ライフサイエンスコーパス: designer

1 -SAMS amiRNA Designer and P-SAMS syn-tasiRNA Designer.

2 nd of factors outside the control of program designers.

3 ; and attract a diverse community of product designers.

4 We used a "designer" AAV, AAV2/Anc80L65, in which the main capsid p

5 reate ultrathin semiconductor metafilms with designer absorption spectra.

6 Such designer acoustic metasurfaces provide a new design meth

7 te means to assist/aid chemists and material designers alike to rationally construct desired function

8 e the site-specific incorporation of diverse designer amino acids into proteins produced in cells and

9 The third-generation designer amphiphile/surfactant, "Nok" (i.e., SPGS-550-M;

10 AMS includes two applications, P-SAMS amiRNA Designer and P-SAMS syn-tasiRNA Designer.

11 nity of micro- and nanomaterials and systems designers and users who wish to evaluate the impact of s

12 ulatory authorities, lighting manufacturers, designers, and engineers.

13 stems are developed to inform policy makers, designers, and operators.

14 We outline a designer approach to endow widely available plain materi

15 ays with sequence-defined glycan probes, and designer arrays from the O-glycome of an antigen-positiv

16 The ability to create designer aTFs will enable applications including dynamic

17 s story as it is the ability to generate the designer azadipyrromethene that opens the door to exciti

18 poorly folded protein, we have now generated designer bacteria selected for their ability to stabiliz

19 ne the activity of E3 ubiquitin ligases with designer binding proteins to steer virtually any protein

20 their promise for the future development of designer biocatalysis for the selective late-stage modif

21 led radical copolymerization of styrene with designer boron or phosphorus containing monomers.

22 heir knowledge system can help institutional designers build more efficient and effective institution

23 ience to generate precise disease models and designer cell samples for personalized therapeutics will

24 The unorthodox use of aerobic enzymes in designer cellulosome machinery effects simultaneous degr

25 type enzyme and properly integrated into the designer cellulosome.

26 chimeric LPMOs were able to self-assemble in designer cellulosomes alongside an endo- and an exo-cell

27 Recently, designer cellulosomes have been developed to incorporate

28 quences and the introduction of thousands of designer changes may affect genome organization and pote

29 charges amplifies temperature sensitivity of designer channels, which accounts for low-voltage sensit

30 gues use a laminin polymerization-competent, designer chimeric BM protein in vivo to restore function

31 By using semisynthetic 'designer' chromatin containing H2B-Ub bearing a site-spe

32 on in liquid crystals (LCs) in patterns with designer complexity.

33 ting technology for fabricating cellularized designer conduits for peripheral nerve regeneration, and

34 The ability to create designer DNA architectures with accurate spatial control

35 Designer DNA architectures with nanoscale geometric cont

36 ul scaffold to construct molecularly precise designer DNA devices.

37 The ability to rapidly and robustly generate designer DNA molecules in an autonomous manner should ha

38 e address safety issues applicable when such designer DNA nanodevices interact with the immune system

39 y designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found

40 designer receptor exclusively activated by a designer drug (DREADD) in dmPFC and isolated actions of

41 designer receptors exclusively activated by designer drug (DREADD) in the hypoglossal motorneurons.

42 g designer receptor exclusively activated by designer drug (DREADD) technology ameliorated narcolepsy

43 designer receptor exclusively activated by a designer drug (DREADD) under control of the glial fibril

44 esigner receptors exclusively activated by a designer drug (DREADD), promotes anxiety-like behavior.

45 designer receptor exclusively activated by a designer drug (DREADD-hM4Di) or a control reporter (AAV-

46 Designer receptors exclusively activated by designer drug (DREADDs) are a novel tool with the potent

47 designer receptors exclusively activated by designer drug (DREADDs) as a means of bidirectionally mo

48 d designer receptor exclusively activated by designer drug also led to the elevation of AMPAR functio

49 designer receptor exclusively activated by a designer drug in PVT neurons, we show that the PVT is ce

50 e designer receptor exclusively activated by designer drug pharmacogenetic approach, transient inhibi

51 a designer receptor exclusively activated by designer drug pharmacogenetic approach.

52 , designer receptor exclusively activated by designer drug technology to specifically manipulate CA1

53 tanyl has enabled the creation of dangerous "designer drug" analogues that escape toxicology screenin

54 rs," which are exclusively activated by the "designer drug" clozapine N-oxide (CNO).

55 designer receptor exclusively activated by a designer drug) in dACC neurons, and examined the effects

56 Designer Receptor Exclusively Activated by a Designer Drug) knock-in mouse line to manipulate intrace

57 (designer receptor exclusively activated by designer drug) receptor hM4Di in sensorimotor cortex and

58 (designer receptor exclusively activated by designer drug) technology for remote and real-time contr

59 (Designer Receptor Exclusively Activated by Designer Drug) to repeatedly and non-invasively inactiva

60 (designer receptor exclusively activated by designer drug), promoted helplessness, indicating that a

61 (designer receptor exclusively activated by designer drug).

62 (designer receptors exclusively activated by designer drug).

63 r designer receptor exclusively activated by designer drug-directed specific increases in CA1 excitat

64 designer receptors exclusively activated by designer drug-mediated (DREADD-mediated) activation of t

65 y designer receptor exclusively activated by designer drugs (DREADD) hM3Dq was used to induce PFC act

66 designer receptors exclusively activated by designer drugs (DREADD) system, to show that CREB levels

67 designer receptors exclusively activated by designer drugs (DREADD) technology to specifically activ

68 'designer receptors exclusively activated by designer drugs (DREADD)' approach, and ChAT-IRES-Cre mic

69 Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools are now

70 designer receptors exclusively activated by designer drugs (DREADD).

71 Designer receptors exclusively activated by designer drugs (DREADDs) are an advanced experimental to

72 Designer receptors exclusively activated by designer drugs (DREADDs) are novel and powerful tools to

73 ry Designer Receptors Exclusive Activated by Designer Drugs (DREADDs) before cisplatin treatment.

74 designer receptors exclusively activated by designer drugs (DREADDs) has made it possible to dissect

75 Designer receptors exclusively activated by designer drugs (DREADDs) have proven to be highly effect

76 Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) hM3Dq and hM4Di.

77 designer receptors exclusively activated by designer drugs (DREADDs) in iDA grafts to noninvasively

78 designer receptors exclusively activated by designer drugs (DREADDs) or by the treatment with glutam

79 xpression of designer receptors activated by designer drugs (DREADDs) suggest that the interaction re

80 designer receptors exclusively activated by designer drugs (DREADDs) technology, we found that stimu

81 designer receptors exclusively activated by designer drugs (DREADDs) to determine the anatomic and f

82 designer receptors exclusively activated by designer drugs (DREADDs) to inhibit LHb activity leads t

83 designer receptors exclusively activated by designer drugs (DREADDs) to selectively activate or inhi

84 designer receptors exclusively activated by designer drugs (DREADDs) were infused and subsequently a

85 Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) were selectively expressed in N

86 Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)) provides a reliable and robust

87 designer receptors exclusively activated by designer drugs (DREADDs), through virtual lesioning of a

88 designer receptors exclusively activated by designer drugs (DREADDs), we show in two AD-like mouse m

89 designer receptors exclusively activated by designer drugs (DREADDs)-mediated synaptic silencing abl

90 designer receptors exclusively activated by designer drugs (DREADDs).

91 designer receptors exclusively activated by designer drugs (DREADDs).

92 q-coupled receptors exclusively activated by designer drugs (Gq-DREADD) during fear extinction had no

93 e presented, including the identification of designer drugs and chemical derivatives not present in t

94 designer receptors exclusively activated by designer drugs displayed a supraspinal, but not spinal,

95 designer receptors exclusively activated by designer drugs excitation or inhibition of the VP.

96 designer receptors exclusively activated by designer drugs in female rats throughout repeated restra

97 designer receptors exclusively activated by designer drugs in ventral tegmental area (VTA) dopamine

98 designer receptors exclusively activated by designer drugs prevents contextual associations.

99 Designer Receptors Exclusively Activated by Designer Drugs system, we reversibly decreased MD activi

100 Designer Receptors Exclusively Activated by Designer Drugs technology enhanced the frequency and amp

101 designer receptors exclusively activated by designer drugs technology, we could suppress food intake

102 n verification, and retrospective testing of designer drugs that elude conventional drug tests.

103 , especially given the growing popularity of designer drugs that target SERT.

104 Designer receptors exclusively activated by designer drugs were used to inhibit orexin activation th

105 (designer receptors exclusively activated by designer drugs) designer receptor system was insufficien

106 (designer receptor exclusively activated by designer drugs) hyperpolarizes membrane potential and su

107 (designer receptors exclusively activated by designer drugs) is widely used for remote manipulation o

108 (designer receptors exclusively activated by designer drugs) mimicked the antidepressant-like respons

109 (designer receptor exclusively activated by designer drugs) receptor hM4di abrogated spontaneous fun

110 (Designer Receptors Exclusively Activated by Designer Drugs) selectively impaired MSO task performanc

111 (designer receptors exclusively activated by designer drugs) selectively in mPFC neurons projecting t

112 (designer receptors exclusively activated by designer drugs) system in which a mutated muscarinic G p

113 (designer receptors exclusively activated by designer drugs) technology by creating ROSA26-based knoc

114 designer receptors exclusively activated by designer drugs), we found that selective inhibition of P

115 cannainol, as well as synthetic derivatives (designer drugs).

116 Designer Receptors Exclusively Activated by Designer Drugs, and suggest its potential as a powerful

117 apidly reacting to emerging threats, such as designer drugs, biological therapeutic agents, and techn

118 synthetic psychoactive substances known as "designer drugs," or "new psychoactive substances" (NPS),

119 ome important targets for the development of designer drugs.

120 designer-receptors-exclusively-activated-by-designer-drugs (DREADD)-mediated inhibition of POMC neur

121 Direct determination of free cordycepin in designer egg using a highly selective mass spectrometric

122 ides a powerful path towards the creation of designer electronic devices.

123 tion of a DNA break at a specific locus by a designer endonuclease can be harnessed to edit a genome.

124 As the designer enforces a controllable break in the symmetry,

125 The designer equilateral silver triangular and spherical nan

126 synthesis of a functional 272,871-base pair designer eukaryotic chromosome, synIII, which is based o

127 I establishes S. cerevisiae as the basis for designer eukaryotic genome biology.

128 As part of the effort to build a designer eukaryotic genome, yeast synthetic chromosome X

129 Predicted designer flow prescriptions indicate significant opportu

130 illustration of theoretical predictions that designer flows can offer multiple ecological and societa

131 ffers a promising new approach to synthesize designer functional materials with atomic precision.

132 ty, properties that are on par with those of designer gels.

133 developmental processes using sophisticated designer genetic tools.

134 d in yeast, facilitating the construction of designer genomes in microbes as well as genomic fragment

135 rrangement and remodelling of liposomes with designer geometry: all of which are exquisitely controll

136 we find that the pharmacologically selective designer Gi-protein-coupled receptor hM4D is a presynapt

137 cent advances such as the ability to produce designer glycans in bacteria, some containing unnatural

138 The development of designer GPCRs known as designer receptors exclusively a

139 Activation of SN DA neurons with designer Gq-coupled receptors exclusively activated by d

140 Vaccine designers have sought to restrict the conformation of th

141 al control of inversion-symmetry breaking in designer heterostructures of oxides and other material c

142 proach here serves as a first example toward designer hydrogel scaffolds viable for biomimetic tissue

143 This device is created by 3D printing of designer hydrogels with functional polydiacetylene nanop

144 A designer Josiphos ligand promotes the generation of chir

145 nsive approach for creating robust, elastic, designer Lunar and Martian regolith simulant (LRS and MR

146 Synthetic approaches to prepare designer materials that localize deformation, by combini

147 for encoding highly complex information into designer metasurfaces, thus having the potential to driv

148 Inspired by the concept of designer metasurfaces, we demonstrate a novel amplitude-

149 Here we demonstrate that vitamin E-derived designer micelles, originally developed for use in synth

150 chnologies will facilitate the production of designer microbes for biosynthesis.

151 rapeutics (e.g., extensive glycosylation or "designer" modifications such as chemical conjugation) or

152 15) present intriguing results showing that "designer" molecular chaperones may hold the key to an ev

153 of allostery has hindered the development of designer molecules, including transcription factors with

154 ch is called a scaffold strand, into various designer nanoscale architectures.

155 onstrates a remarkable capacity for creating designer nanostructures and devices.

156 wo reservoirs and one tunnel exist, however, designers need external aids to complete a cycle, render

157 We demonstrate that dsRNA can be loaded on designer, non-toxic, degradable, layered double hydroxid

158 , we adapt lentiviral vectors as carriers of designer nuclease proteins, providing efficient targeted

159 Bioinformatics-based analysis of designer nuclease specificity confirmed partly substanti

160 Here we used designer nucleases (ZFNs, TALENs, and CRISPR/Cas9) to in

161 The recent development of designer nucleases allows for the efficient and precise

162 Here we demonstrate the use of multiple designer nucleases and variant-aware library design to i

163 Designer nucleases have been successfully employed to mo

164 Designer nucleases have gained widespread attention for

165 Delivery of these designer nucleases into organisms induces various geneti

166 Genome editing by designer nucleases is a rapidly evolving technology util

167 Genome editing with designer nucleases such as TALEN and CRISPR/Cas enzymes

168 Designer nucleases, like zinc-finger nucleases (ZFNs), r

169 monly used tool to assess genomic editing by designer nucleases.

170 llular and organismal response pathways that designer nucleic acid nanodevices are likely to elicit i

171 trategies that could be integrated with such designer nucleic acid scaffolds to either evade or stimu

172 pproach, which is of benefit to analysts and designers of complex systems and networks.

173 re-envisioning the niche as an enabler, not designer, of cell fate.

174 Research on two-dimensional designer optical structures, or metasurfaces, has mainly

175 an essential first step in the creation of a designer organelle.Designer organelles could allow the i

176 step in the creation of a designer organelle.Designer organelles could allow the isolation of synthet

177 The development of 'designer' organelles could be a key strategy to enable f

178 Based on their selectivity, these designer pairs will bolster multicomponent imaging and e

179 The histidine-rich designer peptide LAH4-L1 exhibits antimicrobial and pote

180 us studies have shown that these immunogenic designer peptides are not always effective.

181 on that failed with known ligands for Ni and designer phosphines for Pd.

182 greatly expand possibilities for developing designer photocatalytic substrates.

183 Such designer photonic media with complete control over the o

184 HPAs holds great potential for production of designer platelets for diagnostic, investigative, and, u

185 bility of engineered biocatalysts to produce designer products at high carbon and energy efficiency w

186 dothelial growth factor receptor 3-selective designer protein VEGF-CC152S, using albumin-alginate mic

187 is an important challenge in producing novel designer proteins with unique chemical properties.

188 h offers a powerful tool to engineer diverse designer proteins.

189 tic approach expressing the inhibitory hM4Di designer receptor exclusively activated by a designer dr

190 Here we generated a DREADD (Designer Receptor Exclusively Activated by a Designer Dr

191 We expressed the excitatory hM3Dq designer receptor exclusively activated by a designer dr

192 deno-associated virus vector expressing hM3D designer receptor exclusively activated by a designer dr

193 engineered Gi/o-coupled human muscarinic M4 designer receptor exclusively activated by a designer dr

194 e virally expressed inhibitory hM4Di DREADD (designer receptor exclusively activated by a designer dr

195 virus (AAV)-expressing Cre-dependent DREADD (designer receptor exclusively activated by designer drug

196 sconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug

197 ifferent experimental approaches, especially designer receptor exclusively activated by designer drug

198 olution approaches combining mouse genetics, designer receptor exclusively activated by designer drug

199 Here we use an inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drug

200 Using the designer receptor exclusively activated by designer drug

201 erneurons in the mPFC using hM4Di, a DREADD (designer receptor exclusively activated by designer drug

202 ivo via activation of the inhibitory DREADD (designer receptor exclusively activated by designer drug

203 idal neurons with a CaMKII-driven Gq-coupled designer receptor exclusively activated by designer drug

204 Nts neurons by the excitatory hM3Dq DREADD (designer receptor exclusively activated by designer drug

205 acogenetic activation of these neurons using designer receptor exclusively activated by designer drug

206 al glutamatergic projections remotely with a designer receptor exclusively activated by designer drug

207 e recipient; therefore, we adapted a DREADD (designer receptor exclusively activated by designer drug

208 ive deficits that could be rescued by either designer receptor exclusively activated by designer drug

209 The excitatory designer receptor exclusively activated by designer drug

210 o this end, we expressed the Galphai-coupled designer receptor hM4D in adult striatopallidal neurons

211 RP neurons, and activation of the inhibitory designer receptor hM4Di on AgRP neurons did not affect s

212 of GABA release from PV neurons through the designer receptor hM4Di selectively expressed in PV-cont

213 ors exclusively activated by designer drugs) designer receptor system was insufficient to modulate ba

214 Optogenetic and designer receptor technologies provide unprecedented and

215 Therefore, here we used designer receptor-mediated inactivation of OFC-->BLA or

216 Moreover, designer receptor-mediated transient inactivation of RVP

217 We used viral-mediated gene transfer of designer receptors (DREADDs) to activate vmPFC neurons a

218 pecific postsynaptic transgene expression of designer receptors activated by designer drugs (DREADDs)

219 This review highlights how optogenetics and designer receptors can be applied in the study of Parkin

220 in combination with Cre-dependent inhibitory Designer Receptors Exclusive Activated by Designer Drugs

221 ons using hM3Dq, but neither hM4Di nor rM3Ds designer receptors exclusively activated by a designer d

222 netic method in mice and rats is the DREADD (designer receptors exclusively activated by designer dru

223 ent and reacquisition of alcohol seeking via designer receptors exclusively activated by designer dru

224 Using viral-mediated delivery of designer receptors exclusively activated by designer dru

225 elevant Ca(2+) influx by the introduction of designer receptors exclusively activated by designer dru

226 ion of the vHipp-mPFC pathway using DREADDs (designer receptors exclusively activated by designer dru

227 d this region using CaMKII-driven Gs-coupled designer receptors exclusively activated by designer dru

228 um using the pharmacogenetic technique, the 'designer receptors exclusively activated by designer dru

229 This study evaluates the efficacy of designer receptors exclusively activated by designer dru

230 ed from hPSCs engineered to express DREADDs (designer receptors exclusively activated by designer dru

231 Designer Receptors Exclusively Activated by Designer Dru

232 Designer receptors exclusively activated by designer dru

233 approach to express G(i/o)-coupled DREADDs (designer receptors exclusively activated by designer dru

234 In addition, using designer receptors exclusively activated by designer dru

235 neurons in OFC of PV-Cre mice using DREADDs (Designer Receptors Exclusively Activated by Designer Dru

236 TH-positive neurons in the vPAG/DR using Gq designer receptors exclusively activated by designer dru

237 Directly manipulating these D1 signals using designer receptors exclusively activated by designer dru

238 CaMKII-driven inhibitory Gi-coupled designer receptors exclusively activated by designer dru

239 Designer receptors exclusively activated by designer dru

240 Designer receptors exclusively activated by designer dru

241 This was tested using inhibitory designer receptors exclusively activated by designer dru

242 Our data reveal that using designer receptors exclusively activated by designer dru

243 We review one such technology, Designer Receptors Exclusively Activated by Designer Dru

244 Here, using designer receptors exclusively activated by designer dru

245 neurons and increased their firing rate, and designer receptors exclusively activated by designer dru

246 Using the Designer Receptors Exclusively Activated by Designer Dru

247 Designer receptors exclusively activated by designer dru

248 of modulating activity in the NAc using the Designer Receptors Exclusively Activated by Designer Dru

249 Next, Designer Receptors Exclusively Activated by Designer Dru

250 ergic activation of HC PV interneurons using Designer Receptors Exclusively Activated by Designer Dru

251 uorescence in situ hybridization (FISH), and designer receptors exclusively activated by designer dru

252 Furthermore, using designer receptors exclusively activated by designer dru

253 ream Ca(2+) signaling with the hM3Dq DREADD (designer receptors exclusively activated by designer dru

254 By increasing neuronal activity using designer receptors exclusively activated by designer dru

255 ed metabolic mapping, where DREADD indicates designer receptors exclusively activated by designer dru

256 Inhibition of orexins using designer receptors exclusively activated by designer dru

257 Designer receptors exclusively activated by designer dru

258 chemogenetic locus coeruleus activation via designer receptors exclusively activated by designer dru

259 ection strategies, pharmacologic rescue, and designer receptors exclusively activated by designer dru

260 The chemogenetic technology DREADD (designer receptors exclusively activated by designer dru

261 ved using chemogenetic approach by deploying designer receptors exclusively activated by designer dru

262 The development of designer GPCRs known as designer receptors exclusively activated by designer dru

263 glutamatergic vCA1 to mPFC projections using designer receptors exclusively activated by designer dru

264 an M3 muscarinic receptor (hM3Dq), a type of designer receptors exclusively activated by designer dru

265 In this issue of the JCI, Gaykema et al. use designer receptors exclusively activated by designer dru

266 s in vivo, we harnessed the power of DREADD (designer receptors exclusively activated by designer dru

267 modulation of neuroanatomical circuits using designer receptors exclusively activated by designer dru

268 nstrated that our chemogenetic approach (eg, Designer Receptors Exclusively Activated by Designer Dru

269 transgene strategy to express and stimulate designer receptors that mimicked mGluR5 signaling throug

270 Using virally delivered designer receptors to specifically control LC norepineph

271 DREADD technology posits the use of "designer receptors," which are exclusively activated by

272 as crucial for CB1R-induced feeding, because designer-receptors-exclusively-activated-by-designer-dru

273 nspired approach to protein design where the designer searches for and interactively incorporates nat

274 Protein designers should find this study useful, because it iden

275 ovided a source of inspiration for algorithm designers since the birth of computers.

276 in vitro directed evolution of proteins with designer single-molecule conformational phenotypes of in

277 Thus, designer small molecules that react with RNA targets can

278 f pseudouridylation at these positions using designer snoRNAs results in near complete rescue of spli

279 pramolecular self-assembly enables access to designer soft materials that typically exhibit high-symm

280 enomes using the online Primal Scheme primer designer software.

281 pired by the goal to create a biosensor with designer specificity for real-time detection of unlabele

282 iven approach that could ultimately lead to 'designer' spins with tailored properties.

283 ogy is adopted to prepare a bio-conduit with designer structures for peripheral nerve regeneration.

284 Here in a designer surface plasmon platform consisting of tunable

285 n nanoparticles composed of newly introduced designer surfactants enable the same cross-couplings, al

286 e Fe/ppm Pd nanoparticles and PEG-containing designer surfactants, a facile and selective reduction o

287 at can be programmed to synthesize different designer syngas ratios.

288 This work sets the stage for completion of a designer, synthetic eukaryotic genome.

289 tput, and open up the possibilities of using designer-tailored pulses for controlling molecular dynam

290 atible strains or by engineering a synthetic designer TAL effector to boost SWEET gene expression.

291 Activation of GhSWEET10 by designer TAL effectors (dTALEs) restores virulence of Xc

292 Designer TALEs (dTALEs) for the bHLH transcription facto

293 cycle assessment practitioners and molecular designers that allow rapid assessment of multiple enviro

294 on based on discrete elements that liberates designers to build large-scale microfluidic systems in t

295 xes alignment, granting a practical route to designer topological materials.

296 Protein designers use a wide variety of software tools for de no

297 More recently, a synthetic designer version of yeast Saccharomyces cerevisiae chrom

298 ng closteroviruses have a great potential as designer viruses to pursue functional genomics and for t

299 eractions, thus providing a new strategy for designer water remediation materials.

300 duced a kinetically sensitive dual-frequency designer waveform into the Fourier-transformed large-amp