ライフサイエンスコーパス: desmoglein

1 egulation of KLK5 and abnormal expression of desmoglein 1 (DSG1) and filaggrin, but not PAR2 were ide

2 that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of

3 ated by pathogenic, predominantly IgG4, anti-desmoglein 1 (Dsg1) autoantibodies and is endemic in Lim

4 us (PF), is characterized by pathogenic anti-desmoglein 1 (DSG1) autoantibodies.

5 higus foliaceus (PF), autoantibodies against desmoglein 1 (Dsg1) cause blisters.

6 G4 autoantibody response to the self-antigen desmoglein 1 (Dsg1) cross-reacts with the LJM11 sand fly

7 Desmoglein 1 (Dsg1) is a desmosomal cadherin that is ess

8 ecular specificity to cleave mouse and human desmoglein 1 (Dsg1) once after glutamic acid residue 381

9 istering disease caused by autoantibodies to desmoglein 1 (Dsg1) that cause loss of epidermal cell ad

10 fferentiation-associated proteins, including desmoglein 1 (Dsg1), desmocollin 1 (Dsc1), and keratins

11 ted between extracellular domains 3 and 4 of desmoglein 1 (Dsg1).

12 ed by pathogenic IgG4 autoantibodies against desmoglein 1 (Dsg1).

13 leavage of the desmosomal cadherin component desmoglein 1 (Dsg1).

14 he cutaneous epithelium, and discovered that desmoglein 1 and 2 expression correlated with the state

15 ponents, including desmoplakin, plakoglobin, desmoglein 1 and 2, and desmocollin 1a and 2a.

16 ning of other desmosomal proteins, including desmoglein 1 and 2, plakophilin 2, and plakoglobin.

17 aggrin processing and delayed degradation of desmoglein 1 and corneodesmosin.

18 newborn animals with decreased expression of desmoglein 1 and corneodesmosin.

19 hs in understanding the interactions between desmoglein 1 and plakogloben in staphylococcal-mediated

20 et was coimmunoprecipitated with E-cadherin, Desmoglein 1 and Plakoglobin, suggesting that they form

21 eads to decreased cell surface expression of desmoglein 1 and re-localization of its C terminus diffu

22 is characterized by autoantibody binding to desmoglein 1 and/or 3 (dsg1/dsg3).

23 As tissue damage is mediated by anti-desmoglein 1 antibodies, an initial T cell response is a

24 Collectively, our results identify desmoglein 1 as a novel caspase and metalloproteinase su

25 uring keratinocyte apoptosis and also reveal desmoglein 1 as a previously unrecognized regulator of a

26 Previous work has suggested that desmoglein 1 binds to its catenin partner, plakoglobin,

27 A change in conformation of desmoglein 1 by calcium depletion was shown, with immuno

28 Depletion of calcium from desmoglein 1 completely inhibited its cleavage by exfoli

29 owever, the stoichiometry of the plakoglobin/desmoglein 1 complex does not appear to exceed 2:1.

30 hat UV-induced caspase cleavage of the human desmoglein 1 cytoplasmic tail results in distinct 17- an

31 In contrast, desmoglein 1 defined more differentiated cell population

32 with an increase in corneodesmosomes and in desmoglein 1 expression.

33 cognized syndrome caused by mutations in the desmoglein 1 gene (DSG1).

34 t the complex formed between plakoglobin and desmoglein 1 has an overall molecular weight greater tha

35 l, short hairpin RNA-mediated suppression of desmoglein 1 in differentiated keratinocytes protected c

36 , suggesting that the proper conformation of desmoglein 1 is critical for its cleavage.

37 l that a 276-residue DSCR construct of human desmoglein 1 is intrinsically disordered and forms an in

38 d both by electron microscopy and by reduced desmoglein 1 levels in the stratum corneum (shown by imm

39 The desmoglein 1 membrane proximal region also interacts wit

40 Exfoliative toxin cannot cleave desmoglein 1 pretreated at 56 degrees C or higher or at

41 specificity of exfoliative toxin cleavage of desmoglein 1 resides not only in simple amino acid seque

42 Complementary DNA was isolated from 17 desmoglein 1 specific T cell clones generated from pemph

43 Because cleavage occurs in an area of desmoglein 1 stabilized by calcium, we determined if the

44 th HGF-expressing adenovirus, E-cadherin and Desmoglein 1 were decreased in melanocytes, WM164 and WM

45 Antibodies against desmoglein 1 were detected in 59 of the 60 patients with

46 spase-3 as the preferred enzyme that cleaves desmoglein 1 within its unique repeating unit domain at

47 directed against desmoglein 3 (Dsg3) and/or desmoglein 1(Dsg1).

48 Dsg1 (desmoglein 1) is a member of the cadherin family of Ca(2

49 ation of complexes formed by plakoglobin and desmoglein 1, 2, or 3 are further examined through immun

50 desmoglein 4 shares 41% identity with human desmoglein 1, 37% with human desmoglein 2, and 50% with

51 circulating autoantibodies directed against desmoglein 1, a 160 kDa transmembrane desmosomal molecul

52 ion relied largely upon the up-regulation of desmoglein 1, a desmosomal cadherin that maintains the i

53 Western blotting revealed degradation of desmoglein 1, a key corneodesmosome structural protein,

54 DSG1 encodes desmoglein 1, a major constituent of desmosomes, which c

55 taxis (eotaxin 3, CCL26), barrier molecules (desmoglein 1, DSG1), tissue remodeling (periostin, POSTN

56 highly structured calcium-binding domain of desmoglein 1, resulting in loss of its function.

57 ratinocytes by downregulating E-cadherin and Desmoglein 1, therefore frees melanoma cells from the co

58 WM35, expressed normal level E-cadherin and Desmoglein 1, whereas most melanomas (18 out of 20) expr

59 s foliaceus (PF) possess pathogenic IgG anti-desmoglein 1-(Dsg1) autoantibodies.

60 lysis) and pathogenic autoantibodies against desmoglein 1.

61 ease characterized by autoantibodies against desmoglein 1.

62 mes (CD) as well as CD constituent proteins, desmoglein 1.

63 ssed no E-cadherin and significantly reduced Desmoglein 1.

64 s in the desmosomal proteins desmoplakin and desmoglein 1.

65 CE constituents, including downregulation of desmoglein 1.

66 of junctional integrity through cleavage of desmoglein 1.

67 Some undegraded desmoglein 1/desmocollin 1 redistribute uniformly into c

68 No significant changes in the expression of desmogleins 1 and 2 were detected.

69 creased the protein levels of E-cadherin and desmogleins 1 and 3 by 300, 180, and 40%, respectively.

70 Specific staining of KC for E-cadherin and desmogleins 1 and 3 increased by 235, 228, and 148%, res

71 human desmoglein cDNA sharing homology with desmogleins 1, 2, 3 and we name this desmoglein 4.

72 ression patterns of the desmoglein isotypes, desmogleins 1, 2, and 3 in the cutaneous epithelium, and

73 ein isoforms have been characterized, namely desmogleins 1, 2, and 3 that are expressed in a tissue-

74 us epithelia there are two major isoforms of desmoglein, 1 and 3, with different distributions in epi

75 protease activity, resulting in accelerated desmoglein-1 (DSG-1)/corneodesmosome degradation.

76 y severe skin blistering and pathogenic anti-desmoglein-1 (Dsg1) autoantibodies.

77 Desmoglein-1 (DSG1), a desmosomal protein, maintains the

78 The desmosomal cadherin, desmoglein-1 (DSG1), promotes keratinocyte differentiati

79 ies against the desmosomal core glycoprotein desmoglein-1 (Dsg1).

80 ntibodies against a desmosomal glycoprotein, desmoglein-1 (Dsg1).

81 multiple markers of differentiation (such as desmoglein-1 [Dsg1], keratin-1, and loricrin) and abroga

82 We produced recombinant desmoglein-1 and desmoglein-3, and used them in highly s

83 antibody capable of cross-reacting with both desmoglein-1 and desmoglein-3.

84 to S. aureus showed enhanced degradation of desmoglein-1 and filaggrin, whereas small interfering RN

85 st, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease only.

86 linked immunosorbent assay using recombinant desmoglein-1 and standardized the assay to enable compar

87 In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishman

88 orbed in a concentration-dependent manner by desmoglein-1 but not desmoglein-3.

89 ase in corneodesmosome density and increased desmoglein-1 content, with a decline in serine protease

90 Also antibodies to desmoglein-1 could be absorbed in a concentration-depend

91 A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 oncho

92 barrier function in association with loss of desmoglein-1 expression and has a regulatory role in rep

93 We previously detected IgG antibodies to desmoglein-1 in 97% of patients, but also in 55% of norm

94 PF), autoantibodies against desmoglein-3 and desmoglein-1 induce epidermal cell detachment (acantholy

95 In contrast, beta-catenin binds to desmoglein-1 more weakly than does plakoglobin.

96 Full affinity binding of desmoglein-1 requires sequences C-terminal to the region

97 ), filaggrin, E-cadherin, claudin, occludin, desmoglein-1 was found, independent of CS therapy.

98 paired barrier function (mediated by loss of desmoglein-1), increased production and/or activity of t

99 mosomal junction proteins corneodesmosin and desmoglein-1, was down-regulated by histamine.

100 In PF, desmoglein-1-specific autoantibodies induce blistering.

101 athogenic antibodies to the EC1-2 domains of desmoglein-1.

102 mao Verde differ in IgG subclass response to desmoglein-1.

103 oped world, is mediated by IgG antibodies to desmoglein-1.

104 associated with acquisition of antibodies to desmoglein-1.

105 -dependent manner by desmoglein-3 but not by desmoglein-1.

106 Here we compared the assembly properties of desmoglein 2 (Dsg2) and desmocollin 2 (Dsc2), which are

107 The accumulated levels of desmoglein 2 (Dsg2) and desmocollin 2 increased 1.7-2.0-

108 Ad14p1), use the epithelial junction protein desmoglein 2 (DSG2) as a receptor for infection.

109 t a group of human adenoviruses (HAdVs) uses desmoglein 2 (DSG2) as a receptor for infection.

110 Recently, we identified desmoglein 2 (DSG2) as the main receptor for a group of

111 We recently discovered that desmoglein 2 (DSG2) is a receptor for human adenovirus s

112 The desmosomal cadherin desmoglein 2 (Dsg2) localizes to the intercalated disc c

113 ere enriched with the C-terminal fragment of desmoglein 2 (Dsg2), a desmosomal cadherin often overexp

114 moplakin, plakoglobin, plakophilin 2 (PKP2), desmoglein 2 (DSG2), and desmocollin 2 (DSC2), respectiv

115 in accumulation of the desmosomal cadherin, desmoglein 2 (Dsg2), at cell-cell interfaces accompanied

116 the entire ectodomain of desmosomal cadherin desmoglein 2 (Dsg2), using a combination of small-angle

117 and another Alzheimer's disease risk factor, desmoglein 2 (DSG2).

118 ich binds to the epithelial junction protein desmoglein 2 (DSG2).

119 sm underlying cAMP-mediated strengthening of desmoglein 2 binding was dependent on expression of the

120 Desmoglein 2 gene (DSG2) mutations cause arrhythmogenic

121 Desmoglein 2 modulates extracellular vesicle release fro

122 ular weight greater than that of plakoglobin/desmoglein 2 or plakoglobin/desmoglein 3; however, the s

123 Desmoglein 2 was highly expressed by the least different

124 (JUP), Desmoplakin (DSP), Plakophilin 2, and Desmoglein 2), have been identified in patients with ARV

125 tity with human desmoglein 1, 37% with human desmoglein 2, and 50% with human desmoglein 3.

126 teractions along cell junctions and the mean desmoglein 2-mediated binding forces, whereas N-cadherin

127 e collected at different disease stages from desmoglein 2-mutant mice, a well characterized AC model.

128 In desmoglein 2-mutant mice, cardiomyocyte diameters are no

129 Enhanced desmoglein 2-positive contacts and increased junction le

130 nergic signaling enhances both the number of desmoglein 2-specific interactions along cell junctions

131 yrosine-phosphorylated protein identified as desmoglein 2.

132 (CAR) (Ad2 and Ad5) and the CD46 (Ad35) and desmoglein-2 (Ad7) viral receptors all induce the cGAS/S

133 We have identified desmoglein-2 (DSG-2) as the primary high-affinity recept

134 nd to IEC monolayers and induced cleavage of desmoglein-2 (DSG-2) but not E-cadherin, leading to disr

135 (42%), including desmoplakin (DSP) (n = 6), desmoglein-2 (DSG2) (n = 5), plakophilin-4 (PKP4) (n = 1

136 he palmitoylation of the desmosomal cadherin desmoglein-2 (Dsg2) and characterized the role that palm

137 of transmembrane desmosomal cadherins termed desmoglein-2 (Dsg2) and desmocollin-2 (Dsc2) that affili

138 Desmocollin-2 (Dsc2) and desmoglein-2 (Dsg2) are transmembrane cell adhesion prot

139 Desmoglein-2 (Dsg2) is a desmosomal cadherin that is abe

140 of the other intestinal desmosomal cadherin, desmoglein-2 (Dsg2) that pairs with Dsc2, results in dec

141 akin (n=44; 39%), plakophilin-2 (n=38; 34%), desmoglein-2 (n=30; 26%), and desmocollin-2 (n=1; 1%), w

142 on of chromosome 18 comprising both DSC2 and desmoglein-2 genes.

143 uman intestinal epithelial cells express the desmoglein-2 isoform.

144 rent high-affinity receptors (CAR, CD46, and desmoglein-2), and the magnitude of the cGAS/STING DNA r

145 C caused by mutations in DSG2, which encodes desmoglein-2, a component of the cardiac desmosome.

146 ch disrupting known functional components of desmoglein-2.

147 ibodies (IgG) target the desmosomal cadherin desmoglein 3 (Dsg3) and compromise keratinocyte cell-cel

148 ies primarily targeting desmosomal cadherins desmoglein 3 (DSG3) and DSG1, leading to loss of keratin

149 toantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1.

150 es caused by autoantibodies directed against desmoglein 3 (Dsg3) and/or desmoglein 1(Dsg1).

151 PK activation, whereas the signaling of anti-desmoglein 3 (Dsg3) antibody involved JNK and biphasic p

152 Autoantibodies against desmoglein 3 (Dsg3) have also been detected in sera from

153 autoantibody-mediated disease, in which anti-desmoglein 3 (Dsg3) IgG autoantibodies cause life-threat

154 rder and disorder of the desmosomal cadherin desmoglein 3 (Dsg3) in living cells.

155 ge has been described in B cells reacting to desmoglein 3 (Dsg3) in the autoimmune disease pemphigus

156 or downregulation of the desmosomal cadherin desmoglein 3 (DSG3) in the pathogenesis of PV.

157 ies directed against the desmosomal cadherin desmoglein 3 (Dsg3), the major autoantigen in PV, cause

158 Desmoglein 3 (Dsg3), the pemphigus vulgaris antigen, has

159 ibodies to the keratinocyte adhesion protein desmoglein 3 (Dsg3).

160 e caused by autoantibodies (autoAbs) against desmoglein 3 (Dsg3).

161 well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the

162 the carboxy- terminal cytoplasmic domains of desmoglein 3 are important for targeting it to the desmo

163 a-catenin by 37%, gamma-catenin by 136%, and desmoglein 3 by 300%, whereas pretreatment with 0.25 mm

164 tinocyte cell surface desmocollin 3, but not desmoglein 3 by immunofluorescence, indicating distinct

165 racellular domain of the desmosomal cadherin desmoglein 3 cause potentially fatal blistering of the s

166 These findings indicate that desmoglein 3 clustering and endocytosis are associated w

167 We found that the expression pattern of desmoglein 3 correlated with different types of keratini

168 Desmoglein 3 deficiency in mice leads to a phenotype cha

169 onse to veltuzumab generally correlated with desmoglein 3 enzyme-linked immunosorbent assay index val

170 fundibulum and in epidermal inclusion cysts, desmoglein 3 expression was limited mainly to the basal

171 , these data showed that the perturbation of desmoglein 3 found in the Dsg3bal-Pas mice resulted in d

172 Antibody blockade of desmoglein 3 function in pemphigus vulgaris patients lea

173 Genetic deficiency of desmoglein 3 in mice mimics autoimmunity to desmoglein 3

174 desmoglein 3 in mice mimics autoimmunity to desmoglein 3 in pemphigus vulgaris, with mucosal-dominan

175 e assembly and leads to the incorporation of desmoglein 3 into the desmosome.

176 Desmoglein 3 is a transmembrane component of desmosome c

177 We conclude that binding of plakoglobin to desmoglein 3 is an important step in desmosome assembly

178 localized to the adherens junction, whereas desmoglein 3 is found in desmosomes.

179 the deletion and causing a truncation of the desmoglein 3 polypeptide by 199 amino acids, eliminating

180 generated a myc-tagged truncated Dsg3bal-Pas desmoglein 3 protein and expressed it in keratinocytes.

181 ecause hypomorphic expression of a truncated desmoglein 3 protein led to a spectrum of severe patholo

182 sion of the myc-tagged truncated Dsg3bal-Pas desmoglein 3 protein resulted in a reduction in staining

183 expressing myc-tagged truncated Dsg3bal-Pas desmoglein 3 protein underwent dramatic changes in cell

184 The myc-tagged truncated Dsg3bal-Pas desmoglein 3 protein was found predominantly in the cyto

185 that resulted in expression of a hypomorphic desmoglein 3 protein with a truncation of an extracellul

186 that this region is essential for targeting desmoglein 3 to the desmosome.

187 is issue, we engineered transgenic mice with desmoglein 3 under the control of the involucrin promote

188 3bal-Pas skin, the corresponding protein for desmoglein 3 was completely absent in the oral mucosal e

189 icle, and in cysts arising from these areas, desmoglein 3 was expressed throughout all layers of the

190 Additionally, steady-state levels of desmoglein 3 were decreased and desmosomes were reduced

191 These mice expressed desmoglein 3 with the same distribution in epidermis as

192 via impaired redistribution of desmoplakin, desmoglein 3, desmocollin 3, and E-cadherin to the plasm

193 pattern that may result from autoimmunity to desmoglein 3, desmocollin 3, or both desmosomal cadherin

194 pathology not observed in mice deficient in desmoglein 3, similar human genetic alterations may also

195 nsmembrane and intracellular region of human desmoglein 3, we could show that the cytoplasmic tail is

196 tibodies to the desmosomal adhesion protein, desmoglein 3.

197 those of controls by day 23, as does that of desmoglein 3.

198 with human desmoglein 2, and 50% with human desmoglein 3.

199 are directed against the desmosomal cadherin desmoglein 3.

200 order like that observed for the full-length desmoglein 3.

201 proteins, including the desmosomal cadherin, desmoglein 3.

202 t of plakoglobin/desmoglein 2 or plakoglobin/desmoglein 3; however, the stoichiometry of the plakoglo

203 enic antibodies bind the desmosomal cadherin desmoglein-3 (dsg3), causing epidermal cell-cell detachm

204 ies generated target the desmosomal cadherin desmoglein-3 (Dsg3).

205 e disease mediated by autoantibodies against desmoglein-3 (Dsg3).

206 ies directed against the desmosomal cadherin desmoglein-3 (Dsg3).

207 higus foliaceus (PF), autoantibodies against desmoglein-3 and desmoglein-1 induce epidermal cell deta

208 orbed in a concentration-dependent manner by desmoglein-3 but not by desmoglein-1.

209 popolysaccharide, heat-shock cognate 70, and desmoglein-3 compared with DLE+SLE+ and DLE-SLE+ subject

210 We showed that these antibodies to desmoglein-3 could be absorbed in a concentration-depend

211 s shown that affinity-purified antibodies to desmoglein-3 from patients with pemphigus foliaceus and

212 We detected antibodies to desmoglein-3 in 19 of 276 patients with pemphigus foliac

213 to determine the prevalence of antibodies to desmoglein-3 in patients with pemphigus foliaceus and fo

214 g desmoglein-3, epicutaneous applications of desmoglein-3 induced tolerance that is dependent on LCs.

215 Utilizing a desmoglein-3 mouse model (Dsg3(-/-)) or keratin 5-specif

216 liaceus and fogo selvagem have antibodies to desmoglein-3 that may be involved in the pathogenesis of

217 odies against the desmosomal cadherin, DSG3 (desmoglein-3), cause acantholysis.

218 vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease.

219 We produced recombinant desmoglein-1 and desmoglein-3, and used them in highly sensitive and spec

220 pontaneously to a physiological skin self-Ag desmoglein-3, epicutaneous applications of desmoglein-3

221 ta4 integrin, collagen XVII, E-cadherin, and desmoglein-3, is strongly reduced, whereas, surprisingly

222 ion-dependent manner by desmoglein-1 but not desmoglein-3.

223 of cross-reacting with both desmoglein-1 and desmoglein-3.

224 Among them, Desmoglein 4 (Dsg4) was down-regulated in Smad4-deleted

225 Mutations in desmoglein 4 (DSG4), a novel member of the desmosomal ca

226 The human desmoglein 4 cDNA (3.6 kb) contains an open reading fram

227 of the exon/intron organization of the human desmoglein 4 gene (DSG4) demonstrates that it is compose

228 RT-PCR on multiple tissue cDNA samples that desmoglein 4 has very specific tissue expression in sali

229 The essential role of desmoglein 4 in skin was established by identifying muta

230 We provide evidence that desmoglein 4 is a key mediator of keratinocyte cell adhe

231 Human desmoglein 4 shares 41% identity with human desmoglein 1

232 The mouse desmoglein 4 transcript contains an open reading frame o

233 We identified a cadherin family member, desmoglein 4, which is expressed in the suprabasal epide

234 gy with desmogleins 1, 2, 3 and we name this desmoglein 4.

235 tissue cDNA we have demonstrated that mouse desmogleins 4, 5, and 6 are all expressed in the epiderm

236 The desmoglein 5 transcript contains an open reading frame o

237 ecursor of 1060 amino acid residues, and the desmoglein 6 transcript contains an open reading frame o

238 herin, N-cadherin, VE-cadherin (cadherin-5), desmoglein, alpha, beta and gamma catenin, p120(ctn) and

239 In contrast, the transmembrane proteins desmoglein and desmocollin are efficiently transported t

240 ar interactions of the desmosomal cadherins, desmoglein and desmocollin, are required for epidermal c

241 s of patients with PV express autoAbs toward desmoglein and non-Dsg targets.

242 The desmosomal cadherins, comprising the desmogleins and desmocollins, are calcium-dependent tran

243 ansmembrane components of the desmosome, the desmogleins and desmocollins, are members of the cadheri

244 plasmic domains of the desmosomal cadherins, desmogleins and desmocollins.

245 membrane adhesion molecules and comprise the desmogleins and desmocollins.

246 e presence of desmosomal cadherins, known as desmogleins and desmocollins.

247 s in the stoichiometric relationship between desmogleins and desmocollins.

248 to isoform-specific differences exhibited by desmogleins and desmocollins.

249 osomal cadherin family, which includes three desmogleins and three desmocollins.

250 impairs the trafficking of the desmoplakins, desmoglein, and desmocollin to the cell surface; these p

251 The desmosomal cadherins, desmogleins, and desmocollins mediate strong intercellul

252 Desmogleins are desmosomal cadherins that mediate cell-c

253 d squamous epithelia, such as the epidermis, desmogleins are generally expressed in a differentiation

254 which were distinct for scFvs with different desmoglein-binding specificities.

255 terized, at the genetic level, a novel human desmoglein cDNA sharing homology with desmogleins 1, 2,

256 ed and characterized; pemphigus antigens are desmogleins (cell adhesion molecules in desmosomes), and

257 which is also present in adherens junctions, desmoglein (DSG) 1, 2, 4, and corneodesmosin).

258 PV patients develop pathogenic anti-desmoglein (Dsg) 3 +/- 1 and antimitochondrial antibodie

259 odies against cell surface adhesion proteins desmoglein (Dsg) 3 and Dsg1.

260 d at the surface of keratinocytes, primarily desmoglein (Dsg) 3 and, to a lesser extent, Dsg1.

261 The mPV subset exhibits anti-human desmoglein (Dsg) 3 autoantibodies that fail to recognize

262 It was assumed that PV is caused by anti-desmoglein (Dsg) 3 autoimmunity because absorption of PV

263 or (CAAR), consisting of the PV autoantigen, desmoglein (Dsg) 3, fused to CD137-CD3zeta signaling dom

264 dies against the desmosomal adhesion protein desmoglein (Dsg) 3.

265 ease characterized by autoantibodies against desmoglein (Dsg) 3.

266 us membranes caused by autoantibodies to the desmoglein (DSG) family proteins DSG3 and DSG1, leading

267 determined the feasibility of using an anti-desmoglein (Dsg) mAb, Px44, to deliver a biologically ac

268 ntrast to integrins and classical cadherins, desmoglein (Dsg) molecules are not known to elicit intra

269 ases characterized by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively.

270 ned for desmocollin (DSC)2, occludin (OCLN), desmoglein (DSG)1, tight junction protein 2, and gap jun

271 e levels of the desmosomal adhesion molecule desmoglein (Dsg)3 by reducing its membrane incorporation

272 epletion of the desmosomal adhesion molecule desmoglein (Dsg)3 induced by autoantibodies from patient

273 t is characterized by autoantibodies against desmoglein (Dsg)3, whereas mucosal and skin lesion-produ

274 Desmoglein (Dsg)3-/- (knockout) mice lose hair during te

275 In keratinocytes, several desmoglein (Dsg1-4) and desmocollin (Dsc1-3) isoforms ar

276 ered intercellular attachments are formed by desmogleins (Dsgs) and desmocollins (Dscs), but the natu

277 The desmosomal cadherins, desmogleins (Dsgs) and desmocollins (Dscs), comprise the

278 Desmosomal cadherins, desmogleins (Dsgs) and desmocollins, make up the adhesiv

279 une disease in which antibodies specific for desmogleins (Dsgs) cause loss of keratinocyte cell adhes

280 We conclude that desmoglein expression patterns define compartments of ce

281 cysteine residues are conserved in all four desmoglein family members.

282 cture and function that uniquely defines the desmoglein family of cell adhesion molecules.

283 omolog as well as two additional novel mouse desmoglein genes situated within the mouse cluster.

284 pression of dominant negative E-cadherin and Desmoglein in melanocytes demonstrated that both molecul

285 Since either desmoglein isoform alone can mediate adhesion, the reaso

286 demonstrate that differential expression of desmoglein isoforms affects the major function of epider

287 Three desmoglein isoforms collaborate with desmocollins to bui

288 Until recently, three mouse and three human desmoglein isoforms had been characterized that are expr

289 To date, three human desmoglein isoforms have been characterized, namely desm

290 t study has shown that altering the ratio of desmoglein isoforms influences epidermal barrier functio

291 Here, we examined expression patterns of the desmoglein isotypes, desmogleins 1, 2, and 3 in the cuta

292 e display technologies to isolate human anti-desmoglein monoclonal antibodies from a patient with pem

293 hogenic effects in anti-desmocollin and anti-desmoglein pemphigus, despite their identical clinical p

294 e investigated the roles of both Dsg and non-desmoglein PV antigens.

295 The desmoglein-specific cytoplasmic region (DSCR) is a conse

296 the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies,

297 g that the V(L) is less critical to defining desmoglein specificity.

298 decrease in the detergent-insoluble pool of desmoglein suggested a reduced association with the IF c

299 osphorylated Pg remained associated with the desmoglein tail after both short and long term EGFR acti

300 dulated by the molecular interactions of the desmoglein tail and suggests that these novel regulatory