ライフサイエンスコーパス: derangement

1 oxins that cause hypoglycaemia and metabolic derangement.

2 ecause additional mutations caused excessive derangement.

3 of systemic insulin resistance and metabolic derangement.

4 and transport that paralleled mitochondrial derangement.

5 lts from hyperphagia rather than a metabolic derangement.

6 similar clinical presentation and functional derangement.

7 eases, but equally able to improve energetic derangement.

8 ssion of the disease and resulting metabolic derangement.

9 HIF-1alpha pathway in burn-induced metabolic derangements.

10 ll tension and therefore reflect hemodynamic derangements.

11 ction of p-cresol, prevented these metabolic derangements.

12 eneration, and that ACVR2B/Fc prevents these derangements.

13 duced oxygen consumption and ultrastructural derangements.

14 date because DKA involves multiple metabolic derangements.

15 ased MPB, and tumor resection reverses these derangements.

16 ck fat," that result in endocrine and immune derangements.

17 with further investigation of immunological derangements.

18 n of opportunistic infections, and metabolic derangements.

19 dies dealing with a broad array of metabolic derangements.

20 etween inflammation and associated metabolic derangements.

21 ctor of severity of illness than hemodynamic derangements.

22 effects rather than the causes of acid-base derangements.

23 likely required for these metabolic and HPA derangements.

24 sense microbes, tissue damage, and metabolic derangements.

25 aily dialysis can reverse many of the uremic derangements.

26 perturbations reflecting specific functional derangements.

27 uantifying the extent of a tissue's electric derangement, (2) prospectively determining the amount of

28 s/obstruction (26.2%), metabolic/electrolyte derangements (23.1%), and anemia (12.3%).

29 ase B/mammalian target of rapamycin) pathway derangement accurately discriminates patients with NASH

30 dema, and a composite score of physiological derangement (all P< or =0.01).

31 ure elevation, insulin resistance, and lipid derangements), although these changes have not been asso

32 es do not inevitably result in neural system derangement and dementia in all individuals.

33 ctor, greater than the degree of physiologic derangement and details of medical management.

34 evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channe

35 Endothelial dysfunction drives vascular derangement and organ failure associated with sepsis.

36 tinamide riboside (NR) ameliorates energetic derangement and symptoms in mouse models of mitochondria

37 uscle, and Alzheimer's disease share protein derangements and attrition of postmitotic cells.

38 n hypoxia can be related to microcirculatory derangements and cell edema without evidence of brain is

39 tive jaundice is associated with immunologic derangements and hepatic inflammation and fibrosis.

40 port serves only to supplement physiological derangements and is not therapeutic, patient selection c

41 t unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers ca

42 (hyper-reflective moderator band, trabecular derangement, and sacculations) were assessed.

43 risk for hip fracture, physiologic/metabolic derangements, and complications of anesthesia.

44 accumulation, mitochondrial gene regulatory derangements, and contractile function in MHC-PPARalpha

45 ing of the underlying cellular and molecular derangements, and have resulted in the design of novel t

46 matory state, lipid transport, and metabolic derangements, and organ system effects that particularly

47 between ethnicity, NAFLD severity, metabolic derangements, and sociodemographic characteristics in a

48 is important; the molecular details for the derangement are unknown but are under scrutiny by many i

49 Metabolic derangements are a clinically significant complication o

50 r early cardiovascular disease and metabolic derangements as compared with their uninfected peers.

51 ining reversed obesity-related mitochondrial derangements as evidenced by enhanced mitochondrial bioe

52 We speculate that microbial derangements, as indicated in our study, can demonstrate

53 The latter could contribute to the metabolic derangement associated with DLD deficiency and represent

54 esponsible for producing the transcriptional derangement associated with trisomy.

55 To better understand metabolic derangements associated with early disease, we profiled

56 alcin is one of the drivers of the metabolic derangements associated with glucocorticoid therapy.

57 a curtailment of the hormonal and metabolic derangements associated with high fat diet-induced obesi

58 Rather, the multiple derangements associated with indicators of brain damage

59 tration, hepatocyte apoptosis, and metabolic derangements associated with insulin resistance and impa

60 ension) or metabolic (that is, dyslipidemic) derangements associated with obesity may predispose indi

61 not VAT, is a better marker of the metabolic derangements associated with obesity.

62 Growing knowledge of the physiologic derangements associated with poor outcomes in SAH can im

63 istula, hypoxic lung diseases, and metabolic derangements associated with renal disease.

64 e potential for early detection of metabolic derangements associated with such events.

65 nd tissue glucose >4.5mM minimized metabolic derangement at the injury site.

66 otentials, and physiological and biochemical derangements at both the brain and systemic levels.

67 Black patients had more acute physiologic derangements at intensive care unit admission and longer

68 Black patients had more acute physiologic derangements at intensive care unit admission and were l

69 Sepsis elicits derangements at multiple subcellular sites involved in e

70 These derangements at the integrated system level can be inter

71 Emerging data support multiple derangements attending HIV coinfection, including increa

72 hypoxic-ischaemic injury, sepsis, metabolic derangements, autoimmune diseases, infections and rapidl

73 e hydroxamic acid (SAHA) corrected the VLCFA derangement both in vitro and in vivo, and inhibited the

74 al symptoms, may reflect not only peripheral derangements but also CNS defects.

75 for mitochondria in IR is that mitochondria derangements can cause IR, but IR does not have to invol

76 nding of CA and its response to pathological derangements can help assess the severity of stroke, gui

77 These metabolic derangements can result in structural, functional, and i

78 ic myocardial infarction, and reduce cardiac derangements caused by metabolic disorders.

79 sm at recovery and (iv) subsequent metabolic derangement, cerebral NTP, PCr and inorganic phosphate (

80 addition to these metabolic and biochemical derangements, changes in the intraglomerular hemodynamic

81 characteristics, anatomic and physiological derangement, clinical treatment, and outcomes.

82 gnant prostate cells showed marked metabolic derangements compared with their benign counterparts.

83 Functional and structural derangements contribute to impaired arterial and ventric

84 ling-based predictions of stent-induced flow derangements correlated with spatial distribution of for

85 These data suggest that Paco(2) derangements could be potentially harmful for patients a

86 lure exacerbation and persistent hemodynamic derangement despite intravenous diuretic and inotropic a

87 ith heart failure and persistent hemodynamic derangement despite intravenous inotropic and/or vasodil

88 CRC has been proved to induce metabolic derangements detectable by high through-output technique

89 Findings suggest that individual blood gas derangements do not increase brain damage risk.

90 eomic survey revealed that the mitochondrial derangements during insulin deficiency were related to i

91 paucity of data on the prevalence of Paco(2) derangements during the post-cardiac arrest period and i

92 Concussion results in profound metabolic derangements during which the brain is potentially vulne

93 olescents, and was associated with metabolic derangements, especially obesity, insulin resistance and

94 Multiple derangements exist in sepsis involving several different

95 fe model, envisaged an optimum level of gene derangement for tumor growth, but proposed that the cell

96 ffect modification of ethnicity on metabolic derangements for NAFLD severity.

97 lar risk factor burden, as well as metabolic derangements found in early kidney disease, can account

98 the distinction of adaptations to metabolic derangements from adaptations to heart failure per se.

99 be related to inotropic support or metabolic derangements from chronic heart failure.

100 Although eNOS derangement has been demonstrated in experimental models

101 resultant very long chain fatty acid (VLCFA) derangement has dramatically opposing effects in astrocy

102 Prompt correction of hemodynamic derangements has been shown to improve outcome through a

103 tricular state on ischemia-induced metabolic derangements has not been established.

104 Every blood gas derangement (hypoxemia, hyperoxemia, hypocapnia, hyperca

105 sis-induced mitochondrial-related functional derangement, ii down-regulation of endotoxin/Toll-like r

106 perexcitability is considered a pathological derangement important only as a cause of neuropathic pai

107 es were present in many probands (trabecular derangement in 54%, hyper-reflective moderator band in 3

108 d crucial pathogenic insights that metabolic derangement in adult-like metabolic milieu underlies ARV

109 rmine the role and mechanism of Kupffer cell derangement in exacerbating postburn end organ damage in

110 g NAFLD with more severe liver histology and derangement in glucose and lipoprotein metabolism, which

111 ld be considered part of a multiorgan system derangement in insulin sensitivity.

112 system contributes to this as evidenced by a derangement in key autophagy markers in both mouse and h

113 cal and subcortical pathophysiology, while a derangement in mechanisms of motor attention may be a fe

114 on in cardiac Na(+)-based processes leads to derangement in multiple cardiac components at the level

115 The fundamental derangement in nonalcoholic fatty liver disease is insul

116 was consistent with the observation that the derangement in phosphate metabolism is due to the loss o

117 sK(ATP) channel activation in myocyte volume derangement in response to stress.

118 ion of excess fat mass can be conceived as a derangement in the balance between energy intake and exp

119 The existence of these deposits reflects a derangement in the protein homeostasis machinery.

120 ng "just right" of optimum intermediate gene derangement in tumorigenesis, and in part it is inherent

121 ifying the severity of important physiologic derangements in acute SAH.

122 tation corrects systemic and local metabolic derangements in advanced heart failure, leading to reduc

123 ents, especially growth velocity impairment, derangements in and treatment of abnormal bone mineraliz

124 In addition, there were no discernible derangements in any of the major organ systems, includin

125 In addition we could not discern any derangements in any of the major organ systems, includin

126 Derangements in apoptosis of liver cells are mechanistic

127 n increase in secretion, or both, as well as derangements in barrier properties.

128 patocyte-specific deletion of SIRT1 leads to derangements in bile acid metabolism, predisposing the m

129 study demonstrates the presence of metabolic derangements in BKS-db before the onset of beta-cell fai

130 fied mice is a phenotype of interest because derangements in blood flow may precede detectable change

131 ir, but impaired fibrin clearance results in derangements in bone fracture repair.

132 We found substantial derangements in both neuronal excitability and short-ter

133 Derangements in both oxygenation and ventilation were co

134 PAO1 and 3O-C12-HSL induce barrier derangements in bronchial epithelial cells by lowering t

135 KD), but whether it also worsens CKD-induced derangements in calcium and phosphate homeostasis is unk

136 Derangements in calcium homeostasis occur during sepsis

137 It has been proposed that derangements in cardiac metabolism and oxidative stress

138 acellular volume fraction measures and other derangements in cardiovascular structure.

139 Chronic obesity results in derangements in cardiovascular, respiratory and metaboli

140 These studies suggest metabolic derangements in CFRD originate from an islet dysfunction

141 Derangements in channel function alter the electrical ex

142 ue to tissue hypoperfusion, and investigated derangements in coagulation associated with this.

143 oss of circulating prothrombin, and profound derangements in coagulation function.

144 (adjusted OR: 2.22; 95% CI: 1.14, 4.33), and derangements in coagulation profile (adjusted OR: 1.91;

145 otein-2 (MECP2) gene and is characterized by derangements in cognition, behavior, motor control, resp

146 Moreover, Mkl2(-/-) ES cells exhibit derangements in cytoskeletal organization, cell adhesion

147 out mice, investigators have determined that derangements in epithelial or innate and adaptive immune

148 The neurohormonal and catabolic derangements in HF are at the base of HF symptoms.

149 se may provide a window into the biochemical derangements in human plasma, an approach that could, in

150 Collectively, these data demonstrate that derangements in lipid metabolism in MHC-FATP ventricles,

151 RA exhibited no derangements in liver microcirculation when compared to

152 se, obesity and metabolic syndrome represent derangements in macrophage activation with concomitant l

153 Derangements in metabolism and related signaling pathway

154 on sporadic form of PD, oxidative stress and derangements in mitochondrial complex-I function are con

155 ectron transport chain proteins that produce derangements in mitochondrial function.

156 dy aimed at the fine characterization of the derangements in mitochondrial structure and function con

157 Derangements in normal cellular homeostasis at the prote

158 Oxidative stress leads to derangements in pump function due to changes in the expr

159 Results confirmed the predicted derangements in purine metabolism, but also revealed una

160 esized that 6J mice would experience greater derangements in redox homeostasis/metabolic disease upon

161 eurotransmitter orexin modulates physiologic derangements in sepsis.

162 may counteract some of the pathophysiologic derangements in shock states.

163 ca media is severely disrupted with profound derangements in SMC morphology, cell-cell, and cell-matr

164 Derangements in SNO signaling are implicated in many dis

165 During sepsis, derangements in such tight regulation frequently occur,

166 f specific T cell subsets are key pathogenic derangements in systemic rheumatic diseases, and these i

167 Despite extensive metabolic derangements in T2DM mice, inhibition of a single dys-re

168 f Parkinson disease (PD) is characterized by derangements in the discharge rates, bursting patterns,

169 set of HF; and (4) the pattern of metabolite derangements in the failing heart suggests bottlenecks o

170 The pathogenic roles of these derangements in the heart remain unknown.

171 Derangements in the host vasculature contribute to the c

172 omprehensive data on HE-associated molecular derangements in the human brain are lacking.

173 e ability of GLUT4 blockade to contribute to derangements in the other molecular pathways that influe

174 mphysema and highlights a role for metabolic derangements in the pathophysiology of emphysema.

175 The absence of major cytokeratin derangements in the squamous papillomas may be of ancill

176 of Myocd gene deletion, exhibiting profound derangements in the structure of great arteries as well

177 Mkl2(-/-) null embryos exhibit profound derangements in the tunica media of select arteries and

178 In this review we discuss how derangements in these developmental pathways drive cance

179 d represent potentially reversible metabolic derangements in these individuals.

180 molecular pathways have been elucidated, and derangements in these pathways have been identified as f

181 function or attenuate postprandial metabolic derangements in triglycerides, glucose, or insulin relat

182 Migraine is accompanied by significant derangements in vascular function that may represent imp

183 ker also had significantly more organ system derangement, including noncardiovascular organ system fa

184 e suffer from profound cardiac and pulmonary derangement, including right ventricular strain and nonc

185 or function may result in multiple metabolic derangements, including insulin resistance.

186 e tissue inflammation, and hepatic metabolic derangements, including suppressing hepatic lipogenesis

187 an dysfunction syndrome have multiple immune derangements, including T cell apoptosis and anergy comb

188 ve than saline loading to detect hemodynamic derangements indicative of HFpEF.

189 nce and related metabolic and neuroendocrine derangements induced by uDM.

190 ment of type 2 diabetes lies a key metabolic derangement: insulin resistance (IR).

191 Admission fibrinolytic derangement is common in injured children and adults, an

192 The derangement is likely caused by aberrant protein aggrega

193 rders, a persistent natural killer (NK) cell derangement is observed.

194 rrecting the immediately evident physiologic derangement is only the first step in the care of these

195 ncy leads to neurodegeneration and metabolic derangements is not known.

196 lating high-fat-diet (HFD)-induced metabolic derangements is unknown.

197 involving robust recording of physiological derangements, is necessary to further advance our unders

198 s involved in mitochondrial energy metabolic derangements known to occur during the development of he

199 Each of these neurohormonal derangements may act through increased activity of both

200 These derangements may be further augmented in the presence of

201 uman studies suggest that systemic metabolic derangements may lead to metabolic, functional and struc

202 o evaluate whether baseline BBB permeability derangements may predict HT after recanalization therapy

203 r distributions but with greater physiologic derangement (mean Sequential Organ Failure Assessment sc

204 tion (AF) and to ascertain whether metabolic derangements might instigate this arrhythmia.

205 intracellular vesicle trafficking due to the derangement of actin dynamics.

206 on, possibly contributing to the hemodynamic derangement of acute pulmonary thromboembolism.

207 evidence for inherited predisposition to and derangement of apoptosis and inflammation in lesional de

208 nmental repressive signals, based in part on derangement of cell cycle checkpoints governed by cilia

209 Derangement of circulatory flow affects many vital organ

210 A systemic derangement of CXC chemokines in maternal and fetal circ

211 Derangement of either step can lead to mispatterned CA s

212 We assessed whether, in obesity, derangement of energetics and diastolic function is furt

213 es of resuscitation from cardiac arrest is a derangement of energy metabolism and the loss of adenyla

214 is to liver cancer through cytokine-mediated derangement of gender-specific cellular metabolism.

215 rtal hypertension (PH), a pathophysiological derangement of liver cirrhosis, is characterized by hype

216 ith biliary colic, pancreatitis, unexplained derangement of liver function tests, and/or dilated CBD

217 r static strains lowered mortality (p<0.01), derangement of lung mechanics (p<0.01), and arterial oxy

218 Both CIMR and non-CIMR animals demonstrated derangement of LV torsion after inferior MI.

219 remia is a complex metabolic state marked by derangement of many signaling molecules and metabolic in

220 ion in tumor samples from mice revealed that derangement of metabolites were a reflection of coordina

221 b) How derangement of multiple, cell-specific, molecular proces

222 posthepatectomy hypophosphatemia reflects a derangement of normal hepatorenal messaging and is the r

223 , MYPT1 deficiency may not cause significant derangement of smooth muscle contractility because the e

224 m patients revealed pathways associated with derangement of specific metabolic pathways that are indi

225 We also discuss (a) how derangement of the ADO-CFTR pathway renders CF airways v

226 e, encoding a receptor for Wnt5, resulted in derangement of the glomerular map, ectopic midline glome

227 Loss of wnt5 resulted in severe derangement of the glomerular pattern, whereas overexpre

228 Increasing severity of cirrhosis causes derangement of the hematopoietic niche and loss of HSCs,

229 animals develop cataracts associated with a derangement of the lens capsule basement membrane and al

230 Derangement of the nuclear factor kappaB (NF-kappaB) pat

231 deadly disease characterized by considerable derangement of the proinflammatory, anti-inflammatory an

232 the Ts65Dn mouse model for DS was caused by derangement of the Shh pathway due to overexpression of

233 elops in Alzheimer disease (AD) owing to the derangement of the sleep-wake cycle regulation pathways.

234 ther by a genetically determined, functional derangement of the systemic brain maturation that is age

235 intensive care unit patients on the basis of derangement of their physiology and some past medical hi

236 Derangement of these localization motifs may lead to cys

237 Derangement of these sensory-motor circuits is implicate

238 Derangement of tip-directed Ca2+ gradients is also appar

239 nance of a highly sensitive "set point," the derangement of which may lead to the development of key

240 device (LVAD) reverses some of the metabolic derangements of advanced heart failure.

241 However, substantial derangements of brain activation, poor modulation of fun

242 te infusion favorably attenuates hemodynamic derangements of cardiac failure that develop during exer

243 t of exercise capacity and is accompanied by derangements of contractile state and VAC.

244 Despite the acute derangements of critical illness, both acute and chronic

245 Furthermore, the major pathophysiological derangements of heart failure and a preserved ejection f

246 r the future is to determine how more subtle derangements of ion channel function, which arise from t

247 ked beta-cell death, loss of beta-cell mass, derangements of islet architecture, and impaired glucose

248 Measurements of histopathology derangements of lung samples and studies of intrapulmona

249 Derangements of mineral metabolism occur during the earl

250 o a modest increase in mitochondrial number, derangements of mitochondrial ultrastructure, and develo

251 e used a transgenic mouse model to show that derangements of myotonic dystrophy are reversed by a mor

252 bidity and mortality associated with hepatic derangements of pregnancy.

253 sm render it particularly susceptible to the derangements of the diabetic state.

254 dispersed cells exhibit virtually identical derangements of their dendritic structures.

255 y a vital role in the normal hemostasis, and derangements of their function can lead to hemorrhage or

256 n prevents the deadly metabolic and clinical derangements of type 1 diabetic mice.

257 epsis, and hemorrhage that present as severe derangements of vital signs.

258 and metabolism than adaptive RVH, and these derangements often involve the left ventricle.

259 n in the AD, CfaE G168D exhibited structural derangements only in the adjoining PD compared with CfaE

260 zures due to acute brain injury or metabolic derangements, or unprovoked seizures that are the initia

261 chromoplexy may induce considerable genomic derangement over relatively few events in prostate cance

262 ontrols indicate increased risk of metabolic derangements (particularly involving calcium homeostasis

263 of severe events or if progressive metabolic derangement persists after therapeutic interventions hav

264 RI permeability technique to detect baseline derangements predictive of various forms of HT after rec

265 We investigated the soluble immune derangements present in TM patients and found that IL-6

266 ive complications (ie, physiologic/metabolic derangement, respiratory failure, pulmonary embolism/dee

267 outcome, we constructed the SAH Physiologic Derangement Score (SAH-PDS; range, 0-8) by assigning the

268 The SAH Physiologic Derangement Score may prove useful for rapidly quantifyi

269 rrhage, and rebleeding), the SAH Physiologic Derangement Score was independently associated with poor

270 The severe derangements seen in lipoprotein metabolism in patients

271 Similar to the intracellular derangements seen in the Cys67stop rats, these structure

272 at color, obesity, overgrowth, and metabolic derangements similar to type II diabetes in humans.

273 osmotic activity, and attenuated hemodynamic derangements such as vasoconstriction.

274 Analysis of the mechanisms underlying this derangement suggested that a marked reduction in tubulog

275 ting PI3K alone led to more severe metabolic derangement than inhibiting both PI3K and mTOR.

276 e of TIH involves a more extensive metabolic derangement than previously recognized.

277 nsamination to cope with the liver metabolic derangement that is associated with greater gluconeogene

278 ptomatic hypercalcemia is a common metabolic derangement that is often discovered on routine serum sc

279 ew, without an understanding of the vascular derangements that accompany it.

280 profound, occurring in a timely manner, with derangements that are greater and more protracted than p

281 and is correlated with classical hemodynamic derangements that develop with stress.

282 (ACOX1(-/-)) mice manifest hepatic metabolic derangements that lead to the development of steatohepat

283 Here, we explore vascular derangements that might also contribute to brain damage.

284 eomics was used to identify energy metabolic derangements that occur during the development of cardia

285 Mitochondrial energy metabolic derangements that occur during the early development of

286 the physiological control of feeding and the derangements that occur in obesity and their restoration

287 hwann cells was retarded without significant derangements to myelination or axon caliber.

288 ch signaling in the pathogenesis of anatomic derangements underlying cerebrovascular accidents.

289 anted >3 months, admitted due to hemodynamic derangements, underwent simultaneous comprehensive echoc

290 This derangement was characterized by increased activation of

291 apy of unexpected bleeding when a hemostatic derangement was not anticipated preoperatively.

292 vel permeability technique to illustrate BBB derangements was based on the detection of decreased sig

293 The number of children with metabolic derangements was higher among adolescents with NAFLD tha

294 These derangements were associated with a reduced capacity of

295 Many but not all physiological derangements were more closely associated with the TAPSE

296 Marked mitochondrial structural derangements were observed in hearts of PGC-1alpha/beta-

297 Metabolic derangements were the most common identifiable cause of

298 n ICU, admission diagnosis and physiological derangements, which accurately predicted outcome on admi

299 onstellation of metabolic and cardiovascular derangements, which also includes dyslipidemia, dysglyce

300 traumatic brain hypoxia and microcirculatory derangements with cell edema, we investigated the effect