried out with irradi

68 on as well as Lewis and protic acid-promoted deprotections carefully designed to suppress E/Z isomeri

69 by a fragmentation, aromatization, and N-Boc deprotection cascade.

70 without the need for tedious protection and deprotection chemistry that is very common in traditiona

71 sulfonated near-IR fluorophore and the mild deprotection conditions allowed isolation of the product

72 Diverse deprotection conditions have been developed in conjuncti

73 ation of the free amine, under Boc- or ArSO- deprotection conditions have been examined.

74 This process obviates the need for the harsh deprotection conditions usually required for removal of

75 th solid-phase oligonucleotide synthesis and deprotection conditions, with synthesis yields comparabl

76 er functions were obtained, depending on the deprotection conditions.

77 an be mitigated in specific cases using mild deprotection conditions.

78 sed with other derivatives that require mild deprotection conditions.

79 d bases often requires modified synthetic or deprotection conditions.

80 The rate of the enzymatic deprotection could be tuned by the nature of the 4-acylt

81 N-terminal chain extension through N(alpha)-deprotection/coupling to yield peptide-selenoxo peptide

82 ereocontrol with a minimal use of protection/deprotection cycles.

83 mental conditions are used in the key tandem deprotection-cyclization process.

84 A tandem deprotection-cyclization reaction of 1,1-diacylcycloprop

85 oup is crucial to achieve high photochemical deprotection efficiency.

86 the styrene moiety could be exploited, after deprotection, either to directly conjugate a bioactive c

87 esultant enantiopure tetrahydropyridines and deprotection, enantiopure polyhydroxylated piperidines w

88 ional differences between BsRppH and the RNA deprotection enzymes of distantly related bacteria.

89 namic systems involving wavelength-selective deprotection, focusing on the choice and optimization of

90 dration then gave the desired oxazole 24 and deprotection followed by mesylation and elimination prod

91 r allowed on-column nucleobase and phosphate deprotection, followed by a mild cleavage of the acetyla

92 Ficoll induced both protection and deprotection from HX in different regions of CBP, with t

93 % of sites that undergo either protection or deprotection from hydrogen exchange due to phosphorylati

94 Selective deprotection, further elongation, and stability of these

95 opening, functional group manipulation, and deprotection gave (+)-1-deoxyaltronojirimycin.

96 cutive intramolecular oxidative coupling and deprotection gave dictyodendrins F, H, and I.

97 difluoro-2,4-dione intermediates followed by deprotection gave the 3-deaza-3,3-difluoro-4-hydroxy-4-(

98 of one C-F bond at atmospheric pressure, and deprotection gave the 3-deaza-3-fluorouracil compounds.

99 imidazo-fused benzimidazoquinazolines via a deprotection-GBB reaction sequence.

100 confirmation (mass spectrometry and NMR) and deprotection, generates GalNAc-PP-Und.

101 Deprotection gives stable catechol surfaces whose adhesi

102 desulfonylation and concomitant silyl ether deprotection gives the vitamin D(3) analogue.

103 eaction mixture during coupling and N(alpha)-deprotection has become increasingly popular.

104 The carbonyl deprotection in 22 yielded cyclohexanone 5 that was subj

105 Facile deprotection in hot butanol permits the rapid, multicomp

106 al system that mimics physiological telomere deprotection in human cells and discovered that the telo

107 undergoes selective CuAAC reaction via silyl deprotection in situ to give the ynamine click products.

108 ndary amine moieties, followed by controlled deprotection in solution.

109 Global TMS ether deprotection in the presence of oxygen and subsequent de

110 ketals is a dehydration process, whereas the deprotection is often referred to as hydrolysis, which,

111 a phase-transfer catalyst for O-silyl ether deprotection is reported.

112 en bond by changes in pH or by photochemical deprotection is sufficient to refold a helical oligomer,

113 Telomere deprotection is therefore an epigenetic signal passed be

114 every step (with the exception of the final deprotection) is performed on a gram-scale.

115 iterative PyBOP-mediated couplings and Fmoc deprotections, is rapid (about 5 d), operationally simpl

116 is method has been demonstrated in the final deprotection/isolation of the beta-lactamase inhibitor M

117 '-protecting groups covering a wide range of deprotection kinetics have been tested.

118 on products 3a, 3l, and 3p, which upon silyl deprotection-lactol oxidation were transformed to the tr

119 lished, they used a series of protection and deprotection maneuvers to modify the central portion of

120 Deprotection may be achieved under acidic conditions to

121 methanesulfonic acid has been evaluated as a deprotection method and further extended to more complex

122 The deprotection method developed is fully selective for N-a

123 A new, fast, mild and chemoselective deprotection method to cleave p-methoxybenzyl and 2-naph

124 Mechanistic insight into this deprotection methodology derived by linear free-energy r

125 amate with nucleophiles precludes the use of deprotection methodology that requires N-protonation for

126 Three deprotection methods are demonstrated: thermal cleavage,

127 rotecting groups permitted a one-step global deprotection (Na/NH3(l)).

128 different regions of CBP, with the greatest deprotection occurring at the edges of helices.

129 Telomere deprotection occurs during tumorigenesis and aging upon

130 ly reported the first general method for the deprotection of 4,4-difluoro-4-bora-3a,4a-diaza-s-indace

131 reaction schemes: (i) the chemical oxidative deprotection of a boronic ester by H2O2, (ii) a biomolec

132 idine construction and a chemoselective Peng deprotection of a phenolic MOM ether.

133 riene via an (E,E)-ynediene, and a selective deprotection of a tris(tert-butyldimethylsilyl) ether.

134 hat both the protection of carbonyls and the deprotection of acetals and ketals involve the participa

135 A two-step procedure for deprotection of alkylpinacolyl boronate esters via trans

136 hi reaction conditions followed by a one-pot deprotection of all protecting groups.

137 The reaction involves an in situ deprotection of an isolable N-formylaminopyridine interm

138 mechanism for the boron tribromide mediated deprotection of aryl propargyl ethers based on the isola

139 In addition to allowing selective deprotection of aspartic acid residues for creation of g

140 reaction in this multistep process involves deprotection of Boc-amino ynones and subsequent treatmen

141 Deprotection of Boc-protected products proceeded readily

142 Deprotection of chromosome ends occurs when telomeres be

143 Orthogonal deprotection of diphenol functionality was also demonstr

144 2-14 steps, respectively, without protection/deprotection of functional groups, by a novel tandem dou

145 nitiation of mRNA degradation often requires deprotection of its 5' end.

146 d a chemoenzymatic method for regioselective deprotection of monosaccharide substrates using engineer

147 recycling the tert-butanesulfinyl group upon deprotection of N-tert-butanesulfinyl amines has been ac

148 Deprotection of N-tert-butanesulfinyl-2-substituted pyrr

149 gram scale synthesis of N-acylaziridines by deprotection of N-tosylaziridines and reprotection with

150 rophilic aminating agent released by in situ deprotection of O-Ts activated N-Boc hydroxylamines.

151 The approach relies upon regioselective deprotection of per-O-trimethylsilyl-alpha-D-cholesteryl

152 ate this as a general strategy for selective deprotection of phenolic silyl ethers under neutral cond

153 The deprotection of phosphine-borane adducts was also demons

154 a 2-tosylamidoglucose derivative, selective deprotection of primary C-6 benzyloxy group, LiAlH4-medi

155 Deprotection of protected phenoylated phosphatidylcholin

156 /pyridine migratory cyclization (rather than deprotection of pyrimidine/pyridine group) using 20% NaO

157 We report a practical global deprotection of RNA 2'-O-tert-butyldimethylsilyl (TBS) e

158 Methods for the deprotection of the 2-O-phenacyl and 2-O-(methoxycarbony

159 An efficient deprotection of the 4-methoxyphenethyl group was develop

160 under microwave conditions with concomitant deprotection of the 7-hydroxyl.

161 Deprotection of the acetyl groups under basic conditions

162 Postpolymerization deprotection of the amino groups leads to water-soluble

163 Subsequent deprotection of the aminooxy and N-alkylaminooxy groups

164 Deprotection of the beta-lactam nitrogen atom can be ach

165 The deprotection of the carboxylic acid function to afford t

166 made it possible to achieve partial on-resin deprotection of the completed oligosaccharide, thereby i

167 n reactions, and enabled the one-step global deprotection of the completely assembled, fully protecte

168 ion in the presence of oxygen and subsequent deprotection of the cyano ethyl phosphoester afforded th

169 Deprotection of the dimeric compounds leads to novel fam

170 substituted salicylic acids were prepared by deprotection of the ester and amide groups of ortho-benz

171 ide synthesis (SPPS), followed by orthogonal deprotection of the GlcNAc primers and site-selective se

172 ation with N-formylpiperidine and subsequent deprotection of the hydroxy groups to give novel dicarbo

173 eaction, treatment with HCl in MeOH achieves deprotection of the isopropylidene group and the N-benzy

174 Sequential deprotection of the N- or C-terminus of bicyclic amino a

175 Deprotection of the N-tosyl substituent within the beta-

176 ected UPy groups dimerize after photoinduced deprotection of the o-nitrobenzyl group, the BTA moietie

177 ions proceeded in very good yields (70-84%), deprotection of the oligosaccharide intermediates was ch

178 Deprotection of the pentasaccharide intermediate to give

179 ne ring into a beta-lactam moiety, and final deprotection of the phenolic hydroxyl group.

180 Deprotection of the poly(N-Boc-morpholin-2-one) yields a

181 Deprotection of the resultant polymers afforded poly(1,2

182 Stereoselective reduction and deprotection of the resulting 2,6-cis-6-substituted 4-ox

183 etero-Michael addition followed by reductive deprotection of the resulting benzylidene acetal allowed

184 f phosphoramidite monomers and a single-step deprotection of the resulting oligoribonucleotide produc

185 zed C-H arylation followed by a routine TBAF deprotection of the resulting silacycles.

186 the stereodiscrimination and enables facile deprotection of the sulfonamide products with thioglycol

187 The successful acetal deprotection of the synthesized trans-3 bisadducts affor

188 trobenzyl)(tritylthio)alkylamine, subsequent deprotection of the trityl moiety with TFA, and immediat

189 gies for ring-opening of the new aziridines, deprotection of the Ts group, and subsequent formation o

190 f gyration, respectively, after photoinduced deprotection of the UPy groups; a 30-60% reduction in th

191 droxy-functionalized pillar[5]arenes via the deprotection of their benzylated derivatives by catalyti

192 Subsequent deprotection of these enantiopure templates gave (-)-ADM

193 Further deprotection of these isolated compounds by use of hydro

194 Furthermore, the photo deprotection of these terminal modifications is shown to

195 Deprotection of this aryl methyl ether yielded cacalol.

196 Selective side-chain deprotection of three hexadecamers is also demonstrated,

197 nd to be sufficient to bring about efficient deprotection of various neutral or electron-deficient N-

198 minimizes refunctionalization and protection/deprotection operations, features the highly diastereose

199 minimizes refunctionalization and protection/deprotection operations.

200 Derivatization of the products by tert-butyl deprotection or N-deoxygenation was demonstrated.

201 s that can occur with nonstandard synthesis, deprotection, or purification strategies.

202 l methylenation, a boron tribromide promoted deprotection, ortho- to para- naphthoquinone spiroketal

203 A intermediate to implement a chemoselective deprotection/oxidation sequence to access the requisite

204 sformed to 3,5-disubstituted pyrazolines via deprotection/oxidation, or to substituted 1,3-diamines v

205 molecules, and thus, applying a wet-chemical deprotection/oxidative acetylene coupling protocol exclu

206 ants null for CTC1 display a severe telomere deprotection phenotype accompanied by a rapid onset of d

207 Postsynthetic modification, postsynthetic deprotection, postsynthetic exchange, postsynthetic inse

208 he synthesis is the use of a novel oxidative deprotection procedure, utilizing DMDO, for the conversi

209 sis utilizing a reliable, one-pot, acylation-deprotection procedure.

210 g(alpha-aminoacyl)benzotriazoles followed by deprotection produced unprotected depsides useful for th

211 A deprotection protocol involving ethanethiolate exchange

212 le coupling reactions through protection and deprotection protocols to synthesize these (NN) biradica

213 opening metathesis polymerization (ROMP) and deprotection provide several series of SMAMPs.

214 of the N-O bond of the oxazepinones and Boc-deprotection provided 2-substituted 2,3-dihydropyridin-4

215 cted adenosine derivative followed by global deprotection provides a concise synthesis of the respect

216 rent postsynthetic strategies: postsynthetic deprotection (PSD) and postsynthetic exchange (PSE).

217 IPDMS < TES < TBS, etc.), the deprotection rate can be optimized so that all reaction

218 ts in an increase or decrease in the thermal deprotection rate.

219 ed by an intramolecular version of the boron deprotection reaction can be applied to access the first

220 loying microwave irradiation, protection and deprotection reaction times are dramatically reduced.

221 uction of the core eravacycline structure, a deprotection reaction was developed, allowing for the is

222 The deprotection reaction was performed in the presence of o

223 atly improves the yield of the photochemical deprotection reaction, compared with the corresponding o

224 Herein lies a detailed examination of the deprotection reaction, with a view to optimization and g

225 using mild, nonaqueous conditions in the DNA deprotection reaction.

226 suggest that the superoxide anion drives the deprotection reaction.

227 ediate and isolated pure following efficient deprotection reactions that involved metal-dissolving co

228 The deprotection reactions were carried out at 75 degrees C

229 ove to be important to the efficiency of the deprotection reactions, as shown in the photo reactions

230 oss is not accompanied by increased telomere deprotection, recombination, or T-circle release.

231 l siloxy-crotylation 3a-3o, which upon silyl deprotection-reduction deliver 1,4-diols 5a-5o with exce

232 iomer (LAB) and subsequent one-pot catalytic deprotection-reductive amination.

233 ay free from any functional group protection/deprotection requirements.

234 human cells and discovered that the telomere deprotection response is functionally distinct from the

235 letion of the sidechains, followed by global deprotection, resulted in a stereodivergent route to eig

236 ation, hydroxyl group-assisted in situ N-Boc-deprotection, selective deoxygenation of the xanthate es

237 A straightforward deprotection sequence enables conversion of the protecte

238 enylglycine, a 1-pot activation/displacement/deprotection sequence to introduce the aminooxy function

239 e ester in the 1-pot activation/displacement/deprotection sequence.

240 % after a 30 min microwave-assisted coupling-deprotection sequence.

241 e finally obtained after four- and five-step deprotection sequences, respectively.

242 In both biological realms, this deprotection step is catalyzed by members of the Nudix h

243 te yields are linked to the N-tosylaziridine deprotection step, while acylation with N-hydroxysuccini

244 )F-fluoride ion activation step to the final deprotection step.

245 provides selectivity that avoids protection-deprotection steps and presents unique options for struc

246 procedures, including a number of protection/deprotection steps and purifications.

247 oups, and therefore no formal protection and deprotection steps are required.

248 developed method circumvents protection and deprotection steps as well as tedious ion-exchange and c

249 Further deprotection steps have been successfully applied, leadi

250 owed by the need for multiple protection and deprotection steps owing to the large number of similarl

251 ng groups were chosen to limit the number of deprotection steps required to obtain the final derivati

252 )SiH reductive cleavage served as protection/deprotection steps to provide a versatile entry into the

253 gy, free of coupling reagents and protection/deprotection steps, for the synthesis of oligo(2-hydroxy

254 mes are required for both the protection and deprotection steps, generally resulting in low deprotect

255 l reactivity, coupling reactions, protection/deprotection strategies, and procedures for separation a

256 NH-sulfoximines providing improved (global) deprotection strategies, which is illustrated in the syn

257 ly important molecule employed in protection-deprotection strategies.

258 protected tricarballylic acid C and a global deprotection strategy as the final step.

259 tachment, allowing for a facile introduction/deprotection strategy increasing the synthetic practical

260 ane-based dendrons via a combined protection/deprotection strategy starting from different adamantane

261 eating is exploited in a chemical protection/deprotection strategy to allow selective regions of a na

262 e manner without implementing protection and deprotection strategy under mild reaction conditions.

263 Using a solvent-based, selective deprotection strategy, two different organic azides were

264 deletion of CTC1 does not result in telomere deprotection, suggesting that mammalian CST is not invol

265 In this study, we report a novel form of deprotection that occurs exclusively after DNA replicati

266 After simple Fmoc deprotection, the glycans were printed on NHS-activated

267 For deprotections, the combination of a mild basic condition

268 Hydrogenolytic N-deprotection then gave the corresponding dihydroconduram

269 Protodestannylation and global deprotection then yield these sterically encumbered and

270 nitiation with a protected thiol gives, upon deprotection, thiol-terminated transporters which can be

271 his group renders the protein inactive until deprotection through a bioorthogonal Staudinger reductio

272 ng for the isoxazole ring opening and global deprotection to be achieved in one pot.

273 latter underwent a Swern oxidation and then deprotection to give 1.HBr.

274 18)F-fluorobenzoate conjugation, followed by deprotection to give 4-(18)F-T140 that was exclusively l

275 tive N3-alkylation followed by the SEM-group deprotection (trans-N-alkylation) allows for regioselect

276 e reaction mixture with pyridine followed by deprotection under basic conditions with tetrabutylammon

277 he hydroxyl group, spontaneously underwent N-deprotection under the reaction conditions and regiosele

278 Global deprotection using Birch metal dissolving conditions did

279 The half-life for the nonenzymatic deprotection varied from 0.57 to 35 h depending on the e

280 A detailed study of diphenylmethane deprotection via acid hydrolysis as well as a key lacton

281 In all cases, the photochemical deprotection was accomplished in high yields (>80%).

282 The final global deprotection was achieved by an efficient three-step, on

283 Regioselective 5-O-deprotection was also successfully performed over the (1

284 The crude product after deprotection was collected from the chip and purified on

285 of the ester function during oligonucleotide deprotection was explored and the corresponding C(6') am

286 diation at both 325 and 364 nm, and complete deprotection was found to occur within minutes.

287 s a suitable substrate for gamma-GT-mediated deprotection was identified.

288 UV deprotection was studied for unpatterned samples using X

289 Acid-mediated dendrimer deprotection was successful, and the resulting carboxy-t

290 upport bound alkyne-oligonucleotide prior to deprotection was the most efficient "click conjugation"

291 Deprotections were accomplished via exchange with good n

292 Orthogonal maleimide and thiol deprotections were combined with thiol-maleimide couplin

293 Side chain deprotection with 1% TFA/CH2Cl2 followed by EDCI-mediate

294 ucleophilic radiofluorination and subsequent deprotection with a yield of 28% +/- 15%, a specific act

295 Furthermore, deprotection with dilute hydrochloric acid in ethanol in

296 Deprotection with LiAlH4 allowed isolation of the indivi

297 wave irradiation in acetonitrile followed by deprotection with PhSH.

298 ureido nitrogen are applied for simultaneous deprotections with the Boc and (t)Bu groups.

299 Rather than being all-or-none, telomere deprotection would thus proceed first through TAs before

300 protection steps, generally resulting in low deprotection yields.