ライフサイエンスコーパス: dermal papilla

1 unravel new molecular landscapes within the dermal papilla.

2 f specialized mesenchymal cells known as the dermal papilla.

3 talized DPCs have high resemblance to intact dermal papilla.

4 n interpreting a gradient emanating from the dermal papilla.

5 hought to be determined by the volume of its dermal papilla.

6 rea of the hair cortex and the volume of the dermal papilla.

7 s androgens must regulate is the size of the dermal papilla.

8 large abnormal follicles containing a small dermal papilla.

9 c staining of the nuclei of the cells of the dermal papilla.

10 ent hair buds also show abnormalities in the dermal papilla.

11 es, namely epithelial matrix and mesenchymal dermal papilla.

12 b expressed markers of the dermal sheath and dermal papilla.

13 the diffusible IGF antagonist Igfbp3 in the dermal papilla.

14 o detect genes specifically expressed in the dermal papilla.

15 populate a papillar ectoderm niche near the dermal papilla.

16 base of rete ridges or overlying the tip of dermal papilla.

17 nitor cells that maintain and regenerate the dermal papilla, a key component for hair growth.

18 thought to be controlled by signals from the dermal papilla, a specialized cluster of mesenchymal cel

19 mean 17-fold greater number of cells in the dermal papilla and a 2.4-fold greater volume associated

20 he close reciprocal relationship between the dermal papilla and adjacent HF epithelial cells.

21 ession of IP-associated genes in cultured HF dermal papilla and dermal sheath cup cells (DSCCs) compa

22 tes in the basal layer of the IFE and in the dermal papilla and hair bulb.

23 licles exhibited pigment incontinence in the dermal papilla and in selected outer root sheath keratin

24 oughout the murine hair cycle, including the dermal papilla and lower epithelial strand of late-catag

25 trix expressed SUR1 and Kir6.2, whereas both dermal papilla and sheath exhibited SUR2B and Kir6.1.

26 olled by reciprocal interactions between the dermal papilla and the surrounding epidermal hair precur

27 o correlated with the number of cells in the dermal papilla and with the volume of dermal papilla per

28 d in the outer root sheath, sebaceous gland, dermal papilla, and connective tissue sheath of human an

29 romote the formation of a tightly aggregated dermal papilla, and/or protect the dermal papilla cells

30 interactions that lead to the formation of a dermal papilla anlage and ingrowth of the epidermis.

31 Further, IGF-I receptor expression by the dermal papilla appears to be switched off during the tra

32 The follicle dermal papilla appears to be the site of androgen action

33 Melanocyte stem cells more distant from the dermal papilla are unscathed, thereby preventing hair gr

34 estricted to the hair matrix surrounding the dermal papilla, are found in the precortex and hair shaf

35 stem cell homeostasis beneath the stem cell-dermal papilla-based epithelial-mesenchymal interaction

36 e located in the key follicle regulator, the dermal papilla, by analyzing individual follicular struc

37 s stimulated in both frontal scalp and beard dermal papilla cell cultures by dexamethasone.

38 Dermal papilla cells (DPCs) located in the hair bulb are

39 Dermal papilla cells (DPCs) taken from male androgenetic

40 Human dermal papilla cells (HDPC) express mRNA for the key enz

41 alding occipital and frontal scalp and beard dermal papilla cells (n = 10) were established.

42 that the comparison of the mRNA of cultured dermal papilla cells and fibroblasts can lead to the ide

43 d a previously unrecognised heterogeneity in dermal papilla cells and shown that Sox2-positive cells

44 Communication between dermal papilla cells and the overlying epithelium is ess

45 in large quantities in cultured rat vibrissa dermal papilla cells but undetectable in cultured rat sk

46 this study was designed to determine whether dermal papilla cells cultured from human hair follicles

47 ptor and/or aromatase expression in cultured dermal papilla cells derived from human hair follicles.

48 P-1 expression was absent from hair bulb and dermal papilla cells during early to mid-anagen but was

49 show that Blimp1 is dynamically regulated in dermal papilla cells during hair follicle (HF) morphogen

50 from neonatal foreskins and cultured murine dermal papilla cells from adult GFP transgenic mice and

51 Low passage cultured dermal papilla cells from adult rats stimulate complete

52 ggregated dermal papilla, and/or protect the dermal papilla cells from apoptosis induced by cytokines

53 Once dermal papilla cells have lost hair-inducing properties

54 med global gene expression analysis of human dermal papilla cells in culture and discovered very rapi

55 apitulate this process in humans using human dermal papilla cells in human skin have failed, suggesti

56 and how to enrich for hair follicle-inducing dermal papilla cells in the dermal preparation.

57 imulated and androgen-treated cultured human dermal papilla cells isolated from beard (androgen-sensi

58 uman skin have failed, suggesting that human dermal papilla cells lose key inductive properties upon

59 ed that the osteopontin gene is expressed in dermal papilla cells of pelage follicles during catagen

60 Dermal papilla cells of the hair follicle can be maintai

61 addition, this study supports that cultured dermal papilla cells provide a cell-based model system t

62 n of these genes in cultured beard and scalp dermal papilla cells reflected similar differences in mi

63 ) was significantly upregulated in DSCCs and dermal papilla cells relative to FBs.

64 y skin keratinocytes and fibroblasts without dermal papilla cells served as positive and negative con

65 This implies that androgens stimulate dermal papilla cells to divide or to secrete autocrine m

66 By inducing cultured dermal papilla cells to secrete Wnt themselves, we demon

67 ens do not stimulate mitogenesis in cultured dermal papilla cells, this study was designed to determi

68 inductive capability, and we show that human dermal papilla cells, when grown as spheroids, are capab

69 in the inner root sheath, matrix cells, and dermal papilla cells.

70 s of the VDR status of the keratinocytes and dermal papilla cells.

71 nocytes of the outer root sheath, but not by dermal papilla cells.

72 compared them with Sox2(-) (GFP(-)) CD133(+) dermal papilla cells.

73 duce potentially novel signaling pathways in dermal papilla cells.

74 ibulin-1d, was slightly upregulated in beard dermal papilla cells.

75 ssed at significantly higher levels in beard dermal papilla cells.

76 ivity is a direct effect of Wnt signaling to dermal papilla cells.

77 e, primary keratinocytes, preadipocytes, and dermal papilla cells.

78 in the inner root sheath, matrix cells, and dermal papilla cells.

79 reased [3H] thymidine incorporation by other dermal papilla cells; trypsin treatment significantly re

80 mary DPCs in hair-related studies often lack dermal papilla characteristics.

81 The dermal papilla comprises the specialised mesenchymal cel

82 The volume of the dermal papilla depends on the number of cells it contain

83 in the inner root sheath (IRS), whereas the dermal papilla (DP) and outer root sheath were consisten

84 In neonatal mouse skin, two types of dermal papilla (DP) are distinguished by Sox2 expression

85 assembly strategies for the interactions of dermal papilla (DP) cells with adipose-derived stem cell

86 ls receive cues from specialized mesenchymal dermal papilla (DP) cells.

87 bridization to identify genes induced in the dermal papilla (DP) during anagen as a result of the int

88 The hair follicle dermal papilla (DP) expresses androgen receptors (AR) an

89 Dermal papilla (DP) from laminin-511 mutants showed deve

90 How dermal papilla (DP) niche cells regulate hair follicle p

91 ranscription factor Sox2 is expressed in the dermal papilla (DP) of guard/awl/auchene hair follicles

92 3 (Prom1) is expressed by fibroblasts in the dermal papilla (DP) of the hair follicle (HF).

93 and gain of function of beta-catenin in the dermal papilla (DP) of the hair follicle results in yell

94 ranscription factor Tbx18 specifically marks dermal papilla (DP) precursor cells during embryonic hai

95 The dermal papilla (DP) provide instructive signals required

96 Functional testing of dermal papilla (DP) signaling inputs into hair follicle

97 Systematic ablation of previously identified dermal papilla (DP) signature genes in embryonic DP prec

98 The dermal papilla (DP), a dense aggregate of specialized de

99 The dermal organizing center, the dermal papilla (DP), regulates development of the epider

100 by a specialized mesenchymal population, the dermal papilla (DP), that is embedded in the hair bulb.

101 clusters of precursors for the hair follicle dermal papilla (DP).

102 ts at the base of the follicle, known as the dermal papilla (DP).

103 ls from a specialized mesenchymal niche, the dermal papilla (DP).

104 ion of the Wnt3a gradient is dictated by the dermal papilla (DP).

105 n follicular melanocytes, keratinocytes, and dermal papilla fibroblasts.

106 In addition to the 'core' dermal papilla gene signature, each subpopulation expres

107 expression in the mesenchymal component, the dermal papilla, has hampered progress towards understand

108 n tumours, but confined to the hair follicle dermal papilla in normal postnatal skin.

109 imply that the increase in the volume of the dermal papilla in these follicles is due to an increase

110 sence of ectodermal placode and primodium of dermal papilla in these mice, yet the subsequent hair sh

111 e functional role of Blimp1 in promoting the dermal papilla inductive signaling cascade that initiate

112 limp1 is both a target and a mediator of key dermal papilla inductive signaling pathways including tr

113 Since the follicular dermal papilla is known to control hair growth, and ster

114 d et al show that JAK/STAT5 signaling in the dermal papilla is required for anagen onset in the murin

115 lected similar differences in microdissected dermal papilla isolated from intact beard and scalp foll

116 o key compartments (matrix keratinocytes and dermal papilla) leads to dynamic instabilities in the po

117 uce hair growth independently of mesenchymal dermal papilla niche signals normally required for hair

118 he new follicles formed sebaceous glands and dermal papilla, normally established only in embryogenes

119 It is expressed in the dermal papilla of all pelage hair follicle types from th

120 ception of the sonic hedgehog pathway in the dermal papilla of developing hair follicles.

121 the epidermis (Lef-1, beta-catenin, Shh) and dermal papilla (p75 kDa neurotrophin receptor, alkaline

122 in the dermal papilla and with the volume of dermal papilla per cell.

123 reas Aldh1a3 expression was primarily in the dermal papilla, pre-cortex, and hair shaft during mid-la

124 cate an estrogen receptor pathway within the dermal papilla regulates the telogen-anagen follicle tra

125 s, precursors of adult HF stem cells and the dermal papilla/sheath niche, along with lineage-related

126 Both the follicular epithelium and dermal papilla showed markedly decreased Wnt/beta-cateni

127 Furthermore, we pinpoint KIT-ligand as a dermal papilla signal promoting melanocyte stem cell dif

128 nd the epithelial stem cells that respond to dermal papilla signaling.

129 oth BAB and BAN retained high proportions of dermal papilla signature gene and versican protein expre

130 these genes, sfrp-2 has been identified as a dermal papilla signature gene in mouse pelage follicles.

131 ctors may be involved in the key increase of dermal papilla size necessary for androgen-induced chang

132 ecause hair size has been clearly related to dermal papilla size, one of the key functions androgens

133 ytes, and BMP signaling positively regulates dermal papilla-specific enhancer of the Agouti gene in p

134 da-A1 expression is required until the early dermal papilla stage for guard hair germs to make follic

135 One forms the upper dermis, including the dermal papilla that regulates hair growth and the arrect

136 The mesenchyme-derived dermal papilla that regulates the hair follicle is consi

137 At the core is the dermal papilla, the organizing center, and the epithelia

138 leads to endogenous EDN3 upregulation in the dermal papilla, the secondary hair germ cells, and the e

139 ndrogens are thought to act primarily on the dermal papilla, these changes may have a direct bearing

140 derived from human and rodent epidermis and dermal papilla to reconstitute hair-follicle mini-organs

141 We demonstrate that the intact dermal papilla transcriptional signature can be partiall

142 n large male facial follicles the mean total dermal papilla volume was almost 40-fold higher than in

143 e expression of the estrogen receptor in the dermal papilla was hair cycle-dependent with the highest

144 the outer root sheath, sebaceous gland, and dermal papilla, whereas CCAAT/enhancer-binding protein-b

145 r matrix which forms the hair itself, or the dermal papilla which is responsible for induction of the