ライフサイエンスコーパス: deprotonate

1 and in an activated precursor state (G8:2'OH deprotonated).

2 gap of the K-channel analog only while being deprotonated.

3 e under conditions where the side chains are deprotonated.

4 carboxylic acid and phenol moieties, become deprotonated.

5 ation, which explains why the chromophore is deprotonated.

6 ved species wherein the carboxylate group is deprotonated.

7 its ability to be reversibly protonated and deprotonated.

8 cost, in MCP and MCP-GpA dimers, Lys-40 gets deprotonated.

9 ic effects of bile salts by maintaining them deprotonated.

10 diates when the oxidized phenolic side chain deprotonates.

11 glutamate encounters the matrix channel and deprotonates.

12 A sequence of epoxide ring opening using N-deprotonated 1,2-azaborines followed by an intramolecula

13 monstrated via ion/ion reactions with doubly deprotonated 1,4-phenylenedipropionic acid (PDPA).

14 ivities upon gas-phase reactions with doubly deprotonated 1,4-phenylenedipropionic acid (PDPA).

15 races of the pentahydrazine upon reaction of deprotonated 2-oxa-6-azaadamantane with 2,6-dichloro-2,6

16 and [Pt(C(wedge)N)Cl(dppm)] (2), (C(wedge)N. deprotonated 2-phenylpyridine; dppa. bis(diphenylphosphi

17 leophilic substitution of a fluoroarene with deprotonated 3-methyl-4-piperidinenitrile giving the (3R

18 n subjected to ion/ion reactions with doubly deprotonated 4-formyl-1,3-benzenedisulfonic acid (FBDSA)

19 e formation of its ring-opened isomer (i.e., deprotonated 7-methylenebicyclo[3.3.1]nonan-2-one).

20 bute as conserved elements to the binding of deprotonated 8-HDF and allow predicting 8-HDF binding fo

21 The first triad, Thr12-Lys162-Asp90, acts by deprotonating a water molecule that subsequently binds t

22 for the negative clusters it is carried by a deprotonated acid; the same is true for the neutral clus

23 her solubility in toluene) to more uniformly deprotonate acidic components of complex mixtures by neg

24 comparable to those of organic and inorganic deprotonated acids.

25 tramethylpiperidide), a template base as its deprotonating action is dictated primarily by its 12 ato

26 purity (up to 98% ee) by alpha-alkylation of deprotonated alpha-aminonitriles derived by the Strecker

27 The ligation by four deprotonated amide nitrogens in macrocyclic motifs is th

28 sence of a larger population of the reactive deprotonated amides for Ar = C6F5), (3) "Cs2-I-F" cluste

29 Deprotonated amino groups are much more effective fluore

30 Michael addition of the deprotonated aminonitriles to the acceptors followed by

31 II))1:((-)OCH3) can act as a general base to deprotonate an attacking solvent molecule in the case of

32 yte ions (M + H)(+) in positive ion mode and deprotonated analyte ions (M - H)(-) in negative ion mod

33 carboxylic acid and an amine base, which can deprotonate and protonate respectively depending on the

34 es a group with a pK(a) of 6.6 +/- 0.2 to be deprotonated and a second group with a pK(a) of 9.5 +/-

35 N-Boc alpha-amino nitriles were deprotonated and alkylated with enantiomerically pure di

36 ndance (13)C NMR that the lipid in HAMLET is deprotonated and by chromatography that oleate rather th

37 ional movement out of the channel when it is deprotonated and by its high pKA value when it points in

38 cid is first physisorbed on bismuth and then deprotonated and chemisorbed in formate form, also on bi

39 an be redissolved, and the DMB ligand can be deprotonated and exchanged for benzene to produce the de

40 ir is most useful when the His side chain is deprotonated and is, thus, complementary to the Trp-His

41 lectrons originates from the DNA bases (both deprotonated and neutral).

42 readily available ethyl 4-bromocrotonate is deprotonated and trapped with Ellman imines selectively

43 te is essential for splicing, most likely by deprotonating and activating the downstream nucleophile

44 veal that electron pair repulsion within the deprotonated anion is not the reason behind the lack of

45 ference between the protonated (nonionic) or deprotonated (anionic) states.

46 In this paper, gas-phase reactions of deprotonated anions of benzene, pyridine, pyridazine, py

47 ( approximately 1.16 ns in acidic DMSO) and deprotonated ( approximately 1.4 ns in basic DMSO) compo

48 es generated in the reaction of benzyne with deprotonated arenes or heterocycles has been developed,

49 ed amino acids, the more acidic ammonium ion deprotonates as the media pH is changed from acidic towa

50 s of D422 to Glu, Cys, and Ser show that the deprotonated aspartate is essential for splicing, most l

51 The initial halocyclohexenone can be deprotonated at C-6 and reacted with carbon, fluorine, o

52 mo-3-methoxycyclohex-2-en-1-ones are readily deprotonated at C-6, and the resulting anions react smoo

53 rlier, while phenolic-rich sub-fractions are deprotonated at greater pH values and eluted later.

54 ng: 1) the carboxylic-rich sub-fractions are deprotonated at lower pH values and eluted earlier, whil

55 s ca. 9-10 where the thymine base is largely deprotonated at N3, one-electron oxidation of the thymin

56 approximately 9.0 and thus remains partially deprotonated at neutral pH.

57 de (3(-)) and Ru-monohydride (4(-)) that are deprotonated at nitrogen in the pincer ligand backbone.

58 nts show that the major fraction of Asp85 is deprotonated at pH >3 and that it protonates only at low

59 udied vary significantly but all are largely deprotonated at pH 7.5 except E124.

60 LB-bound SERCA populates an E1 state that is deprotonated at residues E309 and D800 yet protonated at

61 n that the phosphate groups of GTP are fully deprotonated at the start of the hydrolysis reaction, wh

62 strongly suggesting that the aquo ligand was deprotonated at this pH.

63 We find that the carboxylic acid group deprotonates at a significantly higher pH at the surface

64 oxidants in various DNA systems are known to deprotonate, at most, within a few microseconds.

65 xture of protonated (A) absorbing at 397 and deprotonated (B) absorbing at 515 nm chromophores, which

66 of Cu(II) involved His and the nitrogens of deprotonated backbone amide groups, resulting in either

67 one sites and (ii) species with at least one deprotonated base (in addition to several deprotonated p

68 ype of isomer is most likely to occur if the deprotonated base is located at the first or last positi

69 -linearly, indicative of a requirement for a deprotonated base with a relatively high pK(a).

70 ge, an additional bond is formed through the deprotonated beta-OH group (mu4 coordination).

71 2-c-4)(2)][HIr(kappa(2)-P,C-L(mAd))(L(mAd))] deprotonates both H(2)N(2,6-(i-Pr)(2)C(6)H(3)) and HOC(6

72 te glutamate (Glubeta(117)) is positioned to deprotonate bound acyl-CoA and initiate carbon-carbon bo

73 his dangler Mn4A site and not as a partially deprotonated bridge between two metal centers.

74 N-Protected 3-alkylpyrazoles are easily deprotonated by (n)BuLi at the 5-position of the aromati

75 The results suggest that (1) alphaY190 is deprotonated by alphaK145 to strengthen the interaction

76 ith the attacking water being simultaneously deprotonated by an Mg(2+)-bound hydroxide ion.

77 uch as aconitase, which use a serine residue deprotonated by an oxyanion hole.

78 c alpha-protons of sulfoxides are reversibly deprotonated by LiOtBu, and a palladium phosphine comple

79 2-siloxycyclopropanecarboxylate was smoothly deprotonated by lithium diisopropylamide and reacted wit

80 -alkynylbenzamide is predicted to be readily deprotonated by many bases, with subsequent cyclization

81 The fully hydrogenated complex, 4, is first deprotonated by OH(-) to form 5, which then releases hyd

82 chain when the physiological substrates are deprotonated by TbbTIM to form an enediolate phosphate t

83 supported by observing the incorporation of deprotonated -C identical withCPh as ligands on rod-shap

84 enzyme-reactant complex contains an anionic deprotonated C4a-peroxyflavin that is stabilized by stro

85 5 in the class 2 DHOD from Escherichia coli) deprotonates C5 of DHO.

86 use of ion mobility separation, performed on deprotonated carbohydrate ions following their release f

87 e many enzymes with anionic side chains that deprotonate carbon acids.

88 g bidentate inner-sphere coordination of the deprotonated carboxylate group and hydrogen bonding thro

89 -assisted C-H activation mechanism where the deprotonating carboxylate adopts a pseudo-apical geometr

90 ge form where the metal ion interacts with a deprotonated carboxylic acid and the proton is displaced

91 tightly bound, while at pH 7.5 Asp30 becomes deprotonated, causing the conformation to change to an o

92 l properties in the Pr form reminiscent of a deprotonated chromophore as confirmed by resonance Raman

93 n/deprotonation of the chromophore, with the deprotonated cis- and protonated trans-isomers correspon

94 After equilibration, the fully deprotonated citrate ion is present on the surface regar

95 rated C1C2 structure with both E123 and D253 deprotonated closely resembles the available crystal str

96 Deprotonated compounds with only beta-O-4 linkages, or b

97 cular atomic contacts between the WT and the deprotonated cTnI A164H variant.

98 orted that a bimetallic sodium-zinc base can deprotonate cyclic tetrahydrofuran under mild conditions

99 Deprotonating cyclic alkenenitriles with LDA-CuCN avoids

100 catalysis, specifically as a general base to deprotonate Cys-249.

101 Water coordinated to Asp(280) deprotonates Cys(276) to function as an aldehyde trap an

102 and amine groups can be either protonated or deprotonated depending on the pH of the background elect

103 Only s-BuLi deprotonated dimethyl hydroxymethylphosphonamidates at t

104 naturally occurring bromide, brominates the deprotonated DMS(-) anion with a near-diffusion controll

105 as been used to select individual isomers of deprotonated DNA oligonucleotide multianions for subsequ

106 Chemical oxidation of the deprotonated dpm framework results in the four-electron

107 state, especially when the sulfonamide NH is deprotonated, drastically raises the activation barrier

108 onversion is found to occur more readily for deprotonated dThd and its nucleotides than for N3-Me-dTh

109 (in) conformations, and His-37 is protonated/deprotonated during each turnover.

110 rpin-like c-subunits that are protonated and deprotonated during energization of ATP synthesis.

111 e-energy simulations with the protonated and deprotonated E3 residue further showed that the protonat

112 r calculations suggest that an external base deprotonates either G40(N1) or possibly A-1(O2'), which

113 that four-coordinate HIr(N(2))(L(mAd))(2) is deprotonated en route to [Li(12-c-4)(2)][HIr(kappa(2)-P,

114 rate constant for exchange catalyzed by the deprotonated enzyme as 2300 M(-1) s(-1).

115 these nucleotides bind preferentially to the deprotonated enzyme.

116 tagon of metal sites formed around the penta-deprotonated Etglu(5-) ligand; the chirality of N-ethyl-

117 Nucleophiles that are anionic or easily deprotonated exclusively produce cyclopentenones via Naz

118 ning are ruled out by demonstrating that E90 deprotonates exclusively in the nonconductive P(4)(480)

119 ion-induced dissociation (CID) of a range of deprotonated fatty acid standards was studied using line

120 Deprotonated fatty acids in contact with the cell exteri

121 or p-benzoquinones to generate diferric and deprotonated [Fe(2)S(2)((Pr)bbim)(2)](Et(4)N)(2) (1) and

122 ts that a single active site residue must be deprotonated for the hydrolysis of PDC.

123 e to the speciation change of Q(*-) with its deprotonated form (Q(*-)) oxidizing Fe(II) more rapidly

124 The absorption and emission spectra of the deprotonated form are bathochromically shifted by more t

125 (2+)* does not show direct DNA cleavage, the deprotonated form of 1H(2)O(2+)* does via a proton-coupl

126 pH profiles indicated that the deprotonated form of a residue with pK(a) of 6.9 is esse

127 However, the deprotonated form of D46 side chain is also essential, b

128 hylphenyl)imidazol-2-ylidene; "IXy-H" is the deprotonated form of IXy) exhibit metallosilylene-like (

129 -dimethylphenyl)imidazol-2-ylidene-1-yl (the deprotonated form of IXy); Cp* = eta(5)-C5Me5] and Cp*Ru

130 M1M2Cl(py3tren), where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)

131 1-8 and x = 0-1.5), where L(n) stands for a deprotonated form of the benzyl-substituted derivatives

132 ides an estimate of the base strength of the deprotonated form of the complex.

133 , which corresponds to its reaction with the deprotonated form of the substrate, and kobs2, which cor

134 inhibitor isoeugenol is predominantly in its deprotonated form when bound to wild-type VAO, but predo

135 ndicators that involve only a protonated and deprotonated form, a third species, arising from the the

136 tablished by releasing the ligands, in their deprotonated form, from the protein using collision-indu

137 groups (COO(-) and some amine groups in its deprotonated form, NH2) of cysteine attached on the gold

138 resonance energy transfer from protonated to deprotonated form.

139 s absorption spectra, most dramatically when deprotonated forming nitrophenolates.

140 the hydroxylamines deriving from neutral and deprotonated forms of 4-carboxy-TEMPO have been measured

141 other hand, the S(1) lifetimes of the singly deprotonated forms of hypoxanthine and inosine show dras

142 opy discriminates between the protonated and deprotonated forms of the carboxylic acid buffer, and th

143 ic or neutral pH has revealed protonated and deprotonated forms of the iminoquinone that are accompan

144 rbitals were analyzed for the protonated and deprotonated forms.

145 s in the contributions of the protonated and deprotonated forms.

146 hydroxyl group, which is hydrogen-bonded to deprotonated G40, concurrent with G40(N1) moving closer

147 ectroscopy, we demonstrate that the isolated deprotonated GFP chromophore can be trapped in the first

148 lar dynamics simulations with protonated and deprotonated GLU(ex) in the presence/absence of external

149 raction between the membrane surface and the deprotonated Glu134 residue of the rhodopsin-conserved E

150 Finally, the deprotonated Glu286 is found to be in a stable water-med

151 The oxidized cofactor and deprotonated Glu83 are closer in space after hydride tra

152 to allow electrospray-generated ions of the deprotonated glucose molecules to be monitored at their

153 inter-channel distance exerts a force on the deprotonated glutamate, resulting in net directional rot

154 mass spectrometer in the negative ion mode, deprotonated glyceollin precursors yield a diagnostic ra

155 The peak at m/z 337 corresponds to deprotonated glyceollins, whereas the others represent m

156 valuated for a series of singly and multiply deprotonated glycopeptides from the model glycoprotein k

157 ation and are phototransformed either into a deprotonated green fluorescent form by decarboxylation o

158 FT investigation provide indication that the deprotonated guanidine involved in such a catalysis acts

159 ide of C1(A5P), with the PEP phosphate group deprotonated, has the lowest energy barrier ( approximat

160 tructures of FAAH bound to an inhibitor as a deprotonated hemiketal mimicking the enzymatic tetrahedr

161 ctive site catalytic nucleophile Ser241 as a deprotonated hemiketal, but also to Cys269 through the p

162 alpha-ketoheterocycle inhibitors captured as deprotonated hemiketals mimicking the tetrahedral interm

163 found to have the largest effect followed by deprotonated His, Met, Cys, protonated His, Asn, Arg, an

164 amidate complex (25, for N-acetamido) of the deprotonated hydrazide and a Pt-alkyl complex of the cyc

165 rearrangement proceeds in metal complexes of deprotonated hydroxamic acids.

166 the latter remains ultrafast but the singly deprotonated hypoxanthine shows a much longer lifetime o

167 Theory to be very sensitive to the amount of deprotonated-imine character in the wave function, such

168 zation is averted because the heterocycle is deprotonated in situ.

169 flux as His37 is dynamically protonated and deprotonated in the conduction cycle.

170 is observed that stronger acids (i.e., fully deprotonated in the droplets) yielding anions with highl

171 e residues, Tyr7, was previously shown to be deprotonated in the neutron crystal structure at pH 10.

172 group has been measured to be 6.3 and hence deprotonated in the range of maximal enzyme activity.

173 u-oxo bridges of the Mn(4)O(5)Ca cluster are deprotonated in the S(2) state.

174 n bond change in D --> K transition and (ii) deprotonates in K --> M transition.

175 C pair residue Asp(196) (Asp(156) in CrChR2) deprotonates in N --> O transition.

176 The Wheland intermediate is deprotonated intramolecularly in a 1,2-shift but also in

177 The analytes were mostly detected as the deprotonated ion [M - H](-).

178 rs were measured for dissociation of gaseous deprotonated ions (at the -7 charge state) of complexes

179 ured for the loss of neutral ligand from the deprotonated ions of the 1:1 complex of bovine beta-lact

180 lision-induced dissociation performed on the deprotonated ions of the protein-carbohydrate complexes.

181 tly from mouse brain tissue as intact doubly deprotonated ions.

182 In our model, a fraction of the deprotonated M-intermediate of the anti-cycle may be pho

183 howed that FAD can exist in the gas phase as deprotonated (M = C27H31N9O15P2) and protonated forms (M

184 olution using a commercial source produces a deprotonated [M-H]- anion with the gas-phase equilibrium

185 alized with mixed monolayers of hydrophilic (deprotonated mercaptoundecanoic acid, MUA) and hydrophob

186 e rearrangements proceed from the reactive N-deprotonated metal hydroxamates and lead to metal carbam

187 s of H2O and CH2O were also observed for all deprotonated model compounds, which involve a previously

188 e two intestinal microbiota metabolites with deprotonated molecular weights of [M-H]-165/121 and 193/

189 nd to effectively identify the protonated or deprotonated molecule ([M + H](+) or [M - H](-)) while b

190 were confirmed by exact mass search of their deprotonated molecule [M-H](-) and its MS(4) fragmentati

191 In negative ion mode, the deprotonated molecule was observed ([M - H](-) at m/z 39

192 solvent system, without any other additives, deprotonated molecules of brevetoxins do not appear in h

193 or vinyl derivatives, indicating that these (deprotonated) nanoparticles were stabilized instead by t

194 proximately 2.5 x 10(2) M(-1) s(-1)) and the deprotonated, negatively charged form (k(ox,P(-)), 3.4 x

195 by increasing its acidity and by biasing the deprotonated nucleophile into conformations conducive to

196 nm causes efficient charge reduction of the deprotonated oligodeoxynucleotides via electron detachme

197 t gaseous carboxylic acids RCOOH(g) begin to deprotonate on the surface of water significantly more a

198 land, show the presence of aminium ions with deprotonated organic acids; 23% of the detected positive

199 ied in the S2 state as an exchangeable fully deprotonated oxo bridge [Perez Navarro, M.; et al.

200 involving the 2-hydroxyallyl cation and its deprotonated oxyallyl cation have been performed.

201 er to the two carboxylate moieties in doubly deprotonated PDPA to yield [PE - H](-) anions.

202 lities of NETD for the elucidation of doubly deprotonated peptide anions.

203 o induce electron transfer dissociation with deprotonated peptide anions.

204 , ammonium, ammonia, and both protonated and deprotonated peroxynitrite (selectivity coefficients of

205 8 residue stabilizes the structures with the deprotonated phenolic ring in the I- and B-forms.

206 th excess electrons localized exclusively at deprotonated phosphate backbone sites and (ii) species w

207 ne deprotonated base (in addition to several deprotonated phosphates).

208 ation, C(16)H(10)(+*), which is reacted with deprotonated phosphorylated peptides in a 3-D ion trap m

209 ne-amido) complex Fe(a) with a half-reduced, deprotonated PNNP ligand.

210 ons in small covalent model compounds (i.e., deprotonated polyhydroxy alcohols) were measured by nega

211 ates, and internally by fluorides or a penta-deprotonated polyol.

212 imary amine groups in multiply protonated or deprotonated polypeptides in the gas phase via ion/ion r

213 s is partially due to a back-reaction of the deprotonated Pr chromophore at pH 9 after photoexcitatio

214 partners properly, K661 is predicted to get deprotonated prior to substrate binding and to act as an

215 effects of nitroxyl (HNO) from its oxidized/deprotonated product nitric oxide (.NO), but the lack of

216 tive at increasing the extent of charging of deprotonated protein ions in negative ionization mode ES

217 has been proposed to serve as a transiently deprotonated proton donor.

218 Most significantly, we find that a deprotonated pyridine nitrogen on PLP precludes formatio

219 dized to manganese(III) and two of the three deprotonated radicals (NITIm(-)) are reduced to their di

220 Finally, two types of deprotonated radicals are identified: on the one hand, (

221 ule and measuring the ratio of protonated to deprotonated Raman bands.

222 The deprotonated receptor [L(2)](-) is distinctly emissive (

223 wo states per cycle, the late M- (M2) with a deprotonated retinal Schiff base and the consecutive gre

224 II)PhCOOH plus (n)Bu(4)NOH in DMF yields the deprotonated Ru(II) complex, (n)Bu(4)N[Ru(II)(pydic)(tpy

225 PLP remained as an internal aldimine with a deprotonated Schiff base.

226 Acting as a chain-propagating species, the deprotonated semiquinone radical (SQ(*) (-)) generated f

227 sfer from C-6 of the bound nucleotide to the deprotonated side chain of Lys-93 to give the enzyme-bou

228 nner sphere complexes at negatively charged, deprotonated silanol sites is appropriate.

229 In acetonitrile, H(2)TCNQ deprotonates slowly, whereas in N,N-dimethylformamide or

230 At pH 7, the 5-methyl deprotonated species is found; however, at pH ca. 9, N3-

231 The compounds and their protonated and deprotonated species, respectively, were investigated by

232 aggregation concentrations of protonated and deprotonated sphingosine are 1.71 +/- 0.24 microM and 0.

233 sition between protonated state (NH(+) ) and deprotonated state (N).

234 essential effects on host cells when in the deprotonated state and when presented in the context of

235 ylalanine at the surface transition to their deprotonated state at bulk pH values lower than the mole

236 om the extent of charge stabilization of the deprotonated state by the protein environment.

237 membrane fragments in protonated and partly deprotonated state has been mapped by means of atomic fo

238 om the crystal structure of a photoactivated deprotonated state of rhodopsin to the low pH crystal st

239 n the active site cysteine is converted to a deprotonated state prone to oxidation.

240 lowers the pK(a) of Asp85 by stabilizing its deprotonated state.

241 observed stabilization of the protonated or deprotonated state.

242 atio of signal intensities of protonated and deprotonated states being a reliable pH marker (accuracy

243 l polyene chain, for both the protonated and deprotonated states that represent the dark and photoact

244 d characterized in both their protonated and deprotonated states.

245 es between neutral (protonated) and charged (deprotonated) states depending on external pH.

246 The alpha-alkylation of deprotonated Strecker products derived from primary amin

247 Deprotonating substituted cyclohexanecarbonitriles with

248 a brucei brucei (TbbTIM) acts as the base to deprotonate substrate to form an enediolate phosphate tr

249 iated by triplet dioxygen and its binding to deprotonated substrate and only thereafter a spin state

250 o modulate the alphaC-H bond strength of the deprotonated substrate to facilitate the oxidation.

251 e begins with a bidentate chelate binding of deprotonated substrate to the Ni.

252 N atoms are open to oxidative attack in the deprotonated substrate while an internal hydrogen bond h

253 sulfonate retention from singly- and doubly-deprotonated sulfopeptide anions.

254 he intermediacy of sulfenate anions, and the deprotonated sulfoxide was determined to be the resting

255 plexes [((t)Bu-PNP*)Ir(H)2] (2) ((t)Bu-PNP*, deprotonated (t)Bu-PNP ligand) and [((t)Bu-PNP)Ir(H)] (3

256 omplexes [((t)BuPNP*)Ir(R)(OH)] ((t)BuPNP* = deprotonated (t)BuPNP ligand), in a process which utiliz

257 hich in turn serves as the catalytic base to deprotonate the 4'-hydroxyl of the DSMP substrate.

258 h this residue playing the role of a base to deprotonate the amide moiety of Cys20 upon iron binding

259 and hence E3 ligases require a mechanism to deprotonate the amino group at physiological pH to produ

260 d in crystal structures has been proposed to deprotonate the C5 atom of DHO.

261 rrangement is primed for catalysis as it can deprotonate the incoming substrate lysine residue and st

262 re, the base should be anionic to be able to deprotonate the neutral palladium-amine complex and/or e

263 NaOt-Bu was found to deprotonate the phenol product and to prevent formation

264 , Y345/E380; beta-LS, Y348/E382) proposed to deprotonate the respective internal nucleophile.

265 on of arenynes, the esters in the tether can deprotonate the Wheland intermediate, thus avoiding more

266 diate catalysis: a guanosine that we propose deprotonates the 2'-hydroxyl of the nucleotide 5' to the

267 dered insulating by solvent immersion, which deprotonates the hydroxylated LAO surface; interface con

268 the transient Al horizontal lineNTol species deprotonates the methyl group of the NacNac ligand.

269 hich lysine-180 acts as a catalytic base and deprotonates the reactive hydroxyl group of caffeoyl-CoA

270 and cleavage mechanism in which a histidine deprotonates the ribosyl 2'-hydroxyl pinned in place by

271 served His447 is not the catalytic base that deprotonates the substrate in ChOx.

272 neral base for activating the nucleophile by deprotonating the 2'-hydroxyl to initiate the reaction (

273 lycal formation was efficiently prevented by deprotonating the hydroxyl group in position 2 of the gl

274 tes nucleophilic attack of the propeptide by deprotonating the Thr1 hydroxyl group and that both resi

275 Given the high energy cost of deprotonating the tryptophan at the indole nitrogen, thi

276 e carboxy-bipyridyl ligands are successively deprotonated, the energy of the (3)MLCT state rises abov

277 e open conformation, whereas when His-235 is deprotonated, the hydrogen bond dissociates, and the cha

278 Results showed that with the D2.50 residue deprotonated, the M3 receptor is bound by an allosteric

279 intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively

280 In agreement, calculations predict that the deprotonated thymine base has a lower energy barrier (ca

281 azole side chain of the histidine residue is deprotonated to afford Zn-imidazolate chains, with bondi

282 th H(2) to give (PN(H)P)NiH(+), which can be deprotonated to form (PNP)NiH.

283 forms a phenylacetylene adduct that is then deprotonated to give product.

284 H(2)TCNQ is fully deprotonated to the TCNQ(2-) dianion in the presence of

285 e GtCCR2 retinylidene SB chromophore rapidly deprotonates to the Asp-85 homolog, as in BR.

286 Michael addition of the deprotonated tosylamides to the activated alkynes and su

287 ion and release are also accomplished by the deprotonated transporter.

288 heme compound I intermediate to the reactive deprotonated tyrosine, forming Tyr(*).

289 relatively low pKa value, N-Cl-DCAM tends to deprotonate under typical drinking water pH conditions,

290 The FnYs are deprotonated under biological conditions, undergo oxidat

291 N-methylritonavir is expected to be readily deprotonated under physiologic conditions to yield a thi

292 with beta-O-4 linkages, were evaporated and deprotonated using negative-ion mode ESI in a linear qua

293 m cations enable carbonate ions (CO3(2-)) to deprotonate very weakly acidic C-H bonds (pKa > 40), gen

294 complexes Mn4 O4 (H2 O)n (+) (n=1-7) contain deprotonated water with a maximum of four dissociatively

295 systems, because tyrosine Z is oxidized and deprotonated, whereas plastoquinone B is reduced and pro

296 therefore probably is the residue that must deprotonate with a pK of 6.5 for binding of vesamicol an

297 iched secondary allylic carbamates have been deprotonated with sBuLi and reacted with boronic esters.

298 ppaO')][B(C6 F5)4], 4[B(C6 F5)4], was simply deprotonated with the strong base K(N(SiMe3 )2 ) to give

299 show that, at the air-water interface, HMSA deprotonates within a few picoseconds and results in the

300 he otherwise fully protonated chromophore to deprotonate without additional major structural changes.