ライフサイエンスコーパス: desaturase

1 sF (the latter encodes a putative fatty acid desaturase).

2 f the binuclear nonheme iron enzyme Delta(9) desaturase.

3 of a marker of sebaceous glands, Steroyl-CoA desaturase.

4 almitoyl-monogalactosyldiacylglycerol Delta7 desaturase.

5 , the endoplasmic reticulum-localized oleate desaturase.

6 thase, fatty acid synthase, and stearoyl-CoA desaturase.

7 them from the archetype Delta9 stearoyl-ACP desaturase.

8 anes by transcriptionally regulating a lipid desaturase.

9 zation, like the soluble plastidial acyl-ACP desaturases.

10 echanisms of related diiron hydroxylases and desaturases.

11 tically distinct from known plant and fungal desaturases.

12 those of metalloproteins such as fatty acid desaturases.

13 unding member of a novel class of fatty acid desaturases.

14 network that upregulates delta-9 fatty acid desaturases.

15 1 enzymes have been shown to be retinoid 3,4-desaturases.

16 omyces cerevisiae, stearoyl-coenzyme A (CoA) desaturase 1 (OLE1) affects cell viability through the r

17 demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis of unsaturat

18 f lipoprotein secretion, stearoyl coenzyme A desaturase 1 (SCD-1).

19 ntrations, which reflect stearoyl-coenzyme A desaturase 1 (SCD1) activity in the liver and are associ

20 we show that expression of the stearoyl-CoA desaturase 1 (Scd1) gene is downregulated in LSCs and th

21 to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been proposed as an a

22 Stearoyl-coenzyme A desaturase 1 (SCD1) is a well-known enhancer of the meta

23 esin-like protein 2 (TPX2), and stearoyl-CoA desaturase 1 (SCD1), significantly reduced the survival

24 Recent evidences suggest that stearoyl-CoA-desaturase 1 (SCD1), the enzyme involved in monounsatura

25 xpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible for the conv

26 Stearoyl-CoA desaturase 1 (SCD1), the key enzyme involved in endogeno

27 tty acid synthase activity from stearoyl-CoA desaturase 1 (SCD1)-mediated desaturation.

28 fatty acid synthase (FASN), and stearoyl CoA desaturase 1 (SCD1)] to AML and eBL cell lines treated w

29 ey lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD).

30 ghted that modulation of stearoyl-coenzyme A desaturase 1 activity by dietary intervention or genetic

31 x 10(-8)) as a marker of stearoyl coenzyme A desaturase 1 activity, and the ratio of 20:3n-6 to 18:2n

32 Fatty acid desaturase 1 and 2 (FADS1 and FADS2) code for the key de

33 ions of increased muscle stearoyl-coenzyme A desaturase 1 during obesity, starvation and exercise rai

34 g of the pivotal role of stearoyl-coenzyme A desaturase 1 in health and disease.

35 stions as to the role of stearoyl-coenzyme A desaturase 1 in this tissue.

36 Stearoyl-coenzyme A desaturase 1 is a delta-9 fatty acid desaturase that cat

37 The lipogenic enzyme stearoyl-CoA desaturase 1 is highly induced in SIRT3KO mice, and its

38 Stearoyl-coenzyme A desaturase 1 is required to guard against dietary unsatu

39 Therefore, stearoyl-CoA desaturase 1 may play an unexpected role in suppressing

40 netic deletion or inhibition of stearoyl-CoA desaturase 1 promotes inflammation, TLR4 hypersensitivit

41 onse element-binding protein or stearoyl-CoA desaturase 1 resulted in lethality on high sugar diets.

42 ase 1, and inhibition of stearoyl-coenzyme A desaturase 1 via antisense or RNA interference, recapitu

43 unmasked AR-driven pathways, dihydroceramide desaturase 1 was identified as an AR-regulated gene in m

44 he body is tightly regulated by stearoyl-CoA desaturase 1, an enzyme that converts endogenous SFA to

45 a liver-specific loss of stearoyl-coenzyme A desaturase 1, and inhibition of stearoyl-coenzyme A desa

46 the polymorphisms of coding genes fatty acid desaturase 1-3 for the desaturase enzymes that convert s

47 entified capacity to inhibit dihydroceramide desaturase-1 (Des1).

48 ctivity of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1), has been shown to be related to ca

49 provides an overview of stearoyl-coenzyme A desaturase-1 (SCD1) as a novel therapeutic target for me

50 Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monou

51 Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis of monounsat

52 ffect ORCTL3 targets the enzyme stearoyl-CoA desaturase-1 (SCD1) in fatty acid metabolism.

53 r pharmacological inhibition of stearoyl-CoA desaturase-1 (SCD1), the enzyme that converts SFA to MUF

54 n of lipogenic genes, including stearoyl-CoA desaturase-1 (SCD1).

55 o decreased hepatic activity of stearoyl-CoA desaturase-1 (SCD1).

56 synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1).

57 the exercise-suppressed hepatic stearoyl-CoA desaturase-1 and peroxisome proliferator-activated recep

58 a mRNAs were higher, and stearoyl-coenzyme A desaturase-1 and PPARgamma mRNAs were reduced.

59 We identify stearoyl-CoA desaturase-1 as a MSI1 target, revealing a feedback loop

60 Mice with a deletion of the Delta(9)-desaturase-1 isoform (SCD1) either globally (Scd1(-/-))

61 Despite enhanced expression of stearoyl-Co-A desaturase-1, levels of palmitoleic and oleic acids (Del

62 the chromophore produced by dihydroceramide desaturase-1, the putative all-trans retinol isomerase i

63 ybean (Glycine max) genes fatty acid omega-6 desaturase 2 (FAD2) and acyl-acyl carrier protein thioes

64 thway requiring repeated use of a fatty acid desaturase 2 (FADS2) protein to perform Delta6 desaturat

65 Overexpression of fatty acid desaturase 2 (fads2), which metabolizes LA to downstream

66 rrin (TF), hemochromatosis (HFE), fatty acid desaturase 2 (FADS2)/myelin regulatory factor (MYRF), tr

67 for eSNPs in 3 additional genes: fatty acid desaturase 2 (FADS2; P = .002), N-acetyl-alpha-D-galacto

68 ernatively, some teleosts possess fatty acyl desaturases 2 (Fads2) that enable them to biosynthesis D

69 The fatty acid desaturase-2 rs1535 variant, associated with low baselin

70 logous expression in yeast of a linoleoyl 12-desaturase (acetylenase) and a bifunctional desaturase w

71 ative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towa

72 ated the potential of estimated elongase and desaturase activities for use as predictive markers for

73 Intervention had no effect on estimated desaturase activities.

74 alysis, each SD increase of log-stearoyl-coA desaturase activity (16:1n-7/16:0 ratio) was positively

75 r protein and indexes of plasma stearoyl-CoA desaturase activity (SCD).

76 ed approximately 60% increase in steroyl-CoA desaturase activity and approximately 40% decrease in ve

77 d 442insA in ahFAD2B eliminate or knock down desaturase activity and have been demonstrated to produc

78 An association between desaturase activity and risk of type 2 diabetes (T2D) ha

79 hesis of the signal depends on zeta-carotene desaturase activity encoded by the zeta-CAROTENE DESATUR

80 he-sites reactivity could potentially buffer desaturase activity from oxidative inactivation.

81 of SMS-KCNR cells with fenretinide inhibited desaturase activity in a dose-dependent manner.

82 st study to demonstrate decreased fatty acid desaturase activity in humans with asthma.

83 Atherogenicity index and desaturase activity indices were highest in late lactati

84 epithelial cells suggest that inhibition of desaturase activity leads to airway hyper-responsiveness

85 All seven have previously undescribed desaturase activity on very-long-chain fatty acid (VLCFA

86 6 (P = 9.4 x 10(-7)) as a marker of Delta(6)-desaturase activity significantly predicted the worsenin

87 be diverted to catalytic, mixed hydroxylase/desaturase activity with aliphatic C-H bonds.

88 ss both stearoyl- and palmitoyl-ACP Delta(9) desaturase activity, including the predominant isoform S

89 ored carotenoids due to a defect in phytoene desaturase activity.

90 ther in-tumor variety arising from decreased desaturase activity.

91 te that fenretinide inhibits dihydroceramide desaturase, an enzyme involved in the biosynthesis of li

92 of the best characterized integral membrane desaturase and because it retains activity when fused wi

93 position by gas chromatography and estimated desaturase and elongase activities as the ratio of produ

94 esters (CEs) and phospholipids and estimated desaturase and elongase activities in children.

95 tor, BMVCP5, that better maintained phytoene desaturase and heat shock protein70-1 (HSP70-1) inserts

96 showed substantial up-regulation of several desaturase and MnP genes in wood-containing medium.

97 Together, the bifunctional desaturase and the acetylenase provide the enzymatic act

98 through the activity of a fatty acyl Delta11-desaturase and two specialized alcohol-forming fatty acy

99 t an endogenous transcript encoding PHYTOENE DESATURASE and used to analyze the role of miR173 in rou

100 In nature, desaturases and acetylenases are adept at achieving this

101 which arise by the action of membrane-bound desaturases and desaturase-like enzymes.

102 n can differentially alter the expression of desaturases and elongases involved in omega-6 and omega-

103 hioesterase, or by suppression of fatty acid desaturases and elongases, resulted in new overall seed

104 Ferredoxin is a substrate of the desaturases and has been previously shown to be a major

105 se involved in chemical communication (e.g., desaturases and odorant receptors).

106 Desaturases and related enzymes perform O(2)-dependent d

107 yl functionality into Leu-Ala(P) acting as a desaturase, and addition of Gly by DhpK in a Gly-tRNA(Gl

108 ings suggest that SAD6 functions as a Delta9-desaturase, and together with FAD3 it increases the leve

109 genase, stearoyl acyl carrier protein Delta9 desaturase, and variants of Escherichia coli R2 with the

110 ons of yellow/major royal jelly proteins and desaturases, and complete CpG DNA methylation and RNAi t

111 tly regulates the expression levels of lipid desaturases, and inhibition of desaturases blocks NF-kap

112 Although increased lipogenesis, desaturases, and LOX activities characterize NAFL and NA

113 Experiments on the castor desaturase are discussed that provide experimental suppo

114 Delta9-Desaturases are central enzymes in unsaturated fatty aci

115 tably associate at concentrations typical of desaturase assays.

116 triglycerides, whereas adjustment for other desaturase-associated biomarkers (CRP, fetuin-A, ALT, an

117 related to classic membrane bound fatty acid desaturases based on overall sequence conservation.

118 onstitute the switch between hydroxylase and desaturase behavior.

119 vels of lipid desaturases, and inhibition of desaturases blocks NF-kappaB signaling.

120 ice with transgenic expression of an omega-3 desaturase capable of enriching tissues with endogenous

121 DEGS1 is the desaturase catalyzing the last step in the main ceramide

122 Plant desaturases comprise two independently evolved classes,

123 ids produced by previously characterized Z11-desaturase/conjugase MsexD2.

124 n to physically interact with the fatty acid desaturases CrDelta4FAD and CrFAD6, likely donating elec

125 of the ATG start codon of a putative omega-3 desaturase (CrFAD7; locus Cre01.g038600).

126 e (CrtF), and two paralogs of carotenoid 3,4-desaturases (CrtD).

127 In the present study, a bacterial desaturase (crtI) from Pantoea ananatis has been overexp

128 Determination of the long-sought oxidized desaturase crystal structure facilitated structural comp

129 enzymes involved in PUFA metabolism, Delta5 desaturase (D5D) and Delta6 desaturase (D6D), with T2D r

130 of the association between estimated Delta5 desaturase (D5D), Delta6 desaturase (D6D), and stearoyl-

131 en estimated Delta5 desaturase (D5D), Delta6 desaturase (D6D), and stearoyl-CoA desaturase (SCD) acti

132 We examined the hypothesis that delta-6 desaturase (D6D), the rate-limiting enzyme in long-chain

133 tabolism, Delta5 desaturase (D5D) and Delta6 desaturase (D6D), with T2D risk to determine whether ser

134 ependent fashion and is catalyzed by the DHC desaturase (DEGS) in the de novo ceramide pathway.

135 scued by inhibitors or mutations of phytoene desaturase, demonstrating that phytofluene and/or zeta-c

136 in tumor cells by inhibiting dihydroceramide desaturase (DES) activity, which catalyzes the conversio

137 The dihydroceramide desaturase (DES) enzyme is responsible for inserting the

138 enases, the nature of a fifth oxidase, GA(4) desaturase (DES), is unknown.

139 this noncanonical pathway is dihydroceramide desaturase (DES1), which catalyzes equilibrium isomeriza

140 We also found the expression of Stearoyl-CoA desaturase, Desat1 mRNA significantly higher in FB overe

141 Inhibition of lipid desaturases effectively eliminated CSCs, suppressed sphe

142 expansion of the number of C. subvermispora desaturase-encoding genes putatively involved in lipid m

143 regions of the genome including stearoyl-ACP desaturase-encoding genes.

144 This might be an indication of increased desaturase enzyme activity for Hurma olives during natur

145 The Delta(6)-desaturase enzyme converts ALA into EPA and DHA, and gen

146 Desaturase enzymes are composed of two classes, the stru

147 e 1 and 2 (FADS1 and FADS2) code for the key desaturase enzymes involved in the biosynthesis of long

148 ding genes fatty acid desaturase 1-3 for the desaturase enzymes that convert short-chain polyunsatura

149 s studies have shown that fish can also have desaturase enzymes, endogenous synthesis of these FA can

150 In particular, the genes encoding desaturase enzymes, which is a key to the temperature st

151 ed, respectively, by fatty acyl elongase and desaturase enzymes.

152 gnition of substrates by the hydroxylase and desaturase enzymes.

153 w that CrFAD7 is the only omega-3 fatty acid desaturase expressed in C. reinhardtii, and we discuss p

154 The abundance of a plastid acyl-ACP desaturase (FAB2) is decreased to the same degree as fer

155 rs of the plant integral membrane fatty acid desaturase (FAD) family, FAD2, FAD3, FAD6, FAD7, and FAD

156 ssion of Delta4 and Delta6 Delta5 fatty acyl desaturases (Fad), key enzymes for LC-PUFA biosynthesis,

157 Further, the endoplasmic reticulum-localized desaturase FAD2 can associate with FAD3, as can the plas

158 gase enzymes that are homologs of the oleate desaturases FAD2.

159 he microsomal omega-6 and omega-3 fatty acid desaturases, FAD2 and FAD3.

160 reticulum (ER)-localized omega-3 fatty-acid desaturases (Fad3) increase the production of polyunsatu

161 Transgenic over-expression of a fatty acid desaturase (fad3C) gene of soybean driven by 2S albumin

162 ticipants, 31 SNPs in or near the fatty acid desaturase (FADS) 1 and 2 cluster were associated with c

163 hese steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q12.2-q13) a

164 otide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficienc

165 r alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been associated with

166 (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on

167 Fatty acid desaturase (FADS) genes and their variants have been ass

168 c components, such as variants of fatty acid desaturase (FADS) genes, determine the composition of n6

169 s of LC-PUFAs is regulated by the fatty acid desaturase (FADS) genes, of which a human-specific haplo

170 nes coding for microsomal Delta12 fatty acid desaturases (FADs) from the two Santalaceae species were

171 an event is the evolution of the fatty acid desaturases (FADS) genes, which have been claimed to har

172 identified pheromone-biosynthetic fatty acid desaturases (FADs) MsexD3, MsexD5, and MsexD6 abundantly

173 ain fatty acids (FAs) is mediated through FA desaturases (FADS1-FADS2) and may be influenced by dieta

174 of those associated with the membrane-bound desaturase family underscores the latent potential of O(

175 ates heat adaptation by regulating the lipid desaturase FAT-7.

176 t of nematode C-lectin (clec) and fatty acid desaturase (fat) genes.

177 dase (F08A8.1 and F08A8.2), and stearoyl-CoA desaturase (fat-7).

178 onstrated that, with the exception of Delta4 desaturases, fish Fads2 have the ability to operate as D

179 es, and stearoyl acyl carrier protein Delta9-desaturase from plants, suggesting that the oxygen-activ

180 othesis that an archetypal integral membrane desaturase from Saccharomyces cerevisiae, the Delta(9)-a

181 This change in desaturase function enabled the orchid to perfect its ch

182 -insensitive2 (ssi2-2) mutant to confirm the desaturase function of SAD6.

183 g the YXXN domain responsible for the Delta4 desaturase function, and consequently enabling these spe

184 his FoMV vector system, four genes, phytoene desaturase (functions in carotenoid biosynthesis), lesio

185 d DHA, and genetic variation in the Delta(6)-desaturase gene (FADS2) may affect this conversion.

186 latase subunit I gene (ChlI) or the phytoene desaturase gene (PDS).

187 less fat-1 transgenic mice harboring omega-3 desaturase gene capable of converting omega-6 to omega-3

188 saturase profiles with high elongase and low desaturase gene expression in the retina compared with l

189 th increased hepatic FAS activity and Delta9 desaturase gene expression.

190 sequences from the fatty acid oleyl Delta12 desaturase gene FAD2-1A leads to efficient and specific

191 d metabolism genes, including the fatty acid desaturase gene OLE1, which is essential for BMV RNA rep

192 h overexpressing a C. elegans n-3 fatty acid desaturase gene, mfat-1.

193 apable of inducing silencing of the PHYTOENE DESATURASE gene.

194 t, M23, with a known FAD2-1A (for fatty acid desaturase) gene deletion.

195 ty acids and strongly express two fatty acid desaturase genes, omega3 FATTY ACID DESATURASE3 (FAD3) a

196 A plastidial 16:0-ACP desaturase has been engineered to convert 16:0 to 16:1De

197 oluble plant acyl-ACP (acyl carrier protein) desaturases have been studied in far greater detail but

198 Although desaturases have received considerable attention for the

199 the substrate for many FA-modifying enzymes (desaturases, hydroxylases, etc.) and DAG can be derived

200 Expression of tung tree FA conjugase/desaturase in Arabidopsis produced approximately 7.5% ES

201 Coexpression of a pair of fungal 16:0 desaturases in the cytosol reduced the 16:0 level to 11%

202 bserved between both milk FA composition and desaturase indexes (i.e., apparent SCD activity) with mR

203 ation between gene expression and calculated desaturase indexes does not support their use to infer m

204 of CVCs, whereas inhibition of stearoyl-CoA desaturase induced mineralization.

205 the differences in the mechanism of phytoene desaturase inhibition play an important role in differen

206 ded RNA corresponding to the soybean FAD2-1A desaturase intron is sufficient to silence FAD2-1, impli

207 The fact that the soluble desaturase is active as a homodimer prompted us test the

208 One such multigene family, the acyl-CoA desaturases, is composed of certain genes that function

209 In bacteria and fungi one desaturase/isomerase enzyme completes the same series of

210 ng temperature shifts to regulation of lipid desaturase levels and membrane fluidity via an unprecede

211 (Arabidopsis thaliana) acyl-coenzyme A (CoA) desaturase-like (ADS) gene family contains nine genes en

212 the action of membrane-bound desaturases and desaturase-like enzymes.

213 mily contains nine genes encoding fatty acid desaturase-like proteins.

214 ation relative to the ancestral housekeeping desaturase may have allowed proto-SAD5's reaction produc

215 possible mechanisms of how a plastid-located desaturase may impact the omega-3 fatty acid content of

216 The transformation of fatty acids, by desaturases, may have an important role in aiding the di

217 al di-proline motif in the Drosophila Delta9-desaturase mediates protein degradation by a calcium-dep

218 ene (SYNPCC7002_A1248) encodes beta-carotene desaturase/methyltransferase, which converts beta-carote

219 mediated expression of an omega-3 fatty acid desaturase, mfat-1, normalized blood glucose and insulin

220 APDH) mRNA with a concomitant fall in Delta9 desaturase mRNA expression in LmNcb5or null cell line.

221 antage of an Arabidopsis thaliana fatty acid desaturase mutant (fad5) that constitutively forms semic

222 Introduction of the ER fatty acid desaturase mutation, fad2, and to a lesser extent the pl

223 bservations suggest that ADS2 encodes a 16:0 desaturase of MGDG and PG.

224 species and confirmed the function as Delta4 desaturases of Fads2 from medaka and Nile tilapia.

225 which promotes synthesis of the fatty acids desaturase Ole1.

226 that the Delta(9) acyl-CoA integral membrane desaturase Ole1p from Saccharomyces cerevisiae exhibits

227 Regulation of expression of the fatty acid desaturase Ole1p was hitherto the only known mechanism g

228 haromyces cerevisiae, the Delta(9)-acyl-Co-A desaturase Ole1p, also exhibits a dimeric organization.

229 hesis of jasmonate (JA), the effects of this desaturase on aphid resistance are not dependent on JA;

230 cular species lacks the necessary fatty acid desaturase, or a component thereof.

231 Silencing of a desaturase (PDS or ZDS) resulted in the induction of the

232 with magnesium chelatase (ChlH) and phytoene desaturase (PDS) gene sequences from Nicotiana benthamia

233 d differed statistically in normal, phytoene desaturase (PDS) gene silent and diseased (infected by B

234 ne synthase (PSY), two desaturases (phytoene desaturase [PDS] and zeta-carotene desaturase [ZDS]), an

235 ay catalyzed by phytoene synthase (PSY), two desaturases (phytoene desaturase [PDS] and zeta-carotene

236 FADS1 and FADS2 (desaturases) polymorphisms were associated with higher 1

237 We identified seven elongases and five desaturases possibly involved in EPA production in Nanno

238 and heterozygous deletion of dihydroceramide desaturase prevented vascular dysfunction and hypertensi

239 rence between retinal and liver elongase and desaturase profiles with high elongase and low desaturas

240 dipose triglyceride lipase, and stearoyl-CoA desaturase protein was higher in the NWA group, correspo

241 t1 transcripts-all of which yielded the same desaturase protein-and constructed transgenes with the d

242 st step towards the analysis of this unusual desaturase reaction, the FAD4 gene was identified by map

243 Fatty acid desaturases regulate the unsaturation status of cellular

244 This study provides new details of desaturase regulation with therapeutic implications for

245 That soluble desaturases require only one active subunit per dimer fo

246 the FAD3 locus, which encodes the linoleate desaturase responsible for the biosynthesis of linolenic

247 e identification of two Delta9 palmitoyl-ACP desaturases responsible for omega-7 FA biosynthesis, whi

248 on causing an amino acid replacement in this desaturase results in loss of torulene and of red body c

249 inding model to the structure of steroyl-CoA desaturase revealed significant differences in the archi

250 he structure-function relationship for these desaturases reveals that their particular substrate spec

251 Stearoyl-acyl carrier protein desaturase (SACPD) activity is essential for production

252 Stearoyl-acyl carrier protein desaturase (SACPD-C) has been reported to control the ac

253 action of the stearoyl-acyl-carrier-protein desaturase (SAD) homolog SAD5.

254 to investigate TR4 target gene stearoyl-CoA desaturase (SCD) 1 regulation.

255 ), Delta6 desaturase (D6D), and stearoyl-CoA desaturase (SCD) activity and T2D risk.

256 Lipid metabolites of stearoyl-CoA-desaturase (SCD) activity were associated with aberrant

257 e have shown that repression of stearoyl-CoA desaturase (SCD) enzymes, which regulate the intracellul

258 Changes in stearoyl-coenzyme A desaturase (SCD) expression and activity were evaluated

259 uptake and synthesis and higher stearoyl-CoA desaturase (SCD) expression, Ncb5or(-/-) liver accumulat

260 Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and intr

261 Remarkably, liver stearoyl-CoA desaturase (Scd) mRNA expression was by far the most hig

262 s, such as fatty-acid synthase, stearoyl-CoA desaturase (SCD)-1, and apoB.

263 abolism, including induction of stearoyl-CoA desaturase (SCD)-1, which converts saturated to monounsa

264 by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1.

265 of the lipid metabolism enzymes stearoyl-CoA-desaturases (SCD) and S-adenosyl methionine synthetase (

266 ression was compared to that of stearoyl CoA desaturase (Scd1) in B6 mice exposed to diets and enviro

267 these fatty acids (FA) is influenced by the desaturases, SCD1-4 and the elongase, ELOVL6.

268 of Aspergillus nidulans sphingolipid Delta8-desaturase (SdeA), sphingolipid C9-methyltransferases (S

269 luorescent protein and silencing of phytoene desaturase shows that marker gene-assisted silencing is

270 double bond produced by sphingoid LCB Delta8 desaturase (SLD).

271 uble castor Delta9-18:0-acyl carrier protein desaturase, specifically, the hypothesis that the enzyme

272 yl substrate binding tunnel introduces E/Z14-desaturase specificity to mutated MsexD2.

273 nistic difference from the membrane class of desaturases such as the Delta9-acyl-CoA, Ole1p, from yea

274 ime PCR studies demonstrate a higher Delta12 desaturase, superoxide dismutase, and glyceraldehyde 3-p

275 Conversely, natural desaturase systems proceed through stepwise hydrogen ato

276 We describe a mutant of the castor acyl-ACP desaturase (T117R/G188L/D280K) that converts stearoyl-AC

277 Caenorhabditis elegans, encoding an n-3 PUFA desaturase that catalyzes conversion of n-6 into n-3 PUF

278 nzyme A desaturase 1 is a delta-9 fatty acid desaturase that catalyzes the synthesis of monounsaturat

279 rome P450 CYP710A1, which encodes C22-sterol desaturase that converts beta-sitosterol to stigmasterol

280 ilobase region, encoding a single carotenoid desaturase that is absent from green individuals.

281 summarize recent analysis of a castor mutant desaturase that provides valuable insights into the rela

282 membrane-bound stearoyl coenzyme A Delta(9) desaturase that reacts with the oxidoreductase Rv3230c t

283 st signal located in a cluster of fatty acid desaturases that determine PUFA levels.

284 Moreover, expression of stearoyl-CoA desaturase, the enzyme required for the generation of mo

285 Fatty acid synthase and steaoryl-coenzyme A desaturase, the two rate-limiting enzymes in lipogenesis

286 ce by deletion of keratinocyte lathosterol 5-desaturase, then UVR accelerates ionizing radiation-indu

287 Fads2 have the ability to operate as Delta6 desaturases towards C24 PUFA enabling them to synthesise

288 This 'portable desaturase' (Tz(o)Cl) is a bench-stable, commercial enti

289 e biosynthetic activity upstream of phytoene desaturase was similar in Newhall and Cara Cara.

290 tion, whereas Ole1, the essential fatty acid desaturase, was resistant to iron depletion.

291 me, CruS, was only distantly related to CrtD desaturases, was bifunctional, and performed a 3,4-desat

292 lls lacking functional FADS2-mediated Delta6-desaturase were stably transformed with FADS2, FADS1, or

293 ient in the chloroplast 16:1/18:1 fatty acyl desaturase, were discovered to be suppressors.

294 e fat-1 gene encoding for omega-3 fatty acid desaturase, which leads to an increase in endogenous ome

295 , possibly due to the loss of function of FA desaturases, which are iron-requiring enzymes with diiro

296 sm enzymes expressed in skin is the Delta(9)-desaturases, which catalyze the synthesis in Delta(9)-mo

297 -desaturase (acetylenase) and a bifunctional desaturase with Delta(12)-/Delta(14)-regiospecificity fr

298 with FAD3, as can the plastid-localized FAD6 desaturase with either FAD7 or FAD8.

299 turase activity encoded by the zeta-CAROTENE DESATURASE (ZDS)/CHLOROPLAST BIOGENESIS5 (CLB5) gene in

300 (phytoene desaturase [PDS] and zeta-carotene desaturase [ZDS]), and two cis-trans isomerases (zeta-ca