ライフサイエンスコーパス: desmethylclozapine

コーパス検索結果 (１語後でソート)

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1 C-42, and a third by structural analogs of N-desmethylclozapine.

2 about its biologically active metabolite, N-desmethylclozapine.

3 azol-2-one) , and the clozapine metabolite N-desmethylclozapine.

4 perties of AC-42 and AC-260584 but not for N-desmethylclozapine and clozapine, indicating that they m

5 oro-4H-benzo[1,4]oxazin-3-one (AC-260584), N-desmethylclozapine, and clozapine with the M(1) muscarin

6 Western blots revealed that Clozapine, N-desmethylclozapine, and DETC reduce the phosphorylation

7 ns studied, and the docking indicated that N-desmethylclozapine bound to a site distinct from AC-42 a

8 se observations raise the possibility that N-desmethylclozapine contributes to clozapine's clinical a

9 ly, these results indicate that Clozapine, N-desmethylclozapine, DETC, and U0126 protect PC-12 cells

10 In contrast, the functional activity of N-desmethylclozapine did not require Phe77.

11 Clozapine and N-desmethylclozapine displayed substantially increased max

12 idence that the brain penetrant metabolite N-desmethylclozapine is a potent, allosteric agonist at hu

13 verse allosteric agonists AC-42, TBPB, and N-desmethylclozapine may interact with different subsets o

14 In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working

15 prompted us to investigate the effects of N-desmethylclozapine on cloned human M1-M5 muscarinic rece

16 r map the binding site of AC-42, TBPB, and N-desmethylclozapine, point mutations previously reported

17 irected mutagenesis studies suggested that N-desmethylclozapine preferentially activated M1 receptors

18 N-desmethylclozapine preferentially bound to M1 muscarinic

19 chotic disorders, the neuronal activity of N-desmethylclozapine was electrophysiologically investigat

20 In contrast, the activity of N-desmethylclozapine was generally unaffected by the point

21 N-desmethylclozapine was shown to dose-dependently potenti

22 The clozapine metabolite, desmethylclozapine, was considerably more potent than th

23 ponses to AC-42, AC-260584, clozapine, and N-desmethylclozapine were all substantially reduced, but u

24 llosteric compounds such as WIN 51,708 and N-desmethylclozapine were noncompetitive inhibitors.

25 ssues is demonstrated, where clozapine and N-desmethylclozapine were observed from mouse and rat brai

26 omocytoma (PC-12) cell line, Clozapine and N-desmethylclozapine were tested for their ability to prot

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