ライフサイエンスコーパス: design of

1 The design of 3D-printed living materials is guided by quant

2 Here, we report the design of a 3D topological metamaterial without Weyl lin

3 ted DDD85646 (1) as a starting point for the design of a class of potent, brain penetrant inhibitors

4 This novel design of a multilayered conveyor belt structure is fabr

5 e around the twisted chromophore enabled the design of a mutant that displays a twofold increase in i

6 se findings open up promising avenues in the design of a new generation of FA assays.

7 These results lead ultimately to the design of a new protocol in which an achiral hydrogen bo

8 er, these structural insights may aid in the design of a next-generation malaria vaccine.

9 Here we report the design of a novel protein, PS1, that binds a highly elec

10 r B cell receptor repertoire, and direct the design of a personalized therapeutic.

11 These insights led to the design of a reaction protocol with improved yields and a

12 However, the design of a sensitive, selective, stable, and reproducib

13 Here, we report the design of a set of living materials and devices based on

14 Here, the design of a shell-stacked nanoparticle (SNP) is reported

15 However, the design of a small, integrated, and reliable biosensor fo

16 This strategy relies on the design of a spacer-blocking hairpin (SBH) structure at t

17 Herein we report the design of a structure-based annotation system for the id

18 electron-rich anilines than 2, enabling the design of a system consisting of two cages that could re

19 The first is related to the design of a technical strategy and to the selection of C

20 l IDP sequences and demonstrate the rational design of a vast library of multicomponent protein-rich

21 Here, we present the rational design of a wax-printed 3D-muPAD that enables more homog

22 We present a design of acoustic frequency filter based on a two-dimen

23 ntal contributions have enabled the rational design of active sites.

24 These data may also be useful in the design of adaptive testing strategies that reduce unnece

25 tions from time series data and thus for the design of adequate, predictive models.

26 rovide a molecular basis for future rational design of agents that interfere with the initiation and

27 and help guide synthetic approaches for the design of alternative device architectures and approache

28 roof-of-concept application for the rational design of an epitope-specific antibody binding with the

29 atural infection can help guide the rational design of an HIV vaccine.

30 Here we report the design of an interlocked DNA nanostructure that is able

31 We demonstrate for the first time that the design of an optofluidic waveguide system can be optimis

32 approach is further validated by additional designs of angle-switchable metagratings as splitter/ref

33 r host defenses in the research for, and the design of, antibiotic treatment regimens, which hyper-em

34 De novo design of antibodies binding specific epitopes could gre

35 These results support in silico CDR design of antibody specificity as an emerging antibody e

36 developments of rational strategies for the design of antiviral therapies, including monoclonal anti

37 Design of antiviral treatment options and elucidation of

38 rategy helps to address major hurdles in the design of antivirulence vaccines, enabling increased ant

39 t of Pt alloy electrocatalysts relies on the design of architectures with highly active surfaces and

40 tion systems and open up new avenues for the design of artificial 2D materials.

41 However, in the design of artificial heteropolymers the control over the

42 mes and provide valuable information for the design of artificial hydrogenase mimics.

43 r further studies of NSs and potentially the design of attenuated viruses for vaccination studies.IMP

44 young and aged CPCs, which may impact future design of autologous stem cell-based therapies.

45 carbon elimination in kerf which can aid the design of better processes for kef recycling and low cos

46 s and set the stage for the structure-guided design of better translation inhibitors.

47 The rational design of biomolecules is becoming a reality.

48 tion metals and pave the way toward rational design of C-H functionalization catalysts.

49 ty than epoxidation, which suggests that the design of catalysts with increased Lewis acid strength w

50 derstanding of natural gene circuits and the design of cell-based therapeutic strategies.

51 er-based microfluidic devices and permit the design of cellular assays, which can ultimately impact d

52 ular or ionic species are of interest in the design of chemical logic gates and signal amplification

53 arnings to build intrinsic rigidity into the design of clinical candidates.

54 should be considered for the evaluation and design of clinical trials of curcumin and other polyphen

55 c decisions in clinical practice and for the design of clinical trials.

56 sing during cognition and is relevant to the design of cognitive enhancers based on stimulating the c

57 se of targeted drugs and potentially for the design of combination therapies.

58 proposed algorithms provide a framework for design of combination therapy that tackles tumor heterog

59 number of current challenges related to the design of complex chemical systems are discussed, includ

60 Our results will help permit the rational design of complex new molecular materials in which multi

61 a detailed methodology for the analysis and design of complex synthetic chemistry schemes.

62 co These results can help guide the rational design of complex therapeutic interventions, which targe

63 bility over a wide temperature range through design of compositionally graded multilayer (CGML) archi

64 ying structural insights to apply toward the design of compounds with improved permeability can be di

65 l agonists may be useful for structure-based design of compounds with tailored efficacy profiles.

66 uble-click macrocyclization approach for the design of constrained peptide inhibitors having non-heli

67 Our structure should inform rational design of countermeasures against HCMV, other herpesviru

68 3 enzyme presented a unique challenge in the design of covalent inhibitors with appropriate pharmacod

69 ' may serve as ideal models for the ultimate design of crops with enhanced drought tolerance.

70 ion, providing guiding tools to the rational design of cryoprotectant containing nano formulations an

71 hepatocytes will be critical for the future design of curative antiviral therapies against chronic h

72 substrate specificity would also aid in the design of custom proteases capable of selectively and co

73 s serve as a platform for interpretation and design of cytoskeletal materials experiments, as well as

74 The design of diagnostic and preventive strategies have been

75 DPs and opens exciting possibilities for the design of disordered ensembles, disorder-to-order transi

76 ranslates into a direct path to the rational design of donor and acceptor compounds which differ only

77 tion of short channels can be adopted in the designs of dosage forms, implants or stents to enhance t

78 itation under field conditions to inform the design of 'Drought-Net', a relatively low-cost CDE that

79 the space of opportunities for the rational design of drug polypharmacology.

80 These results may aid in the rational design of drugs containing the difluoromethyl moiety.

81 ons can lead to disease, and facilitates the designing of drugs which prevent or mimic the interactio

82 udy represents a novel approach for rational design of early-life vaccines.

83 The design of effective therapies for cancer treatment depen

84 Design of efficacious Treg-based therapies and establish

85 enzymatic activity, which is a basis for the design of efficient catalysts for the oxygen reduction r

86 oblems with managing adverse effects and the design of efficient clinical trials.

87 e, we present new approaches directed at the design of efficient entry inhibitors to minimize the dev

88 diction of hybridization kinetics allows the design of efficient probe sequences for genomics researc

89 hysics and enzymology and aims to inform the design of efficient self-assembled microenvironment cata

90 pected to have promising implications in the design of electrochemical sensors or biosensors for the

91 of cis-regulatory grammar and hampering the design of engineered genes for synthetic biology applica

92 such supramolecular complexes, enabling the design of engineered, hierarchical structures and functi

93 Exploiting the power of Design of Experiments (DoE) and a dedicated LC-MS/MS met

94 Design of experiments (DOE) is an established methodolog

95 ost and modular nature as well as fully open design of FlyPi make it a highly versatile tool in a ran

96 of the most promising architectures for the design of functional molecular machines with unprecedent

97 ening chronic HF should be considered in the design of future acute HF trials.

98 ted view of cholera that is important to the design of future disease control strategies.

99 This technology may be helpful in the design of future high-resolution sensory prostheses base

100 enzyme targets and has significance for the design of future inhibitor molecules based on this chemi

101 g molecules and cellular response to aid the design of future living materials and devices.

102 renders a chemical-biological basis for the design of future oxygen-reduction catalysts.

103 ng diagnostics, decentralized monitoring and design of future points of care.

104 lower mutant HTT levels in patients and the design of future therapeutics.

105 ndings have significant implications for the design of future vaccines that target GEM T cells.

106 These findings may be important for the designs of future secondary prevention trials for Alzhei

107 Application of the experimental design of genome-wide association studies (GWASs) is now

108 logy of these receptors and for the rational design of GPCR-targeted drugs.

109 A strategy is outlined for the design of hand-twisted helical crystals.

110 her, these findings provide guidance for the design of HDR donor vectors and the selection of HDR-enh

111 source-specific models of health impacts in design of health-risk minimizing emissions control polic

112 smooth Chebyshev nets to address the inverse design of hemispherical elastic gridshells.

113 Through deliberate geometrical design of heterostructures and superlattices, we demonst

114 Rational design of high efficient and low cost electrocatalysts f

115 of polymer nanocomposites is crucial to the design of high-energy-density dielectric materials with

116 The rational design of high-performance devices requires a detailed u

117 g and quantum dynamics to guide the rational design of higher-order synthetic circuits consisting of

118 This respectful attitude will guide the design of higher-quality models and facilitate the use o

119 Rational design of highly efficient bifunctional electrocatalysts

120 ificant examples of an emerging field in the design of highly selective anion receptors.

121 We report the structure-guided design of HIV-1 cyclically permuted gp120 that forms hom

122 ibe a general strategy for the computational design of homo-oligomeric protein assemblies with bindin

123 atures and therefore offers insight into the design of hydrolytically stable porous materials.

124 Advances in the design of immunogens that antigenically mimic the HIV en

125 These results may aid the design of immunogens that elicit antibodies to the trime

126 , offering a next-generation approach in the design of immunotherapeutic approaches for cancer manage

127 ns regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in

128 lar activity were exploited for the rational design of improved analogues.

129 hetic) nitrogen fixation and to the rational design of improved synthetic N2 fixation catalysts.

130 controls immune surveillance may promote the design of individualized NK cell-targeted therapies to l

131 ion while also suggesting an approach to the design of inhibitors of polyQ amyloid growth that focuse

132 and PDK4 with E2.E3BP is not promising; (ii) Design of inhibitors to interfere with interaction of E2

133 ive understanding is needed for the rational design of intervention strategies to actively control th

134 aces, and to harvest benefit from it for the design of intrinsically icephobic materials.

135 s represents a new paradigm for the rational design of ionophores that can rapidly and precisely moni

136 terized, which presents difficulties for the design of large-scale trials for new treatments.

137 ent strategy has not been widely seen in the design of lead-free perovskites for photovoltaic applica

138 d-wetted devices, and provide a tool for the design of less thrombogenic devices.

139 It also has important implications for the design of lifespan experiments as autotoxins can influen

140 o summarize criteria that must be met during design of ligand-targeted drugs (LTDs) to achieve the re

141 hoton upconversion have been employed in the design of light-responsive DDSs.

142 nd provide vital principles for the rational design of long-coherence electronic qubits.

143 Designing of MAE conditions showed promising results for

144 ilor elastic material parameters through the design of magnetic properties.

145 findings have important implications for the design of maternal vaccination strategies that could syn

146 at the mechanistic level can facilitate the design of maximally insulated systems featuring heterolo

147 We report the rational design of metal-organic layers (MOLs) that are built fro

148 ed motifs were prepared based on the careful design of metallo-organic ligands (MOLs).

149 Previous designs of metasurfaces were limited to small deflection

150 Hence, the design of minimally frustrated sequences can reduce chap

151 anding of these phenomena and facilitate the design of mitigation strategies.

152 ave the way for dynamics analysis and system designs of mode-locked fiber lasers.

153 s gained from this study can inform rational design of modular heteromultivalent nanoparticles for en

154 The design of molecular nanodevices attracted great interest

155 These results can inform the design of more cost-effective surveillance programs to d

156 tem disorders and suggest strategies for the design of more effective drugs.

157 ntally benign mining process, as well as the design of more effective post-mining restoration strateg

158 f how solid tumours are rejected may aid the design of more effective protocols for adoptive T-cell t

159 developed here should enable flexibility in design of more sophisticated devices based on 2D materia

160 system behaviour, and facilitates predictive-design of motility-based pattern formation.

161 be regarded as promising candidates for the design of multi-target disease-modifying drugs for treat

162 nteractions and this principle can guide the design of multi-target drugs i.e. polypharmacology.

163 f binary alloys plays a critical role in the design of multicomponent alloys.

164 general method for the de novo computational design of multicross-linked proteins with predictable an

165 ovides a promising approach towards rational design of multifunctional, elastic SEIs that overcome th

166 entional semiconductor heterostructures, the design of multijunctions is critical to achieve carrier

167 These findings inform the design of multispin systems to transfer spin coherence b

168 udies using Tau-derived peptides enabled the design of mutants that disrupt Tau interactions with pho

169 We address the physicochemical makeup/design of nanomaterials through the lens of the physical

170 The rational design of nanomedicines is a challenging task given the

171 anoconfined water paves the way for a better design of nanoporous materials for energy applications;

172 ns represents an enabling technology for the design of nanoscale electronic devices.

173 s finding has important implications for the design of new allergy vaccines.

174 ased MOFs open new opportunities in rational design of new and superior decontamination materials.

175 A critical step toward the rational design of new catalysts that achieve selective and effic

176 lementary steps of this process will aid the design of new catalytic systems and their real-world app

177 us becoming increasingly interesting for the design of new energy storage devices.

178 ns) make it a useful simulation tool for the design of new experiments, as well as for the conception

179 ules holds great promise for the tailor-made design of new functional materials.

180 onalization and will serve as a guide in the design of new graphene functionalization concepts.

181 otentially important new direction in future design of new HIV vaccines.

182 gained from these studies could help in the design of new inhibitors against morbilliviruses and pro

183 rge numbers of materials and facilitates the design of new materials.

184 found impact on the optimization and de novo design of new NM with better in vivo performance.

185 xpected to find numerous applications in the design of new NMR experiments.

186 herefore, the work provides new idea for the design of new nonfullerene acceptors applicable in comme

187 The design of new or enhanced functionality in materials is

188 heir use in pharmacology, thus prompting the design of new peptidomimetic foldamers.

189 Ralpha, which provide new strategies for the design of new RXRalpha-based antitumor agents and drug c

190 the angiotensin receptors, and may guide the design of new selective ligands.

191 possibility of targeting MT dynamics in the design of new therapeutic agents.

192 tion of nutritional risk for disease and the design of new treatments for the behavioral deficits ass

193 es will help to pave the way for the spatial design of next-generation heterogeneous porous media.

194 ioinspired approach may pave the way for the design of next-generation high-performance solid electro

195 lly-used cancer nanomedicines can enable the design of next-generation nanomedicines that can address

196 nthetic organisms that can be applied to the design of novel artificial light-harvesting devices.

197 ow-affinity partners, and may facilitate the design of novel biosensors.

198 sular polysaccharide epitopes can aid in the design of novel glycoconjugate vaccines.

199 +) Treg cells that could be targeted for the design of novel immunotherapies for allergic disorders.

200 in KR2 may provide a basis for the rational design of novel light-driven ion pumps with optogenetic

201 important consequences for the analysis and design of novel magnetic resonance shift and optical emi

202 y of great interest due its relevance to the design of novel mechanical metamaterials with unique/unu

203 oviding important implications regarding the design of novel miRNA-based therapeutic strategies again

204 he novel Crwn-THF moiety sheds lights in the design of novel PIs.

205 combat fractional killing and facilitate the design of novel strategies.

206 to cucurbituril chemistry, but also for the design of novel supramolecular architectures.

207 using a polypharmacological approach in the design of novel therapeutic agents in preference to comp

208 ighlights numerous potential targets for the design of novel therapeutics.

209 are predictive of weight gain to inform the design of obesity-preventive programs in adolescents.

210 protocols may allow more versatility in the design of organic electronic devices; yet, controlling t

211 identical active sites and guide the future design of organophosphate hydrolases that hydrolyze comp

212 may open new opportunities for the rational design of other 3D transition-metal-based electrocatalys

213 n cancer, therefore we leveraged the modular design of our fusion gene construction methodology to sc

214 reviewed here and a novel principle for the design of oxygen electrocatalysts is proposed.

215 This work highlights the promising design of PDI-based acceptors by the ring-fusion strateg

216 nd receptors, which will be valuable for the design of peptide-based cancer prognosis, diagnosis and

217 ized by protective antibodies may facilitate design of peptidomimetics to focus vaccine responses on

218 ic application of two such principles in the design of peptoid foldamers yields a new and unique seco

219 ions have broad-ranging implications for the design of phage applications in biotechnology, phage the

220 c pathways is indispensable for the rational design of plant and microbial systems for the production

221 ular simulations in the characterisation and design of PMMs.

222 cle, we summarize the recent advances in the design of polypeptide-based supramolecular structures, i

223 These tools will likely contribute to the design of population-targeted AIDS vaccines by effective

224 themselves as interesting candidates for the design of portable optical biosensor platforms consideri

225 POR function will enable the structure-based design of potent modulators of these clinically relevant

226 his benefit has often been overlooked in the design of previous field studies, leaving the net impact

227 a newly designed web tool that automates the design of primers for overlapping PCR.

228 ulation of the limb, will help to inform the design of prostheses that can restore function or accele

229 The design of proteolysis-targeting chimeras (PROTACs) is a

230 This study sheds light on the design of radiation-tolerant materials that do not exper

231 This new understanding permits the design of rational cytokine and intracellular signaling

232 otating parts and gaseous analytes makes the design of RDE cells that allow for headspace analysis ch

233 ts have implications for the next-generation design of receptors used in adoptive T cell therapies.

234 the development and potential use of various designs of recombinant HIV-1 envelope glycoprotein trime

235 , but also has potential applications in the design of recommendation algorithms.

236 observations will have implications for the design of reductive processes involving Sm(II)-mediated

237 yet interconnected subsystems and integrated design of resource reuse across the entire system.

238 at imbalance-aware ML is a key issue for the design of robust and accurate prediction algorithms and

239 eduction in acidic electrolyte, the rational design of sacrificial metal-organic frameworks toward th

240 s of nanomaterial cytotoxicity and guide the design of safer nanomedical technologies.

241 machine learning community by following the design of scikit-learn.

242 ghlighting the challenges in structure-based design of selective inhibitors for either enzyme.

243 The design of selective matrix metalloproteinase (MMP) inhib

244 These results provide insights into the design of selective thiol-Michael reactions that can be

245 xpected to have general implications for the design of selective transformations involving deprotonat

246 s to emphasize the newest development in the design of sensing and biosensing platforms based on func

247 s offer important guidance for the molecular design of SERS-active organic semiconductors and easily

248 exponent has a drastic effect on the optimal design of shell shapes.

249 Ms can provide important information for the design of SILMs for CO2 capture.

250 2D bioelectronics research is focused on the design of simple-to-use and cheaper biodevices, while im

251 tumor, substantiating the importance of the design of size and charge dual-transformable nanomedicin

252 itation by HIV, and provide insight into the design of small molecule and protein inhibitors for HIV

253 Advances in the design of small molecule anion carriers are reviewed in

254 e of these pathways may lead to the rational design of small molecules that modulate aging and hence

255 ions and their direct incorporation into the design of small-molecule catalysts and enzymes.

256 ly using competing pathways that may aid the design of soft nanostructures with tunable dynamic prope

257 offers a versatile approach to the rational design of strongly coupled excitonic circuits using spat

258 s well as a promising starting point for the design of structural analogs with improved activity.

259 This review covers the smart designs of structural materials inspired by natural mate

260 ngs are expected to be useful for the future design of structured platinum alloy nanocatalysts.Core-s

261 ein crystals, and will be useful for optimal design of such materials.

262 SmI2 can be rendered enantioselective by the design of suitable ligands.

263 Here, we report the design of sulfonyl fluoride probes that covalently label

264 The modular design of Syn-TEF1 defines a general framework for devel

265 ein, we demonstrate a novel strategy for the design of synthetic agents that mimic natural glycosidas

266 nes, the method described herein streamlines design of synthetic allosteric riboswitches and small mo

267 are reviewed in addition to advances in the design of synthetic anion channels.

268 Our findings enable rational design of synthetic donor DNAs for efficient genome edit

269 it behaviours and also benefits the rational design of synthetic gene networks.

270 rine has become an important element for the design of synthetic molecules for use in medicine, agric

271 d ThermoAlign was developed that ensures the design of target-specific primer pairs for DNA amplifica

272 ing, and thus could provide guidance for the design of temporally controlled strategies to extend lif

273 sibly around room temperature by appropriate design of the electrostatic and chemical environment.

274 stic gridshells with a focus on the rational design of the final shapes.

275 The design of the Hex nanocarrier is modular, which enables

276 tem is a direct consequence of the molecular design of the metal precursor and the support, resulting

277 rangements of a monomer followed by sequence design of the newly formed interfaces.

278 nanoparticles, and provides insights for the design of the next-generation of nanoscale drug delivery

279 William Kannel et al. described the sampling design of the Offspring Study and presented selected bas

280 The design of the peptides is based on the C-terminal D4 dom

281 vide important insights into the mechanistic design of the ptRNase superfamily, and presents a struct

282 Given the family design of the sample, we are also able to demonstrate th

283 ve to Ce(3+) and utilize this finding in the design of the sensor platform.

284 We present the design of the study and describe the findings of the fir

285 The design of the study was as an open labeled, randomized,

286 nowledge on parameters of the model from the design of the toxicity test (tested concentrations and o

287 erstanding of translation regulation and the design of therapeutic molecules.

288 cuss the implications of our results for the design of therapies that can overcome persistence and, i

289 The self-complementary design of these modules facilitates their assembly in bo

290 nsideration of model differences enables the design of tile systems that robustly exhibit the desired

291 onary states and should be considered in the design of TiO2-containing devices.

292 Through rational design of training and validation sets, key diastereosel

293 which we predict will ultimately lead to the design of truly tailorable carbon fiber/polymer hybrid m

294 and is important for the structure-inspired design of tubulin-targeting agents.

295 Herein we report a rational design of uGFPc toward an unprecedentedly high fluoresce

296 e report a counterintuitive strategy for the design of ultrastrong steel alloys by high-density nanop

297 indings provide mechanistic guides to aid in design of vaccine strategies against fast mutating patho

298 netic diversity is a major challenge for the design of vaccines against variable viruses.

299 nesis of arenaviruses and may facilitate the design of vaccines and treatments against arenavirus-cau

300 using a Y-junction microfluidic device, the design of which was optimized for each printer: fused de