ライフサイエンスコーパス: desmoplastic

1 s with low PDGF, though tumorigenic, are non-desmoplastic.

2 appears to be related more to the degree of desmoplastic activity and cellular proliferation than ne

3 mpanied by hyperplastic changes in cells and desmoplastic alterations in the surrounding stroma.

4 The xenografts are desmoplastic and comprised of 30% myofibroblasts and 60

5 D, and one tumor showed combined features of desmoplastic and conventional.

6 atty acid translocase CD36, which is seen in desmoplastic and disease-free high mammographic density

7 Malignant cells drive the generation of a desmoplastic and immunosuppressive tumor microenvironmen

8 r analysis, including 38 classic, 30 nodular desmoplastic, and 18 large-cell anaplastic (LCA) medullo

9 cancers with Snail1(+) CAF tended to exhibit desmoplastic areas with anisotropic fibers, lymph node i

10 ma in neoadjuvant chemotherapy-treated human desmoplastic cancers and orthotopic tumor xenografts rev

11 roblasts (CAF) are abundant in the stroma of desmoplastic cancers where they promote tumor progressio

12 CCAs are also highly desmoplastic cancers with a tumor microenvironment rich

13 onse and extending survival of mice carrying desmoplastic cancers.

14 RETp was assessed in 71 non-desmoplastic cutaneous melanomas (non-DMs) and 70 desmop

15 incidence of tumors closely resembling human desmoplastic ductal cholangiocarcinomas in their morphol

16 ation of the composition and distribution of desmoplastic elements and T-cell infiltration is necessa

17 cinoma (CCA) is characterized by an abundant desmoplastic environment.

18 CAF apoptosis, diminishing expression of the desmoplastic extracellular matrix protein tenascin C, su

19 om 19 patients diagnosed with desmoid tumor, desmoplastic fibroma, periosteal desmoid tumor, osteofib

20 prior diagnosis of liver lesions, had proved desmoplastic hepatic metastases that resembled cirrhosis

21 est patients where they were associated with desmoplastic histology.

22 ification of these mutations among the dense desmoplastic host reaction characteristic of primary pan

23 or vascular density and restrained growth of desmoplastic human lung cancer xenografts and syngeneic

24 This dramatic desmoplastic ICC-like phenotype, which was not observed

25 alignant grading in this 3D culture model of desmoplastic ICC.

26 arcinoma (2 children), ependymoma (1 child), desmoplastic infantile ganglioglioma (2 children), and m

27 y epithelial cells that subsequently induces desmoplastic-like phenotypes in neighboring fibroblasts.

28 Desmoplastic malignancies such as cholangiocarcinoma (CC

29 ns were responsible for a high proportion of desmoplastic medulloblastoma in children younger than 3

30 studies have established that patients with desmoplastic melanoma (DM) have thicker primary tumors.

31 Desmoplastic melanoma (DM) is a variant of melanoma char

32 DM behaves differently from conventional non-desmoplastic melanoma (NDM).

33 on burden (median of 62 mutations/Mb) ranked desmoplastic melanoma among the most highly mutated canc

34 Desmoplastic melanoma is an uncommon variant of melanoma

35 plastic cutaneous melanomas (non-DMs) and 70 desmoplastic melanomas (DMs).

36 Melanocytic nevus cells in the dermis and desmoplastic melanomas often display characteristics of

37 ome and high-coverage exome sequencing of 20 desmoplastic melanomas, followed by targeted sequencing

38 inoma (PDAC) is characterized by a prominent desmoplastic microenvironment that contains many differe

39 al adenocarcinoma (PDAC) exists in a complex desmoplastic microenvironment, which includes cancer-ass

40 e-dependent reduction in stromal collagen in desmoplastic models of human breast, pancreatic, and ski

41 Rather, desmoplastic murine stroma dominates the xenograft micro

42 omas, 34 medulloblastomas (23 classic, eight desmoplastic-nodular, two large cell, one anaplastic), 1

43 and OS were both 89% (95% CI, 67 to 100) for desmoplastic/nodular (n = 11), 61% (95% CI, 51 to 71) an

44 Histology (hazard ratio, 0.19 for desmoplastic/nodular and 45.97 for large-cell/anaplastic

45 a with extensive nodularity, four of 20 with desmoplastic/nodular medulloblastomas, and one of 108 wi

46 Analysis showed that the desmoplastic/nodular subtype was a favorable factor in p

47 ure studies will use histopathologic typing (desmoplastic/nodular versus nondesmoplastic/nodular) to

48 matrix (ECM) proteins, which are abundant in desmoplastic pancreatic tumor, are as potent as growth f

49 ng drives a minority of MB, correlating with desmoplastic pathology and favorable outcome.

50 mour cell Wnt7a expression correlates with a desmoplastic, poor-prognosis stroma and poor patient out

51 ocarcinoma (PDAC) is the presence of a dense desmoplastic reaction (stroma) that impedes drug deliver

52 ng collagen-rich milieu and suggest that the desmoplastic reaction actively contributes to PDAC progr

53 s undertaken to test the hypothesis that the desmoplastic reaction alters PDAC gene expression and ce

54 lar and molecular interactions mediating the desmoplastic reaction and aggressive malignancy of mass-

55 le myofibroblasts that are implicated in the desmoplastic reaction and metastatic growth.

56 We show here that this desmoplastic reaction generates inordinately high inters

57 thelial-stromal interactions responsible for desmoplastic reaction in breast cancer using cultured 3T

58 s contained large hypertrophic cytoplasm and desmoplastic reaction in the prostatic intra-epithelial

59 In summary, desmoplastic reaction primarily occurs via the action of

60 pic culture model reproduced key features of desmoplastic reaction that closely mimicked those of the

61 Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflamma

62 therapeutic approaches to block the stromal desmoplastic reaction that likely plays an important rol

63 plays a predominant role in the formation of desmoplastic reaction through the synthesis of connectiv

64 However, when cases with extensive desmoplastic reaction were excluded, a statistically sig

65 und malignant breast epithelial cells (i.e., desmoplastic reaction) arises from the breast adipose ti

66 ollowing histologic factors: neovascularity, desmoplastic reaction, cellular proliferation and mitoch

67 renchymal changes, which include peritumoral desmoplastic reaction, inflammatory cell infiltration, a

68 a thick tumor border containing peritumoral desmoplastic reaction, peritumoral inflammation, and vas

69 fibrotic reaction around the tumor known as desmoplastic reaction.

70 a pronounced collagen-rich fibrosis known as desmoplastic reaction; however, the role of fibrosis in

71 expression studies in tumours accompanied by desmoplastic reactions.

72 a in cirrhotic liver tissues as well as with desmoplastic regions of human HCC samples.

73 ombinant GRN alone was sufficient to promote desmoplastic responding tumor growth.

74 in pancreatic cancer cell lines and the host desmoplastic response in the resected pancreatic cancer

75 The desmoplastic response to human breast carcinoma is a hos

76 ression data primarily mirrors the prominent desmoplastic response to the infiltrating neoplasm.

77 stromal and/or angioendothelial cells of the desmoplastic response to the invasive tumor, and four of

78 sive pancreatic cancers and their associated desmoplastic response, we performed in situ hybridizatio

79 s characterized by an exuberant inflammatory desmoplastic response.

80 fferences in gene expression within the host desmoplastic response.

81 pecific or organ-specific differences in the desmoplastic responses.

82 One patient (desmoplastic round cell tumor [DSRCT]) achieved a confir

83 arcomas, two alveolar rhabdomyosarcomas, two desmoplastic round cell tumors, and one each of infantil

84 sarcoma (SS), clear cell sarcoma (CCS), and desmoplastic small round cell tumor (DSRCT) are soft-tis

85 Desmoplastic small round cell tumor (DSRCT) is a rare di

86 Desmoplastic small round cell tumor (DSRCT) is a rare sa

87 Desmoplastic small round cell tumor (DSRCT) is an abdomi

88 Desmoplastic small round cell tumor (DSRCT) is defined b

89 This translocation underlies desmoplastic small round cell tumor (DSRCT), which is no

90 One patient each with hepatoblastoma or desmoplastic small round cell tumor achieved a partial r

91 Eleven of 14 patients with desmoplastic small round cell tumor had primary abdomina

92 one primitive neuroectodermal tumor, and one desmoplastic small round cell tumor).

93 ry site are characteristic of intraabdominal desmoplastic small round cell tumor.

94 nslocation EWSR1-WT1 found in the aggressive desmoplastic small round cell tumor.

95 phroma, dermatofibrosarcoma protuberans, and desmoplastic small round cell tumor; one sarcoma predisp

96 cells, the only available in vitro model for Desmoplastic Small Round Cell Tumors (DSRCT), while havi

97 with metastatic Ewing family tumors (EFT) or desmoplastic small round cell tumors (DSRCT).

98 yosarcomas, 28 of 29 osteosarcomas, 35 of 37 desmoplastic small round cell tumors, 2 of 3 synovial sa

99 related primitive neuroectodermal tumors and desmoplastic small round cell tumors.

100 11;22)(p13;q12) and descriptively designated desmoplastic small round-cell tumor (DSRCT) are a distin

101 is the defining chromosomal translocation in desmoplastic small round-cell tumors (DSRCT), a rare but

102 The desmoplastic stroma comprises many inflammatory cells, i

103 t of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated fibrobl

104 d molecular information sufficient to induce desmoplastic stroma differentiation of normal fibroblast

105 situ transcript labeling to characterize the desmoplastic stroma induced by infiltrating ductal carci

106 iated immunosuppressive cells and a uniquely desmoplastic stroma that functions as a barrier to T cel

107 Desmoplastic stroma, a consistent hallmark of PDAC, has

108 ast tumors are characterized by an extensive desmoplastic stroma, abundantly populated by fibroblasts

109 r-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progress

110 tology, become hypovascular and accumulate a desmoplastic stroma, ultimately recapitulating the prima

111 trated that organoid-activated CAFs produced desmoplastic stroma.

112 PDAC), drives formation of a fibroblast-rich desmoplastic stroma.

113 tumors that form with a myofibroblast-rich, desmoplastic stroma.

114 ancreatic cancer is characterized by densely desmoplastic stroma.

115 in combination with gemcitabine depleted the desmoplastic stroma.

116 ty of neoplastic cells embedded in a densely desmoplastic stroma.

117 ETV1 is critical in the desmoplastic stromal expansion and metastatic progressio

118 l cancer and the induction of its associated desmoplastic stromal niche.

119 The characteristic desmoplastic stromal reaction of pancreatic adenocarcino

120 examination revealed osteolysis and a strong desmoplastic stromal response, which indicated intense s

121 PC3 and LNCaP bone tumors showed a desmoplastic stromal response, which indicated intense s

122 aplasia and ductal dysplasia with remarkable desmoplastic stromal responses in all 25 bitransgenic mi

123 Cutaneous melanomas, particularly the desmoplastic subtype, are highly neurotropic; thus we so

124 ly found in cutaneous melanoma, particularly desmoplastic subtypes, and responds to GDNF inducing eve

125 ow thickness, 3 of which were histologically desmoplastic; the other 2 had nodular components.

126 Using cholangiocarcinoma as a desmoplastic tumor model, we investigated the sensitivit

127 fficacy of nanotherapeutics in patients with desmoplastic tumors.

128 heterogeneous NP distribution in stroma-rich desmoplastic tumors; namely the abnormal tumor vasculatu

129 -95) for classic histology, 77% (49-100) for desmoplastic tumours, and 57% (33-80) for large-cell ana