ライフサイエンスコーパス: desmosome

1 dium channel, gap junctions, and the cardiac desmosome.

2 of the intercellular adhesive junction, the desmosome.

3 provide new insight into Perp's role in the desmosome.

4 ble scaffold for cytoplasmic assembly at the desmosome.

5 des desmoglein-2, a component of the cardiac desmosome.

6 essential for targeting desmoglein 3 to the desmosome.

7 lein 3 are important for targeting it to the desmosome.

8 l is sufficient to target the protein to the desmosome.

9 though keratin filaments no longer anchor at desmosomes.

10 esive core of intercellular junctions called desmosomes.

11 of adherens junctions, tight junctions, and desmosomes.

12 ive core of intercellular junctions known as desmosomes.

13 are transmembrane cell adhesion proteins of desmosomes.

14 ions, cadherin-based adherens junctions, and desmosomes.

15 e adjacent myocardium with gap junctions and desmosomes.

16 ARVC, at least in a subset, is a disease of desmosomes.

17 sistent with the absence of alpha-catenin in desmosomes.

18 usion of beta-catenin and alpha-catenin from desmosomes.

19 et of Exocyst complexes that are enriched at desmosomes.

20 in structural integrity in tissues that lack desmosomes.

21 in the cytoplasm and translocate to nascent desmosomes.

22 to core components of adherens junctions or desmosomes.

23 odulating adhesive strength and stability of desmosomes.

24 e change in the known protein composition of desmosomes.

25 e cohesive than cells with calcium-dependent desmosomes.

26 ort for the concept of hyper-adhesiveness in desmosomes.

27 ncorporated into both adherens junctions and desmosomes.

28 structure, including adherens junctions and desmosomes.

29 er of the p120ctn subfamily that is found in desmosomes.

30 pates in cell-cell adhesion mediated through desmosomes.

31 selective disruption of tight junctions and desmosomes.

32 plakophilin 1, is integrated into functional desmosomes.

33 are essential for the cell adhesive role of desmosomes.

34 hair follicles, or in the ultrastructure of desmosomes.

35 decorating the extracellular faces of split desmosomes.

36 led dilated intercellular spaces and reduced desmosomes.

37 herens junctions and desmosomal cadherins in desmosomes.

38 hose of the sarcomere, the cytoskeleton, and desmosomes.

39 electron tomography reconstructions of human desmosomes.

40 y inducing calcium-independent hyperadhesive desmosomes.

41 e causes structural alterations of epidermal desmosomes.

42 horylation and subsequent destabilization of desmosomes.

43 minantly on the interaction of keratins with desmosomes.

44 cluding the formation of tight junctions and desmosomes, abolished invasiveness, and reduced cell mot

45 Intercalated discs composed of desmosomes, adherens junctions, and gap junctions provid

46 Furthermore, PKP-1 expression transforms desmosome adhesion from a calcium-dependent to a calcium

47 Perp localizes specifically to desmosomes, adhesion junctions important for tissue inte

48 st complex in the assembly or maintenance of desmosomes, adhesive junctions that link intermediate fi

49 s and connexin 43 in the skin, and result in desmosome aggregation, widening of intercellular spaces,

50 ese findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation

51 The pathways driving desmosome and adherens junction assembly are temporally

52 tions confirms that ARVC is a disease of the desmosome and cell junction.

53 ike junctions display structural features of desmosome and gap junctions, but its function at the BTB

54 revealed that K14(+) cells were enriched for desmosome and hemidesmosome adhesion complex genes, and

55 as galvanized interest in the biology of the desmosome and its interactions with other junctional mol

56 Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell-cell adhesion.

57 re, we review the molecular blueprint of the desmosome and models for assembling its protein componen

58 gene, which encodes a major component of the desmosome and the adherens junction, had been identified

59 p-1 armadillo repeat domain localized to the desmosome and the cytosol.

60 Desmosomes and adherens junctions are intercellular adhe

61 s revealed the disruption of the assembly of desmosomes and adherens junctions in Jup mutant epidermi

62 Plakoglobin is a component of both desmosomes and adherens junctions located at the interca

63 lar junctions formed by cadherins, including desmosomes and adherens junctions, comprise two dimensio

64 Mechanical continuity is provided by desmosomes and adherens junctions, while gap junctions p

65 occurs for the adhesive function provided by desmosomes and adherens junctions.

66 ization of tight junctions, deterioration of desmosomes and basement membrane (BM), and hyperbranchin

67 lar prion protein (PrP(c)) is a component of desmosomes and contributes to the intestinal barrier fun

68 as accompanied by a loss of desmoplakin from desmosomes and decreased adhesive strength following 18-

69 us vulgaris (PV) IgG is reduced in maturated desmosomes and dependent on PKC signaling.

70 er disruption, mediated in part by defective desmosomes and dysregulated transforming growth factor b

71 Desmosomes and gap junctions are distinct structural com

72 onents of specialized cell junctions such as desmosomes and hemidesmosomes are mediated through the s

73 ll and cell-matrix adhesion complexes, i.e., desmosomes and hemidesmosomes, respectively.

74 cardiomyocytes to maintain the integrity of desmosomes and intermediate filament networks in vitro a

75 tosis with genistein prevented disruption of desmosomes and loss of adhesion in the presence of PV Ig

76 iation, the presence of junctional complexes/desmosomes and microvilli, and the production of membran

77 s represent the fundamental adhesive unit of desmosomes and provide a structural framework for unders

78 highlights the tissue-specific functions of desmosomes and reveals that the canonical functions for

79 rm-repeat proteins that can be found in both desmosomes and the nucleus.

80 altering the dynamics of Dsg3 assembly into desmosomes and the turnover of cell surface pools of Dsg

81 play a critical role in the organization of desmosomes and tissue integrity.

82 localizes with periplakin and desmoplakin at desmosomes and with periplakin at the interdesmosomal pl

83 are desmogleins (cell adhesion molecules in desmosomes), and pemphigoid antigens are found in hemide

84 Coated pits, junctional complexes, desmosomes, and basement membranes appeared normal in mu

85 -ATPase in the formation of tight junctions, desmosomes, and epithelial polarity with the use of the

86 terations in tight junctions (TJ), adherens, desmosomes, and gap junctions, suggesting perturbations

87 ns (TJs), basal ectoplasmic specializations, desmosomes, and gap junctions.

88 developed brush borders, tight junctions and desmosomes, and goblet and enteroendocrine cells were pr

89 mimics the toxin-cleaved cadherin, disrupts desmosomes, and reduces the mechanical integrity of kera

90 ricosities were rich in mitochondria and had desmosome- and hemidesmosome-like junctions with other a

91 Since desmosomes appear early in mouse tissue development we h

92 cell-cell adhesion is normally reduced, and desmosomes are absent.

93 Desmosomes are adhesive intercellular junctions prominen

94 Desmosomes are adhesive junctions that provide mechanica

95 Desmosomes are anchoring junctions that exist in cells t

96 We show that epidermal desmosomes are calcium-dependent until embryonic day 12

97 Desmosomes are cell adhesion junctions required for the

98 Desmosomes are cell-cell adhesion structures that integr

99 Desmosomes are cell-cell junctions that maintain tissue

100 Desmosomes are critical elements of intercellular juncti

101 novel target of AHR signaling and show that desmosomes are critical for AHR agonists to block branch

102 Desmosomes are dynamic junctions between cells that main

103 Desmosomes are essential adhesion structures in most epi

104 Desmosomes are highly specialized anchoring junctions th

105 Desmosomes are intercellular adhesive junctions and atta

106 Desmosomes are intercellular adhesive junctions that imp

107 Desmosomes are macromolecular cell-cell junctions that p

108 ws that HaCaT cells with calcium-independent desmosomes are more cohesive than cells with calcium-dep

109 ntegrity, and numerous structural defects in desmosomes are observed in Perp-deficient skin, suggesti

110 Desmosomes are prominent adhesive junctions present betw

111 However, the notion that desmosomes are static structures that exist simply to gl

112 ocollins (DSCs), transmembrane components of desmosomes, are regulated at the transcriptional level.

113 which is accompanied by severe disruption of desmosome as well as costamere architecture and composit

114 are more extended in wild type than knockout desmosomes, as if intermediate filament connections prod

115 Without keratins, desmosomes assemble but are endocytosed at accelerated r

116 o protein plakophilin 3 (Pkp3) mediates both desmosome assembly and E-cadherin maturation through Rap

117 isorder and shown to play important roles in desmosome assembly and organization.

118 The mechanisms controlling desmosome assembly and remodeling in epithelial and card

119 nocytes largely through its contributions to desmosome assembly and structure.

120 Nguyen et al. demonstrate a role for Perp in desmosome assembly and trafficking and pemphigus IgG-med

121 at SERCA2-deficiency is sufficient to impede desmosome assembly and weaken intercellular adhesive str

122 derived cell lines was sufficient to disrupt desmosome assembly and weaken intercellular adhesive str

123 on of truncated Dsg2 protein interferes with desmosome assembly and/or maintenance to disrupt cell-ce

124 koglobin, suggesting that p0071 may regulate desmosome assembly by controlling plakoglobin availabili

125 Dsg1.myc, but not Dsc1a, Dsc1b, disrupted desmosome assembly in a cell-type-specific manner, and d

126 esults suggest that EGFR inhibition promotes desmosome assembly in oral squamous cell carcinoma cells

127 Instead, impaired adhesion through aberrant desmosome assembly may explain the diminished tumor deve

128 ent to rescue the defective DP localization, desmosome assembly, and intercellular adhesive strength

129 rnalization of newly synthesized Dsg3 during desmosome assembly, correlating with their pathogenic ac

130 nction assembly but dramatically compromised desmosome assembly, resulting in keratin filament retrac

131 e data suggest that in addition to mediating desmosome assembly, the nuclear pool of Pkp can influenc

132 , a known regulator of DP-IF association and desmosome assembly, to the plasma membrane by up to 70%.

133 During calcium-induced desmosome assembly, treatment of primary human keratinoc

134 ulate DP-IF interactions required for normal desmosome assembly.

135 contribute to actin-dependent regulation of desmosome assembly.

136 Dsg3, thereby driving Dsg3 biosynthesis and desmosome assembly.

137 ey may also participate in the regulation of desmosome assembly.

138 termine the role of plakophilin-1 in de novo desmosome assembly.

139 cruitment of desmoplakin to the membrane and desmosome assembly.

140 ide a structural framework for understanding desmosome assembly.

141 ese effects, indicating a key role for PG in desmosome assembly.

142 tion, suggesting that EGFR blockade promotes desmosome assembly.

143 erin is apparently not sufficient to disrupt desmosome assembly.

144 e, promoting its activation and facilitating desmosome assembly.

145 e we identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (C

146 ay provide novel treatments for PV and other desmosome-associated blistering diseases.

147 This work reveals essential desmosome-associated components that control cortical mi

148 on the function of the adherens junction and desmosome-associated protein plakoglobin is unknown.

149 caused late depletion of Dsg3 from preformed desmosomes at 24 hours, with effects on multiple desmoso

150 Desmosomes at blister sites were occasionally split, wit

151 ace through costameres at the sarcolemma and desmosomes at intercalated disks.

152 some signaling may be effective for treating desmosome autoimmune blistering disorders.

153 The molecular components of desmosomes belong to the cadherin superfamily, the plaki

154 ve junctions and discovered the formation of desmosomes between the invading and entotic cells.

155 lly in intestinal epithelia and localizes to desmosomes but not tight junctions.

156 lost from the centrosome and is recruited to desmosomes by desmoplakin (DP).

157 lapse of the cytoskeleton and disassembly of desmosomes caused by upstream events involving Src and E

158 isease; and arrhythmogenic cardiomyopathy as desmosome, cell junction disease.

159 Similarly, trophectodermal desmosomes change from calcium-dependence to hyper-adhes

160 Desmosomes change to a lower affinity, calcium-dependent

161 l et al. (2014) now show that the structural desmosome complex participates in targeted trafficking o

162 Desmoglein 3 is a transmembrane component of desmosome complexes that mediate epidermal cell-to-cell

163 Plakophilin 2 (PKP2), a desmosome component, modulates the activity and localiza

164 a key signaling event, phosphorylation of a desmosome component, PKP1 (plakophilin-1) by RIPK4 (rece

165 maintenance of adherens junctions and other desmosome components at the plasma membrane.

166 dium is underscored by frequent mutations of desmosome components found in human patients and animal

167 Silencing CSN or desmosome components shifts the balance of EGFR modifica

168 In complex epithelia, desmosomes contain multiple representatives of the desmo

169 skeleton-unbound and a cytoskeleton-anchored desmosome-containing pool revealed that Dsg3, in contras

170 ts the cellular and molecular biology of the desmosome, current knowledge on the relation of desmosom

171 in accordance with premature dissolution of desmosomes, demonstrated both by electron microscopy and

172 of microtubules to cell-cell junctions in a desmosome-dependent manner.

173 and DP as central players in coordination of desmosome-dependent TGF-beta1/p38 MAPK signaling in card

174 These mutations involve proteins that form desmosomes, directly implicating altered cellular biomec

175 Three phases of desmosome disassembly were distinguished.

176 n in response to adhesion formation, altered desmosome distribution, and mechanically defective adhes

177 i-Dsg antibodies prevent assembly of nascent desmosomes due to steric hindrance, thus rendering acant

178 age likely contributes to the dismantling of desmosomes during keratinocyte apoptosis and also reveal

179 Our findings support a functional role for desmosomes during mammary morphogenesis and also in bloc

180 activation accelerated DP redistribution to desmosomes during the first hour of junction assembly, w

181 on status of desmosomal cadherins can affect desmosome dynamics.

182 ein palmitoylation as a mechanism regulating desmosome dynamics.

183 inant inheritance, reduced penetrance, and 7 desmosome-encoding causative genes are known.

184 merase chain reaction (PCR) amplification of desmosome-encoding genes was performed, PCR products wer

185 all of the proteins necessary to assemble a desmosome, except plakophilin-1.

186 ts (IFs) to sites of intercellular adhesion, desmosomes facilitate formation of a supercellular scaff

187 ilament cytoskeleton into the cell membrane, desmosomes facilitate the maintenance of cell shape and

188 Desmosomes first assemble in the E3.5 mouse trophectoder

189 oxin caused actin rearrangement and impaired desmosome formation, consistent with impaired barrier fu

190 te the balance between adherens junction and desmosome formation.

191 that a novel Nrf2-miR-29-Dsc2 axis controls desmosome function and cutaneous homeostasis.

192 r human genetic alterations may also disrupt desmosome function and induce a disease course distinct

193 ng protein desmoplakin (DP) is essential for desmosome function and tissue integrity, but its role in

194 Loss of desmosome function is associated with severe congenital

195 Desmosome function is inseparably linked to structure, a

196 standing the critical role of desmoplakin in desmosome function.

197 ain still allowed its incorporation into the desmosome, further truncation, leaving only the intracel

198 Over 50% of affected individuals have desmosome gene mutations, most commonly in PKP2, encodin

199 blished in simple epithelia, the function of desmosomes has not been addressed.

200 A fundamental difference is that desmosomes have a highly ordered structure in their extr

201 philin-2, a gene highly expressed in cardiac desmosomes, have been shown to cause ARVC.

202 In stratified epithelia, desmosomes impart mechanical strength to tissues by orga

203 Desmosomes in adult tissues are termed hyper-adhesive be

204 bilisation is one of several roles played by desmosomes in animal development.

205 Electron microscopy showed smaller and fewer desmosomes in cells expressing mutant plakoglobin.

206 ocyte line HaCaT acquire calcium-independent desmosomes in confluent culture.

207 ly, localizes to both adherens junctions and desmosomes in epithelial cells and exhibits homology to

208 icroscopy demonstrated a lack of well-formed desmosomes in keratinocytes treated with pathogenic comp

209 ociation and fosters Ca(2+) insensitivity of desmosomes in keratinocytes, presumably by rendering DP

210 Dsc2 impairs the formation of hyper-adhesive desmosomes in keratinocytes, whereas Dsc2 overexpression

211 The importance of desmosomes in maintaining the homeostasis of the myocard

212 mouse skin to visualize the organization of desmosomes in situ.

213 microscopy identified widened and distorted desmosomes in the ARVC-hiPSC-CMs.

214 , we identified Nrf2 as a novel regulator of desmosomes in the epidermis through the regulation of mi

215 5.5 to E16.5, and the cornified envelope and desmosomes in the newborn mice were ultrastructurally no

216 Desmosomes in tissues are resistant to disruption by che

217 protein desmoplakin (DP) into newly forming desmosomes, in part by disrupting PKC-dependent regulati

218 tations in several components of the cardiac desmosome including plakophilin-2 (PKP2), the most preva

219 genes encoding cell adhesion proteins of the desmosome, including plakoglobin (JUP).

220 sed DSC2 protein plays a role in maintaining desmosome integrity and function.

221 encodes desmoplakin, a primary component of desmosomes, intercellular adhesion junctions most abunda

222 sduction machinery; however, the role of the desmosome-intermediate filament (DSM-IF) network is poor

223 all layers of the skin, focal detachment of desmosomes into the intercellular spaces, and perinuclea

224 en calcium-dependent and calcium-independent desmosomes involves no quantitative change in the known

225 ce of plakophilin (PKP)2, a component of the desmosome, is essential for the proper function and dist

226 Although skeletal muscle lacks desmosomes, it contains multiple desmosomal components,

227 hesion between epidermal cells, breakdown of desmosome-keratin filaments, and abnormal keratinization

228 3 and PKP2 form a protein complex within the desmosome-like junction to regulate cell adhesion at the

229 , basal ectoplasmic specialization (ES), and desmosome-like junction.

230 ls of junction proteins of TJ, basal ES, and desmosome-like junction.

231 uch as cell-cell intermediate filament-based desmosome-like junctions and cell-cell actin-based adher

232 ut keratinocytes form substantial numbers of desmosome-like junctions and have a relatively normal in

233 Desmosome-like junctions display structural features of

234 Electron microscopy revealed absence of desmosome-like structures and regional loss of intercala

235 r blocking of endocytosis reconstituted both desmosome localization at the plasma membrane and epithe

236 ight junctions become calcium-independent as desmosomes mature.

237 Desmosomes mediate intercellular adhesion through desmos

238 To better understand how PV IgG alters desmosome morphology and function in vivo, biopsies from

239 Perp is a component of the desmosomes, multiprotein complexes involved in cell-to-c

240 ions, and gap junctions (GJs), together with desmosomes near the basement membrane, constitute the bl

241 In addition, desmosome numbers are normal, but their inner plaques an

242 established, the significance of keratins in desmosome organization has not been fully resolved.

243 koglobin levels rescues cadherin expression, desmosome organization, and functional adhesion in cells

244 protein (P-cadherin) and eight components of desmosomes (plakophilin (PKP) 1 and 2, desmoplakin, plak

245 whereas sustained RhoA activity compromised desmosome plaque maturation.

246 that PKP2 loss prevents the incorporation of desmosome precursors enriched in the plaque protein desm

247 panied by increased EGFR activity, increased desmosome processing and the presence of immature epider

248 Members of the desmosome protein family are integral components of the

249 Mice lacking the desmosome protein Perp exhibit blistering in their strat

250 gap junction protein connexin 43 (Cx43) and desmosome protein plakophilin-2 are working synergistica

251 eg):THY1(neg):DDR2(neg) signature, expresses desmosome proteins and differentiates to adipocytes in A

252 ell-cell adhesion protein E-cadherin and the desmosome proteins DSG2 and DSC2 are important for aggre

253 reduced binding of PG(TR) but not PG(WT) to desmosome proteins DSP and DSG2.

254 ed in cell-cell junctions and interacts with desmosome proteins in the intestinal epithelium.

255 FAPs expressed desmosome proteins, including desmoplakin, predominantly

256 sed primarily by mutations in genes encoding desmosome proteins.

257 oint mutations in genes encoding for cardiac desmosome proteins.

258 mechanism in DSG2-related and probably other desmosome-related ACs.

259 Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molec

260 ions, gap junctions, adherens junctions, and desmosomes represent intricate structural intercellular

261 PV dsg3 autoantibodies were used to initiate desmosome signaling in human keratinocyte cell cultures.

262 ing the end-organ by inhibiting keratinocyte desmosome signaling may be effective for treating desmos

263 Targeting desmosome signaling via inhibition of p38MAPK and HSP27

264 cellular domain is ordered at the individual desmosome, single cell, and cell population levels compa

265 and endocytosis are associated with reduced desmosome size and adhesion defects in tissue of patient

266 However, due to desmosome size, molecular complexity, and dynamics, the

267 variants in genes encoding components of the desmosome, specialized intercellular junctions that conf

268 Desmosome splitting was recapitulated in vitro by exposi

269 hat plakophilin-1 plays an important role in desmosome stability and/or assembly.

270 ding further insights into the complexity of desmosome structure and regulation.

271 1 assembles into both adherens junctions and desmosomes, suggesting that this protein may regulate th

272 drome, and skin from these patients exhibits desmosomes that are reduced in size and number.

273 conclude that kazrin is a novel component of desmosomes that associates with periplakin.

274 y may be key to explaining the plasticity of desmosomes that maintain tissue integrity in their hyper

275 PMN and epithelial intercellular junctions (desmosomes) that regulate PMN transepithelial migration

276 The transmembrane components of the desmosome, the desmogleins and desmocollins, are members

277 Although mutant Dsg2 localizes to endogenous desmosomes, there is a significant delay in its incorpor

278 essed, defects extend to adherens junctions, desmosomes, tight junctions and cortical actin dynamics.

279 Although the importance of desmosomes to epidermal coherence and keratin organizati

280 desmosomal plaque, a structure that connects desmosomes to the intermediate filament cytoskeleton of

281 ell-cell borders and prevents alterations in desmosome ultrastructure in keratinocytes treated with P

282 ICD were decreased, consistent with altered desmosome ultrastructure in plakoglobin CKO hearts.

283 ssing and the presence of immature epidermal desmosomes, upregulated epidermal transglutaminase activ

284 in functioning at the adherens junctions and desmosomes, was shown to be either lost or weakly expres

285 In the developing lens, which has no desmosomes, we discovered that vimentin became linked to

286 omparing tomograms of wild type and knockout desmosomes, we have assigned particular densities to des

287 Ultra-structural analyses revealed that desmosomes were absent in Jup mutant myocardia, whereas

288 plakophilin-1 was expressed in these cells, desmosomes were assembled, as assessed by electron micro

289 g to Dsg3, electron microscopy revealed that desmosomes were dramatically disrupted and keratinocyte

290 The desmosomes were intact in all strains.

291 Numerous, large desmosomes were present at this interface in wild-type m

292 te levels of desmoglein 3 were decreased and desmosomes were reduced in size in patient tissue.

293 e adhesion persisted in the mutant mice, the desmosomes were smaller and less numerous.

294 catenin, is also a structural constituent of desmosomes, where it binds to the cytoplasmic domains of

295 Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the i

296 by specialized cell-cell junctions known as desmosomes, which are characterized by the presence of d

297 ing tight junctions, adherens junctions, and desmosomes, which concentrate in the apical junctional r

298 encodes desmoglein 1, a major constituent of desmosomes, which connect the cell surface to the kerati

299 etically determined abnormalities of cardiac desmosomes, which leads to detachment of myocytes and al

300 rment of both the morphology and function of desmosomes, without noticeable effect on adherens juncti