ライフサイエンスコーパス: desmoglein 3

1 those of controls by day 23, as does that of desmoglein 3.

2 tibodies to the desmosomal adhesion protein, desmoglein 3.

3 with human desmoglein 2, and 50% with human desmoglein 3.

4 are directed against the desmosomal cadherin desmoglein 3.

5 order like that observed for the full-length desmoglein 3.

6 proteins, including the desmosomal cadherin, desmoglein 3.

7 erin, P-cadherin, and a desmosomal cadherin, desmoglein 3.

8 urfaces was eliminated by preadsorption with desmoglein 3.

9 ion-dependent manner by desmoglein-1 but not desmoglein-3.

10 of cross-reacting with both desmoglein-1 and desmoglein-3.

11 well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the

12 mphigus vulgaris and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively.

13 higus foliaceus (PF), autoantibodies against desmoglein-3 and desmoglein-1 induce epidermal cell deta

14 vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease.

15 We produced recombinant desmoglein-1 and desmoglein-3, and used them in highly sensitive and spec

16 1 antibodies in pemphigus foliaceus and anti-desmoglein 3 antibodies in pemphigus vulgaris are pathog

17 the carboxy- terminal cytoplasmic domains of desmoglein 3 are important for targeting it to the desmo

18 affinity-purified anti-desmoglein 1 and anti-desmoglein 3 autoantibodies from pemphigus vulgaris sera

19 n, the pathogenic anti-desmoglein 1 and anti-desmoglein 3 autoantibodies in pemphigus vulgaris had pr

20 orbed in a concentration-dependent manner by desmoglein-3 but not by desmoglein-1.

21 a-catenin by 37%, gamma-catenin by 136%, and desmoglein 3 by 300%, whereas pretreatment with 0.25 mm

22 tinocyte cell surface desmocollin 3, but not desmoglein 3 by immunofluorescence, indicating distinct

23 racellular domain of the desmosomal cadherin desmoglein 3 cause potentially fatal blistering of the s

24 odies against the desmosomal cadherin, DSG3 (desmoglein-3), cause acantholysis.

25 These findings indicate that desmoglein 3 clustering and endocytosis are associated w

26 popolysaccharide, heat-shock cognate 70, and desmoglein-3 compared with DLE+SLE+ and DLE-SLE+ subject

27 We found that the expression pattern of desmoglein 3 correlated with different types of keratini

28 We showed that these antibodies to desmoglein-3 could be absorbed in a concentration-depend

29 Desmoglein 3 deficiency in mice leads to a phenotype cha

30 Many desmosomal components were identified (desmoglein 3, desmocolin A/B, desmoplakin I, plakoglobin

31 via impaired redistribution of desmoplakin, desmoglein 3, desmocollin 3, and E-cadherin to the plasm

32 pattern that may result from autoimmunity to desmoglein 3, desmocollin 3, or both desmosomal cadherin

33 rast, animals mutant for both P-cadherin and desmoglein 3 die before weaning.

34 in neonatal mice, it was proposed that anti-desmoglein 3 (Dsg 3) autoantibody causes PV.

35 presence of autoantibodies directed against desmoglein 3 (Dsg 3), a protein expressed on keratinocyt

36 lity of the purified full-length autoantigen desmoglein 3 (Dsg 3).Therefore, we expressed Dsg 3 using

37 ibodies (IgG) target the desmosomal cadherin desmoglein 3 (Dsg3) and compromise keratinocyte cell-cel

38 ies primarily targeting desmosomal cadherins desmoglein 3 (DSG3) and DSG1, leading to loss of keratin

39 toantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1.

40 es caused by autoantibodies directed against desmoglein 3 (Dsg3) and/or desmoglein 1(Dsg1).

41 PK activation, whereas the signaling of anti-desmoglein 3 (Dsg3) antibody involved JNK and biphasic p

42 phigus vulgaris (PV), autoantibodies against desmoglein 3 (Dsg3) cause loss of cell-cell adhesion of

43 Autoantibodies against desmoglein 3 (Dsg3) have also been detected in sera from

44 autoantibody-mediated disease, in which anti-desmoglein 3 (Dsg3) IgG autoantibodies cause life-threat

45 rder and disorder of the desmosomal cadherin desmoglein 3 (Dsg3) in living cells.

46 ge has been described in B cells reacting to desmoglein 3 (Dsg3) in the autoimmune disease pemphigus

47 or downregulation of the desmosomal cadherin desmoglein 3 (DSG3) in the pathogenesis of PV.

48 the skin mediated by autoantibodies against desmoglein 3 (Dsg3) on epidermal keratinocytes.

49 skin and is caused by autoantibodies against desmoglein 3 (Dsg3) on epidermal keratinocytes.

50 ies directed against the desmosomal cadherin desmoglein 3 (Dsg3), the major autoantigen in PV, cause

51 Desmoglein 3 (Dsg3), the pemphigus vulgaris antigen, has

52 ibodies to the keratinocyte adhesion protein desmoglein 3 (Dsg3).

53 e caused by autoantibodies (autoAbs) against desmoglein 3 (Dsg3).

54 s and pemphigus foliaceus autoantibodies are desmoglein-3 (Dsg3) and desmoglein-1 (Dsg1), respectivel

55 abasilar layers of skin and mucosae and anti-desmoglein-3 (Dsg3) autoantibodies bound to the surface

56 enic antibodies bind the desmosomal cadherin desmoglein-3 (dsg3), causing epidermal cell-cell detachm

57 ies directed against the desmosomal cadherin desmoglein-3 (Dsg3).

58 ies generated target the desmosomal cadherin desmoglein-3 (Dsg3).

59 e disease mediated by autoantibodies against desmoglein-3 (Dsg3).

60 onse to veltuzumab generally correlated with desmoglein 3 enzyme-linked immunosorbent assay index val

61 pontaneously to a physiological skin self-Ag desmoglein-3, epicutaneous applications of desmoglein-3

62 Both P-cadherin and desmoglein 3 expression are restricted to the basal and

63 fundibulum and in epidermal inclusion cysts, desmoglein 3 expression was limited mainly to the basal

64 , these data showed that the perturbation of desmoglein 3 found in the Dsg3bal-Pas mice resulted in d

65 s lesions in neonatal mice, whereas the anti-desmoglein 3 fraction induced pemphigus vulgaris-like le

66 s shown that affinity-purified antibodies to desmoglein-3 from patients with pemphigus foliaceus and

67 Antibody blockade of desmoglein 3 function in pemphigus vulgaris patients lea

68 t of plakoglobin/desmoglein 2 or plakoglobin/desmoglein 3; however, the stoichiometry of the plakoglo

69 Genetic deficiency of desmoglein 3 in mice mimics autoimmunity to desmoglein 3

70 desmoglein 3 in mice mimics autoimmunity to desmoglein 3 in pemphigus vulgaris, with mucosal-dominan

71 We detected antibodies to desmoglein-3 in 19 of 276 patients with pemphigus foliac

72 to determine the prevalence of antibodies to desmoglein-3 in patients with pemphigus foliaceus and fo

73 g desmoglein-3, epicutaneous applications of desmoglein-3 induced tolerance that is dependent on LCs.

74 e assembly and leads to the incorporation of desmoglein 3 into the desmosome.

75 Desmoglein 3 is a transmembrane component of desmosome c

76 We conclude that binding of plakoglobin to desmoglein 3 is an important step in desmosome assembly

77 localized to the adherens junction, whereas desmoglein 3 is found in desmosomes.

78 Thus, desmoglein 3 is identified as a target antigen in intrae

79 ta4 integrin, collagen XVII, E-cadherin, and desmoglein-3, is strongly reduced, whereas, surprisingly

80 Utilizing a desmoglein-3 mouse model (Dsg3(-/-)) or keratin 5-specif

81 at loss of P-cadherin leads to a more severe desmoglein 3 mutant phenotype in the double knockout mic

82 rent defect in epithelial cell adhesion, the desmoglein 3 mutant phenotype resembles that of patients

83 ies labeled a recombinant desmosomal protein desmoglein 3 on immunoblotting and the immunolabeling of

84 the deletion and causing a truncation of the desmoglein 3 polypeptide by 199 amino acids, eliminating

85 generated a myc-tagged truncated Dsg3bal-Pas desmoglein 3 protein and expressed it in keratinocytes.

86 ecause hypomorphic expression of a truncated desmoglein 3 protein led to a spectrum of severe patholo

87 sion of the myc-tagged truncated Dsg3bal-Pas desmoglein 3 protein resulted in a reduction in staining

88 expressing myc-tagged truncated Dsg3bal-Pas desmoglein 3 protein underwent dramatic changes in cell

89 The myc-tagged truncated Dsg3bal-Pas desmoglein 3 protein was found predominantly in the cyto

90 that resulted in expression of a hypomorphic desmoglein 3 protein with a truncation of an extracellul

91 ion, the purified anti-desmoglein 1 and anti-desmoglein 3 showed no cross-reactivity.

92 pathology not observed in mice deficient in desmoglein 3, similar human genetic alterations may also

93 liaceus and fogo selvagem have antibodies to desmoglein-3 that may be involved in the pathogenesis of

94 lgaris (PV) is mediated by autoantibodies to desmoglein 3, the pemphigus vulgaris antigen (PVA).

95 nt extracellular domains of desmoglein 1 and desmoglein 3 to obtain affinity-purified anti-desmoglein

96 that this region is essential for targeting desmoglein 3 to the desmosome.

97 is issue, we engineered transgenic mice with desmoglein 3 under the control of the involucrin promote

98 3bal-Pas skin, the corresponding protein for desmoglein 3 was completely absent in the oral mucosal e

99 icle, and in cysts arising from these areas, desmoglein 3 was expressed throughout all layers of the

100 nsmembrane and intracellular region of human desmoglein 3, we could show that the cytoplasmic tail is

101 Additionally, steady-state levels of desmoglein 3 were decreased and desmosomes were reduced

102 These mice expressed desmoglein 3 with the same distribution in epidermis as