ライフサイエンスコーパス: destabilize

1 s, the cellular genome becomes significantly destabilized.

2 The dimeric helicates are entropically destabilized.

3 inance hierarchy of rats was formed and then destabilized.

4 ently cleaved by the activated peptidase and destabilized.

5 Cl(-) channels but that the majority remain destabilized.

6 onfiguration that stretch activation rapidly destabilizes.

7 ing, whereas the 1,5-triazole is carbocation-destabilizing.

8 the key affinity mutations in the CDRs were destabilizing.

9 predicted that 81% of AD-HIES mutations are destabilizing.

10 Depletion of TIRR destabilizes 53BP1 in the nuclear-soluble fraction and a

11 BP12 dissociation, and disease mutations all destabilize a D354-R375 salt-bridge, which normally acts

12 d stabilize a mismatched ternary complex and destabilize a matched ternary complex, and provided evid

13 fermentation can conditionally stabilize or destabilize a mutualism, indicating the potential import

14 positive feedback loops that are required to destabilize a spatially uniform state of the cell.

15 This destabilizing activity is dependent on the presence of D

16 Among these, the microtubule-destabilizing activity of pseudolaric acid B (PAB) holds

17 m and pericytes; and increases in the vessel destabilizing agent, angiopoietin-2.

18 mor growth and vascularization using tubulin-destabilizing agents.

19 Thus, most AD-HIES STAT3 mutations are destabilizing; agents that modulate chaperone protein fu

20 s-dependent reductions in the secretion of a destabilized, aggregation-prone protein and increases it

21 tial channel 1 (Trpc1)-mediated Ca(2+) entry destabilizes AJs.

22 olidation theory proposes that retrieval can destabilize an existing memory trace, opening a time-dep

23 activity, whereby eIF2alpha phosphorylation destabilizes an autoregulatory intramolecular interactio

24 et and the N-terminal cap helix that in turn destabilizes an N-terminal latch region against the PAS

25 lective fishing can rapidly and continuously destabilize and degrade ecosystems even after fishing ha

26 s, K101E and K101C/E107C, which respectively destabilize and stabilize oligomers.

27 Although thermodynamically destabilized and aggregation-prone, these mutants were f

28 cell Clec16a-Nrdp1-USP8 mitophagy complex is destabilized and dysfunctional after lenalidomide treatm

29 lar disulfide, the Rgg2Sd dimer interface is destabilized and Rgg2Sd can adopt multiple conformations

30 onged cycles of stretch forces, caveolae are destabilized and the plasma membrane is prone to rupture

31 ituent is a sigma-donor, the ground state is destabilized, and the reactivity is enhanced.

32 at the interface of adjacent protein layers destabilize archaeal chromatin, reduce growth rate, and

33 ing (Ca(2+) signalling silencing) and Ca(2+) destabilizing (arrhythmogenic unstable Ca(2+) signalling

34 articularly on conditions that cause them to destabilize, ascend, and accumulate in voluminous but ep

35 h-affinity binding is observed until LacY is destabilized at alkaline pH.

36 ase, which poly(ADP-ribosyl)ates and thereby destabilizes AXIN, also can polymerize, but the relevanc

37 We find that BAF47 loss destabilizes BAF complexes on chromatin, absent signific

38 ) of BCL2 and BIK, LARP1 stabilizes BCL2 but destabilizes BIK with the net effect of resisting apopto

39 (CDK1) at two conserved sites in this region destabilizes binding to Mis18alpha:Mis18beta, limiting c

40 heat-sensitive M. vaginatus could ultimately destabilize biocrusts when precipitation changes are com

41 Moreover, C5-methylation destabilizes both nOpi* and nNpi* dark states, thus prev

42 tes that protonation of the buried histidine destabilizes both PrP variants, but produces a more dras

43 the intron downstream of the branch point to destabilize branching-specific factors and release the b

44 Similar systems could be destabilized by any of several mechanisms, contributing

45 tabilized while non-native conformations are destabilized by our optimization, making the funnel-like

46 as the only ER-associated chaperone that was destabilized by reductive stress.

47 levels despite the decrease in RDH10 protein destabilized by the absence of DHRS3, hence demonstratin

48 ld produce the unobserved indole product, is destabilized by the electron-withdrawing phthalimide sub

49 ion of CAMKIIgamma with a specific inhibitor destabilized c-Myc and reduced tumor burden.

50 SCP1 strongly dephosphorylated c-Myc Ser62, destabilized c-Myc protein and suppressed c-Myc transcri

51 d in Adams-Oliver Syndrome patients strongly destabilize cell-cell contacts and (ii) CdGAP mRNA level

52 Reduction of NOTCH1 destabilizes cellular junctions and triggers endothelial

53 t monolayer, can also be used to selectively destabilize chain-chain interactions near the headgroups

54 Non-physiological destabilizing conditions used in many in vitro aggregati

55 profiles are stratified into stabilizing and destabilizing conditions.

56 HuR and PARN destabilize Ctn RNA in absence of ADAR2, indicating that

57 We propose that dNedd4Lo destabilizes dAmph in muscles, leading to impaired T-tub

58 ition step, the target enzyme is designed to destabilize detection probe derived from an aptamer spec

59 timescale protein motions, consistent with a destabilized dimer interface.

60 nvironmental toxin, formaldehyde, stalls and destabilizes DNA replication forks, engendering structur

61 degradation with a small molecule by using a destabilizing domain (DD).

62 We demonstrate that fusing an FKBP12-derived destabilizing domain to Cas9 (DD-Cas9) enables condition

63 forms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimu

64 ein-based transport, whereas the microtubule-destabilizing drugs, eribulin and vincristine, which bin

65 This destabilizing effect is supported by ab initio calculati

66 e novel sequons can cause disease due to the destabilizing effect of a bulky N-glycan.

67 ns are expected to compensate for the genome-destabilizing effect of environmental DNA damage and may

68 ntext, and resolve ambiguities regarding the destabilizing effect of H2A.X phosphorylation.

69 rticles that is insufficient to overcome the destabilizing effect of scattering force and Brownian mo

70 ised DNA binding with reduced stability, the destabilizing effect of T158M being more severe.

71 Conversely, Prickle in the same cell has a destabilizing effect on Frizzled.

72 ligand-protein interactions and an indirect destabilizing effect on intraprotein interactions that i

73 The equatorial C-F bond has a much greater destabilizing effect on TS2 due to the more efficient th

74 To show the destabilizing effect, we measured discordant gene expres

75 ains can suppress transformation, the genome-destabilizing effects of aneuploidy confer an evolutiona

76 The destabilizing effects of D302A are perpetuated in the fu

77 and TEV) and found them to be susceptible to destabilizing effects of human alpha-defensins HNP-1 and

78 a et al. characterize for the first time the destabilizing effects of mutations in the region of AT t

79 Moreover, the destabilizing effects of these mutations were compensate

80 The destabilizing effects of TTR deuteration are rather simi

81 bond dipoles in the equatorial conformer, a destabilizing electrostatic effect that is shielded by t

82 al crosslinking showed that Rca structurally destabilizes elements of the Rubisco active site with re

83 ry structures and almost devoid of loops and destabilizing elements, such as cavities.

84 The mutations that cause destabilizing evQTLs were found to be associated with mo

85 The vascular-destabilizing factor Angiopoietin-2 (Angpt-2) has been i

86 The mRNA-destabilizing factor tristetraprolin (TTP) binds in a se

87 nase p38, increases the activity of the mRNA-destabilizing factor tristetraprolin, and thereby inhibi

88 econd, p38-mediated inactivation of the mRNA-destabilizing factor tristetraprolin, which we show is a

89 renders it constitutively active as an mRNA-destabilizing factor.

90 mics of miRNA activity in living cells using destabilized fluorescent proteins (dsFPs).

91 Reduced abundance can destabilize food webs, leading to cascading indirect eff

92 -encoded competition between stabilizing and destabilizing forces, and genetic alterations in these m

93 Here we report that CK1alpha similarly destabilizes FOXO4 in RAS-mutant cells by phosphorylatio

94 By contrast, ivacaftor further destabilized full-length F508del-CFTR and accelerated ch

95 s: stabilizing poly-U and UUAG sequences and destabilizing GC-rich signals.

96 Here, using a transgenic mouse line with destabilized GFP, we identified an 11-kb genomic region

97 nd deficits in grid cell function, including destabilized grid fields and reduced firing rates, as we

98 strate that SALL4 promotes open chromatin by destabilizing heterochromatin protein 1alpha (HP1alpha)

99 uronal three-dimensional genome organization destabilize higher order chromatin at specific loci that

100 Substitution mutations around the interface destabilized higher-order complex formation and altered

101 We conclude that conditions that destabilize HMW oAbeta or retard the sequestration of sm

102 We conclude that conditions that destabilize HMW oligomers or retard the sequestration of

103 city with inhibitors or febrile temperatures destabilized HSP90-buffered mutants, exacerbating FA-rel

104 ts indicate that MPK3/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF express

105 Our results indicated that reductase becomes destabilized in the absence of UBIAD1, resulting in redu

106 tly classify the mutations as stabilizing or destabilizing in 84% of the cases, and obtain statistica

107 cement occurs via direct dissociation of the destabilized incumbent strand from the substrate strand.

108 ved Glu and Val counterpart residues in NusG destabilized interactions between the RfaH domains and a

109 first time essential in vivo stabilizing and destabilizing interactions of the core proteins required

110 um sensing but competition and cheating will destabilize it.

111 eoxycholate interact with purified ToxRp and destabilize it.

112 Here, we studied NTD mutations designed to destabilize its structure utilizing NMR and fluorescence

113 Our results support a model in which dynein destabilizes its microtubule substrate by using its moti

114 Destabilized JB12 was degraded by ER-associated degradat

115 ions that mimic constitutive phosphorylation destabilized K fibers in vivo and reduced the efficiency

116 nds on Cyclin A/Cdk1 activity and that MYPT1 destabilizes k-MT attachments by negatively regulating P

117 eviously, we demonstrated that Cyclin A/Cdk1 destabilizes k-MT attachments to promote faithful chromo

118 ly, pathogenic PSEN or APP mutations further destabilize labile E-S complexes and thereby promote gen

119 own of USP9X significantly downregulated and destabilized LATS and resulted in enhanced nuclear trans

120 tigate how a pore-forming, virucidal peptide destabilizes lipid vesicles in a surface-based experimen

121 impaired MECP2 binding to methylated DNA and destabilized MeCP2 protein in an age-dependent manner, l

122 tressors increase turf and macroalgal cover, destabilizing microbiomes, elevating putative pathogen l

123 netochore-targeting assay, we show that Mps1 destabilizes microtubule attachments (K fibers) epistati

124 on in vivo, and suggest that RPM-1 signaling destabilizes microtubules to facilitate growth cone coll

125 that rigosertib indeed directly binds to and destabilizes microtubules using cell biological, in vitr

126 ishing that rigosertib kills cancer cells by destabilizing microtubules.

127 y role in regulating microtubule dynamics by destabilizing microtubules.

128 Diabetes mellitus destabilized microvascular vessels of the heart, affecti

129 ve Ipl1/Aurora B complexes to preferentially destabilize misattached kinetochores.

130 other hand, the four ZFs in the structurally destabilized Miz1-4(A86K) mutant bound to the DNA consen

131 corresponding to nine chemokine 3'-UTRs that destabilized mRNA in a reporter assay.

132 miR171 destabilizes mRNAs encoding the root-specific family of

133 red an alpha-tubulin (TBA-7) that appears to destabilize MTs.

134 riants form amyloids, whereas their strongly destabilized mutants form both amyloids and nonamyloid a

135 In the more destabilized mutants, the capacity of this network is ov

136 Helix-destabilizing mutants designed based on our model shift

137 A destabilizing mutation, L68Q, increases the rate of doma

138 Destabilizing mutations are often implicated in disease,

139 hat a correct combination of stabilizing and destabilizing mutations is key for immunoglobulin light-

140 To disentangle these two effects, we use destabilizing mutations that shift the Tm and Cm.

141 Additionally, some variants destabilize MutSbeta, potentially masking the effects of

142 YTHDF2 binds and destabilizes N(6)-methyladenosine (m(6)A)-modified mRNA.

143 Destabilized nanobodies can be used to deliver fluoresce

144 vironment feedback interactions that rapidly destabilize neural and behavioral dynamics demonstrating

145 factor that inhibits nerve regeneration and destabilizes neuromuscular junctions.

146 somes at locations where we expected to find destabilized nucleosomes, for example, at transcription

147 chromosomes that receive a crossover and is destabilized on those lacking crossovers, a process that

148 ed that Larsen syndrome associated mutations destabilize or even unfold domain 17.

149 recipitate broad-faces, while simultaneously destabilizing other interfaces.

150 In the destabilizing P405M mutant, increased flexibility is evi

151 ion, and charge transfer in competition with destabilizing Pauli repulsions.

152 Inhibition of EGF signalling by gefitinib destabilizes PD-L1, enhances antitumour T-cell immunity

153 protein, responding to both stabilizing and destabilizing perturbations.

154 opic agent urea do not affect native Env but destabilize perturbed states induced by cold or CD4Ms an

155 ion with GSK3beta facilitates control of the destabilizing phosphorylation of beta-catenin at Ser-33/

156 The S443D mutation destabilizes prefusion F proteins by disrupting a hydrog

157 n of the antigen-binding site is generally a destabilizing process and that co-enrichment for compens

158 phenotype can also be induced by agents that destabilize protein structure.

159 that under homeostatic conditions, the mRNA-destabilizing protein tristetraprolin (TTP) regulates ap

160 The microtubule-destabilizing protein, stathmin, has recently been shown

161 uitin-modifying enzyme, TNFAIP3, or the mRNA-destabilizing protein, ZFP36.

162 ability, recent work shows that crowding can destabilize proteins through transient attractive intera

163 diseases is associated with mutations that, destabilizing proteins native state, promote their aggre

164 stability by limiting the interaction of RNA-destabilizing proteins with their cognate substrates.

165 mer interface, which remarkably include both destabilizing (Q89H and Y96Q) and stabilizing (T94H) mut

166 absence of these helicases is suppressed by destabilizing R-loops while Pif1 and Rrm3 binding to tDN

167 he number of HO collisions leading to genome-destabilizing R-loops.

168 ge urban centers in the midcontinental US by destabilizing regional agricultural systems, thereby con

169 up, albeit the 1,5 triazole is significantly destabilizing relative to phenyl.

170 In this paper, we use conditionally destabilized reporters that undergo misfolding and ubiqu

171 Destabilizing residues within the VL domain are likely t

172 sequences are also replete with coiled-coil destabilizing residues.

173 ing any CDR loop in the VH domain triggers a destabilizing response in all CDR loops in the VL domain

174 In the absence of ACP, the complex is destabilized resulting in a profound depletion of FeS th

175 rotein (RP) mRNAs whereas glucose starvation destabilized RP transcripts through Hog1.

176 o triplet-favored ions resulting from both a destabilized singlet state (Huckel antiaromatic) and a s

177 as storm events and surface snowmelt runoff destabilize smaller hot spring environments with smaller

178 tabilizes Smo, whereas desumoylation by Ulp1 destabilizes Smo in a phosphorylation independent manner

179 -25B mutations impair synaptic exocytosis by destabilizing SNARE assembly, rather than stabilizing SN

180 RO-destabilizing solutes (urea, KCl) reduce ka comparably (

181 y analyzing effects of RO-stabilizing and RO-destabilizing solutes on association (ka) and dissociati

182 In contrast, increasing the number of helix-destabilizing, ss-branched valine or isoleucine residues

183 human PBMCs or mouse splenocytes containing destabilizing STAT3 mutations with either HSF1A or GGA i

184 Treatment of EBV cells containing destabilizing STAT3 mutations with either HSF1A or GGA n

185 ions provide insight into how ATP hydrolysis destabilizes strand exchange products.

186 nd stabilize the membrane-embedded partially destabilized SV40, thereby preventing premature viral di

187 ow low aggregation propensity and moderately destabilized sw ApoMb variants form amyloids, whereas th

188 Our findings indicate that RIN1 destabilizes synaptic connections and is a key player in

189 in the 3' untranslated regions of mRNA, and destabilizes target mRNAs through direct recruitment of

190 by inhibiting translation initiation and by destabilizing target mRNAs.

191 Considerable evidence indicates that miRNAs destabilize targeted mRNAs by recruiting enzymes that fu

192 Here we report that FAF1 destabilizes TbetaRII on the cell surface by recruiting

193 stently, the Arg116 and Arg117 substitutions destabilize TC binding to 48S PICs reconstituted in vitr

194 compete with Met-tRNAi for eIF2-GTP and can destabilize TC.

195 sphorylated eIF2, eIF2B outcompetes eIF5 and destabilizes TC.

196 minyl radical and sigma-electron acceptor to destabilize the aminyl radical cation.

197 Furthermore, nucleic acid binding mutants destabilize the association of SUV39H1 with chromatin in

198 DMSO concentrations higher than 4% (v/v) destabilize the avidin tetramer toward dissociation and

199 nulus had been disrupted and that this could destabilize the capsid.

200 ABSTRACT: Imbalances of ionic currents can destabilize the cardiac action potential and potentially

201 ell apoptosis by forming discrete pores that destabilize the cellular membrane.

202 dimer interface and high NaCl concentrations destabilize the clamp, but neither facilitates the forma

203 ion, and that disruption of this balance can destabilize the clock.

204 Both R13P and K16D substitutions destabilize the closed complex at UUG codons in reconsti

205 hypothesized that the bulky residues should destabilize the closed conformation and eliminate the ap

206 e the A1-GpIbalpha complex and to indirectly destabilize the complex through the N-terminal linker.

207 we made mutations in atlastin to selectively destabilize the crossover conformation and used fluoresc

208 the Escherichia coli beta-sliding clamp that destabilize the dimer interface to determine whether the

209 encounters the ordered N-terminal domain to destabilize the ESCRT-III lattice.

210 ognize and bind target DNAs, and they likely destabilize the formation of functional complexes.

211 These elements can potentially destabilize the genome by initiating their own replicati

212 we propose that the activating substitutions destabilize the inactive conformation of MEK1, resulting

213 inating this barrier is the use of strain to destabilize the localized semibullvalene.

214 tiaromatic character, which is understood to destabilize the macrocycle upon conjugation.

215 missense mutations (T158M, R106W, and P101S) destabilize the MeCP2 MBD and disrupt the recognition of

216 raction, in incompatible pollen tubes, might destabilize the mitochondria and contribute to arrest po

217 Disease-linked mutations tend to destabilize the native dimeric structure of SOD1, and pl

218 nt CRY2 phosphorylation to both activate and destabilize the photoreceptor.

219 Mutations in the cytoplasmic alphaL8-9 loop destabilize the protein but do not affect Na,K-ATPase ac

220 conjugated circuits (piCCs) and stabilize or destabilize the resulting H-bonded complexes.

221 le residues at the interface may drastically destabilize the SOD1 homodimer, with several modificatio

222 These epithelial changes further destabilize the tear film, amplify inflammation, and cre

223 d that mutations in the HIV-1 envelope (Env) destabilize the V3 loop, rendering neutralization-resist

224 knockdown of KLF15 reduced cell survival and destabilized the actin cytoskeleton in differentiated hu

225 GluA2-C528L destabilized the AMPAR-CNIH3 complex but stabilized the

226 Inhibition of HSP90 with PU-H71 destabilized the BCR kinases and caused apoptosis of CLL

227 conformation, we identified conditions that destabilized the dimer and measured the effects of these

228 r74 and Phe76) in the dimerization interface destabilized the dimer in solution and severely diminish

229 Substitution of Cys14 to Ala, which destabilized the N-terminal Fe4 S4 cluster in vitro, cau

230 even the rather mild L28A mutation severely destabilized the NTD, drastically reducing TDP-43's in v

231 Both deletions destabilized the outer capsid.

232 y proteins revealed that claudin-1 induction destabilized the SD protein complex in podocytes, with s

233 Under insonation, the ultrasound energy destabilized the SED disrupted membranes, resulting in m

234 (G)N2H2...O2(T) hydrogen bond, significantly destabilized the transient tautomeric and anionic specie

235 istically, we found that TAT-Kalpha2 peptide destabilized the viral membranes, depending on their lip

236 Exposure to systemic antibiotics destabilized the wound microbiota, rather than altering

237 hat glutathionylation of C408 allosterically destabilizes the active-like state of BAK1 and stabilize

238 Functionally, ZIKV-NS2A, but not DENV-NS2A, destabilizes the AJ complex, resulting in impaired AJ fo

239 bly of several other N-DRC subunits and also destabilizes the assembly of several closely associated

240 Instead, the lack of PsaI destabilizes the association of PsaL and PsaH to PSI, bo

241 a hypermorphic Zap70 mutation, W131A, which destabilizes the autoinhibitory conformation of Zap70, r

242 A single triplet mismatch destabilizes the complex, and in this case, no translati

243 show that substrate shortening progressively destabilizes the consecutive enzyme-substrate (E-S) comp

244 In vivo, the alf4 mutation destabilizes the CUL1 subunit of the SCF Reduced CUL1 le

245 Tyr or Ala eliminates the cooperativity and destabilizes the dimer.

246 al perturbation in the A2 domain and thereby destabilizes the domain by approximately 10 kJ/mol, prom

247 sposition and trans-V(D)J recombination that destabilizes the genome and shares features with reporte

248 The D302A substitution destabilizes the I-domain by 4 kcal/mol, whereas H305A h

249 loid that dissipates the hairpin species and destabilizes the interaction of hnRNP K with the Mid-reg

250 rds the guanine nucleotide-binding site, and destabilizes the interface between the Galphai1 Ras and

251 PbI2 does not support bridging, its presence destabilizes the large (100) faces of NPLs, providing me

252 with MCM subunits Mcm2, 4 and 6, which both destabilizes the Mcm2-5 interface and inhibits MCM ATPas

253 t hairpin RNA (shRNA) in breast cancer cells destabilizes the Myc protein and increases pT58 levels,

254 pts this elaborated interaction network, and destabilizes the NS1 dimeric assembly in vitro.

255 cts as an incessantly active "agitator" that destabilizes the packing of adjacent residues, causing a

256 Its depletion destabilizes the pluripotency network and triggers diffe

257 efficiencies suggest that m(6)A selectively destabilizes the portion of the hairpin stem where the U

258 Conversely, RelQ's enzymatic activity destabilizes the RelQ:RNA complex.

259 Eliminating ATRX in senescent cells destabilizes the senescence-associated heterochromatic f

260 e propose that Ca(2+) binding allosterically destabilizes the terminal regions of C2alpha and thereby

261 twisted intermediate state ((1)p*) and that destabilizing the (1)p* state by an electron-withdrawing

262 eptor binding, we hypothesize that mutations destabilizing the ApoE4 intermediate state change hinge

263 f myosin in a small region at the cell rear, destabilizing the axial symmetry of a moving cell.

264 of channel gating revealed that AITC acts by destabilizing the closed channel, whereas menthol stabil

265 lex led to delayed fimbria assembly, whereas destabilizing the complex resulted in no fimbriation.

266 nds strongly, increasing the steric bulk and destabilizing the complexes.

267 minus all the way to the C terminus, without destabilizing the dimeric state.

268 rearrangement by potentially stabilizing or destabilizing the domain interfaces of integrin.

269 tail from its pincerlike head domains before destabilizing the head-tail interfaces.

270 o suppression of the local magnetic moments, destabilizing the initial fcc structure.

271 GITR mAb are thought to act by depleting and destabilizing the intratumoral T regulatory cell (Treg)

272 rvature and lipid ordering, constricting and destabilizing the membrane neck, causing scission.

273 astrulation through two distinct mechanisms: destabilizing the myosin II (MII) hexameric complex and

274 nd acting as natural "anti-chaperones", i.e. destabilizing the native conformation of the toxins.

275 er of this class, prevents pore formation by destabilizing the prepore into a poorly structured dodec

276 RNA-DNA complex formation, thus additionally destabilizing the protospacer duplex.

277 USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this rea

278 dentified various mechanisms responsible for destabilizing the V3 loop; here, we determined, via muta

279 important in preventing sensory signals from destabilizing the walking pattern.

280 kin 6 (IL-6) among others, and stabilize and destabilize them, respectively.

281 ed that manipulating cocaine-cue memories by destabilizing them through interfering with the reconsol

282 Disruption of the D411-S4 interactions destabilizes these early closed states, leaving hERG cha

283 ith tight junctions, its downregulation also destabilizes these junctions.

284 We propose that Stu2 destabilizes these plus ends to indirectly contribute to

285 of the reverse reaction, as conditions that destabilize this conformation also trigger reversal.

286 Amino acid deletions that destabilize this region impair the viral replication cyc

287 l analysis and unraveled how phosphorylation destabilizes this highly conserved salt-bridge in tempor

288 Our data indicate ATP binding destabilizes this interaction via an allosteric link bet

289 osphorylation of Dam1 protein by Ipl1 kinase destabilizes this interaction.

290 Destabilizing this interaction accelerates RNA duplex un

291 al inputs are decreased: (1) the L state can destabilize through a Hopf bifucation as the external in

292 After PNG activation GNU is destabilized, thus inactivating PNG.

293 model whereby bile salts or other detergents destabilize ToxR, increasing its interaction with ToxS t

294 l) they increase kd, demonstrating that they destabilize TS relative to reactants and RO, and that TS

295 ween two phenylalanine residues leading to a destabilized uS12 that was poorly tolerated in 40S subun

296 with USP7 target engagement in cells, FT671 destabilizes USP7 substrates including MDM2, increases l

297 unfold the wild-type titin(I27) domain and a destabilized variant far more rapidly when pulling from

298 Instead, the dynamic TIM23 complex is destabilized when the PC levels are reduced, whereas the

299 demonstrate that weberite-type order becomes destabilized with increasing values of this size ratio,

300 stable than less substituted isomers but are destabilized within smaller concave environments (TON) b