ライフサイエンスコーパス: design principle

1 n transmission per energy used as a synaptic design principle.

2 ols are available to apply 1D diffusion as a design principle.

3 of cellular metamaterials based on Kirigami design principles.

4 eriving general and straightforward catalyst design principles.

5 grown on LaAlO3 (111) substrates fulfil the design principles.

6 yotes or bacteria, little is known about the design principles.

7 tanding of zwitterionic materials to provide design principles.

8 he sense that they are derived from rational design principles.

9 these arise, and whether they embody general design principles.

10 ote gridded streets and similar New Urbanist design principles.

11 moters can be modified using straightforward design principles.

12 nt lignin transformation based on ecological design principles.

13 ion system (GIS) techniques and cartographic design principles.

14 rea appears organized according to different design principles.

15 ials for the future, we must first learn the design principles.

16 ture studies are proposed for generating FPE design principles.

17 s and genomes according to arbitrary sets of design principles.

18 m colloidal structures, guided by biological design principles.

19 pact on their ability to apply instructional design principles (49%) and present in face-to-face sett

20 to tailor active particles; (2) attempts to design principles according to which active particles in

21 Great strides in understanding the design principles adapted by nature have led to a tremen

22 sives detector by applying this bio-inspired design principle and making the device "sniff" like a do

23 the direct correlation between their modular design principle and various interesting properties.

24 ecision and analysis procedure incorporating design principles and ability to examine design decision

25 We derive design principles and adaptive treatment strategies, ide

26 We have also derived design principles and chemical strategies for controllin

27 or dynamical systems by identifying critical design principles and codifying them into a compiler aut

28 e results further our understanding of ZF-TF design principles and corroborate the use of ZF-TFs targ

29 Here, we present design principles and demonstrations for gravity-driven,

30 Design principles and implementation approaches for frag

31 w provides a pertinent insight into relevant design principles and inspires further research in this

32 g simplified circuits are able to reveal key design principles and molecular programs that underlie t

33 Advances in bioinspired design principles and nanomaterials have led to tremendo

34 Ring synV chromosome can extends Sc2.0 design principles and provides a model with which to stu

35 mmarizes the current state-of-the-art on the design principles and synthetic strategies toward COFs b

36 The design principles and synthetic strategies towards HAT d

37 We describe ABP design principles and use case studies to illustrate the

38 in (TTR) was conceived of by structure-based design principles and was chemically synthesized.

39 of cancer nanomedicines: (i) physicochemical design principles, and (ii) clinical trial design, which

40 Design principles are also established for some of the C

41 y of suitable materials, and new chromophore design principles are needed.

42 ional to a three-dimensional process and the design principles are only now becoming established.

43 of this Review will be predominantly on the design principles around the construction of temperature

44 With these design principles as a blueprint, we experimentally cons

45 We discuss design principles at donor/acceptor interfaces for optim

46 nocrystals) with both top-down and bottom-up design principles at the submicron level.

47 Here we introduce a new design principle based on preassembled components of the

48 his understanding significantly differs from design principles based on ex situ characterization tech

49 Persistence of this design principle becomes apparent after the material pro

50 We illustrate this design principle by demonstrating higher CO2 capacity an

51 ains are established, and thus ascertain the design principle by which the geometry of this unique an

52 We confirm the validity of our design principles by showing that the kinetics of self-a

53 is Tutorial Review, we discuss the different design principles by which molecular machines can be eng

54 The reported design principles can be extended to construct higher-or

55 The design principles constrain the set of configurations th

56 ons suggests that systems employing the same design principles could be implemented in other host org

57 Here we begin to explore how selective design principles deduced from spin-based systems could

58 Molecular design principles demonstrated here could have broad imp

59 are supported by experimental data, and the design principles derived from the descriptors provide a

60 nile rat somatosensory cortex suggest common design principles, despite the particular morphological

61 Escherichia coli, we seek to understand the design principles determining the regulation of its tran

62 Our results demonstrated that the design principles developed for DNA circuits could be re

63 eties beyond conventional CB and SB based on design principles developed from these simulation studie

64 se results suggest that a general structural design principle directs the vision-dependent patterning

65 We also outline design principles, employing both intramolecular and int

66 ection by taking advantage of the structural design principles evolved by nature.

67 However, relatively few predictive design principles exist that permit both rational and mo

68 This unique design principle exploits liquid-liquid interface as a p

69 This work presents a design principle for a material that gains unique proper

70 tablished continuous BCR-ABL inhibition as a design principle for ABL tyrosine kinase inhibitors (TKI

71 pproach we describe here represents a unique design principle for aptamer-based electrochemical senso

72 rganization and reveal the conservation of a design principle for cell polarization that is based on

73 [CpMo(H2)(CO)(P2N2)](+) isomers, providing a design principle for controlling heterolytic cleavage of

74 ance sheds light on the effectiveness of the design principle for developing safe and stable Li metal

75 These findings suggest a design principle for efficient energy harvesting from si

76 tein and peptide self-assembly is a powerful design principle for engineering of new biomolecules.

77 on of the photoconductance leads to a simple design principle for enhancing the performance of molecu

78 ral selection, and (iv) provides a universal design principle for evolution.

79 ble supramolecular polymers, and it offers a design principle for functional, structurally defined su

80 This may indicate a topological design principle for future power grids: avoid dead ends

81 a protein interactions formed the basis of a design principle for imidazo[4,5-b]pyridine-derived Auro

82 Besides insight, this finding provides a design principle for improved control of nanoparticle se

83 g-runout landslides, and can be couched as a design principle for low-friction interfaces.

84 terminal emitter trimer is thus an essential design principle for maintaining the efficient light-har

85 discuss the classification of and propose a design principle for mechanical metamaterials that can b

86 cores cooperativity and synergy as a general design principle for multiobjective optimization in biol

87 ial organization can be a similarly powerful design principle for overcoming limitations of speed and

88 s water and proton diffusivity invokes a new design principle for PEMs.

89 roof-of-concept for, to our knowledge, a new design principle for protein-DNA recognition in the huma

90 f sequence and position may serve as a basic design principle for proteins with tunable conformations

91 hesin-dockerin interaction is now a standard design principle for synthetic biology(2,3).

92 is geometric frustration that leads to a new design principle for the assembly of chiral molecules.

93 We introduce a new mechanical design principle for the conducting airway tree in which

94 Here, we introduce an advanced design principle for the stable installment and implemen

95 The unifying design principle for these materials is the avoidance of

96 We identified the structural design principle for this divergence: Insertions at key

97 This general design principle for transcriptional control of a metabo

98 A potentially general design principle for transmembrane protein function emer

99 We demonstrate design principles for (I) ligands to anchor the complex

100 These elements may provide design principles for a generic mechanosensory protein m

101 We defined three design principles for a synthetic genome as follows: fir

102 We sought design principles for a vaccine to prevent HIV transmiss

103 e adsorption resistance might help to refine design principles for anti-fouling surfaces.

104 hetic systems provide important insight into design principles for biological oscillators, but have l

105 synthetic biology should develop predictive design principles for biological systems operating in co

106 ated chains so that we can better define the design principles for conjugated molecules for their app

107 inant genes provides unique insight into the design principles for constructing useful synthetic asse

108 synthetic attachments that reveal important design principles for controlled adhesion.

109 These findings led to a set of new design principles for creating antifouling topographies,

110 udies on well-defined oligomers to establish design principles for creating aromatic poly(carbamates)

111 Our results imply fundamentally distinct design principles for dendritic arbors compared with vas

112 In this tutorial review, we discuss the design principles for dynamic systems involving waveleng

113 These insights provide fundamental design principles for engineering of PSII reaction cente

114 These mechanism studies explore diverse design principles for engineering scRNA signal transduct

115 assembly are identified, aiming to establish design principles for fabrication of arbitrary 3D surfac

116 Design principles for fullerene-free acceptors remain un

117 In this work, we describe a set of design principles for fusing ncRNAs to RNA aptamers to e

118 ave also provided key insights into chemical design principles for future classes of MCC-based anolyt

119 transport in Li-ion conductors and serve as design principles for future discovery and design of imp

120 These findings suggest a set of new design principles for gene delivery by the synergistic c

121 tochastic thermodynamics, we derive a set of design principles for growing controlled assemblies far

122 tiform, bal-istiform, rajiform) and provides design principles for highly agile bioinspired underwate

123 l models of the human liver, but engineering design principles for how to deploy these tools effectiv

124 Our findings establish the design principles for improved glycan conjugate vaccines

125 Basic design principles for improving object visibility are di

126 he identification and application of generic design principles for improving palliative care in the E

127 The proposed mechanism suggests practical design principles for inducing and controlling both cond

128 Our results highlight new design principles for long T1 and T2 times by demonstrat

129 hemicellulose-based materials may offer new design principles for material formulations.

130 sible nonredox reaction and demonstrates new design principles for micro/nanomotors.

131 The design principles for naturally occurring biological mat

132 Our concepts propose design principles for networks predicting how behavior a

133 materials and highlight electrode structure design principles for obtaining the desired electrochemi

134 dings provide possibilities in advancing the design principles for photo-rechargeable lithium ion bat

135 First the design principles for polymer-drug conjugates are discus

136 nd metal oxide component, and we set out the design principles for producing high-selectivity Pd-base

137 This work offers design principles for programmable biochemical reactions

138 Our findings offer design principles for programming efficient transport in

139 PC60BM), and there are as yet no established design principles for realizing improved materials.

140 natural long-range interactions and provide design principles for RNA-based attenuator devices to be

141 dels and available experimental data suggest design principles for similarly functioning pH-responsiv

142 From these findings, we formulate design principles for simultaneous optimization of built

143 These multi-stem complexes offer new design principles for the assembly of DNA architectures.

144 tated CR complex and function terms provides design principles for the engineering of transcriptional

145 ing effective models, here we outline simple design principles for the optimization of shift currents

146 he cursor control setting, but the available design principles for these decoders are such that it ha

147 We sought to establish design principles for this class of biosensor by charact

148 The analysis indicates that bioinspired design principles from ecosystems can lead to both envir

149 develop a deeper understanding of biological design principles from the bottom up, by building circui

150 ity of reflectins as the centrally important design principle governing biophotonic tunability in thi

151 ynthetic biology approach to investigate the design principles governing cell polarization.

152 Here, we investigate the design principles governing the dynamics of these propor

153 Origami- and kirigami-based design principles have recently received strong interest

154 gain advantages from three general and basic design principles: (i) Compact representation of the lon

155 t but related strategies that have used this design principle in constructing new configurations of m

156 Our analysis suggests a new design principle in controlling cellular plasticity thro

157 tituent mechanism, can serve as an effective design principle in controlling the interaction strength

158 ponse pathways, and may constitute a general design principle in signaling pathways.

159 powerful tool to predict and decode circuit design principles in an unbiased manner, and to quantita

160 way towards real-time analysis of materials design principles in devices as they actually operate.

161 ified designed sequence is crucial to verify design principles in genome synthesis.

162 The increasing popularity of biomimetic design principles in nanomedicine has led to therapeutic

163 Our approach can be used to uncover similar design principles in other developmental systems.

164 gineer the SNPs highlighted the need to keep design principles in perspective; specifically, potency

165 s may provide templates for studying protein design principles in radically simplified environments.

166 indings provide a general framework to guide design principles in synthetic biology.

167 Thus, we demonstrate that design principles inspired by the complex signal-transdu

168 The key design principle is based on a nitrobenzofurazan-coumari

169 Here, the design principle is demonstrated by cyclometalation with

170 his initial discovery, a directed heavy atom design principle is demonstrated that will allow for the

171 nction-oriented organic synthesis, a general design principle is presented to build high-performance

172 The design principle is straightforward, the extent of trans

173 A striking example of this design principle is structural coloration, where interfe

174 Its guiding design principle is that the target structure is the sin

175 This design principle is tunable and also allows us to bypass

176 quantitative understanding of the underlying design principles is still lacking.

177 The work describes the design principles, large hydrophobic P3 residue and smal

178 olecular and synthetic biology is to uncover design principles linking RNA structure to function to u

179 This design principle may be useful to engineer novel materia

180 This result yields a previously unidentified design principle, namely that of optimal resource alloca

181 rocycles provide important insights into the design principles necessary for the preparation of new u

182 estable predictions provides insights into a design principle of biological clockwork, with implicati

183 Our finding highlights the design principle of building large biological containers

184 Here, we report a molecular design principle of conjugated polymers to achieve conce

185 This simple and effective design principle of host-guest interactions driven fluor

186 rd these compounds is described based on the design principle of iron(III)-catalyzed carbonyl-olefin

187 ugh their direct relation to S, suggests the design principle of matching the internal symmetry with

188 The design principle of NDP-V is to reduce the conformationa

189 stems), and therefore underlie a fundamental design principle of PPI in a crowded environment.

190 nd thus provides a structural glimpse of the design principle of the molecular transducer for cold an

191 o-3D printed prototypes demonstrate that the design principle of the peacock spiders' scales could in

192 The load driver implements the design principle of timescale separation: inclusion of t

193 Design principles of a new class of microwave thin film

194 Delineating design principles of biological systems by reconstitutio

195 ollowed by a discussion on the similarity of design principles of biomaterials and macromolecular the

196 rfere with network elements to elucidate the design principles of cellular networks.

197 tches, synthetic biologists have learned the design principles of complex natural regulatory networks

198 ing properties have been developed using the design principles of crystal engineering and structure-p

199 he GSR will provide crucial insight into the design principles of early stress-response modules and t

200 es bottom-up approaches to understanding the design principles of eukaryotic transcriptional complexe

201 studies have generated new insights into the design principles of gene regulatory networks.

202 een biological processes, suggesting general design principles of genetic interactomes.

203 However, general design principles of highly efficient inhibitors are lac

204 Herein we report design principles of highly responsive pH sensors based

205 Directly testing the design principles of how dual-timescale circuits control

206 n animals have been studied extensively, the design principles of information processing in such grou

207 c matrix provide important insights into the design principles of lithium metal anodes.

208 be used to evaluate our understanding of the design principles of nanopores and channels.

209 view, we describe and discuss the underlying design principles of natural photoreceptors that have em

210 dy thus provides important insights into the design principles of natural photosynthetic complexes.

211 d by nature can be achieved by mimicking the design principles of natural photosynthetic proteins.

212 This feature, and other design principles of our work, might enhance the study a

213 stabilization of membrane proteins, and the design principles of peptide sequences.

214 ng alloy complexity may pave the way for new design principles of radiation-tolerant structural alloy

215 l effects on defect dynamics may inspire new design principles of radiation-tolerant structural alloy

216 cellular and purified systems to uncover the design principles of self-organized MT networks in the c

217 To provide design principles of such triadic nanorods, we examined

218 tinct cell types, providing insight into the design principles of the Notch signaling system, and the

219 The design principles of the silencing system is systematica

220 Here, we demonstrate the design principles of the supramolecular buffering by rin

221 The concepts are general and design principles of the technologically desirable FM fe

222 The main design principles of traditional and backbone degradable

223 Our findings suggest that the hierarchical design principles offered by hard biological organisms c

224 ining folding-mechanistic behaviors, and the design principles orchestrating the signal transduction

225 The device design principles presented here balance the photonic an

226 leaves are governed by the same fundamental design principles previously established for ferns, coni

227 of these objectives, the derivation of these design principles provides guidance for improved reagent

228 n R and leveraging Bioconductor software and design principles, provides for the coordinated represen

229 each of which employed different fundamental design principles ranging from a pattern recognition met

230 Together, the data suggest design principles relevant to many developing tissues.

231 study illustrates some of the key practical design principles required for the future application of

232 questions that remain to be addressed to the design principles required for useful applications.

233 as9-based histone deacetylase (HDAC) and the design principles required to achieve locus-specific his

234 a generalist circuit, obeying computational design principles resembling those governing other highe

235 stematically conducted to comprehend various design principles responsible for electrochemical profil

236 cale, stochastic modeling to investigate the design principles responsible for robust establishment o

237 Indeed, the "design principles" shaping the optical properties of the

238 These design principles should facilitate the development of i

239 Implementation of these unique methods and design principles should greatly empower molecular progr

240 erogeneity of amyloid fibrils as well as the design principles showing how the molecular structures o

241 The tool incorporates visualization design principles such as focus+context and visual data

242 diverse building blocks and modern foldamer design principles, such as the stereochemical patterning

243 ed ultrasensitivity and positive feedback, a design principle that can be applied to the construction

244 This reveals an underlying design principle that is maintained across large changes

245 ting and sensory elements suggests a general design principle that may underlie the function of a var

246 This finding supports the design principle that semiflexible receptors can facilit

247 These similarities reveal design principles that are likely to be broadly applicab

248 area of research has strongly benefited from design principles that considered the ligand geometry an

249 The fundamental design principles that control the structural determinan

250 Learning from the design principles that defined success for the clinicall

251 subtilis to uncover widely relevant general design principles that describe the structure-function r

252 We introduce design principles that enable robust and scalable circui

253 n database analysis principles to facilitate design principles that may help to mediate an accelerate

254 Additional calculations illustrate some design principles that might lead to stable carbenes tha

255 for quantum information processing requires design principles that minimize electron spin decoherenc

256 The design principles that support persistent electronic coh

257 Uncovering biochemical design principles that underpin such response dynamics i

258 omparison between all chimeras tested led to design principles that will facilitate further engineeri

259 this assay system to show that a dualsteric design principle, that is, molecular probes, carrying tw

260 Using this design principle, three PDI acceptors, N,N-bis(n-octyl)-

261 Thus, we identified a general design principle to achieve robust synchronization: An a

262 ance of ATP and cofactor driving forces as a design principle to alter metabolic flux.

263 h-affinity sites, our results point to a new design principle to deploy polyamides and perhaps other

264 In 1903, Alexander Graham Bell developed a design principle to generate lightweight, mechanically r

265 Here we report the electrode design principle to improve specific capacity and cyclin

266 nic photovoltaic (OPV) devices, the material design principles to apply may be expected to differ.

267 We introduce a set of general design principles to create intricate DNA tessellations

268 ed to take advantage of some set of physical design principles to ensure robust vesiculation against

269 rther, it should be possible to use the same design principles to fabricate structures on a longer le

270 extraordinary selectivity are reported, and design principles to guide discovery of new orthogonal c

271 We derived the following design principles to guide the design of circuits that b

272 Our model allows us to propose design principles to optimize the efficacy of this class

273 We use these design principles to predict statistics of the affinitie

274 ighlight successful applications of rational design principles to provide chemical probes and lead co

275 ement between theory and experiment presents design principles to rationally control the lasing modes

276 raction but most importantly may reveal drug design principles to reduce hERG affinity.

277 We focus on: (1) attempts to formulate design principles to tailor active particles; (2) attemp

278 emonstrate that kinesin-8 motors use diverse design principles to target MT plus ends, which likely t

279 icrobial activity and establishes innovative design principles toward the development of antimicrobia

280 and effector, thereby providing insight into design principles underlying how receptors and their ass

281 rch highlight, we provide an overview of the design principles underlying small fluorescent probes th

282 The replication in synthetic systems of design principles underlying such structural motifs has

283 of PTX drug delivery systems and analyze the design principles underpinning each delivery strategy.

284 We design principled unsupervised methods to derive hyperpa

285 etworks and proteolysis that illustrates the design principles used by bacteria to generate the compl

286 The anchor design principle was extended to microcantilevers via fi

287 This device is based on design principles we have reported previously for detect

288 On the basis of these design principles we predict novel low-gap perovskites f

289 Based on this design principle, we experimentally demonstrate waveguid

290 Using this design principle, we generate a ratiometric fluorescent

291 Utilizing this design principle, we have successfully detected the acti

292 Using a similar design principle, we report spectroscopic evidence for t

293 Experimental design principles were subsequently used to guide a form

294 immune responses are variations on a common design principle wherein the cells that sense infections

295 lting materials combinations and their basic design principles will be outlined.

296 ent and correct use of terminology and study design principles will improve clinical research, advanc

297 ementation of new reporting and experimental design principles will improve experimental work, speed

298 iterative process that incorporates modular design principles with hierarchical performance optimiza

299 Finally, we illustrate the design principles with representative examples, aiming a

300 These data provide design principles with which the electromagnetic behavio