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1 ale of water heating (<20 ps), single-strand destacking (700 ps to 2 ns), and hairpin destacking (mic
3 idual sheets of the invasion assay were then destacked and the number of cells in each layer quantifi
4 se results suggest that binding-induced base destacking at the rRNA A site is a critical factor in de
5 rRNA binding affinity and drug-induced base destacking being important determinants in the prokaryot
6 intermediate collapsed structures, labile in destacking but compact in nature, and indicates that mel
7 ot appear to have practical value because of destacking caused by the changing organic composition th
12 and destacking (700 ps to 2 ns), and hairpin destacking (microseconds and longer) in solutions of var
13 design process, since aminoglycoside-induced destacking of A1492 and A1493 is thought to be a determi
14 these binding reactions being coupled to the destacking of adenine residues from the terminal G-tetra
15 By contrast, the binding of G418 induces the destacking of base 1492 when either rRNA A site serves a
16 lution as compared to a Tris glycine system, destacking of proteins down to 6.5 kDa, and a 100-fold b
17 ic rRNA A-site being dictated by the coupled destacking of the adenine residues at positions 1492 and
19 the protein binding cavity with concomitant destacking of the opposing complementary 2-Ap nucleotide
20 ational change in the rRNA that involves the destacking of two adenine residues (A1492 and A1493 in E
22 ide of the CPD lesion was more disrupted and destacked than the 3'-side in substrate-protein complexe
24 ncement of fluorescence could be observed by destacking the molecules in organic solvents, such as is
25 e largely explained by the energetic cost of destacking the templating base and stacking of pyrene nu
26 ification of the extent of drug-induced base destacking, thereby providing a convenient tool for eval
27 ts; not only are the bases almost completely destacked upon coordination to the metal in both cases,
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