ライフサイエンスコーパス: destabilization

1 ge site through A2-domain-fold thermodynamic destabilization.

2 , whereas the beta-epimer led to significant destabilization.

3 tin cytoskeleton and causing global membrane destabilization.

4 tors might block the kinase-induced membrane destabilization.

5 scripts through its PIN domain, causing mRNA destabilization.

6 increasing the sensitivity of MagLev without destabilization.

7 a two distinct modes of action-epistasis and destabilization.

8 evised to enhance retrieval-dependent memory destabilization.

9 ination on TBA-7 may be responsible for this destabilization.

10 ucts and these adducts lead to lipid bilayer destabilization.

11 onpigmented melanomas via HIF-1alpha protein destabilization.

12 hat are important for APC- or Tnks-dependent destabilization.

13 mation, while EpB3b interactions cause their destabilization.

14 cient nodes fail to mature and undergo rapid destabilization.

15 d by Pd(0) utilizing amide bond ground-state destabilization.

16 lated via tristetraprolin-mediated GILZ mRNA destabilization.

17 proportional to the extent of the mutagenic destabilization.

18 sclerotic process, from initiation to plaque destabilization.

19 reas clpt2 null mutants showed only marginal destabilization.

20 such positive feedback would result in mood destabilization.

21 xicity seen for many vectors due to membrane destabilization.

22 SD-95 in the brain, which stems from protein destabilization.

23 or leading to its ubiquitination and protein destabilization.

24 ISPR/Cas9 activity based on conditional Cas9 destabilization.

25 nsight into how strain accumulates to induce destabilization.

26 icyte loss alone is sufficient for capillary destabilization.

27 uscle cell (SMC) death contributes to plaque destabilization.

28 Numb uncouple Numb from p53 and lead to p53 destabilization.

29 e oxidative stress and the PKC pathway in TJ destabilization.

30 ation and inhibit parasite-promoted membrane destabilization.

31 e occurrence of galvanic corrosion and scale destabilization.

32 confirm that larvae are subject to constant destabilization.

33 lk can be one of the main causes of UHT milk destabilization.

34 because they induce relatively low indirect destabilizations.

35 Q helicases; however, the relatively weak GQ destabilization activity of RECQ5 compared to BLM and WR

36 dy sought to determine whether microvascular destabilization affects organ function and therapeutic n

37 of cell migration and also found that talin destabilization affects the usage of different integrin

38 dings, depletion of PIH1D1 resulted in MRE11 destabilization and affected DNA-damage repair processes

39 g force of Rca is fine-tuned to avoid global destabilization and allow for precise enzyme repair.

40 sed hydration may be responsible for bilayer destabilization and antimicrobial function.

41 are resistant to retrieval-dependent memory destabilization and are associated with an increase in t

42 isruption of the quadruplex leads to micelle destabilization and cargo release.

43 in stathmin in MCPyV ST-mediated microtubule destabilization and cell motility and implicate the cell

44 at such tagging can cause unintended protein destabilization and concomitant effects.

45 es were resistant to soluble CD4-induced Env destabilization and decay.

46 ctivated after ligand stimulation because of destabilization and degradation of c-Cbl and Cbl-b.

47 retin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric struc

48 wedge insertion is not required for AP site destabilization and eversion.

49 as well as Aihara, early put forth that the destabilization and excited state antiaromaticity of the

50 terases, including evidence for ground-state destabilization and functional active-site networks that

51 event T cell proliferation and reduce plaque destabilization and inflammatory markers thus providing

52 o interferes with retrieval-dependent memory destabilization and inhibits the initiation of reconsoli

53 new OI mutation in SERPINH1 that results in destabilization and mislocalization of HSP47 and seconda

54 olidated inhibits retrieval-dependent memory destabilization and modification of the fear memory trac

55 a result, significant challenges arise when destabilization and particle removal are a requirement.

56 Steeper gradients caused lipid bilayer destabilization and pore instability, limiting the total

57 tantly, HDAC6 deacetylates CIDEC, leading to destabilization and reduced lipid droplet fusion.

58 with ULBP2 mRNA, leading to ULBP2 transcript destabilization and reduced ULBP2 surface expression in

59 que storage- and pH-dependent conformational destabilization and refolding of the hole-hole homodimer

60 r, acting as a trigger for further RH domain destabilization and subsequent unfolding.

61 ance of NMDAR subunit composition for memory destabilization and suggest a mechanism for why some mem

62 of the protein responsible for a structural destabilization and the acquisition of novel biologic pr

63 hich surprisingly revealed that ground state destabilization and transition state stabilizing effects

64 While their roles in mRNA destabilization and translational repression are well ap

65 erentiation, Rbfox1 targets pumilio mRNA for destabilization and translational silencing, thereby pro

66 viral IAP evolution in which degron-mediated destabilization and ubiquitination potential have been r

67 tin loop relaxation required for nucleosomal destabilization, and by comparative analyses of the inte

68 s to active site obstruction, hexameric ring destabilization, and discrete quaternary structure trans

69 ation is implicated in atherogenesis, plaque destabilization, and maladaptive processes in myocardial

70 A visual destabilization appeared after 8days of storage with the

71 om ARHGAP18-knockout mice showed microtubule destabilization, as evidenced by altered morphology and

72 s corona discharge, arcing, and electrospray destabilization, because of the presence of polar mobile

73 al evidence was obtained for the fraying and destabilization brought on by NCp7 in its biochemical fu

74 at RECQ5 is not primarily associated with GQ destabilization, but could substitute for the more effic

75 uncover a new function for TREX1 in protein destabilization, but they also suggest a novel mechanism

76 activation and downstream Kv4.3 channel mRNA destabilization by Ang II.

77 We show that chromatin destabilization by clusters of DNA double-strand-breaks

78 n of basal SPHK1 activity enables EC-barrier destabilization by edemagenic agonists.

79 line aptamer and constitutive target protein destabilization by means of ubiquitin fusion.

80 Incorporating TAR destabilization by NC into the mfold-based model reveals

81 Destabilization by pH or His-104 mutation shifts the ACD

82 In the case of BB, cleavage leads to destabilization by the RING E3 ligase PROTEOLYSIS 1 (PRT

83 tin matrix, which was not affected by H-bond destabilization by urea.

84 This mutation-induced destabilization can account for the high propensity of A

85 The destabilization caused by F508del manifests itself in de

86 the stereoconfiguration at C5' with greater destabilization characteristic of (R)-epimers.

87 This destabilization decreases as a function of the distance

88 of RNA [AAGA GGG AUGAC] resulting in thermal destabilization (Delta T m - 10 degrees C per lesion).

89 d versions of Cas9 fused to the FKBP12-L106P destabilization domain in an effort to improve Cas9 perf

90 Our in vivo blunt-end cloning method and destabilization-domain-fused Cas9 variant increase the r

91 tic Ocean) as an archive to investigate PF-C destabilization during the last glacial-interglacial per

92 We exploit the destabilization effect of lipopolysaccharide, an amphiph

93 ion of endothelial cells through microtubule destabilization, enhanced the plasma membrane-bound frac

94 h non-germ-line amino acid content, v-domain destabilization, expression and formulation issues.

95 -terminal fragment of Pih1 contains multiple destabilization factors and acts as a degron when fused

96 rom the core region resulted merely in rotor destabilization (ie, drifting).

97 revealed that Fab binding had caused capsid destabilization in regions containing key residues confe

98 Of note, the H12 destabilization in the active state shifts the conformat

99 We present evidence that pH-induced destabilization in the CH2/3 domain interface of IgG inc

100 rast, PEI- and PMAO-PEG-coated QDs displayed destabilization in the hydroponic medium, and generated

101 roscopy suggest partial unfolding and domain destabilization in the presence of the mutation.

102 significant part, responsible for the prion destabilization in these conditions, underlining the phy

103 mammalian evolution has caused local protein destabilization in two human proteins linked to disease:

104 nd varies from slight stabilization to large destabilization, in some cases leading to formation of o

105 ly glycosylated in vitro, whereas structural destabilization increases glycosylation efficiency.

106 ely, were quantified energetically, with the destabilization increasing linearly for each "incorrect

107 e transport, a decisive infection step where destabilization initiates this non-enveloped virus for m

108 demonstrates that the primary source of the destabilization is a loss of connectivity in proximity o

109 ein depletion by promoter shutoff or protein destabilization is an important tool in investigation of

110 posed to repair broken forks, but how genome destabilization is avoided was unknown.

111 Furthermore, glucose-driven MT destabilization is balanced by new microtubule formation

112 cular dynamic simulations indicate that this destabilization is due to eGFP-promoted entropic stabili

113 The source of this destabilization is illuminated by the X-ray crystal stru

114 Here we demonstrate that PTEN destabilization is induced by EGFR- or oncogenic PI3K mu

115 The duplex destabilization is mediated, in part, by Cas9/guide RNA

116 eas the association of ssDNA reeling with GQ destabilization is more helicase-specific.

117 The destabilization is reflected in melting points that are

118 This DND1-dependent mRNA destabilization is required for the survival of mouse PG

119 st, viral vhs-mediated loss of IFI16 by mRNA destabilization is revealed to be dominant in tumor-deri

120 Atherosclerotic plaque destabilization is the major determinant of most acute c

121 ith p73alpha, indicating that oncosuppressor destabilization largely mirrors the low intracellular st

122 hat MCPyV ST expression promotes microtubule destabilization, leading to a motile and migratory pheno

123 horylates Thr27 of ID2, leading to HIF2alpha destabilization, loss of glioma stemness, inhibition of

124 On the other hand, the destabilization model explains the other three-quarters

125 A rat destabilization model of osteoarthritis (OA) was used to

126 That this destabilization occurs in solution correlates well with

127 grin receptor activation requires TM complex destabilization of 1.5 +/- 0.2 kcal/mol, revealing a siz

128 -O bond in the Phax conformer and additional destabilization of 3-Pheq conformer by repulsion of unid

129 This latter interaction is notable for the destabilization of a flexible helix that bridges the pho

130 al programs similar to those observed during destabilization of a mature CM phenotype in the explant

131 ond formation could be developed through the destabilization of a metal amido complex via photoredox

132 Destabilization of a non-enveloped virus generates a mem

133 intended corroborates the model of preceding destabilization of a progenitor attractor.

134 nt channels produced a temperature-dependent destabilization of activation and fast inactivation.

135 ification of tubulin, and showed evidence of destabilization of additional anterograde transport comp

136 siological AIM-cleavage process that induces destabilization of AIM and its excretion in urine.

137 l counterpart, as a consequence of increased destabilization of anomeric charge development by the el

138 or density was decreased by CA, suggesting a destabilization of anthocyanins.

139 only by expected cytoplasmic miRNA-mediated destabilization of APA mRNA isoforms, but also by affect

140 the basic mechanisms that control growth and destabilization of atherosclerotic plaques.

141 thought to have been driven primarily by the destabilization of carbon from surface sedimentary reser

142 suggesting autophagy locally facilitates the destabilization of cell-matrix contact sites.

143 tent with premature loss of arm cohesion and destabilization of chiasmata, the frequency at which rec

144 has been implicated in the retrieval-induced destabilization of cocaine- and fear-related memories in

145 genes and transcription inhibition leads to destabilization of cohesin on chromatin.

146 of native conformation) and negative design (destabilization of competing folds).

147 Rcf1 and partner proteins and results in the destabilization of complex IV and alteration of its enzy

148 The same E3 ubiquitin ligase promotes the destabilization of components of two distinct protein-im

149 horylation of beta-tubulin and the resulting destabilization of cortical microtubules.

150 ient CX3CL1 production is accompanied with a destabilization of CX3CL1 mRNA associated with the induc

151 ty was ascribable to a temperature-dependent destabilization of cytochrome a heme.

152 active histone modifications but only slight destabilization of DNA methylation.

153 epithelial morphology and characteristics by destabilization of E-cadherin and induction of beta-cate

154 Consistent with destabilization of E-cadherin, NCX1 knockdown cells show

155 ase and Akt pathways and leads to downstream destabilization of endothelial cell-cell junctions.

156 way, known to induce amoeboid properties and destabilization of endothelial junctions.

157 hat acute exposure of neurons to E2 leads to destabilization of GABAARs and gephyrin at inhibitory sy

158 Loss of PCM1 results in destabilization of GABARAP, but not LC3B, through protea

159 Intriguingly, we find that destabilization of gamma occurs only when FoF1 operates

160 We show that the mutation induces a destabilization of gelsolin second domain, without compr

161 -stage process for the initial events in the destabilization of GPCRs by octylglucoside: (i) highly m

162 ain insights into the mechanism of detergent destabilization of GPCRs, we used atomistic molecular dy

163 bile acids is mediated by posttranslational destabilization of HilD.

164 idence obtained by exploiting hypA1-mediated destabilization of HypA(Trs120)/HypC(Trs130)/Trs65 assem

165 e of the other mRNAs and that this selective destabilization of inner-membrane-protein mRNAs is aboli

166 ntegrity of a globular protein and the local destabilization of its amyloidogenic segments may be a f

167 cause of the high water lead levels was the destabilization of lead-bearing corrosion rust layers th

168 40) in mice results in nemaline myopathy and destabilization of leiomodin-3 (LMOD3).

169 show that downregulation of RBFOX1 leads to destabilization of mRNAs encoding for synaptic transmiss

170 N-Myc is required for tumor maintenance, and destabilization of N-Myc through Aurora A kinase inhibit

171 that aberrant function of LRRK2 may lead to destabilization of neural circuits.

172 difiers induce preferential stabilization or destabilization of occluded or nonoccluded states of the

173 ck activation promoted dephosphorylation and destabilization of Pck2, whereas it enhanced Pck1 levels

174 Destabilization of PGC1alpha is attributable to decrease

175 The destabilization of physiological tetramers by PD-causing

176 F through activation of c-src and subsequent destabilization of pVHL.

177 decreasing cluster size due to thermodynamic destabilization of reaction products.

178 olayers could lead to both stabilization and destabilization of reentrant activity.

179 rgan formation in plants by coordinating the destabilization of regulatory proteins.

180 Loss of Oma1 activity leads to a specific destabilization of respiratory supercomplexes and conseq

181 mice results in marked post-transcriptional destabilization of RGS7 and substantial loss of its asso

182 ted cardiomyopathy that is associated with a destabilization of small HSPs as the result of a disrupt

183 ation resulted in increased SIRT1 levels and destabilization of steady-state MYC protein.

184 outward-facing conformations or in a global destabilization of structure.

185 crease in activity mainly occurs through the destabilization of the active site loop involved in subs

186 a homozygous mutation in AP3D1 that leads to destabilization of the adaptor protein 3 (AP3) complex.

187 of dominant clusters is consistent with the destabilization of the B2 structure measured by calorime

188 type, and this appears to be correlated with destabilization of the beta-annulus at the icosahedral 3

189 lative position of cis-double bonds, causing destabilization of the ceramide's interactions and later

190 n hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1, consist

191 uggests the potential for a gradual trend of destabilization of the climate with respect to such shif

192 mRNA harboring a UUG start codon, indicating destabilization of the closed PIN state with a UUG-antic

193 clpt1 and clpt1 clpt2 mutants showed partial destabilization of the ClpPR complex, whereas clpt2 null

194 Destabilization of the coiled-coil domains by site-direc

195 design of cancer therapeutics optimized for destabilization of the complex.

196 ctions within the SMC5/6 complex, leading to destabilization of the complex.

197 ch point to an allosteric effect rather than destabilization of the dimeric structure.

198 g site) and the V3 crown, suggesting general destabilization of the distal region of the trimer apex.

199 rane conductance regulator (CFTR) results in destabilization of the domain, intramolecular interactio

200 Destabilization of the double stranded RNA was measured

201 ha-helical structure without overall thermal destabilization of the enzyme.

202 to the electrospray (ES) chamber, precluding destabilization of the ES tip, even when brought very cl

203 expected from the documented linkage between destabilization of the folded state and formation of mis

204 In contrast to the significant destabilization of the folded structure at high temperat

205 We report that destabilization of the FPC results in reduced spore viab

206 ed KRAS gene expression via hnRNPA1-mediated destabilization of the G-quadruplex on the KRAS promoter

207 A pronounced destabilization of the gamma C-terminal helix during hyd

208 ded N-terminal region of the sequence and by destabilization of the globular segment of the protein.

209 T3), for proteasomal degradation to initiate destabilization of the heterochromatic state of endogeno

210 MCPyV small tumor antigen (ST) promotes the destabilization of the host cell microtubule network, wh

211 a direct role for both HPV E6 and E7 in the destabilization of the host genome by blocking the homol

212 encies depend on the equilibrium between the destabilization of the hydrophobic pocket, the overall f

213 as much reduced despite the mutation-induced destabilization of the Ig20 structure that supposedly we

214 degrades gap-junctional Cx43, leading to the destabilization of the immune synapse and the impairment

215 EOT is observed, which is attributed to the destabilization of the LbL film upon enzymatic degradati

216 izing effect on the A-RNA conformation and a destabilization of the left-handed Z-RNA.

217 es, vinculin activation requires substantial destabilization of the main head-tail interface, which i

218 A promising candidate should display a small destabilization of the matched base pair compared with t

219 nuated articular cartilage damage induced by destabilization of the medial meniscus (DMM) OA-inducing

220 In this study, we performed the destabilization of the medial meniscus (DMM) surgery at

221 s (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for ev

222 PV4 did not prevent OA development following destabilization of the medial meniscus (DMM).

223 Moreover, cartilage damage after surgical destabilization of the medial meniscus of the knee was i

224 OA was induced by destabilization of the medial meniscus.

225 This suggests that destabilization of the membrane-proximal coiled coil res

226 to establish an antiproliferative state via destabilization of the miR-regulated transcriptome.

227 mismatches correlates with the thermodynamic destabilization of the mismatch, also consistent with bi

228 the preterminal integrity, and when absent, destabilization of the motor nerves results in muscle re

229 domonas can regulate gene expression both by destabilization of the mRNA and by translational repress

230 ausing production of a truncated protein and destabilization of the mRNA.

231 penetrance of the phenotype and the level of destabilization of the mutant.

232 inding protein, IGF2BP3, which prevented the destabilization of the nuclear RNA 7SK, a process normal

233 canonical bases with little or preferably no destabilization of the overall duplex.

234 This is paralleled with a destabilization of the peroxide resulting from the addit

235 events are accompanied by pronounced thermal destabilization of the photosynthetic complexes, as evid

236 e same region, resulting in perturbation and destabilization of the probe duplex.

237 Computational modeling suggests that destabilization of the reactant by filled-filled orbital

238 nd the protist Chlamydomonas, accompanied by destabilization of the retrograde IFT dynein motor.

239 h terminally deleted viruses could be due to destabilization of the ribonucleoprotein complexes forme

240 analyses will be needed to determine whether destabilization of the RING peroxin complex observed in

241 sodes have the potential to induce a drastic destabilization of the Sahelian agroecosystem.

242 s located in the axial position but produces destabilization of the silacyclohexane ring.

243 cts with Skp nonspecifically, accompanied by destabilization of the Skp trimer and similar to denatur

244 tochondrial translation defect was caused by destabilization of the small mitoribosomal subunit and i

245 Destabilization of the SRX by piperine was confirmed by

246 Destabilization of the stem-loop immediately upstream of

247 We show that this leads to specific destabilization of the supercomplex, and that changes in

248 gned mutations, we demonstrate that stepwise destabilization of the talin rod R3 subdomain decreases

249 --> beta(3) substitutions caused significant destabilization of the tertiary structure as measured by

250 drogenase (hlGPDH) results in a 9.1 kcal/mol destabilization of the transition state for enzyme-catal

251 effect), which corresponds to a 9.1 kcal/mol destabilization of the transition state for GPDH-catalyz

252 t aggregation of the samples correlates with destabilization of the turn-like structure defined by ph

253 We find that destabilization of the UBL results from rearrangements t

254 ockdown of CYFIP1 in cancer cells led to the destabilization of the WASF3 complex, loss of WASF3 func

255 evidence that the kinesin-13 KLP-7 promotes destabilization of the whole cellular microtubule networ

256 L silencing, this effect was attributable to destabilization of the WRB transcript and not of WRB pro

257 throid or myeloid lineage is preceded by the destabilization of their high-dimensional attractor stat

258 nvert part of the binding energy into active destabilization of their substrates, using the energy di

259 folding landscape, resulting in the dramatic destabilization of this specific structure that is requi

260 of antithrombotic agents by focusing on the destabilization of thrombi rather than the prevention of

261 to alpha3beta4 and alpha3beta2 suggest that destabilization of toxin contacts with residues at the p

262 Surprisingly, bile salt destabilization of ToxRp enhanced the interaction betwee

263 Thus, destabilization of TRAF2 by miR-17 reduced the ability o

264 ange of effects, from local stabilization or destabilization of transient secondary structure to glob

265 P78 complex, and suppression of GRP78 led to destabilization of WASF3 at the mitochondrial membrane,

266 Similarly, destabilization of wild-type E-S complexes by temperatur

267 This paradox points to nucleosome destabilization or eviction as a defining feature of the

268 There was also no role for lysosomal destabilization or neutrophil elastase in pneumolysin-me

269 embly process through solvent evaporation or destabilization or through DNA-guided crystallization.

270 omplexes leads to slow but progressive nodal destabilization over 10 months, primarily affecting beta

271 standing of processes of C stabilization and destabilization over various timescales, soil types, and

272 in addition to the emulsions caused emulsion destabilization probably due to depletion or bridging ef

273 We present a detailed survey of the ongoing destabilization process of the Mosul dam.

274 s Aurora A kinase inhibitors promoting N-Myc destabilization progress in the clinic.

275 Lysosomal destabilization rates increased directly with Cu influx

276 sidence time on InhA due to transition-state destabilization rather than ground-state stabilization.

277 In these experimental systems, destabilization/regression was driven by lysophosphatidi

278 nsions of the original stress-induced duplex destabilization (SIDD) method, which analyzes stress-dri

279 reveal the novel principle that coordinated destabilization-stabilization drives membrane transport

280 This destabilization strongly affected E-cadherin anchoring t

281 US outside the rib meristem leads to protein destabilization, suggesting a new tier of regulation in

282 cancer; knockdown of Dub3 resulted in Snail1 destabilization, suppressed EMT and decreased tumour cel

283 supposed to be a major factor in microtubule destabilization, the binding of 14-3-3zeta to MAP2c enha

284 2 and to confirm its implication in UHT milk destabilization, the enzyme was purified and added to mi

285 These results strongly suggest that Nox2 destabilization through disrupting TRPC3-Nox2 complex un

286 Here, we describe the destabilization through mutagenesis of the dimer interfa

287 ane fusion mediated by progressive S protein destabilization through receptor binding and proteolytic

288 e droplet size and did not show any physical destabilization throughout the study.

289 st balance catalytic function with inhibitor destabilization to provide a fitness advantage.

290 Second, both caused Lipoplex destabilization to release double- and single-strand siR

291 oviding an under-appreciated mechanism for C destabilization under elevated moisture.

292 luding that: (i) modifying the stem leads to destabilization unless adenosine is the opposing basepai

293 Here, we show that EnHD undergoes destabilization upon fusing it to eGFP regardless of the

294 anion transporter, band 3, triggers membrane destabilization, vesiculation, and fragmentation, we dis

295 UHT milk destabilization was investigated during 90days of storag

296 Strong emulsion destabilization was observed, with smaller aggregates an

297 The destabilization was rescued by inhibition of ROCK and hi

298 Oxidative auto-inactivation and destabilization were observed in the absence of a suitab

299 Products of Lipoplex destabilization were separated, identified, and/or quant

300 normal morphology, which undergo accelerated destabilization within a month, resulting in rapid volta