ライフサイエンスコーパス: dermomyotome

1 the somite remains epithelial and is called dermomyotome.

2 rsoventral axis into sclerotome, myotome and dermomyotome.

3 coming restricted to epithelial cells of the dermomyotome.

4 e ectoderm stimulates the development of the dermomyotome.

5 nvolvement of WNT proteins in patterning the dermomyotome.

6 th a change in the morphology of the ventral dermomyotome.

7 MyoD family members are concentrated in the dermomyotome.

8 ription factor gene expressed in the central dermomyotome.

9 of the dorsal compartment of the somite: the dermomyotome.

10 and Pax3 in a pattern reminiscent of amniote dermomyotome.

11 he central proportion of the Pax3(+)/Pax7(+) dermomyotome.

12 nation of premyogenic cells from the lateral dermomyotome.

13 le the distal rib arises from regions of the dermomyotome.

14 ressed in the neural tube, neural crest, and dermomyotome.

15 , and congregate abnormally near the lateral dermomyotome.

16 r the central epithelial sheet region of the dermomyotome.

17 3-FKHR in the dorsal neural tube and lateral dermomyotome.

18 differentiation of presomitic mesoderm into dermomyotome.

19 ovide the dorsalizing signals to specify the dermomyotome.

20 aintain the epithelial characteristic of the dermomyotome.

21 that are generated by the lateral lip of the dermomyotome.

22 xial mesoderm and its dorsal derivative, the dermomyotome.

23 neously, until they reach the margins of the dermomyotome.

24 d in the dorsomedial lip (DML) of the somite dermomyotome, a finding recently substantiated through s

25 x3 modulates c-met expression in the lateral dermomyotome, a function that is required for the approp

26 neuronal and sensory-specific markers in the dermomyotome, a mesodermal derivative.

27 The dermomyotome, a transient structure from which axial mus

28 r muscle growth in amniotes develop from the dermomyotome, an epithelium at the external surface of t

29 myotome and simultaneously drive that of the dermomyotome, an epithelium containing muscle, dermis an

30 the opposite effect, causing an increase in dermomyotome and a shift in myoblast fate from epaxial t

31 r cells emigrate from the ventral lip of the dermomyotome and colonize the limbs, tongue and diaphrag

32 the dorsomedial and dorsolateral lips of the dermomyotome and entry into the myotome or dispersal int

33 ous role in maintaining cell survival in the dermomyotome and initiating early activation of the myog

34 d when muscle precursors delaminate from the dermomyotome and migrate into the limb.

35 here muscle precursor cells migrate from the dermomyotome and move into the myotome, and later in myo

36 Notably, both the dermomyotome and myotome fail to adopt a normal epitheli

37 a-Catenin is necessary within the somite for dermomyotome and myotome formation and delamination of l

38 ys an important role in the expansion of the dermomyotome and myotome in Wnt-3a-treated embryos.

39 ockdown embryos correlates with a deficit in dermomyotome and myotome marker gene expression, suggest

40 myogenic compartment (newly formed somites, dermomyotome and myotome).

41 les form from the morphologically continuous dermomyotome and myotome, whose epaxial-hypaxial subdivi

42 o results in a mediolateral expansion of the dermomyotome and myotome.

43 ved in compartmentalization of somites, that dermomyotome and sclerotome differentiation are independ

44 tially in the lateral portion of the somitic dermomyotome and subsequently migrate to their target li

45 expression becomes restricted to the lateral dermomyotome and to the migratory muscle precursors givi

46 We found that the mutant dermomyotomes and myotomes failed to organize and to elo

47 In chick embryo, Ebp1 was expressed in the dermomyotome, and myogenic differentiation of muscle pro

48 rning of somites to give rise to sclerotome, dermomyotome, and myotome involves the coordination of m

49 Surrounding tissues, such as the notochord, dermomyotome, and sclerotome also exhibit differential e

50 tely and growth and survival of cells in the dermomyotome are not affected.

51 s the target of Shh signaling in the epaxial dermomyotome, as MyoD activation by recombinant Shh prot

52 Measurements of the dermomyotome at different stages of development shows th

53 and segmental patterning of the myotome and dermomyotome bear interesting similarities with those of

54 uscle precursors delaminate from the ventral dermomyotome but fail to migrate laterally into the limb

55 yf5 and Pax3 in the dorsal medial lip of the dermomyotome, but is not expressed in the forming myotom

56 l dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment t

57 age 20, the premature differentiation of the dermomyotome caused by shh overexpression cannot be resc

58 yzed using fluorescent vital dye labeling of dermomyotome cells and cell-fate assessment by confocal

59 r cell populations located in the epithelial dermomyotome compartment of the each somite.

60 Dermomyotome contains skeletal muscle precursors that ar

61 Wnt signals are important in early stages of dermomyotome development, but the signal that acts to sp

62 be provide a dorsalizing signal(s) directing dermomyotome development.

63 Other injected regions of the dermomyotome did not give rise to myotome fibers.

64 y, competition to specify the sclerotome and dermomyotome domains within the naive mesoderm can be ob

65 maintained when cells from the En1-positive dermomyotome enter the myotome and dermatome, thereby su

66 t whereby myotomal precursor cells leave the dermomyotome epithelium and enter the subjacent myotome

67 ablation of the dorsomedial lip (DML) of the dermomyotome epithelium blocks further primary myotome g

68 ition of myotome fibers and expansion of the dermomyotome epithelium occurs in a lateral-to-medial di

69 ells of the vertebrate body originate in the dermomyotome epithelium of the embryonic somites.

70 the transplanted DML also gives rise to the dermomyotome epithelium overlying the new myotome growth

71 to either the cranial or caudal lips of the dermomyotome epithelium, nor were any such translational

72 he epaxial primary myotome and the overlying dermomyotome epithelium.

73 dial direction in concert with the overlying dermomyotome epithelium.

74 ents from the epithelial sheet region of the dermomyotome exhibited full DML growth and morphogenetic

75 factor, in the regulation of sclerotome and dermomyotome formation.

76 use that En1-expressing cells of the central dermomyotome give rise to dorsal dermis and epaxial musc

77 The ventrolateral dermomyotome gives rise to all muscles of the limbs thro

78 Our results indicate that the mouse central dermomyotome gives rise to dermis, muscle, and brown fat

79 The dermomyotome gives rise to the trunk and limb muscle and

80 the dorsalizing signal(s) that patterns the dermomyotome has not been identified.

81 oretically injected at specific sites in the dermomyotome in ovo and the fates of dye-labeled cells m

82 rmation also regulate the development of the dermomyotome in the anterior somite compartment.

83 le have been shown to arise from the central dermomyotome in the chick.

84 growth and morphogenesis of the myotome and dermomyotome in the epaxial domain of the body.

85 w that SFRP2-expressing cells can reduce the dermomyotome-inducing activity of WNT1 and WNT4, but not

86 ax3, Myf5 and Lbx1 expression indicates that dermomyotome induction occurs in Nog;Grem1 double mutant

87 of this balance in multipotent cells of the dermomyotome influences cell fate; upregulation of Foxc2

88 of limb-innervating motor neurons to that of dermomyotome-innervating MMCm cells using the LIM factor

89 brate somite is its organisation into dorsal dermomyotome, intermediate myotome and ventral sclerotom

90 ls that migrate from the lateral edge of the dermomyotome into the limb bud.

91 al patterning of somites into sclerotome and dermomyotome involves antagonistic actions of ventralizi

92 ome lips, respectively, and expansion of the dermomyotome is greatest along its mediolateral axis coi

93 The dorsomedial lip (DML) of the somite dermomyotome is the source of cells for the early growth

94 The dermomyotome is then patterned along its mediolateral ax

95 driven by the early epaxial enhancer in the dermomyotome, is necessary for early myotome formation,

96 gulation of, a population of Pax3-expressing dermomyotome-like cells in the zebrafish.

97 myf5 but fail to make muscle and remain in a dermomyotome-like state characterised by pax3 and meox e

98 located in the dorsomedial and ventrolateral dermomyotome lips, respectively, and expansion of the de

99 e WNT family members can maintain and induce dermomyotome marker expression in presomitic mesoderm ex

100 myogenic differentiation and by inducing the dermomyotome marker meox1.

101 sion labels a central subdomain of the avian dermomyotome, medially abutting the expression domain of

102 ly repressing cell fates that promote either dermomyotome/myotome or sclerotome differentiation, resp

103 Thus, the En1-expressing central dermomyotome normally gives rise to three distinct fates

104 Dmrt2 is expressed in the dermomyotome of developing vertebrate somites.

105 e developing limb bud from the ventrolateral dermomyotome of limb adjacent somites.

106 itive myoblasts delaminate from the hypaxial dermomyotome of limb level somites and migrate into the

107 somites, and preferentially localized in the dermomyotome of more rostral somites before diminishing

108 al myogenic progenitors in the dorsal medial dermomyotome of newly forming somites, and immunohistolo

109 xpression is markedly reduced in the lateral dermomyotome of Splotch embryos lacking Pax3.

110 , we have found three genes expressed in the dermomyotome of the early somite.

111 gnaling plays a major role in patterning the dermomyotome of the somitic mesoderm.

112 et or SF/HGF, the initial development of the dermomyotome proceeds appropriately and growth and survi

113 imary myotome growth while ablation of other dermomyotome regions does not.

114 edial portion of the cranial boundary of the dermomyotome, regions in close proximity to the dorsal r

115 s of the somites give rise to sclerotome and dermomyotome, respectively.

116 oblast growth factors (FGFs) produced by the dermomyotome selectively attract MMCm axons in vitro.

117 Wnt6 in the surface ectoderm at the time of dermomyotome specification prompted us to investigate th

118 NA causes a premature differentiation of the dermomyotome, subsequently inhibiting all further growth

119 genic progenitor cells from the dorsolateral dermomyotome that are fated to form the non-migratory hy

120 skeletal muscle is derived from cells of the dermomyotome that detach and migrate into the limb buds

121 lecular marker for the medial compartment of dermomyotome (the 'medial lip') to demonstrate that BMP

122 ch encodes a secreted ligand that signals to dermomyotome through the membrane receptor tyrosine kina

123 or commitment of cells from the dorsolateral dermomyotome to the myogenic lineage.

124 cells, which are known to reside within the dermomyotome, translocate to the subjacent myotome layer

125 ted DMLs were replaced with fragments of the dermomyotome ventrolateral lip of wing-level somites or

126 expressed within the dorsomedial lip of the dermomyotome, where Pax3-expressing cells first initiate