ライフサイエンスコーパス: deregulation

1 fords novel insights into the impact of SOX2 deregulation.

2 is a complex disease, characterized by gene deregulation.

3 e 10 is an upstream regulator of renal PPM1A deregulation.

4 iated with a loss of stemness and cell cycle deregulation.

5 ism for high-risk-associated transcriptional deregulation.

6 ), revealing an alternative mechanism of Rb1 deregulation.

7 al memory and whether it depends on HPA axis deregulation.

8 n cancer, resulting in widespread epigenetic deregulation.

9 SD1 inactivation therefore causes epigenetic deregulation across cancer sites, and has implications f

10 tivity with olaparib resulted in global gene deregulation, affecting approximately 11% of the genes e

11 display significantly greater transcriptome deregulations after chronic stress compared with pyramid

12 CRP binding, indicating possible complement deregulation also on this ligand.

13 tions, white matter disease, cerebrovascular deregulation, altered neuroplasticity, and changes in gl

14 Cells lacking PTEN exhibit cell cycle deregulation and cell fate reprogramming.

15 Transcriptional deregulation and changes in mitochondrial bioenergetics,

16 s driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic dysfunction, wit

17 Further, pentose phosphate pathway deregulation and impaired fatty acid oxidation collectiv

18 genomic lesions resulting in transcriptional deregulation and increased cell proliferation and surviv

19 ncer risk by FXR inactivation, leading to BA deregulation and increased colon cell proliferation.

20 ated with cell-cycle transcriptional program deregulation and increased proliferation index in NMZL.

21 tum, phenocopied Mecp2-null mice in dopamine deregulation and motor dysfunction.

22 ta provide new insights into MPNST signaling deregulation and suggest that co-targeting of PAK1/2/3 a

23 inflammation in pancreatitis, mechanisms of deregulation, and connections among disordered pathways.

24 id differentiation mainly through epigenetic deregulations, and impairs haematopoietic stem-cell self

25 We discuss CRTC deregulation as a new driver of aging that integrates th

26 patients and mouse models, uncovering a p53 deregulation as common denominator.

27 Our findings implicate MYC deregulation as the underlying cause of the observed ass

28 chemokine ligands/receptors whose epigenetic deregulation associates with key epigenetic enzymes, rep

29 tive data integration method to characterize deregulation between miRNA and mRNA due to environmental

30 This deregulation can explain the mitochondrial uncoupling an

31 of energy and metabolic homeostasis and its deregulation can lead to obesity and type II diabetes (T

32 for establishing cellular diversity, and its deregulation can result in pathological conditions.

33 lial integrity is vitally important, and its deregulation causes early stage cancer.

34 f alternative splicing and the fact that its deregulation causes hereditary disease and cancer.

35 Together, these data suggest that Dgkkappa deregulation contributes to FXS pathology and support a

36 stability of most cellular proteins, and its deregulation contributes to human diseases including can

37 erall, our results illuminate how epigenetic deregulation contributes to neuroblastoma pathogenesis,

38 beta-Catenin deregulation directly disrupts cilium maintenance and si

39 l a new mechanism of autophagy control whose deregulation disrupts mitochondrial integrity and energy

40 SOX2 deregulation drives dysplasia, and loss of tumor promote

41 Their deregulation during cancer initiation and progression ca

42 uggest a novel common mechanism of NF-kappaB deregulation during lymphomagenesis.

43 hway activating PKCiota perpetuates cyclin E deregulation during ovarian tumorigenesis.

44 Their deregulation following changes in expression, transcript

45 Our results demonstrate that miRNA deregulation happens very early in HCC in humans, implyi

46 y, in a separate analysis (step 3), the IL-8 deregulation has also appeared to be an important progno

47 E2F, a family of transcription factors whose deregulation has been associated to cancer progression,

48 l has been described as an oncogene, and its deregulation has been implicated in the progression of s

49 onmental factors on mechanisms of epigenetic deregulation in brain cancer.

50 the cell multiplication decision and in its deregulation in cancer cells.

51 Our results suggest that epigenetic deregulation in cancer not only targets tissue-specific

52 Our results provide an example of EGFR deregulation in cancer through silencing of components o

53 30 is a promising approach to overcome Dicer deregulation in cancer.

54 c screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation (Pik3c

55 To provide a basis for studying epigenome deregulation in CLL, here we present genome-wide chromat

56 al for cortical function and may be sites of deregulation in developmental brain disorders.

57 We propose that in obesity, there is deregulation in differentiation of intestinal epithelial

58 ngs highlight the involvement of AMPK/mTORC1 deregulation in DM1 muscle pathophysiology and may open

59 , epigenetic models to better describe RUNX3 deregulation in GC have not emerged.

60 port the oncogenic relevance of proteostasis deregulation in hematopoietic cells, and they unveil nov

61 l an important mechanism contributing to Myc deregulation in human breast cancer.

62 a pivotal role in animal development and its deregulation in humans causes birth defects and several

63 a community resource for studying epigenome deregulation in leukaemia and demonstrated the feasibili

64 te a unique paradigm of transcription factor deregulation in leukemia in which DUX4 deregulation resu

65 ems to facilitate further study of chromatin deregulation in lung cancer.

66 onent of the PTEN/PI3K/AKT signaling pathway deregulation in RMS cells and that targeting TBX2 in RMS

67 a previously unappreciated role of epigenome deregulation in the genesis of 13% of HPV-negative HNSCC

68 lting from such genomic perturbations is the deregulation in the metabolism of tumor cells.

69 This cognitive deficit is consecutive to PKA deregulation in the mPFC that prevents Ophn1 KO mice to

70 s using mouse embryonic fibroblasts revealed deregulation in the transcripts of both HET and KO anima

71 issue microenvironment in regulating barrier deregulations in tissue-specific manner.

72 regulate G1 to S phase transition and their deregulation induces oncogenesis.

73 this study was to evaluate whether microRNA deregulation inhibits the regenerative potential of mese

74 This deregulation interferes with the two-pronged binding of

75 Wnt pathway deregulation is a common characteristic of many cancers.

76 Post-transcriptional deregulation is a defining feature of metastatic cancer.

77 Epigenetic deregulation is a hallmark of cancer characterized by fr

78 Metabolic deregulation is a hallmark of human cancers, and the gly

79 isease; (2) to test the hypothesis that SOX2 deregulation is a key early event in the pathogenesis of

80 Thus, we propose that mitochondrial calcium deregulation is a novel pathogenic mechanism of cognitiv

81 nd differentiation and we suggest that sox10 deregulation is an important driver of the neural crest-

82 glycogen metabolism, and immune regulation; deregulation is associated with diseases such as cancer,

83 ite range of biological functions, and their deregulation is associated with inflammatory, metabolic,

84 MicroRNA (miRNA) deregulation is common in human colorectal cancers, but

85 has potent signaling functions and that its deregulation is connected to disease.

86 regulation of Kr-h1 expression and that this deregulation is derived from a deficiency of miR-2 miRNA

87 g tissue homeostasis and organ size, and its deregulation is frequently observed in human cancer.

88 cellular responses to Ca(2+) signals and its deregulation is implicated in cancer, cardiac, neurodege

89 is and pro-survival signaling pathways whose deregulation is often associated with tumor genesis and

90 Transcriptional deregulation is one of the core tenets of cancer biology

91 This local protein synthesis deregulation is proposed to underlie the observed defect

92 Its deregulation is strongly linked to disease onset and pro

93 an size control and tissue homeostasis, with deregulation leading to cancer.

94 glucose metabolism, malate-aspartate shuttle deregulation leads to a specific proliferative block due

95 f hormone action and signalling events whose deregulation leads to breast tumourigenesis.

96 lly important to T cell development, and its deregulation leads to leukemia.

97 in maintaining cellular homeostasis, and its deregulation leads to the corruption of a plethora of ce

98 Parkin-deficient cells, suggesting that Rab7 deregulation may be at least partially responsible for t

99 oRNA (miRNA) and messenger RNA (mRNA), whose deregulation may be sensitive to environmental insult le

100 esions, suggesting unrecognized (epi)genetic deregulation mechanisms.

101 model for haploinsufficient transcriptional deregulation mediated by higher order genome architectur

102 s in several gene clusters and a significant deregulation of 10 microRNAs.

103 ylation contribute to the observed recurrent deregulation of 235 lncRNAs.

104 of basal neural progenitor cells (NPCs) via deregulation of a beta-catenin/Brn2/Tbr2 transcriptional

105 Unexpectedly, a pH-dependent deregulation of a red pigment, identified as oosporein,

106 In obese individuals, deregulation of a specific adipokine, chemerin, contribu

107 -) mice display sex-specific transcriptional deregulation of a wide range of bile and steroid metabol

108 How deregulation of actin regulators promotes cancer cell in

109 In sum, deregulation of all three PPs appears central to neoplas

110 he regulation of critical cellular pathways, deregulation of AMPK is associated with the pathology of

111 We hypothesized that deregulation of an angiogenic factor, angiopoietin-2 (An

112 These tumors lack deregulation of APC/beta-catenin signaling components, w

113 Although the disease most commonly linked to deregulation of AS in several genes is cancer, many repo

114 for impaired lysosomal acidification in the deregulation of autophagy and beta-cell function under l

115 Deregulation of autophagy has been linked to multiple de

116 Deregulation of BA homeostasis has been linked to hepato

117 lack of the SLE risk variant Def6 results in deregulation of Bcl6 protein synthesis in T cells as a r

118 rent B-cell receptor pathway activation, and deregulation of BCL6.

119 Finally, RUNX1 loss-mediated deregulation of beta-catenin and mitosis is ameliorated

120 ther, our study's findings indicate that the deregulation of beta-catenin by ERK2-activated CSN6 is i

121 uction in neuronal Mcl-1 protein levels, and deregulation of both mitochondrial bioenergetics and Ca(

122 tigate the dire consequences of simultaneous deregulation of both the Ras and Hippo pathways.

123 Deregulation of C/EBPalpha by microRNAs during granulopo

124 gous-deleted neuroblastomas, indicating that deregulation of calcineurin and mitochondrial dynamics c

125 It is possible that deregulation of cellular growth control plays a more imp

126 ent microarray analysis revealed significant deregulation of central cell cycle regulatory genes.

127 M1-associated muscle pathology is related to deregulation of central metabolic pathways, which may id

128 We suggest that the deregulation of central, interaction-prone proteins may

129 y-causing lamin A mutation to an unsuspected deregulation of chromatin states and spatial conformatio

130 The 4 phenocopy is associated with the deregulation of Ci control, an overreduced cellular stat

131 d in a group of shift workers experiencing a deregulation of circadian clock genes compared to a cont

132 One such mechanism is deregulation of CREB-regulated transcriptional coactivat

133 Deregulation of CRTC1 dephosphorylation, nuclear translo

134 However, deregulation of cyclin E leads to inefficient assembly o

135 al potential modification, oxidative stress, deregulation of cytoplasmic Ca(2+) levels, and Ca(2+) cy

136 Deregulation of deiodinase function and thyroid hormone

137 DA excitation period and did not exhibit the deregulation of Deltapsim that was observed in their wil

138 e, in wild type C57BL/6 mice, we related the deregulation of distinctive set of tissue-specific oncot

139 Collectively, our results demonstrate that deregulation of DNMT1-associated lncRNAs contributes to

140 Conversely, deregulation of Dnmt3b is thought to generally promote t

141 nding and innate GTPase activity, leading to deregulation of downstream signal transduction.

142 , to fight metastasis and therapy resistance.Deregulation of E2F family transcription factors is asso

143 Such molecular re-programming results in deregulation of early development checkpoints culminatin

144 sures of ecdysone with juvenoids resulted in deregulation of ecdysone- and farnesoid-regulated genes,

145 Deregulation of endothelial responses to flow-induced sh

146 chondrial dysfunction has been linked to the deregulation of energy homeostasis, the precise mechanis

147 Thus, deregulation of Eph/ephrin would allow RasV12 cells to g

148 cases and was accompanied by transcriptional deregulation of ERG, expression of a novel ERG isoform,

149 Deregulation of FGFR-mediated signaling involving the Ra

150 These data suggest that deregulation of FOXC1 or its downstream genes play a maj

151 Deregulation of FOXM1 occurs in a wide variety of epithe

152 Crohn's disease could lead to or result from deregulation of FOXP3/EZH2-enforced T cell gene networks

153 Moreover, splicing deregulation of FUS and TDP-43 target genes as well as m

154 th patients frequently exhibiting mutations, deregulation of gene expression, or alterations in the f

155 nd/or superantigen stimulation and molecular deregulation of genes (NOTCH2 and KLF2) involved in the

156 We find that deregulation of H4K20 methylation had no impact on origi

157 y maintain postnatal tissue homeostasis, and deregulation of hedgehog during injury leads to aberrant

158 t heightened inflammation is associated with deregulation of homeostatic interactions between intesti

159 The anemia signature indicated deregulation of host erythropoiesis, and the lung inflam

160 chitinases, suggesting a broader role beyond deregulation of host immunity.

161 oproteins have emerged as key players in the deregulation of host innate immune pathways that are req

162 Deregulation of ID complex SUMOylation compromises cell

163 Loss of Tnip1 in keratinocytes leads to deregulation of IL-17-induced gene expression and exagge

164 d mucosa proteomic analysis indicated severe deregulation of intracellular bile acid (BA) homeostasis

165 vel mechanism of p53 inactivation that links deregulation of IRES-mediated p53 translation with tumor

166 Mutations in human DDX3X and deregulation of its expression are linked to tumorigenes

167 e linked to systemic pathologies through the deregulation of kallikrein-like proteinase (KLK) family

168 many human diseases are associated with the deregulation of kinase activity.

169 d by Dicer-1 and miRNA depletion is due to a deregulation of Kr-h1 expression and that this deregulat

170 e of cardiomyocyte differentiation and broad deregulation of lineage-specific gene expression during

171 ytokines reduces Atg2 expression, permitting deregulation of lipid droplets.

172 , hepatocyte ATX ablation and the consequent deregulation of lipid homeostasis was also shown to atte

173 ancreatic ER stress, impaired autophagy, and deregulation of lipid metabolism.

174 and is linked to the translocation-mediated deregulation of MAF and MAFB, a known poor prognostic fa

175 ome analysis of G9a knockdown cells revealed deregulation of many cell cycle regulatory genes.

176 ted triple-transgenic mice with constitutive deregulation of matriptase and simultaneous inducible ex

177 Deregulation of matriptase is a consistent feature of hu

178 histone demethylase, results in the temporal deregulation of meiotic transcription and affects female

179 Although deregulation of MEK/extracellular signal-regulated kinas

180 sion or recurrent mutations of PcG genes and deregulation of microRNAs (miRNAs) or transcription fact

181 Deregulation of microRNAs (miRs) contributes to progress

182 Deregulation of microRNAs can alter expression levels of

183 We provide mechanistic insight by showing deregulation of miR-124 targets in BMP signaling drives

184 Therefore, deregulation of miRNAs was assessed in whole lungs from

185 timulus; this was accompanied by a prolonged deregulation of mitochondrial bioenergetics.bok deficien

186 tive oxygen species and less ATP, and to the deregulation of mitochondrial dynamics, causing in conse

187 ss-of-function mutations in ANKZF1 result in deregulation of mitochondrial integrity, and this may pl

188 Our data also suggest that the deregulation of mitochondrial nucleoside diphosphate kin

189 Deregulation of mitophagy leads to an increased number o

190 Deregulation of mTOR complex 1 (mTORC1) signalling incre

191 le PNH-related mutations are associated with deregulation of mTORC1 and AKT activities.

192 Deregulation of mTORC1 has been associated with the path

193 Thus deregulation of mTORC1-dependent pathways controlling pr

194 An in situ approach revealed deregulation of multiple factors such as transporters, t

195 ription factor leading to altered pathogenic deregulation of multiple genes in muscles.

196 omic and phosphoproteomic profiling revealed deregulation of multiple pathways, significantly the Not

197 Transcriptional deregulation of oncogenic pathways is a hallmark of canc

198 Deregulation of p16INK4A is a critical event in melanoma

199 Deregulation of paRNA-based epigenetic networks may cont

200 amycin-based experiments, found differential deregulation of pathways involved.

201 ve high levels of activated AKT owing to the deregulation of phosphoinositide-3 kinase (PI3K) signali

202 reast cancer cell de-differentiation through deregulation of PR and Stat5a, two transcription factors

203 d therapy of genetic disorders linked to the deregulation of primary cilia.

204 Deregulation of protein and lipid kinase activities lead

205 Deregulation of proteolytic systems is a known path lead

206 Deregulation of quiescence exit is associated with many

207 Moreover, deregulation of RAB1 expression has been linked to a myr

208 Deregulation of several microRNAs in B cells leads to th

209 ric disorders, which are associated with the deregulation of several neurotransmission systems.

210 germline hypomorphic variants of SUFU cause deregulation of SHH signaling, resulting in recessive de

211 Cancer is fueled by deregulation of signaling pathways in control of cellula

212 Our data suggest that the transcriptional deregulation of SNCA is associated with sequence-depende

213 Deregulation of some aspects of DDR orchestration is pot

214 impaired migration of neural crest cells and deregulation of sox10 expression from the early stages.

215 enetic and microenvironmental context, acute deregulation of SOX2 drives bronchial dysplasia.

216 Deregulation of sphingolipid biosynthesis and their recy

217 A growing body of evidence links deregulation of sphingolipids to several diseases, inclu

218 Deregulation of synaptic plasticity may contribute to th

219 drome and its development is associated with deregulation of systemic lipid and glucose homeostasis.

220 of the vascular microenvironment, including deregulation of TF, with a possible impact on the biolog

221 In turn, cell-intrinsic deregulation of TGF-beta signaling is associated with in

222 , many vascular malformations are related to deregulation of TGF-beta/BMP signaling.

223 d vascular malformations that are induced by deregulation of TGF-beta/BMP signaling: hereditary hemor

224 y argued to be attributable to the extent of deregulation of the alpha subunit of hypoxia-inducible f

225 Deregulation of the beta-catenin signaling has long been

226 At diagnosis, deregulation of the bone morphogenetic protein (BMP) pat

227 ultaneous targeting of AKT and WEE1 enhanced deregulation of the cell cycle and DNA damage repair pat

228 Deregulation of the cell cycle machinery is a hallmark o

229 n, are promoted by recent regulatory changes-deregulation of the commodity markets, and policies prom

230 results support a new role for vIRF1 through deregulation of the deubiquitinating enzyme USP7 to inhi

231 ostulated that it may be responsible for the deregulation of the filtering bleb and subsequent loss o

232 etion of this locus via CRISPR-Cas9 leads to deregulation of the genes predicted to interact with the

233 Here we show that deregulation of the homeobox transcription factor gene D

234 ks) support a disease mechanism in which the deregulation of the IL21 signalling pathway, in addition

235 Notably, we found that deregulation of the Lin28/let-7 axis with reduced produc

236 In association with insulin resistance and deregulation of the lipid metabolism (accumulation of li

237 ition, sustained infection results in global deregulation of the methylome across >80,000 CpGs and sp

238 tively activated macrophages, contributed by deregulation of the miR-155 target gene the liver X rece

239 3/EHF is the initial event that triggers the deregulation of the miR-424/COP1/STAT3 axis.

240 The significant deregulation of the miRNAs defining the network was conf

241 their protein synthesis contributing to the deregulation of the NF-kappaB-signaling pathway.

242 Taken together, our data demonstrate that deregulation of the PI3K-AKT/ mTORC1/ p70S6K pathways, a

243 Deregulation of the Ras-mitogen activated protein kinase

244 Deregulation of the receptor tyrosine kinase mesenchymal

245 nd in human tumors, our results suggest that deregulation of the RNF168/53BP1 pathway could alter the

246 etween gene expression and the proteome, and deregulation of the splicing machinery is linked to seve

247 ale spiking activity recordings a concurrent deregulation of the spontaneous network activity and hom

248 h the anticancer compound Minnelide revealed deregulation of the TGFbeta signaling pathway in CAF, re

249 transfected with HOPX revealed a widespread deregulation of the transcription of genes related to ep

250 Deregulation of the transforming acidic coiled-coil prot

251 nism of action for these compounds involving deregulation of the tricarboxylic acid cycle activity an

252 Deregulation of the ubiquitin ligase E6 associated prote

253 Together, these results implicate deregulation of the Wnt/beta-catenin pathway in CNS infl

254 Loss of APC function results in deregulation of the Wnt/beta-catenin signaling pathway c

255 Deregulation of the Wnt/beta-catenin signaling pathway d

256 ception is in RPGN where podocytes undergo a deregulation of their differentiated phenotype and proli

257 depend on the growth stage of cells and that deregulation of their relative abundance alters LD morph

258 Deregulation of these metabolic pathways results in cons

259 Herein, we review the mechanisms of deregulation of these oncogenes.

260 Deregulation of this centralized signaling pathway has b

261 The deregulation of this enzyme results in dampened mitochon

262 However, deregulation of this pathway can initiate and promote hu

263 a critical pathway for these processes, and deregulation of this pathway is associated with human br

264 Deregulation of TLX1 expression has recently been propos

265 impaired in FL-N/35 primary hepatocytes via deregulation of TNFalpha/SOCS3.

266 n, and many diseases are associated with the deregulation of transcriptional networks.

267 ial in the regulation of gene expression and deregulation of translation is associated with a wide ra

268 Such deregulation of Tregs may contribute to the perpetuation

269 egulates most aspects of cellular life, thus deregulation of ubiquitylation has been linked with a nu

270 Thus, deregulation of ULK1 signaling by UV-induced DNA damage

271 Because oncogenic lesions often cause deregulation of vascular effectors, including procoagula

272 Deregulation of VHR is observed in various malignant dis

273 om cell cycle control to developmental fate, deregulation of which contributes to developmental defec

274 ant R-spondin/LGR4 signaling with consequent deregulation of Wnt (co)receptor turnover as a driver of

275 Deregulation of Wnt signaling has been associated with s

276 erebellar disease pathogenesis caused due to deregulation of Wnt signaling.

277 Deregulation of ZAP-70 using tyrosine kinase inhibitors,

278 t role in mammary gland homeostasis and that deregulation of Zpo2 may promote breast cancer developme

279 Although deregulations of miRNAs have been frequently reported in

280 Interplays of PcG and miRNA deregulations often establish a vicious signal-amplifica

281 tion of beta-catenin was unable to drive Wnt deregulation or induce the CPC phenotype.

282 Transcriptional deregulation plays a major role in acute myeloid leukemi

283 Epigenetic deregulation plays an important role in liver carcinogen

284 naling, as two key pathways where epigenetic deregulation preferentially targets extracellular compon

285 ighly pleiotropic transcription factor whose deregulation promotes cancer.

286 In the liver, Hippo pathway deregulation promotes hyperplasia and hepatocellular car

287 o tumor invasion and metastases, whereas its deregulation reduces resistance to chemotherapeutic drug

288 actor deregulation in leukemia in which DUX4 deregulation results in loss of function of ERG, either

289 It is also unknown whether barrier deregulations, similar to the gut, characterize other vi

290 ghtly regulated in normal cells, whereas its deregulation strongly correlates with the progression of

291 rt a novel mechanism of alternative splicing deregulation that may play a role in various other disea

292 r these genes exhibit patterns of epigenomic deregulation that transcend cancer types.

293 rols TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.

294 as a consequence of the C/EBPalpha and -beta deregulation the expression of MYC is decreased with ass

295 tive memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegen

296 the compounds, and significant HO-1 protein deregulation was confirmed with each of the nine nephrot

297 transcription factors, while plasticity gene deregulation was differentially mediated.

298 olving EP300 and CREBBP may cause epigenetic deregulation with potential for therapeutic targeting.

299 ot explain genetic evidence correlating eIF3 deregulation with tissue-specific cancers and developmen

300 Here, we define a novel consequence of Ulp1 deregulation, with a major impact on SUMO pathway functi