ライフサイエンスコーパス: desmocollin

1 the cell adhesion molecules, E-cadherin and desmocollin.

2 of the desmosomal cadherins, desmogleins and desmocollins.

3 n molecules and comprise the desmogleins and desmocollins.

4 smosomal cadherins, known as desmogleins and desmocollins.

5 , which includes three desmogleins and three desmocollins.

6 ometric relationship between desmogleins and desmocollins.

7 fic differences exhibited by desmogleins and desmocollins.

8 Desmocollin 1 (Dsc1) is part of a desmosomal cell adhesi

9 ted proteins, including desmoglein 1 (Dsg1), desmocollin 1 (Dsc1), and keratins 1 and 10 (K1/K10), in

10 Some undegraded desmoglein 1/desmocollin 1 redistribute uniformly into corneocyte env

11 of its companion suprabasal cadherin, Dsc1 (desmocollin 1).

12 ophilin and more weakly with desmoplakin and desmocollin 1.

13 plakophilin 1, and the cytoplasmic domain of desmocollin 1.

14 downregulated genes (keratin 2A [KRT2A] and desmocollin-1 [DSC-1]) were randomly selected for furthe

15 ifferentiation-specific desmocollin isoforms desmocollin-1 and desmocollin-3 are functionally equival

16 These observations suggest that desmocollin-1 can function as a desmosomal cadherin both

17 Transgenic human desmocollin-1 colocalized with endogenous desmosomal mar

18 This raises the question of whether basal desmocollin-1 could alter desmosomal functions and compr

19 ed a specific expression of transgenic human desmocollin-1 in epidermal basal cells.

20 In this study, we misexpressed human desmocollin-1 in mouse epidermis, under control of the k

21 Desmocollin-1 is strictly confined to suprabasal layers

22 A punctate distribution of desmocollin-1 was demonstrated at the cell membrane by i

23 oglobin bind with similar weak affinities to desmocollin-1.

24 Transfection of these cells with bovine Desmocollin 1a (Dsc1a) caused dramatic changes in the su

25 specifically associates with itself and with desmocollin 1a (Dsc1a).

26 plakin, plakoglobin, desmoglein 1 and 2, and desmocollin 1a and 2a.

27 ontrast, the interaction of plakoglobin with desmocollin-1a is sensitive to deletion of either end of

28 Of the desmosomal glycoproteins, desmocollin 2 (Dsc2) and desmoglein 2 (Dsg2) were expres

29 akophilin 2 (PKP2), desmoglein 2 (DSG2), and desmocollin 2 (DSC2), respectively, cause ARVC.

30 sembly properties of desmoglein 2 (Dsg2) and desmocollin 2 (Dsc2), which are widely expressed, with D

31 ccumulated levels of desmoglein 2 (Dsg2) and desmocollin 2 increased 1.7-2.0-fold, and both desmosoma

32 ) (n = 5), plakophilin-4 (PKP4) (n = 1), and desmocollin-2 (DSC2) (n = 1).

33 Desmocollin-2 (Dsc2) and desmoglein-2 (Dsg2) are transme

34 We identified desmocollin-2 (Dsc2) as a major target of Nrf2-induced m

35 of 5' untranslated region till exon 1, 1 the desmocollin-2 (DSC2) duplication of exons 7 to 9, and 1

36 intestinal epithelial desmosomal cadherins, desmocollin-2 (Dsc2) loss promotes colonic epithelial ca

37 mal cadherins termed desmoglein-2 (Dsg2) and desmocollin-2 (Dsc2) that affiliate with the underlying

38 truncation mutation, c.1660C>T (p.Q554X) in desmocollin-2 (DSC2), in affected individuals and determ

39 ns to mediate adhesion, desmoglein-1 (Dsg1), desmocollin-2 (Dsc2a) and plakoglobin were expressed in

40 2 (n=38; 34%), desmoglein-2 (n=30; 26%), and desmocollin-2 (n=1; 1%), whereas 21 patients (16%) had a

41 ll as novel molecules, among them fibulin-2, desmocollin-2, the glycosaminoglycans syndecan-3, and ve

42 the antimetastatic, tumor suppressor genes, desmocollin 3 (DSC3) and MASPIN, which are frequently si

43 nfected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though

44 of 85 normal serum samples immunoprecipitate desmocollin 3 (P = 0.003).

45 These data demonstrate that desmocollin 3 is a pathogenic autoantigen in pemphigus v

46 We now demonstrate that desmocollin 3 is an autoantigen in pemphigus vulgaris, i

47 erved in pemphigus vulgaris, suggesting that desmocollin 3 might be a target of autoantibodies in som

48 Additionally, anti-desmocollin 3 sera cause loss of keratinocyte cell surfa

49 ar adhesion, and adsorption with recombinant desmocollin 3 specifically prevents this pathogenic effe

50 8 activation causes internalization of Dsg3, desmocollin 3, and desmoplakin.

51 redistribution of desmoplakin, desmoglein 3, desmocollin 3, and E-cadherin to the plasma membrane.

52 sera cause loss of keratinocyte cell surface desmocollin 3, but not desmoglein 3 by immunofluorescenc

53 ay result from autoimmunity to desmoglein 3, desmocollin 3, or both desmosomal cadherins.

54 Mice with an epidermal-specific deletion of desmocollin 3, the other major desmosomal cadherin isofo

55 cific desmocollin isoforms desmocollin-1 and desmocollin-3 are functionally equivalent in basal epide

56 distinct cellular pathogenic effects in anti-desmocollin and anti-desmoglein pemphigus, despite their

57 between desmosomal cadherins (desmoglein and desmocollin) and plakoglobin, we have sought to identify

58 The full-length desmocollins apparently did not interact with any other

59 t, the transmembrane proteins desmoglein and desmocollin are efficiently transported to the cell surf

60 Desmocollins are cadherin-like glycoproteins that are lo

61 of the desmosomal cadherins, desmoglein and desmocollin, are required for epidermal cell adhesion.

62 al cadherins, comprising the desmogleins and desmocollins, are calcium-dependent transmembrane adhesi

63 onents of the desmosome, the desmogleins and desmocollins, are members of the cadherin family of cell

64 ne desmosomal glycoproteins, desmogleins and desmocollins, are widely considered to function as adhes

65 s a decrease of Dsg3 and desmoplakin but not desmocollin (Dsc) 3 in the Triton-insoluble fraction of

66 desmosomal cadherins, desmoglein (Dsg), and desmocollin (Dsc).

67 The desmosomal cadherin desmocollin (Dsc)1 is expressed in upper epidermis where

68 cell culture samples were immunostained for desmocollin (DSC)2, occludin (OCLN), desmoglein (DSG)1,

69 ratinocytes, several desmoglein (Dsg1-4) and desmocollin (Dsc1-3) isoforms are coexpressed.

70 chments are formed by desmogleins (Dsgs) and desmocollins (Dscs), but the nature of trans-cellular in

71 desmosomal cadherins, desmogleins (Dsgs) and desmocollins (Dscs), comprise the adhesive core of inter

72 he goal of this study was to investigate how desmocollins (DSCs), transmembrane components of desmoso

73 e carboxy-termini of classical cadherins and desmocollins have been shown to play an important role i

74 We propose that the differentiation-specific desmocollin isoforms desmocollin-1 and desmocollin-3 are

75 Desmosomal cadherins, desmogleins (Dsgs) and desmocollins, make up the adhesive core of intercellular

76 The desmosomal cadherins, desmogleins, and desmocollins mediate strong intercellular adhesion.

77 smosomal components that may be required for desmocollin-mediated adhesion, we constructed a chimeric

78 f the broad cadherin family (desmogleins and desmocollins) that are linked to the intermediate filame

79 n two classes of cadherins, desmogleins, and desmocollins, that bind to the cytoplasmic protein plako

80 ficking of the desmoplakins, desmoglein, and desmocollin to the cell surface; these proteins show a d

81 Three desmoglein isoforms collaborate with desmocollins to build the adhesive core of desmosomes.

82 The desmocollins, together with the desmogleins, are members

83 Surprisingly none of the desmocollin-transfected cell lines showed significant ad