ライフサイエンスコーパス: desmosterol

1 to be reliable for the analysis of 7-DHC and desmosterol.

2 terol and lanosterol and increased levels of desmosterol.

3 s)) that lack cholesterol and likely contain desmosterol.

4 meostatic and anti-inflammatory functions of desmosterol.

5 en cultures were supplemented with exogenous desmosterol.

6 ient conversion yet of a C22 intermediate to desmosterol (5) or its acetate 6.

7 ro cell assay and led to the accumulation of desmosterol, a Delta5,24 sterol precursor of cholesterol

8 The accumulation of desmosterol, a known liver-X receptor (LXR) activator, w

9 Desmosterol, a late precursor containing the same 5-6 do

10 Desmosterol also inhibited processing of the sterol resp

11 d a significant steady-state accumulation of desmosterol, an immediate precursor to cholesterol.

12 l was substituted with various sterols, only desmosterol and 7-dehydrocholesterol supported internali

13 ro, to participate in the cellular efflux of desmosterol and amyloid-beta peptide (Abeta).

14 ression of Abcg1 or Abcg4 promoted efflux of desmosterol and cholesterol from cells to HDL, and combi

15 24 unsaturated cholesterol precursor sterols desmosterol and zymosterol exerting the largest effects.

16 antagonized by its putative natural ligand, desmosterol (and possibly cholesterol).

17 explored the effects of immediate (7-DHC and desmosterol) and evolutionary (ergosterol) precursors of

18 osterol, dihydrocholesterol, ergosterol, and desmosterol), and six do not (25-hydroxycholesterol, lan

19 astrocytes, promoting efflux of cholesterol, desmosterol, and possibly other sterol biosynthetic inte

20 Our assay also showed that desmosterol antagonized the export of Abeta, presumably

21 show that Abcg4 was able to export Abeta and desmosterol at the BBB level and these processes could b

22 Desmosterol bound to purified LXRalpha and LXRbeta in vi

23 sterol requirement for HSV-1 entry and that desmosterol can operate in virus entry.

24 70% and doubled the rate of plasma membrane desmosterol conversion to cholesterol.

25 Levels of serum and liver desmosterol correlated strongly (r = 0.667, P = 1 x 10(-

26 Desmosterol failed to increase expression of the LXR tar

27 plex virus 1 (HSV-1) required cholesterol or desmosterol for virion-induced membrane fusion.

28 Depletion of desmosterol from these cells resulted in diminished HSV-

29 Serum desmosterol had a higher correlation with the accumulati

30 Whether desmosterol has a more specific role in the pathophysiol

31 imate connection between HCV replication and desmosterol homeostasis and that the enzymes responsible

32 Levels of desmosterol in serum and the liver were associated with

33 es) were similar, suggesting cholesterol and desmosterol in the HSV envelope support similar levels o

34 These results suggest that serum desmosterol is a marker of disturbed cholesterol metabol

35 the cholesterol biosynthetic pathway, namely desmosterol, lathosterol, and lanosterol, as well as 27-

36 Serum desmosterol levels (P = 2 x 10(-6) ) and the serum desmo

37 Serum desmosterol levels and the desmosterol-to-cholesterol ra

38 Both serum and liver desmosterol levels correlated positively with steatosis

39 hat the enzymes responsible for synthesis of desmosterol may be novel targets for antiviral design.

40 ng studies of the Abcg4 dimer suggested that desmosterol showed thermodynamically favorable binding a

41 Cholesterol functioned more effectively than desmosterol, suggesting that the hydrocarbon tail of cho

42 ain (e.g., campesterol, beta-sitosterol, and desmosterol) supported long-term growth of mutant cells,

43 were genetically defined to synthesize only desmosterol to demonstrate that cholesterol is important

44 ully entered DHCR24(-/-) cells, which lack a desmosterol-to-cholesterol conversion enzyme, indicating

45 1 on DHCR24(-/-) fibroblasts, which lack the desmosterol-to-cholesterol conversion enzyme, resulted i

46 terol levels (P = 2 x 10(-6) ) and the serum desmosterol-to-cholesterol ratio (P = 5 x 10(-5) ) were

47 Serum desmosterol levels and the desmosterol-to-cholesterol ratio were higher in individu

48 had a much lower DHA concentration, a lower desmosterol-to-cholesterol ratio, reduced motility, abno

49 o sperm motility, to sperm count, and to the desmosterol-to-cholesterol ratio.

50 vide evidence that regulated accumulation of desmosterol underlies many of the homeostatic responses,

51 25-, and 27-hydroxylase; thus, the effect of desmosterol was LXR-dependent and did not require conver

52 In vitro, lanosterol and desmosterol were found to protect striatal neurons expre

53 ol precursors (cholestenol, lathosterol, and desmosterol) were measured in 50 IF patients at a median