コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 g that wild-type L3 is required for ribosome depurination.
2 reamplification, probably via the process of depurination.
3 yl bond by DNA glycosylase or by spontaneous depurination.
4 ites were generated in DNA by partial acidic depurination.
5 ciently protected against 4-OH-E(1)-mediated depurination.
6 rates recruitment of RTA to the ribosome for depurination.
7 7 underwent glycolysis, followed by complete depurination.
8 ude faster than that of random "spontaneous" depurination.
9 r mutations other than those attributable to depurination.
14 rg176 are more important than Arg179 for the depurination activity and toxicity of Stx1A1 and Stx2A1.
17 Mutation of a single arginine reduced the depurination activity of Stx1A1 more than that of Stx2A1
18 faster than would be expected by spontaneous depurination alone, suggesting that there may be residua
23 Methylation protection and interference, and depurination and depyrimidation interference provided a
24 ommon DNA lesions resulting from spontaneous depurination and excision of damaged nucleobases by DNA
28 ediated cell death, indicating that ribosome depurination and translation inhibition do not account e
30 as a minor nonspecific effect on the rate of depurination, and a major specific effect on the rate of
38 t are not directly involved in the catalytic depurination at the active site exhibit >150-fold reduce
39 ard acid-catalyzed and glycosylase-catalyzed depurination by 2'-fluorination and toward base-catalyze
40 binding stimulates the catalysis of ribosome depurination by orienting the active site of RTA toward
46 least two arginines was necessary to reduce depurination by Stx2A1 to a level similar to that of Stx
49 bind to apurinic sites formed by spontaneous depurination, chemical attack, or other glycosylases.
50 -infected flies show a strong signal of rRNA depurination consistent with RIP-dependent modification
52 asic sites that arise in DNA from hydrolytic depurination/depyrimidination of the nitrogenous bases f
53 , as measured by the reduction of human rRNA depurination detected by our novel TaqMan-based RT-qPCR
54 enerated in nucleic acids due to spontaneous depurination, DNA damage or base excision of mismatched
55 In order to understand the implications of depurination during DNA synthesis, the detritylation kin
56 d trimer oligonucleotides were used to study depurination during the chemical synthesis of oligonucle
60 genomes, occurring with higher frequency at "depurination hot spots." Recently, we discovered a site-
61 ogues are more susceptible to acid-catalyzed depurination illustrating that the enzyme-catalyzed mech
62 ation of the catalytic intermediate for self-depurination in double-stranded DNA requires a stem-loop
68 These results indicate that self-catalyzed depurination is not unique to single-stranded DNA; rathe
69 y and show that the temporal pattern of rRNA depurination is similar to the pattern of PAP mRNA desta
70 ir requirement at the base of the loop: self-depurination is suppressed by 5'-C.G-3', 5'-A.T-3', or a
71 des and report on the susceptibility of X to depurination, its miscoding potential during replication
72 be only slightly less stable than guanine to depurination (k(X)/k(G) = 1.19), whereas at pH <or= 4 th
77 dy, evidence is presented for self-catalyzed depurination mediated by cruciform formation in plasmid
78 RTA) and saporin-L1 (SAP) catalyze adenosine depurination of 28S rRNA to inhibit protein synthesis an
79 w that recombinant Spiroplasma RIP catalyzes depurination of 28S rRNAs in a cell-free assay, as well
81 ribosomal inactivating activity arises from depurination of a single adenine from position A(4324) i
82 eir protein synthesis-inhibitory activity by depurination of a single adenine residue from the 28S rR
83 ) from castor beans catalyzes the hydrolytic depurination of a single base from a GAGA tetraloop of e
85 Ricin A-chain (RTA) catalyzes the hydrolytic depurination of a specific adenosine at position 4324 of
86 ) has, for many years, been considered to be depurination of a specific adenyl residue of ribosomal R
88 Toxin A-chain (RTA) catalyzes the hydrolytic depurination of A4324, the first adenosine of the GAGA t
90 near the active-site pocket is required for depurination of cytosolic ribosomes but not for cap bind
92 DNA enzyme that catalyzes the site-specific depurination of DNA with a catalytic rate enhancement of
95 ting proteins (RIPs) catalyze the hydrolytic depurination of one or more adenosine residues from euka
97 Further, VPg is a potent inhibitor of PAP depurination of RNA in wheat germ lysate and competes wi
100 used to establish the kinetic parameters for depurination of short RNA, DNA, and RNA-DNA hybrids of G
102 d activity assay that detects ricin mediated depurination of synthetic substrates was improved throug
104 The observations suggest that self-catalyzed depurination of the 5' G residue of the loop consensus s
106 he spectra, it appears that the slow rate of depurination of the N7Gua adducts during active repair m
109 showed that ribosomal stalk is required for depurination of the SRL by ricin toxin A chain (RTA).
113 explored the acid-catalyzed (non-enzymatic) depurination of these substrates, which appears to follo
114 C terminus is also required for toxicity and depurination of tobacco ribosomes in vivo, but not for a
118 mmon DNA lesions that arise from spontaneous depurination or by base excision repair (BER) of modifie
119 plasmid or genomic calf thymus DNA via mild depurination or by simple incubation at physiological co
120 B1-N7-dG adduct undergoes either spontaneous depurination or imidazole-ring opening yielding formamid
121 a 1-h incubation and eliminates artifactual depurination or loss of AP sites during DNA isolation.
122 Stx2 have similar requirements for ribosome depurination, PAP has different requirements, providing
123 g to an elution solvent designed to minimise depurination (PCR buffer) facilitates the elution of int
124 lkylation by alkyltransferase-S-CH2CH2Br and depurination, plus another as yet uncharacterized system
126 (k(X)/k(G) = 1.19), whereas at pH <or= 4 the depurination rate exceeded that of G by more than an ord
132 kbone cleavage by a mechanism similar to the depurination reactions employed in the chemical degradat
133 )) and pH-independent (1.4 x 10(-8) x s(-1)) depurination reactions for dX as well as the dissociatio
136 based depurination assays, we show that the depurination side reaction is the limiting factor for th
138 9-yl)-1,4-dideoxy-1,4-imino-D-ribitol at the depurination site binds four times better (0.57 microM)
139 with 1,4-dideoxy-1,4-imino-D-ribitol at the depurination site binds with a K(d) of 1.3 microM and im
140 roxymethyl)-3-hydroxytetrahydrofuran] at the depurination site binds with a Kd of 3.2 microM and tigh
142 D-ribitol moiety, a 4-azasugar mimic, at the depurination site in the tetraloop of a 14mer oligonucle
143 Stem-loop RNA with phenyliminoribitol at the depurination site increases the affinity substantially (
144 oop RNA with p-nitrophenyl O-riboside at the depurination site is not a substrate, but binds tightly
145 xymethyl)pyrrolidine was incorporated at the depurination site of a 14-base RNA stem-loop, the Kd was
146 Introduction of a deoxyadenosine at the depurination site of short RNA oligonucleotides restores
147 poration of the C-riboside formycin A at the depurination site provides an increased pKa of the adeni
148 ficity studies, the 2'-hydroxyl group at the depurination site seems to be critical for recruitment a
149 with a deoxyguanosine on the 5'-side of the depurination site was also synthesized on the basis of s
151 e specificities of RTA for the two adenylate depurination sites in a RNA substrate with a GAGA tetral
153 suffer from greater rates of acid-catalyzed depurination than dG and are sensitive to the acidic deb
154 cleoside is more resistant to acid-catalyzed depurination than previously described 8-bromo-2'-deoxya
155 adducts, not the abasic sites resulting from depurination, that are responsible for the stimulation o
157 er expulsion of F- ion (lethal event) or (b) depurination to form Ade and hexose-derived 6-carboxyl f
160 n internal thymidine standard not subject to depurination was monitored by reverse phase HPLC analysi
162 ct indicated that some of the adducts led to depurination with the release of the Gly136-Arg147 pepti
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。