ライフサイエンスコーパス: design

1 dynamic covalent motif for dynamic material design.

2 fan dose was successfully achieved per study design.

3 presentation, with implications for vaccine design.

4 netic resonance imaging in a cross-sectional design.

5 le predicted from efforts in de novo protein design.

6 s of GPCR conformational plasticity for drug design.

7 key control parameter for synthetic circuit design.

8 e scales and applied a proxy-phenotype study design.

9 arlow weights to account for the case-cohort design.

10 trial using a multiarm, multistage, platform design.

11 ers were optimized using a central composite design.

12 g the high relevance of this cavity for drug design.

13 at this may have for bioinformatics database design.

14 lly relevant context using a fully factorial design.

15 e to routine patient care and clinical trial design.

16 ng a major challenge in tuberculosis vaccine design.

17 ntrast media was evaluated in a case-control design.

18 ssessed using established methods, per study design.

19 ent, and nucleic acid based biosensor device design.

20 e a potential mechanism of universal vaccine design.

21 ion conformation of polymers through monomer design.

22 r has been exploited in knowledge-based drug design.

23 rtant asset in future anti-inflammatory drug design.

24 atient and caregiver perspectives into trial design.

25 he applied voltage or changing the electrode design.

26 , providing a new structural lead for ligand design.

27 ent-related functional MRI (fMRI) experiment design.

28 nd unmeasured confounding using family-based designs.

29 arch results through effective visualization designs.

30 rigorous experimental or quasi-experimental designs.

31 ome might occur with some Zika virus vaccine designs.

32 dynamical mean field theory calculations to design a new class of Mott multiferroics-double perovski

33 Here, we designed a genetic screen around E. coli that identified

34 Towards this aim, we have designed a holographic on-chip microscope operating at a

35 We designed a metasurface that converts left- and right-cir

36 monstrate the capabilities of our method, we designed a spatial-mode demultiplexer, wavelength demult

37 fication systems based on the trnL gene were designed (A-, B-, C- and D-trnL systems).

38 We designed ADAGE signature analysis to perform gene set an

39 Protein design advancements have led to biotechnological strateg

40 nd xiamycin families of natural products was designed, aiming to access several natural products from

41 Protein design algorithms enumerate a combinatorial number of ca

42 lloying is a novel idea with implications in designing all 2D device architecture as the structural p

43 Therefore, the new design allows a 30-fold longer reaction time and a 40-fo

44 om Alb-R26(Met) HCC versus control livers to design an "educated guess" drug screen, which led to the

45 We designed an approach to target an extracellular matrix p

46 Here, we design and analyze a model of mechanotransduction where

47 Herein is reported the design and application of a reagent for the direct funct

48 We report the design and application of single-chain cofactor-free kin

49 Additionally, we design and compare the performance of networks with N-st

50 Hence, we have made its electro-mechanical design and computer programme available online.

51 Serious problems in the experimental design and data interpretation raise concerns about the

52 f large libraries of desired mutants through design and efficient organization of primers.

53 drug discovery that can influence and triage design and execution impacting the likelihood of rapidly

54 Recent developments in the design and fabrication of efficient sensor platforms bas

55 elopment opens up avenues for pulse sequence design and lays a foundation for understanding the contr

56 e investigations, drug discovery, prosthetic design and neuropathic pain investigations.

57 This article describes the design and some of the approaches pursued in the interac

58 In this study, we report the design and synthesis of a series of diarylureas derived

59 In this work, we discuss the design and synthesis of the DiPyrO tag, characterize its

60 s challenging and entails material structure design and tailoring across a range of length scales.

61 an AIDS Cohort Collaboration on Research and Design and the general population using data from the Su

62 ignificantly affected by the microstructural design and the sintering process used in their manufactu

63 We used survey design and weighting variables to produce national estim

64 roperties is usually carried out by rational design and/or directed evolution.

65 In addition, well-designed and -powered studies should be conducted for as

66 ifferent liquid chromatographic columns were designed and 3D printed in titanium as 2D serpentine, 3D

67 hodiperylenetetraimide and vinylene units is designed and applied in all-polymer solar cells (all-PSC

68 Therefore, for vaccine purposes, we have designed and characterized a recombinant hRSV F protein,

69 rown on flexible exfoliated graphene foil is designed and constructed for both electrochemical and ph

70 ace nonlinearity polarization in an in-house designed and fabricated air-silica photonic crystal fibe

71 or agonists procaterol and BI-167107 (4), we designed and synthesized a collection of novel hydroxy-s

72 c and enantiopure analogues of CJ-16,264 was designed and synthesized through the developed synthetic

73 new benzimidazole-based compounds have been designed and synthesized.

74 We designed and tested 22,660 mini-proteins of 37-43 residu

75 suppressing inertial cavitation behavior was designed and validated using a dual-transducer system op

76 Herein, by elaborately designing and choosing two flexible molecules with C3v m

77 gies is not trivial and requires novel study designs and data analytical methods.

78 sent appropriate linear mixed models for all designs and develop effect size measures.

79 Here, Ash et al. deviate from standard designs and fabricate frequency tailorable phononic crys

80 rally inconsistent, with variations in study designs and methods across populations and geographic lo

81 uent optimization using structure-based drug design, and parallel medicinal chemistry led to the iden

82 ngths include large sample size, prospective design, and virtually complete follow-up; however, histo

83 suit various biological goals, experimental designs, and laboratories' preferences.

84 the number of subjects, refine experimental designs, and replace live animals.

85 Recently, many new approaches, study designs, and statistical and analytical methods have eme

86 to states with independent values of OAM and designed another device that performs this operation for

87 e loops could serve as excellent targets for designing anti-CVA6 vaccines.Coxsackievirus A6 (CVA6) ca

88 se promising results suggest that a rational design approach can be used to generate an effective vac

89 Our design approach opens new avenues for optically controll

90 Here, we report a new design approach that employs the one-dimensional (1D) sp

91 Through a rational design approach we discovered a highly selective and pot

92 nce of the ligand response of the rationally designed, artificial theophylline riboswitch RS3.

93 tein functions inside cells, de novo protein design as well as defining the role of protein misfoldin

94 le effector functionLess (SEFL) antibody was designed as an IgG1 antibody with a constant region that

95 nd challenges in RNA structural modeling and design, as recently discussed during the second Tellurid

96 omposition and properties of these films are designed at the atomic scale using layer-by-layer assemb

97 " approach, and the second was computational design based on DeltaDeltaG calculations in Rosetta.

98 ap, a genetically encoded cyclic peptide was designed based on the sonic hedgehog (Shh)-binding loop

99 parent compound, treatment systems should be designed based on the ultimate pharmaceutical concentrat

100 Designed-bioactive anthropogenic contaminants (biocides,

101 ing a physical model of the cytoskeleton and designing biomimetic active materials.

102 functional genomics level to support tailor-designed breeding.

103 The meta-analysis was prospectively designed, but not registered.

104 sitive patients) and a randomized controlled design by pre-approval trials and 2) the treatment-by-bi

105 tifunctional core-satellite nanoconstruct is designed by assembling copper sulfide (CuS) nanoparticle

106 this purpose, the target capturing step was designed by functionalization of 3-aminopropyltrimethoxy

107 Analogues of 5172-mcP1P3 were designed by incorporating diverse quinoxalines at the P2

108 microscopic structural quantity, "softness," designed by machine learning to be maximally predictive

109 Hence, a diffusion model was designed by Wu Lab (School of Dentistry, University of C

110 rm to decode cancer metabolic plasticity and design cancer therapies targeting metabolism.

111 photosynthesis system for energy storage is designing catalysts that can thrive in an assembled devi

112 The design challenge was not just to choose market rules to

113 Our results show how design changes in vehicle parameters (e.g., mass, engine

114 rically positioned remote amide group in the designed chiral binaphthyl-based ligand plays the essent

115 s a graded association also in the cosibling design comparing siblings with varying degree of discord

116 Designing complexes with sufficiently long values of T2

117 Our results suggest that designing compounds to target specific receptor states,

118 g, double-blind placebo-controlled crossover design conducted from January 21, 2009, to September 29,

119 rial, 3 groupsx4 time points mixed factorial design conducted from July 2015 to March 2016.

120 The spacing between two synthetic plants, a design consideration introduced by the authors in a rece

121 Furthermore, we discuss key experimental design considerations, including the choice of the metho

122 nanophotonic system significantly alters the design criteria for the necessary conducting front elect

123 her branches of artificial intelligence have designed crucial ingredients towards autonomous learning

124 nd standardizing parameters across the study design, data collection, monitoring, analysis, integrati

125 platform structure and makes clinical trial design decisions more explicit.

126 Structure-based vaccine design depends on extensive structural analyses of antig

127 es in the Fourier space with greatly reduced design dimensionality.

128 This parallel-design, double-blind, randomized clinical trial, called

129 , proteins should be taken into account when designing experiments to assess degradation of Mg-based

130 idered, glycosylation was the most prominent design factor affecting tracer uptake, specificity, and

131 e high-throughput-discovery and materials-by-design feedback loop.

132 the AlN/GaN DA as a promising active region design for high efficiency mid- and deep-UV device appli

133 patient selection may inform clinical trial design for immunotherapy in pancreatic cancer.

134 We are excited to introduce a new design for JEM.

135 various advanced electrocatalysts have been designed for the ORR or the OER; however, the origin of

136 Trial designs for new transplant immunosuppression must be int

137 ibitors of MBLs are currently unavailable as design has been limited by the incomplete knowledge of t

138 This group of rare designed hexasaccharides will help understand HCII funct

139 Designing high-performance and cost-effective electrocat

140 cal performance and can guide future work on designing high-performance MXene-based materials for ene

141 Nevertheless, designing high-throughput reporter assay experiments suc

142 tering) and can be customized to employ user-designed image features or classifiers.

143 l enable novel routes for PTP-selective drug design, important for managing diseases such as cancer a

144 ions in humans, mechanistic experiments were designed in a mouse model of resuscitated hemorrhagic sh

145 PRODIGEN was designed in collaboration with bioinformaticians who res

146 and possibly other cleaved TM helices may be designed, in part, to make their backbones accessible fo

147 The design included a chamber with glass windows allowing im

148 This single-cohort design included all persons born in Denmark (N = 1683385

149 The study offers design insights for developing low-cost surface microflu

150 We demonstrate that double heterojunctions designed into colloidal semiconductor nanorods allow bot

151 Although clinical trial design is challenging, due in part to a lack of robust b

152 The design is flexible enough to accommodate varying levels

153 Design jobs can be run online via the NUPACK web applica

154 etalloprotease thermolysin with purposefully designed ligands using high-resolution crystallography a

155 mates have varied, with differences in study design, location, follow-up duration, and vaccine compos

156 y disease cell therapy investigational trial design may be informed by new anatomic and perfusion ins

157 The obtained results revealed that the designed model can accurately determine colorant concent

158 quantum bits, and enriches the guidelines to design molecule-based systems with enhanced quantum cohe

159 Bioelectronics moves toward designing nanoscale electronic platforms that allow in v

160 ss in bacteria could be a useful strategy to design new approaches to antibacterial therapy.

161 foldamers can be of invaluable assistance in designing new bioactive compounds.

162 dels after IDIF treatment and eventually for designing new molecules toward AD therapeutic drugs.

163 the importance of subtypes and genotypes in designing nonsurgical therapeutic strategies for uterine

164 disorders and to help medicinal chemists to design novel dynamin ligands, which could be useful in t

165 Here, we report the design of a set of living materials and devices based on

166 This strategy relies on the design of a spacer-blocking hairpin (SBH) structure at t

167 tions from time series data and thus for the design of adequate, predictive models.

168 and help guide synthetic approaches for the design of alternative device architectures and approache

169 atural infection can help guide the rational design of an HIV vaccine.

170 er-based microfluidic devices and permit the design of cellular assays, which can ultimately impact d

171 c decisions in clinical practice and for the design of clinical trials.

172 se of targeted drugs and potentially for the design of combination therapies.

173 Our results will help permit the rational design of complex new molecular materials in which multi

174 e, we present new approaches directed at the design of efficient entry inhibitors to minimize the dev

175 of cis-regulatory grammar and hampering the design of engineered genes for synthetic biology applica

176 A strategy is outlined for the design of hand-twisted helical crystals.

177 atures and therefore offers insight into the design of hydrolytically stable porous materials.

178 , offering a next-generation approach in the design of immunotherapeutic approaches for cancer manage

179 It also has important implications for the design of lifespan experiments as autotoxins can influen

180 findings have important implications for the design of maternal vaccination strategies that could syn

181 at the mechanistic level can facilitate the design of maximally insulated systems featuring heterolo

182 be regarded as promising candidates for the design of multi-target disease-modifying drugs for treat

183 anoconfined water paves the way for a better design of nanoporous materials for energy applications;

184 lementary steps of this process will aid the design of new catalytic systems and their real-world app

185 ules holds great promise for the tailor-made design of new functional materials.

186 found impact on the optimization and de novo design of new NM with better in vivo performance.

187 xpected to find numerous applications in the design of new NMR experiments.

188 sular polysaccharide epitopes can aid in the design of novel glycoconjugate vaccines.

189 to cucurbituril chemistry, but also for the design of novel supramolecular architectures.

190 ic application of two such principles in the design of peptoid foldamers yields a new and unique seco

191 ts have implications for the next-generation design of receptors used in adoptive T cell therapies.

192 , but also has potential applications in the design of recommendation algorithms.

193 2D bioelectronics research is focused on the design of simple-to-use and cheaper biodevices, while im

194 d ThermoAlign was developed that ensures the design of target-specific primer pairs for DNA amplifica

195 nanoparticles, and provides insights for the design of the next-generation of nanoscale drug delivery

196 nsideration of model differences enables the design of tile systems that robustly exhibit the desired

197 onary states and should be considered in the design of TiO2-containing devices.

198 Through rational design of training and validation sets, key diastereosel

199 indings provide mechanistic guides to aid in design of vaccine strategies against fast mutating patho

200 r host defenses in the research for, and the design of, antibiotic treatment regimens, which hyper-em

201 tion of short channels can be adopted in the designs of dosage forms, implants or stents to enhance t

202 As such, the design opportunities afforded by supramolecular chemistr

203 ion, compartmentalised chemical networks and designed oscillators.

204 h as stirring rate, that may be exploited to design other quasicrystal-forming self-assembly chemistr

205 We designed our strategy to select against re-targeting the

206 This insight can be invoked to design polymer electrodes with kinetic selectivity towar

207 Heterogeneity in study design prevented meta-analysis.

208 The tool incorporates visualization design principles such as focus+context and visual data

209 ed to take advantage of some set of physical design principles to ensure robust vesiculation against

210 We then designed provisional HRCT diagnostic criteria based on t

211 METHOD: A self-designed questionnaire was developed in Arabic and used

212 re an objective and systematic framework for designing RCTs that incorporates these considerations on

213 f only 3.8 x 2.5 mum, and is well within the design rules of a typical silicon photonics process, wit

214 ole of ionic correlations in NP assembly and design rules to utilize the salting-out process to cryst

215 equent spreading of MDRPa, including a newly designed shower drain, disinfecting siphons underneath t

216 findings are relevant within the context of designing soft semiconductors that exhibit high solubili

217 end, we show how intelligent sampling of the design space inputs can make deep learning methods more

218 acteristic of D. hamiltonii could be used to design specific assays, enhancing its applicability for

219 This paper will help researchers to better design spin trapping experiments for food matrices.

220 trification, which may contribute to further design strategies to control greenhouse gas emissions fr

221 iew, we have selected two such lineage-based design strategies to illustrate how such in-depth analys

222 igand class regarding stability and variable design strategies.

223 re, function, and evolution with a bottom-up design strategy.

224 ng cognitive and depressive outcomes in well-designed studies incorporating comprehensive psychiatric

225 n study 3, with the use of a 2 x 2 factorial design, subjects consumed a maize meal fortified with an

226 Therefore, here we report the design, synthesis and evaluation of novel GDC-0449 analo

227 We report the design, synthesis, and electron spin relaxation properti

228 We report the design, synthesis, and spectroscopic characterization of

229 inhibiting, long chain-based compounds were designed, synthesized and evaluated against MRSA and men

230 w class of light-driven molecular motors was designed, synthesized, and studied.

231 Our results suggest that new experimental designs targeting a majority of inhibitory neurons may b

232 ection component is an integrated relational design that allows the flexibility to capture any type o

233 This Communication describes a new molecular design that yields ultranarrowband organic photodetector

234 drive technologies, highlight new gene drive designs that might achieve better outcomes, and explain

235 olecular assays and portable optical imaging designs that permit on-site diagnostics with a cost-effe

236 as conducted to evaluate in a noninferiority design the relative safety and efficacy of ridaforolimus

237 a double-blind placebo-controlled crossover design, the immune system in 22 sample donors was transi

238 h are being incorporated into their chemical design), their modularity in being fused to create multi

239 s/activity may offer a novel opportunity for designing therapeutic approaches for these diseases.

240 ridge homogeneous and heterogeneous catalyst design through fine-tuned edge-site environments of the

241 This work provides a paradigm for interphase design to address the dendrite challenge, paving the way

242 We adopted a commonly used diary-based design to conduct a social contact survey in Hong Kong i

243 double-blind, placebo-controlled, crossover design to determine how intranasally administered oxytoc

244 re employ computational and structure-guided design to develop improved native-like trimers that redu

245 tacles can be overcome with thoughtful study design to ensure maximal risk mitigation.

246 We used a matched case-cohort design to estimate the risk of deaths by suicide and att

247 inkle lithography integrated with concurrent design to produce quasi-random nanostructures in amorpho

248 farcts were randomly assigned in a factorial design to target levels of systolic blood pressure (130-

249 roach, we conducted four large-scale studies designed to assess people's conceptions of mental life m

250 ed recollection and recognition memory tests designed to assess recollection and familiarity for the

251 review of the cumulative evidence from RCTs designed to assess the effect of omega-3 polyunsaturated

252 The study was not designed to assess whether resistance had an impact on L

253 n the subtype of tumor where the therapy was designed to be active.

254 iple, independent data sources.The study was designed to compare relevant data published by the Food

255 e ART (Arterial Revascularization Trial) was designed to compare survival after bilateral internal th

256 parental allergens, the hybrid molecule was designed to cover relevant epitopes and evaluated in sil

257 s, all trimeric and monomeric Env immunogens designed to date have failed to elicit such antibodies.

258 The study was designed to detect a difference of 10% in accuracy by a

259 djust for confounders and therefore were not designed to determine if earlier or immediate treatment

260 The study was designed to determine the role of long noncoding RNA (ln

261 alently cross-linked CarHC hydrogel was also designed to encapsulate and release bulky globular prote

262 initiative being implemented across 76 ICUs designed to engage strategically the ABCDEF bundle throu

263 This study was designed to evaluate serum lipid metabolite changes that

264 ized, placebo-controlled trials specifically designed to evaluate statin therapy in patients with can

265 This is a cross-sectional study designed to evaluate the histologic characteristics of g

266 Within a randomized trial designed to examine nonspecific effects of early MV rece

267 ing, gene filtering, and normalization steps designed to facilitate downstream analysis of large, het

268 DNAproDB is a web-based interactive tool designed to help researchers study these complexes.

269 can also be selectively increased using ASOs designed to hybridize to other translation inhibitory el

270 ly developed for certain enzymes, HTS assays designed to identify ligands that block protein binding

271 zyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and t

272 ctegravir, a novel, potent, once-daily INSTI designed to improve on existing INSTI options with the b

273 iant systems of sensors, circuits and radios designed to intimately interface with the soft tissues o

274 We argue that human-like machines should be designed to make decisions in transparent and comprehens

275 QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, e

276 Microfluidic and CFD circulation models were designed to mimic tumor progression by escalating flow c

277 It was designed to overcome the spectral congestion and line br

278 However, current models are designed to quantify growth under conditions for which g

279 c reward therapy for social anxiety disorder designed to reduce attention dwelling on threats.

280 , unpleasant, and neutral olfactory stimuli, designed to separate distinct phases of reward processin

281 tive Citation Ratio (RCR), a metric that was designed to serve in that capacity, measures the influen

282 of LINCS L1000, every two landmark genes are designed to share a single channel.

283 s in these patients and treatment algorithms designed to target neuropathic pain.

284 rameters obtained from a best-fit procedure, designed to yield simulated tumors as close as possible

285 riven-TENGs are deposited on simplified wing designs to match the electrical performance with variati

286 ronchopulmonary dysplasia, but appropriately designed trials are lacking.

287 explored, but they were often ecological in design, used broad census geographic levels, lacked indi

288 In a design using basic features of revealed preference theor

289 ure of protein excited states and rationally design validating experiments.

290 The flexible nanofluidic structure design, wafer-scale fabrication, single-digit nanometre

291 A cross-sectional survey design was used to collect data from primary care NPs.

292 ospective, single-group, observational study design was used to test the contribution of sociodemogra

293 Using a split half-sibling design, we exposed embryos of 10 families from each of t

294 subsequent CVD.With the use of a case-cohort design, we profiled 202 lipid species at baseline and af

295 Using a longitudinal experimental design, we quantified the ontogenetic profile of bite-fo

296 proaches that use segmented speech and block designs, which report more laterality in speech processi

297 nal registry databases, we used a corelative design with full siblings alongside a general Swedish po

298 ablation, a novel irrigated RF catheter was designed with a diamond-embedded tip (for rapid cooling)

299 Many CARs are designed with elements that augment T cell persistence a

300 stretchable, and self-adhesive hydrogels are designed with intrinsically unstructured proteins.