ライフサイエンスコーパス: desmoglein 1

1 n disease mediated by autoantibodies against desmoglein 1.

2 g in an endemic area have antibodies against desmoglein 1.

3 of junctional integrity through cleavage of desmoglein 1.

4 lysis) and pathogenic autoantibodies against desmoglein 1.

5 ease characterized by autoantibodies against desmoglein 1.

6 mes (CD) as well as CD constituent proteins, desmoglein 1.

7 CE constituents, including downregulation of desmoglein 1.

8 ssed no E-cadherin and significantly reduced Desmoglein 1.

9 s in the desmosomal proteins desmoplakin and desmoglein 1.

10 how that repeats 1-4 are involved in binding desmoglein-1.

11 athogenic antibodies to the EC1-2 domains of desmoglein-1.

12 mao Verde differ in IgG subclass response to desmoglein-1.

13 oped world, is mediated by IgG antibodies to desmoglein-1.

14 associated with acquisition of antibodies to desmoglein-1.

15 -dependent manner by desmoglein-3 but not by desmoglein-1.

16 ation of complexes formed by plakoglobin and desmoglein 1, 2, or 3 are further examined through immun

17 human desmoglein cDNA sharing homology with desmogleins 1, 2, 3 and we name this desmoglein 4.

18 ression patterns of the desmoglein isotypes, desmogleins 1, 2, and 3 in the cutaneous epithelium, and

19 ein isoforms have been characterized, namely desmogleins 1, 2, and 3 that are expressed in a tissue-

20 desmoglein 4 shares 41% identity with human desmoglein 1, 37% with human desmoglein 2, and 50% with

21 circulating autoantibodies directed against desmoglein 1, a 160 kDa transmembrane desmosomal molecul

22 ion relied largely upon the up-regulation of desmoglein 1, a desmosomal cadherin that maintains the i

23 Western blotting revealed degradation of desmoglein 1, a key corneodesmosome structural protein,

24 DSG1 encodes desmoglein 1, a major constituent of desmosomes, which c

25 he cutaneous epithelium, and discovered that desmoglein 1 and 2 expression correlated with the state

26 ponents, including desmoplakin, plakoglobin, desmoglein 1 and 2, and desmocollin 1a and 2a.

27 ning of other desmosomal proteins, including desmoglein 1 and 2, plakophilin 2, and plakoglobin.

28 esmoglein 3 to obtain affinity-purified anti-desmoglein 1 and anti-desmoglein 3 autoantibodies from p

29 In addition, the pathogenic anti-desmoglein 1 and anti-desmoglein 3 autoantibodies in pem

30 By immunoprecipitation, the purified anti-desmoglein 1 and anti-desmoglein 3 showed no cross-react

31 aggrin processing and delayed degradation of desmoglein 1 and corneodesmosin.

32 newborn animals with decreased expression of desmoglein 1 and corneodesmosin.

33 soluble recombinant extracellular domains of desmoglein 1 and desmoglein 3 to obtain affinity-purifie

34 hs in understanding the interactions between desmoglein 1 and plakogloben in staphylococcal-mediated

35 et was coimmunoprecipitated with E-cadherin, Desmoglein 1 and Plakoglobin, suggesting that they form

36 eads to decreased cell surface expression of desmoglein 1 and re-localization of its C terminus diffu

37 is characterized by autoantibody binding to desmoglein 1 and/or 3 (dsg1/dsg3).

38 us epithelia there are two major isoforms of desmoglein, 1 and 3, with different distributions in epi

39 We produced recombinant desmoglein-1 and desmoglein-3, and used them in highly s

40 antibody capable of cross-reacting with both desmoglein-1 and desmoglein-3.

41 to S. aureus showed enhanced degradation of desmoglein-1 and filaggrin, whereas small interfering RN

42 st, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease only.

43 linked immunosorbent assay using recombinant desmoglein-1 and standardized the assay to enable compar

44 No significant changes in the expression of desmogleins 1 and 2 were detected.

45 creased the protein levels of E-cadherin and desmogleins 1 and 3 by 300, 180, and 40%, respectively.

46 Specific staining of KC for E-cadherin and desmogleins 1 and 3 increased by 235, 228, and 148%, res

47 The anti-desmoglein 1 antibodies in pemphigus foliaceus and anti-

48 These findings suggest that the anti-desmoglein 1 antibodies in pemphigus vulgaris are pathog

49 As tissue damage is mediated by anti-desmoglein 1 antibodies, an initial T cell response is a

50 In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishman

51 Collectively, our results identify desmoglein 1 as a novel caspase and metalloproteinase su

52 uring keratinocyte apoptosis and also reveal desmoglein 1 as a previously unrecognized regulator of a

53 The anti-desmoglein 1 autoantibodies in pemphigus vulgaris induce

54 dies; however, the pathogenicity of the anti-desmoglein 1 autoantibodies in pemphigus vulgaris remain

55 of pemphigus vulgaris sera also contain anti-desmoglein 1 autoantibodies; however, the pathogenicity

56 Previous work has suggested that desmoglein 1 binds to its catenin partner, plakoglobin,

57 orbed in a concentration-dependent manner by desmoglein-1 but not desmoglein-3.

58 A change in conformation of desmoglein 1 by calcium depletion was shown, with immuno

59 Depletion of calcium from desmoglein 1 completely inhibited its cleavage by exfoli

60 owever, the stoichiometry of the plakoglobin/desmoglein 1 complex does not appear to exceed 2:1.

61 ase in corneodesmosome density and increased desmoglein-1 content, with a decline in serine protease

62 Also antibodies to desmoglein-1 could be absorbed in a concentration-depend

63 hat UV-induced caspase cleavage of the human desmoglein 1 cytoplasmic tail results in distinct 17- an

64 the E-cadherin extracellular domain and the desmoglein-1 cytoplasmic domain, and these cells formed

65 In contrast, desmoglein 1 defined more differentiated cell population

66 Some undegraded desmoglein 1/desmocollin 1 redistribute uniformly into c

67 protease activity, resulting in accelerated desmoglein-1 (DSG-1)/corneodesmosome degradation.

68 egulation of KLK5 and abnormal expression of desmoglein 1 (DSG1) and filaggrin, but not PAR2 were ide

69 that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of

70 ated by pathogenic, predominantly IgG4, anti-desmoglein 1 (Dsg1) autoantibodies and is endemic in Lim

71 us (PF), is characterized by pathogenic anti-desmoglein 1 (DSG1) autoantibodies.

72 higus foliaceus (PF), autoantibodies against desmoglein 1 (Dsg1) cause blisters.

73 G4 autoantibody response to the self-antigen desmoglein 1 (Dsg1) cross-reacts with the LJM11 sand fly

74 Desmoglein 1 (Dsg1) is a desmosomal cadherin that is ess

75 ecular specificity to cleave mouse and human desmoglein 1 (Dsg1) once after glutamic acid residue 381

76 istering disease caused by autoantibodies to desmoglein 1 (Dsg1) that cause loss of epidermal cell ad

77 fferentiation-associated proteins, including desmoglein 1 (Dsg1), desmocollin 1 (Dsc1), and keratins

78 nds to DP and Dsc1a, and to a lesser extent, desmoglein 1 (Dsg1), while PG binds to Dsg1 and more wea

79 ed by pathogenic IgG4 autoantibodies against desmoglein 1 (Dsg1).

80 leavage of the desmosomal cadherin component desmoglein 1 (Dsg1).

81 ted between extracellular domains 3 and 4 of desmoglein 1 (Dsg1).

82 y severe skin blistering and pathogenic anti-desmoglein-1 (Dsg1) autoantibodies.

83 Desmoglein-1 (DSG1), a desmosomal protein, maintains the

84 he desmosomal cadherins to mediate adhesion, desmoglein-1 (Dsg1), desmocollin-2 (Dsc2a) and plakoglob

85 The desmosomal cadherin, desmoglein-1 (DSG1), promotes keratinocyte differentiati

86 s autoantibodies are desmoglein-3 (Dsg3) and desmoglein-1 (Dsg1), respectively.

87 utoantibodies against the desmosomal antigen desmoglein-1 (Dsg1).

88 ies against the desmosomal core glycoprotein desmoglein-1 (Dsg1).

89 ntibodies against a desmosomal glycoprotein, desmoglein-1 (Dsg1).

90 multiple markers of differentiation (such as desmoglein-1 [Dsg1], keratin-1, and loricrin) and abroga

91 directed against desmoglein 3 (Dsg3) and/or desmoglein 1(Dsg1).

92 taxis (eotaxin 3, CCL26), barrier molecules (desmoglein 1, DSG1), tissue remodeling (periostin, POSTN

93 s foliaceus (PF) possess pathogenic IgG anti-desmoglein 1-(Dsg1) autoantibodies.

94 A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 oncho

95 with an increase in corneodesmosomes and in desmoglein 1 expression.

96 barrier function in association with loss of desmoglein-1 expression and has a regulatory role in rep

97 cognized syndrome caused by mutations in the desmoglein 1 gene (DSG1).

98 t the complex formed between plakoglobin and desmoglein 1 has an overall molecular weight greater tha

99 l, short hairpin RNA-mediated suppression of desmoglein 1 in differentiated keratinocytes protected c

100 nosorbent assay to detect antibodies against desmoglein 1 in serum samples from 60 patients with ende

101 We previously detected IgG antibodies to desmoglein-1 in 97% of patients, but also in 55% of norm

102 paired barrier function (mediated by loss of desmoglein-1), increased production and/or activity of t

103 PF), autoantibodies against desmoglein-3 and desmoglein-1 induce epidermal cell detachment (acantholy

104 , suggesting that the proper conformation of desmoglein 1 is critical for its cleavage.

105 The prevalence of antibodies against desmoglein 1 is high among normal subjects living in an

106 pt that the production of antibodies against desmoglein 1 is initiated by exposure to an unknown envi

107 l that a 276-residue DSCR construct of human desmoglein 1 is intrinsically disordered and forms an in

108 Dsg1 (desmoglein 1) is a member of the cadherin family of Ca(2

109 d both by electron microscopy and by reduced desmoglein 1 levels in the stratum corneum (shown by imm

110 The desmoglein 1 membrane proximal region also interacts wit

111 In contrast, beta-catenin binds to desmoglein-1 more weakly than does plakoglobin.

112 Exfoliative toxin cannot cleave desmoglein 1 pretreated at 56 degrees C or higher or at

113 Full affinity binding of desmoglein-1 requires sequences C-terminal to the region

114 specificity of exfoliative toxin cleavage of desmoglein 1 resides not only in simple amino acid seque

115 and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively.

116 highly structured calcium-binding domain of desmoglein 1, resulting in loss of its function.

117 Complementary DNA was isolated from 17 desmoglein 1 specific T cell clones generated from pemph

118 In PF, desmoglein-1-specific autoantibodies induce blistering.

119 Because cleavage occurs in an area of desmoglein 1 stabilized by calcium, we determined if the

120 ratinocytes by downregulating E-cadherin and Desmoglein 1, therefore frees melanoma cells from the co

121 ), filaggrin, E-cadherin, claudin, occludin, desmoglein-1 was found, independent of CS therapy.

122 mosomal junction proteins corneodesmosin and desmoglein-1, was down-regulated by histamine.

123 th HGF-expressing adenovirus, E-cadherin and Desmoglein 1 were decreased in melanocytes, WM164 and WM

124 Antibodies against desmoglein 1 were detected in 59 of the 60 patients with

125 WM35, expressed normal level E-cadherin and Desmoglein 1, whereas most melanomas (18 out of 20) expr

126 spase-3 as the preferred enzyme that cleaves desmoglein 1 within its unique repeating unit domain at